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1. 发明授权

US06770799B2 Expression of recombinant human acetylcholinesterase in transgenic plants 有权
公开(公告)号：US06770799B2
公开(公告)日：2004-08-03
申请号：US09810861
申请日：2001-03-16
申请人： Tsafrir S. Mor , Hermona Soreq , Charles J. Arntzen , Hugh S. Mason
发明人： Tsafrir S. Mor , Hermona Soreq , Charles J. Arntzen , Hugh S. Mason
IPC分类号： A01H100
CPC分类号： C12N15/8242 , C12N9/18 , C12N15/8257
摘要： Briefly stated, the invention includes a method of making a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase, comprising the steps of introducing into at least one plant cell a polynucleotide that encodes a human acetylcholinesterase, and regenerating from the plant cell a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase in at least one tissue type of the transgenic plant. Another embodiment of the invention includes a method of making a physiologically active human acetylcholinesterase, comprising the steps of introducing into at least one plant cell a polynucleotide that encodes a human acetylcholinesterase, regenerating from the plant cell a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase in at least one tissue type of the transgenic plant, and isolating or purifying from the transgenic plant or a part thereof a physiologically active human acetylcholinesterase.

2. 发明申请

US20130164288A1 READTHROUGH ACETYLCHOLINESTERASE (ACHE-R) FOR TREATING OR PREVENTING PARKINSON'S DISEASE 审中-公开
标题翻译：准备乙酰胆碱酯酶（ACHE-R）治疗或预防帕金森病
公开(公告)号：US20130164288A1
公开(公告)日：2013-06-27
申请号：US13820525
申请日：2011-09-07
申请人： Hermona Soreq , Ilya Ruderfer , Yoseph Shaaltiel
发明人： Hermona Soreq , Ilya Ruderfer , Yoseph Shaaltiel
IPC分类号： C12N9/18 , C12N9/96
CPC分类号： A61K38/465 , A61K47/60 , C12N9/18 , C12Y301/01007
摘要： A method of treating or preventing Parkinson's disease in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of AChE-R, wherein the AChE-R is devoid of an N-terminal extension. An additional method of treating or preventing Parkinson's disease in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of AChE-R, wherein the AChE-R comprises a modification for increasing bioavailability.
摘要翻译：公开了在有需要的受试者中治疗或预防帕金森病的方法。该方法包括向受试者施用治疗有效量的AChE-R，其中AChE-R缺乏N-末端延伸。公开了一种在受试者中治疗或预防帕金森病的另外的方法。该方法包括向受试者施用治疗有效量的AChE-R，其中AChE-R包含用于提高生物利用度的修饰。

3. 发明申请

US20130018081A1 AChE ANTISENSE OLIGONUCLEOTIDE AS AN ANTI-INFLAMMATORY AGENT 审中-公开
标题翻译： AChE抗体寡核苷酸作为抗炎剂
公开(公告)号：US20130018081A1
公开(公告)日：2013-01-17
申请号：US13351171
申请日：2012-01-16
申请人： Hermona Soreq , Raz Yirmiya , Amir Dori , Gal Ifergane , Michal Ivri
发明人： Hermona Soreq , Raz Yirmiya , Amir Dori , Itzhak Wirguin , Gal Ifergane
IPC分类号： A61K31/7105 , A61P25/00 , A61P29/00 , A61P27/02 , A61P1/04 , A61P17/00 , A61P13/00 , A61P25/02 , A61P37/00 , A61P1/00 , A61P11/00
CPC分类号： A61K48/00 , A61K9/0019 , A61K9/08 , A61K31/7088
摘要： Disclosed is a novel use for AChE antisense oligonucleotides as anti-inflammatory agents, wherein said oligonucleotides are preferably as denoted by SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:7. Methods of treatment of inflammatory conditions, as well as fever, and particularly inflammation-associated neuropathies such as Guillain-Barré Syndrome, are described.
摘要翻译：公开了用于AChE反义寡核苷酸作为抗炎剂的新用途，其中所述寡核苷酸优选如SEQ ID NO：1，SEQ ID NO：2和SEQ ID NO：7所示。描述了治疗炎性病症以及发烧的方法，特别是炎症相关神经病如吉兰巴利综合征。

4. 发明授权

US07838493B2 Acetylcholinesterase (ACHE)-derived peptide as an inducer of granulocytopoiesis, uses and methods thereof 有权
标题翻译：乙酰胆碱酯酶（ACHE）衍生肽作为粒细胞生成的诱导剂，其用途及方法
公开(公告)号：US07838493B2
公开(公告)日：2010-11-23
申请号：US10589116
申请日：2005-02-10
申请人： Hermona Soreq , Dan Grisaru , Varda Deutsch , Chava Perry , Marjorie Pick
发明人： Hermona Soreq , Dan Grisaru , Varda Deutsch , Chava Perry , Marjorie Pick
IPC分类号： A61K38/00
CPC分类号： A61K38/465 , C12Y301/01007
摘要： The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.
摘要翻译：本发明描述了AChE-R衍生肽（也称为ARP）作为造血细胞分化和扩增的诱导剂，特别是针对粒细胞群体的用途。此外，还提出了使用ARP作为血小板生成素和促炎细胞因子的诱导剂。在造血干细胞的移植前引发中还可以使用ARP。本文还描述了利用ARP的其他用途和方法。

