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1. 发明申请

US20080021168A1 LOW MOLECULAR WEIGHT GRAFT COPOLYMERS 审中-公开
标题翻译：低分子量GRAFT共聚物
公开(公告)号：US20080021168A1
公开(公告)日：2008-01-24
申请号：US11459233
申请日：2006-07-21
申请人： Klin A. Rodrigues , Ngoc Thuy Le
发明人： Klin A. Rodrigues , Ngoc Thuy Le
IPC分类号： C08F297/02
CPC分类号： C08F251/00 , C08F289/00
摘要： Low molecular weight graft copolymer comprising a synthetic component formed from at least one or more olefinically unsaturated carboxylic acid monomers or salts thereof, and a natural component formed from a hydroxyl-containing natural moiety. The number average molecular weight of the graft copolymer is about 100,000 or less, and the weight percent of the natural component in the graft copolymer is about 50 wt % or greater based on total weight of the graft copolymer. Processes for preparing such graft copolymers are also disclosed.
摘要翻译：包含由至少一种或多种烯属不饱和羧酸单体或其盐形成的合成组分和由含羟基天然部分形成的天然组分的低分子量接枝共聚物。接枝共聚物的数均分子量为约100,000以下，接枝共聚物中天然成分的重量百分比为接枝共聚物总重量的约50重量％以上。还公开了制备这种接枝共聚物的方法。

2. 发明申请

US20060111370A1 Heterocyclic aspartyl protease inhibitors 有权
公开(公告)号：US20060111370A1
公开(公告)日：2006-05-25
申请号：US11149027
申请日：2005-06-09
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan Ye , Johannes Voigt , Corey Strickland , Elizabeth Smith , Andrew Stamford , William Greenlee , Robert Mazzola , John Caldwell , Jared Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy Le , Kurt Saionz , Suresh Babu , Rachael Hunter , Michelle Morris , Huizhong Gu , Gang Qian , Dawit Tadesse
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan Ye , Johannes Voigt , Corey Strickland , Elizabeth Smith , Andrew Stamford , William Greenlee , Robert Mazzola , John Caldwell , Jared Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Tao Guo , Thuy Le , Kurt Saionz , Suresh Babu , Rachael Hunter , Michelle Morris , Huizhong Gu , Gang Qian , Dawit Tadesse
IPC分类号： A61K31/519 , A61K31/497 , A61K31/513 , A61K31/4439 , A61K31/454 , A61K31/4245 , C07D413/02 , C07D403/02
CPC分类号： C07D233/46 , C07D233/70 , C07D233/88 , C07D239/22 , C07D239/70 , C07D271/07 , C07D273/00 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

3. 发明授权

US07733874B2 Communicating packets between devices involving the use of different communication protocols 失效
标题翻译：在涉及使用不同通信协议的设备之间通信数据包
公开(公告)号：US07733874B2
公开(公告)日：2010-06-08
申请号：US11553968
申请日：2006-10-27
申请人： Wayne Charles Carlson , Erika Marianna Dawson , Gavin Stuart Johnson , Trang Thuy Le , Matthew Hank Sabins , Peter Grimm Sutton , Harry Morris Yudenfriend
发明人： Wayne Charles Carlson , Erika Marianna Dawson , Gavin Stuart Johnson , Trang Thuy Le , Matthew Hank Sabins , Peter Grimm Sutton , Harry Morris Yudenfriend
IPC分类号： H04L12/28
CPC分类号： H04L63/061 , G06F21/6218 , G06F21/79 , G06F21/80 , H04L69/08
摘要： Provided are a method, system, and article of manufacture for receiving an initial request from a first device to a second device. A response to the initial request is received from the second device to the first device. Each response and request received from the first device to the second device is processed by accessing the response or request from a packet encoded using a first communication protocol; generating a packet including the accessed response or request into a packet encoded using a second communication protocol; and transmitting the generated packet to the second device. Each response and request received from the second device to the first device is processed by accessing the response or request from a packet encoded using the second communication protocol; generating a packet including the accessed response or request into a packet encoded using the first communication protocol; and transmitting the generated packet to the second device.
摘要翻译：提供了一种用于接收从第一设备到第二设备的初始请求的方法，系统和制品。从第二设备接收对初始请求的响应到第一设备。通过从使用第一通信协议编码的分组访问响应或请求来处理从第一设备接收到第二设备的每个响应和请求; 将包括所访问的响应或请求的分组生成到使用第二通信协议编码的分组中; 以及将生成的分组发送到所述第二设备。通过从使用第二通信协议编码的分组访问响应或请求来处理从第二设备接收到的第一设备的每个响应和请求; 将包括所访问的响应或请求的分组生成到使用所述第一通信协议编码的分组中; 以及将生成的分组发送到所述第二设备。

