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1. 发明申请

US20100009384A1 ACTR-1, a novel human acyltransferase and uses thereof 有权
公开(公告)号：US20100009384A1
公开(公告)日：2010-01-14
申请号：US12217258
申请日：2008-07-02
申请人： Rosana Kapeller-Libermann , Thomas Joseph Logan
发明人： Rosana Kapeller-Libermann , Thomas Joseph Logan
IPC分类号： G01N33/53 , C07H21/00 , C12N5/00 , C12N9/10 , C07K16/00 , C12P21/00 , C12N9/99
CPC分类号： C12N9/1029 , A61K38/00 , C12Y203/01015
摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

2. 发明申请

US20080241133A1 Novel 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor 失效
标题翻译：小分子25869,25934,26335,5049,21117,38692,46508,16816,16839,49937,49931和49933分子及其用途
公开(公告)号：US20080241133A1
公开(公告)日：2008-10-02
申请号：US12150094
申请日：2008-04-24
申请人： Rory A. J. Curtis , Thomas Joseph Logan , Maria Alexandra Glucksmann , Rachel E. Meyers , Mark J. Williamson , Laura A. Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
发明人： Rory A. J. Curtis , Thomas Joseph Logan , Maria Alexandra Glucksmann , Rachel E. Meyers , Mark J. Williamson , Laura A. Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
IPC分类号： A61K39/395 , C12N15/11 , C12N5/06 , C07K14/00 , C07K16/18 , A61K31/70 , A61P43/00 , C12P21/04 , G01N33/566 , C12Q1/68 , A61K38/00
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , C07K14/395 , C07K14/43545 , C07K14/43581 , C07K14/43595 , C07K14/463 , C07K14/465 , C07K14/47 , C07K2319/00 , C12N9/00 , C12N9/0071 , C12N9/0083 , C12N9/1205 , C12N9/18 , C12N9/20 , C12N9/88 , C12N2310/3513 , C12Y207/01001 , C12Y301/04003
摘要： The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 gene has been introduced or disrupted. The invention still further provides isolated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 proteins, fusion proteins, antigenic peptides and anti-25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为25869,25934,26335,50516,21117,38692,46508,16816,16839,49937,49931和49933核酸分子。本发明还提供反义核酸分子，包含25869,25934,26335,50521,21117,38692,46508,16816,16839,4467,49931或49933核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入或破坏25869,25934,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933基因的非人转基因动物。本发明还进一步提供了分离的25869,2593,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933蛋白，融合蛋白，抗原肽和抗-25869,25934,26335,50365,211117,38692 ，46508,16816,16839,49937,49931或49933抗体。还提供了利用本发明组合物的诊断和治疗方法。

3. 发明授权

US07052888B2 ACTR-1 a novel human acyltransferase and uses thereof 有权
标题翻译： ACTR-1是一种新的人类酰基转移酶及其用途
公开(公告)号：US07052888B2
公开(公告)日：2006-05-30
申请号：US09935290
申请日：2001-08-21
申请人： Rosana Kapeller-Libermann , Thomas Joseph Logan
发明人： Rosana Kapeller-Libermann , Thomas Joseph Logan
IPC分类号： C12N9/10 , C07H21/04
CPC分类号： C12N9/1029 , A61K38/00 , C12Y203/01015
摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的酰基转移酶家族成员的分离的核酸分子，命名为ACTR-1核酸分子。本发明还提供了反义核酸分子，含有ACTR-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了ACTR-1基因的非人类转基因动物。本发明还进一步提供了分离的ACTR-1蛋白，融合蛋白，抗原肽和抗ACTR-1抗体。还提供了利用本发明组合物的诊断方法。

4. 发明申请

US20110150860A1 NOVEL 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 AND 49933 MOLECULES AND USES THEREFOR 审中-公开
标题翻译：新型25869,25934,26335,50365,211117,38692,46508,16816,16839,49937,49931和49933分子及其用途
公开(公告)号：US20110150860A1
公开(公告)日：2011-06-23
申请号：US12755449
申请日：2010-04-07
申请人： Rory A.J. Curtis , Thomas Joseph Logan , Maria Alexandra Glucksmann , Rachel E. Meyers , Mark J. Williamson , Laura A. Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
发明人： Rory A.J. Curtis , Thomas Joseph Logan , Maria Alexandra Glucksmann , Rachel E. Meyers , Mark J. Williamson , Laura A. Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
IPC分类号： A61K39/395 , C07H21/04 , C07K14/00 , C07K16/00 , C12P21/06 , G01N33/53 , G01N33/48 , G01N33/50 , C12N5/10 , A61K31/711 , A61K38/16 , A61K31/7088 , A61P35/00 , A61P3/00 , A61P7/00 , A61P19/00 , A61P25/00 , A61P31/12
CPC分类号： C07K14/47 , A61K38/00 , G01N2500/00 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 gene has been introduced or disrupted. The invention still further provides isolated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 proteins, fusion proteins, antigenic peptides and anti-25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为25869,25934,26335,50516,21117,38692,46508,16816,16839,49937,49931和49933核酸分子。本发明还提供反义核酸分子，包含25869,25934,26335,50521,21117,38692,46508,16816,16839,4467,49931或49933核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入或破坏25869,25934,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933基因的非人类转基因动物。本发明还进一步提供了分离的25869,2593,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933蛋白，融合蛋白，抗原肽和抗-25869,25934,26335,50365,211117,38692 ，46508,16816,16839,49937,49931或49933抗体。还提供了利用本发明组合物的诊断和治疗方法。