5. 发明授权

US07063948B1 Uses of antibodies against AChE and peptides thereof 有权
标题翻译：使用抗AChE抗体及其肽
公开(公告)号：US07063948B1
公开(公告)日：2006-06-20
申请号：US09980263
申请日：2000-05-31
申请人： Hermona Soreq , Daniela Kaufer , Alon Friedman , Shlomo Seidman
发明人： Hermona Soreq , Daniela Kaufer , Alon Friedman , Shlomo Seidman
IPC分类号： G01N17/26 , C07K16/00 , C07K5/00
CPC分类号： C07K16/40 , G01N2800/2821
摘要： The invention relates to antibodies recognizing acetylcholinesterase or a C-terminal peptide derived from acetyl-cholinesterase, useful in diagnosing central nervous system (CNS) stress, elevated glucocorticoid level, disruption of the blood-brain barrier or Alzheimer's disease. The invention also relates to methods for the diagnosis of central nervous system (CNS) stress, elevated glucocorticoid level or disruption of the blood-brain barrier in a mammal, by use of the antibodies of the invention.
摘要翻译：本发明涉及可用于诊断中枢神经系统（CNS）应激，升高的糖皮质激素水平，血脑屏障或阿尔茨海默氏病破坏的乙酰胆碱酯酶或源自乙酰胆碱酯酶的C-末端肽的抗体。本发明还涉及通过使用本发明的抗体诊断中枢神经系统（CNS）应激，升高的糖皮质激素水平或哺乳动物血脑屏障破坏的方法。

6. 发明授权

US06987211B1 Transgenic non-human mammals producing a cholinesterase in their milk 失效
标题翻译：转基因非人哺乳动物在其牛奶中产生胆碱酯酶
公开(公告)号：US06987211B1
公开(公告)日：2006-01-17
申请号：US09310638
申请日：1999-05-12
申请人： Hermona Soreq , Haim Zakut , Moshe Shani
发明人： Hermona Soreq , Haim Zakut , Moshe Shani
IPC分类号： A01K67/027 , C12P21/00
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A01K2227/50 , A01K2267/03 , A01K2267/0356 , C12N9/18 , C12Q1/46
摘要： The present invention relates to novel alternative forms of human acetylcholinesterase (AChE) and nucleotide sequences encoding the same. The genes encoding the novel forms of human AChE have been identified in various malignant tumor cells. In a further aspect, the invention relates to a transgenic animal assay system for evaluating efficacy of drugs against cholinergic proteins, prior to or in the course of therapeutic treatment. Transgenic animals, preferably developing tadpole of Xenopus or mice which express human AChE, are used. The transgenic animal assay system is also useful for evaluating the toxicity of substances which potentially block human AChE (e.g. organophosphorous compounds).
摘要翻译：本发明涉及人乙酰胆碱酯酶（AChE）的新型替代形式及其编码的核苷酸序列。已经在各种恶性肿瘤细胞中鉴定了编码人类AChE的新型形式的基因。在另一方面，本发明涉及用于在治疗治疗之前或治疗过程中评价药物对胆碱能蛋白的功效的转基因动物测定系统。使用转基因动物，优选发育表达人AChE的非洲爪蟾的t us或小鼠。转基因动物测定系统也可用于评估可能阻断人类AChE（例如有机磷化合物）的物质的毒性。

7. 发明授权

US5215909A Human cholinesterase genes 失效
标题翻译：人胆碱酯酶基因
公开(公告)号：US5215909A
公开(公告)日：1993-06-01
申请号：US572911
申请日：1990-08-15
申请人： Hermona Soreq
发明人： Hermona Soreq
IPC分类号： C12N9/18
CPC分类号： C12N9/18
摘要： This invention is directed to genetically engineered proteins having human ChE activity, and more particularly, the activity of human AChE or human pseudo-ChE. The invention also provides for DNA sequences encoding such proteins, and more specifically DNA sequences comprising the entire coding region for encoding such complete proteins, and DNA expression vectors comprising such sequences. The invention also provides for DNA, which as been joined outside living cells, capable of infecting culturable cells, to be maintained therein and in progenies thereof which is adapted to encode such active proteins. The invention further provides culturable cells infected with recombinant DNA defined above, and to purified proteins having human ChE activity produced by such cells. There are further provided antibodies interacting with human AChE and pseudo-ChE and assays based on the use of such antibodies. The invention also provides compositions counteracting the effects of succinylcholine and of organophosphorus, containing as active ingredient an effective dosage of proteins defined above.
摘要翻译：本发明涉及具有人ChE活性的基因工程蛋白质，更具体地说，涉及人AChE或人类伪ChE的活性。本发明还提供了编码这种蛋白质的DNA序列，更具体地，包括编码这种完整蛋白质的整个编码区的DNA序列，以及包含这些序列的DNA表达载体。本发明还提供了能够感染可培养细胞的活体细胞外的DNA，其被保持在其中，并且其后代适于编码这种活性蛋白质。本发明还提供了用上述定义的重组DNA感染的可培养细胞，以及由这些细胞产生的具有人ChE活性的纯化蛋白质。进一步提供与人AChE和假ChE相互作用的抗体以及基于使用这种抗体的测定。本发明还提供了抵消琥珀酰胆碱和有机磷的作用的组合物，其含有作为活性成分的有效剂量的上述蛋白质。