4. 发明申请

US20080200445A1 Heterocyclic aspartyl protease inhibitors 有权
公开(公告)号：US20080200445A1
公开(公告)日：2008-08-21
申请号：US11710582
申请日：2007-02-23
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan Ye , Johannes Voigt , Corey Strickland , Elizabeth Smith , Andrew Stamford , William Greenlee , Robert Mazzola , John Caldwell , Jared Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy Le , Kurt Saionz , Suresh Babu , Rachael Hunter , Michelle Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan Ye , Johannes Voigt , Corey Strickland , Elizabeth Smith , Andrew Stamford , William Greenlee , Robert Mazzola , John Caldwell , Jared Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy Le , Kurt Saionz , Suresh Babu , Rachael Hunter , Michelle Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A61K31/506 , A61K31/4178 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/541 , A61P31/00 , C07D233/02 , C07D271/00 , C07D413/14 , C07D409/14 , C07D409/04 , C07D403/06 , C07D401/14 , C07D401/12 , C07D401/10 , C07D401/06 , C07D239/04 , A61P9/00 , A61P25/00 , A61K31/5377 , A61K31/4545 , A61K31/4709 , A61K31/498
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula 1. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

5. 发明授权

US07117333B2 Apparatus, system, and method to estimate memory for recovering data 有权
标题翻译：用于估计用于恢复数据的存储器的装置，系统和方法
公开(公告)号：US07117333B2
公开(公告)日：2006-10-03
申请号：US10648582
申请日：2003-08-25
申请人： Ralph Thomas Beeston , Kirby Grant Dahman , Gavin Stuart Johnson , Trang Thuy Le
发明人： Ralph Thomas Beeston , Kirby Grant Dahman , Gavin Stuart Johnson , Trang Thuy Le
IPC分类号： G06F12/00
CPC分类号： G06F12/0223
摘要： The process, apparatus, and system estimate the size of a data block in a data buffer to efficiently recover the data block to the memory of a computer. The data block resides in a data buffer prior to being written to a destination medium. If the data block cannot be written to the destination medium, the process, apparatus, and system create a data block size estimate. The data block size estimate may be based on the size of the largest data block in the data buffer. Alternately, the data block size estimate may be based on the size of a data block in the memory of the computer. The computer reserves a memory space proportional to the data block size estimate and recovers the data block to the memory space.
摘要翻译：过程，装置和系统估计数据缓冲器中的数据块的大小以有效地将数据块恢复到计算机的存储器。在将数据块写入目标介质之前，数据块驻留在数据缓冲区中。如果数据块不能被写入目标介质，则处理，装置和系统创建数据块大小估计。数据块大小估计可以基于数据缓冲器中最大数据块的大小。或者，数据块大小估计可以基于计算机的存储器中的数据块的大小。计算机保留与数据块大小估计成比例的存储空间，并将数据块恢复到存储器空间。