5. 发明授权

US07820403B2 ACTR-1, a novel human acyltransferase and uses thereof 有权
标题翻译： ACTR-1，一种新的人类酰基转移酶及其用途
公开(公告)号：US07820403B2
公开(公告)日：2010-10-26
申请号：US12217258
申请日：2008-07-02
申请人： Rosana Kapeller-Libermann , Thomas Joseph Logan
发明人： Rosana Kapeller-Libermann , Thomas Joseph Logan
IPC分类号： C12Q1/48 , C07K1/00
CPC分类号： C12N9/1029 , A61K38/00 , C12Y203/01015
摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的酰基转移酶家族成员的分离的核酸分子，命名为ACTR-1核酸分子。本发明还提供了反义核酸分子，含有ACTR-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了ACTR-1基因的非人类转基因动物。本发明还进一步提供了分离的ACTR-1蛋白，融合蛋白，抗原肽和抗ACTR-1抗体。还提供了利用本发明组合物的诊断方法。

6. 发明授权

US06686185B1 25934, a novel fatty acid desaturase and uses therefor 失效
标题翻译： 25934，一种新型脂肪酸去饱和酶，并用于此
公开(公告)号：US06686185B1
公开(公告)日：2004-02-03
申请号：US09723806
申请日：2000-11-28
申请人： Thomas Joseph Logan , Maria Alexandra Glucksmann
发明人： Thomas Joseph Logan , Maria Alexandra Glucksmann
IPC分类号： C12N902
CPC分类号： C12N9/0071 , A61K38/00 , C12N9/0083
摘要： The invention provides isolated nucleic acids molecules, designated 25934 nucleic acid molecules, which encode a novel desaturase family member. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25934 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25934 gene has been introduced or disrupted. The invention still further provides isolated 25934 proteins, fusion proteins, antigenic peptides and anti-25934 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The invention also provides methods for modulating fatty acid metabolism utilizing the compositions of the invention. Accordingly, methods of treating, preventing and/or diagnosing cardiovascular disorders, such atherosclerosis, hypertriglyceridemia, hypercholesterolemia, and hyperlipidemia, are disclosed.
摘要翻译：本发明提供编码新型去饱和酶家族成员的分离的核酸分子，命名为25934核酸分子。本发明还提供了反义核酸分子，含有25934个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中已导入或破坏了25934基因的非人转基因动物。本发明还进一步提供了分离的25934蛋白，融合蛋白，抗原肽和抗25934抗体。还提供了利用本发明组合物的诊断方法。本发明还提供了利用本发明组合物调节脂肪酸代谢的方法。因此，公开了治疗，预防和/或诊断心血管疾病，动脉粥样硬化，高甘油三酯血症，高胆固醇血症和高脂血症的方法。

7. 发明授权

US07410785B2 ACTR-1, a novel human acyltransferase and uses thereof 有权
标题翻译： ACTR-1，一种新的人类酰基转移酶及其用途
公开(公告)号：US07410785B2
公开(公告)日：2008-08-12
申请号：US11325013
申请日：2006-01-04
申请人： Rosana Kapeller-Libermann , Thomas Joseph Logan
发明人： Rosana Kapeller-Libermann , Thomas Joseph Logan
IPC分类号： C12N9/10 , C07K1/00
CPC分类号： C12N9/1029 , A61K38/00 , C12Y203/01015
摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的酰基转移酶家族成员的分离的核酸分子，命名为ACTR-1核酸分子。本发明还提供了反义核酸分子，含有ACTR-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了ACTR-1基因的非人类转基因动物。本发明还进一步提供了分离的ACTR-1蛋白，融合蛋白，抗原肽和抗ACTR-1抗体。还提供了利用本发明组合物的诊断方法。

8. 发明授权

US07157240B2 MID 4460, a human tyrosine phosphatase family member and uses therefor 失效
标题翻译： MID 4460，一种人酪氨酸磷酸酶家族成员，并用于此
公开(公告)号：US07157240B2
公开(公告)日：2007-01-02
申请号：US10245539
申请日：2002-09-17
申请人： Thomas Joseph Logan
发明人： Thomas Joseph Logan
IPC分类号： C12Q1/42
CPC分类号： C12N9/16 , C12Q1/42 , G01N33/573
摘要： The invention provides isolated nucleic acids molecules, designated MID 4460 nucleic acid molecules, which encode novel tyrosine phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MID 4460 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a MID 4460 gene has been introduced or disrupted. The invention still further provides isolated MID 4460 proteins, fusion proteins, antigenic peptides and anti-MID 4460 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的酪氨酸磷酸酶家族成员的分离的核酸分子，命名为MID 4460核酸分子。本发明还提供了反义核酸分子，含有MID 4460核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了MID 4460基因的非人类转基因动物。本发明还进一步提供了分离的MID 4460蛋白，融合蛋白，抗原肽和抗MID 4460抗体。还提供了利用本发明组合物的诊断和治疗方法。

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