8. 发明申请

US20110039791A1 ACETYLCHOLINESTERASE (ACHE)-DERIVED PEPTIDE AS AN INDUCER OF GRANULOCYTOPOIESIS, USES AND METHODS THEREOF 审中-公开
标题翻译：乙酰胆碱酯酶（ACHE）衍生肽作为颗粒细胞的诱导剂，其用途及其方法
公开(公告)号：US20110039791A1
公开(公告)日：2011-02-17
申请号：US12889564
申请日：2010-09-24
申请人： Hermona Soreq , Dan Grisaru , Varda Deutsch , Chava Perry , Marjorie Pick
发明人： Hermona Soreq , Dan Grisaru , Varda Deutsch , Chava Perry , Marjorie Pick
IPC分类号： A61K38/16 , C12N5/00 , A61P37/00 , A61P29/00 , A61P19/02
CPC分类号： A61K38/465 , C12Y301/01007
摘要： The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.
摘要翻译：本发明描述了AChE-R衍生肽（也称为ARP）作为造血细胞分化和扩增的诱导剂，特别是针对粒细胞群体的用途。此外，还提出了使用ARP作为血小板生成素和促炎细胞因子的诱导剂。在造血干细胞的移植前引发中还可以使用ARP。本文还描述了利用ARP的其他用途和方法。

9. 发明申请

US20100216868A1 AGENTS, COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIES IN WHICH REGULATING AN ACHE-ASSOCIATED BIOLOGICAL PATHWAY IS BENEFICIAL 审中-公开
标题翻译：治疗与ACHE相关生物通道有关的病理学的代理，组合物和方法是有益的
公开(公告)号：US20100216868A1
公开(公告)日：2010-08-26
申请号：US12450023
申请日：2008-03-06
申请人： Hermona Soreq , Iftach Shaked , Ran Avni , Ari Meerson
发明人： Hermona Soreq , Iftach Shaked , Ran Avni , Ari Meerson
IPC分类号： A61K31/711 , C07H21/04 , A61P25/16 , A61P25/28 , A61P35/02 , A61P7/00 , C12N5/02
CPC分类号： A61K31/7088 , C12N15/1013 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/321 , C12N2310/3231 , C12N2320/50 , C12N2310/3521
摘要： The present invention provides agents which are capable of regulating the function of a micro-RNA component which can be used to regulate an AChE-associated biological pathway. In addition, the present invention provides methods and pharmaceutical compositions for the treatment of various pathologies related to AChE-associated biological pathways such as apoptosis, aberrant cholinergic signaling, abnormal hematopoietic proliferation and/or differentiation, cellular stress, exposure to inflammatory response-inducing agents, and/or exposure to organophosphates or other AChE inhibitors.
摘要翻译：本发明提供能够调节可用于调节AChE相关生物学途径的微RNA组分的功能的试剂。此外，本发明提供了用于治疗与AChE相关生物学途径相关的各种病理学的方法和药物组合物，例如细胞凋亡，异常胆碱能信号传导，异常造血增生和/或分化，细胞应激，暴露于炎性反应诱导剂，和/或暴露于有机磷酸盐或其他AChE抑制剂。

10. 发明申请

US20070037241A1 Method and kit for assessing anxiety or disposition thereto in a subject 失效
标题翻译：评估受试者焦虑或处置情况的方法和试剂盒
公开(公告)号：US20070037241A1
公开(公告)日：2007-02-15
申请号：US11400224
申请日：2006-04-10
申请人： Hermona Soreq , Ella Sklan , Raz Yirmiya , Keren Ailon , Irit Shapira-Lichter
发明人： Hermona Soreq , Ella Sklan , Raz Yirmiya , Keren Ailon , Irit Shapira-Lichter
IPC分类号： C12Q1/46
CPC分类号： C12Q1/6883 , C12Q1/34 , C12Q1/46 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/573 , G01N2800/301
摘要： The invention provides methods/kits for assessing levels of trait or state anxiety in a subject by comparing genotypes and/or expression patterns at the ACHE, PON1 and/or BChE genes to the genotype and/or expression pattern of the genes in a reference population whose genotype and/or expression pattern of the genes is known or by correlating AChE levels activity to those of PON.
摘要翻译：本发明提供了通过将ACHE，PON1和/或BChE基因的基因型和/或表达模式与参考群体中基因的基因型和/或表达模式进行比较来评估受试者的性状或状态焦虑水平的方法/试剂盒其基因的基因型和/或表达模式是已知的或通过将AChE水平活性与PON的活性相关联。

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