6. 发明申请

US20050043290A1 Cyclic amine BACE-1 inhibitors having a heterocyclic substituent 有权
标题翻译：具有杂环取代基的环胺BACE-1抑制剂
公开(公告)号：US20050043290A1
公开(公告)日：2005-02-24
申请号：US10911030
申请日：2004-08-04
申请人： Jared Cumming , Ying Huang , Guoqing Li , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes Voigt , Yusheng Wu , Jianping Pan , Tao Guo , Douglas Hobbs , Thuy Le , Jeffrey Lowrie
发明人： Jared Cumming , Ying Huang , Guoqing Li , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes Voigt , Yusheng Wu , Jianping Pan , Tao Guo , Douglas Hobbs , Thuy Le , Jeffrey Lowrie
IPC分类号： C07D207/26 , C07D207/277 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/55 , C07D43/02
CPC分类号： C04B35/632 , C07D207/277 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is X is —O—, —C(R14)2— or —N(R)—; Z is —C(R14)2— or —N(R)—; t is 0, 1, 2 or 3; each R and R2 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, alkenyl or alkynyl; each R14 is H, alkyl, alkenyl, alkynyl, halo, —CN, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, —OR35, —N(R24)(R25) or —SR35; R41 is alkyl, cycloalkyl, —SO2(alkyl), —C(O)-alkyl, —C(O)-cycloalkyl or -alkyl-NH—C(O)CH3; and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I and methods of treating cognitive or neurodegenerative diseases with compounds of formula I. Also disclosed are pharmaceutical compositions and methods of treatment comprising compounds of formula I in combination with other agents useful in treating cognitive or neurodegenerative diseases.
摘要翻译：公开了下式的新化合物或其药学上可接受的盐或溶剂化物，其中R 1是X是-O - ， - C（R 14）2 - 或-N（R） - ; Z是-C（R 14）2 - 或-N（R） - ; t为0,1,2或3; 每个R和R 2独立地是H，烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，烯基或炔基; 每个R 14是H，烷基，烯基，炔基，卤素，-CN，卤代烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，-OR 35，-N（R 24））（R 25）或-SR 35; R 41是烷基，环烷基，-SO 2（烷基），-C（O） - 烷基，-C（O） - 环烷基或 - 烷基-NH-C（O）CH 3; 其余变量如本说明书中所定义。还公开了包含式I化合物的药物组合物和用式I化合物治疗认知障碍或神经变性疾病的方法。还公开了药物组合物和治疗方法，其包含式I化合物与用于治疗认知或神经变性的其它药剂疾病

7. 发明授权

US08428861B1 Wrong way detection system 有权
标题翻译：错误的方式检测系统
公开(公告)号：US08428861B1
公开(公告)日：2013-04-23
申请号：US12797287
申请日：2010-06-09
申请人： Ray Williams , Thuy Le , Tracy Marks
发明人： Ray Williams , Thuy Le , Tracy Marks
IPC分类号： G06F17/10
CPC分类号： G08G1/056 , G08G1/095 , G08G1/164
摘要： The Wrong Way Detection System includes detection stations deployed at each egress point along a tollway in addition to various locations along the tollway's mainline. The detection hardware communicates preferably via fiber optic network to a customized software platform housed at a centrally located Incident Management Center (IMC) of the system, where each site is monitored 24/7 in real time for wrong way vehicles. Once a vehicle is detected, operators at the IMC are able to immediately dispatch law enforcement officers and monitor the vehicle's whereabouts via CCTV cameras.
摘要翻译：错误检测系统包括沿着收费站的每个出口点部署的检测站，以及沿着收费站主干线的各个位置。检测硬件优选地通过光纤网络传送到安装在系统的位于中心位置的事故管理中心（IMC）处的定制软件平台，其中每个站点被实时地全天候监控用于错误的方式车辆。一旦检测到车辆，IMC的操作人员可以立即派出执法人员并通过闭路电视摄像机监控车辆的下落。

8. 发明申请

US20080148041A1 Communicating Packets Between Devices Involving the Use of Different Communication Protocols 失效
标题翻译：在涉及使用不同通信协议的设备之间通信数据包
公开(公告)号：US20080148041A1
公开(公告)日：2008-06-19
申请号：US11553968
申请日：2006-10-27
申请人： Wayne Charles Carlson , Erika Marianna Dawson , Gavin Stuart Johnson , Trang Thuy Le , Matthew Hank Sabins , Peter Grimm Sutton , Harry Morris Yudenfriend
发明人： Wayne Charles Carlson , Erika Marianna Dawson , Gavin Stuart Johnson , Trang Thuy Le , Matthew Hank Sabins , Peter Grimm Sutton , Harry Morris Yudenfriend
IPC分类号： H04L9/00 , G06F21/00
CPC分类号： H04L63/061 , G06F21/6218 , G06F21/79 , G06F21/80 , H04L69/08
摘要： Provided are a method, system, and article of manufacture for receiving an initial request from a first device to a second device. A response to the initial request is received from the second device to the first device. Each response and request received from the first device to the second device is processed by accessing the response or request from a packet encoded using a first communication protocol; generating a packet including the accessed response or request into a packet encoded using a second communication protocol; and transmitting the generated packet to the second device. Each response and request received from the second device to the first device is processed by accessing the response or request from a packet encoded using the second communication protocol; generating a packet including the accessed response or request into a packet encoded using the first communication protocol; and transmitting the generated packet to the second device.
摘要翻译：提供了一种用于接收从第一设备到第二设备的初始请求的方法，系统和制品。从第二设备接收对初始请求的响应到第一设备。通过从使用第一通信协议编码的分组访问响应或请求来处理从第一设备接收到第二设备的每个响应和请求; 将包括所访问的响应或请求的分组生成到使用第二通信协议编码的分组中; 以及将生成的分组发送到所述第二设备。通过从使用第二通信协议编码的分组访问响应或请求来处理从第二设备接收到的第一设备的每个响应和请求; 将包括所访问的响应或请求的分组生成到使用所述第一通信协议编码的分组中; 以及将生成的分组发送到所述第二设备。

9. 发明申请

US20060287294A1 Aspartyl protease inhibitors 有权
标题翻译：天冬氨酰蛋白酶抑制剂
公开(公告)号：US20060287294A1
公开(公告)日：2006-12-21
申请号：US11451195
申请日：2006-06-12
申请人： Zhaoning Zhu , Brian McKittrick , Andrew Stamford , Tao Guo , Thuy Le
发明人： Zhaoning Zhu , Brian McKittrick , Andrew Stamford , Tao Guo , Thuy Le
IPC分类号： A61K31/554 , A61K31/553 , A61K31/551 , C07D285/36 , C07D243/10 , C07D223/14
CPC分类号： C07D471/10 , C07D239/70 , C07D487/10 , C07D491/10 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein U, W, A, R, R1, R2, R6a and R7, are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，其中U，W，A，R，R 1，R 2， R 6a和R 7如说明书中所定义; 以及包含式I化合物的药物组合物。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m 1激动剂或m 2 H 2拮抗剂组合治疗认知或神经变性疾病的方法。

10. 发明申请

US20050119227A1 Cyclic amine bace-1 inhibitors having a benzamide substituent 有权
标题翻译：具有苯甲酰胺取代基的环胺类Bace-1抑制剂
公开(公告)号：US20050119227A1
公开(公告)日：2005-06-02
申请号：US10910987
申请日：2004-08-04
申请人： Jared Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas Hobbs , Thuy Le , Jeffrey Lowrie , Kurt Saionz , Suresh Babu
发明人： Jared Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas Hobbs , Thuy Le , Jeffrey Lowrie , Kurt Saionz , Suresh Babu
IPC分类号： A61K31/55 , A61K31/553 , A61K31/554 , A61K31/675 , C07D207/09 , C07D211/26 , C07D217/18 , C07D241/04 , C07D243/08 , C07D401/06 , C07D403/12 , C07D403/14 , C07D413/06 , C07F9/38
CPC分类号： C07D243/08 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/26 , C07D209/52 , C07D211/26 , C07D211/46 , C07D217/18 , C07D233/32 , C07D241/04 , C07D241/08 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/06 , C07D409/12 , C07D413/06
摘要： Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is R is —C(O)—N(R27)(R28) or and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.
摘要翻译：公开了下式的化合物或其药学上可接受的盐或溶剂化物，其中R 1是R是-C（O）-N（R 27） > 28 ）或其余变量如说明书中所定义。还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。还公开了治疗认知或神经变性疾病的药物组合物和方法，其包含式I化合物与除式I以外的β-分泌酶抑制剂，HMG-CoA还原酶抑制剂，γ-分泌酶抑制剂，甾族抗炎剂，N-甲基-D-天冬氨酸受体拮抗剂，胆碱酯酶抑制剂或抗淀粉样蛋白抗体。

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