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1. 发明申请

US20090076201A1 (METH) ACRYLOYLOXYTETRAHYDROFURANS AND PROCESS FOR PRODUCTION THEREOF 审中-公开
标题翻译：（METH）丙烯酰氧基聚四氢呋喃及其生产方法
公开(公告)号：US20090076201A1
公开(公告)日：2009-03-19
申请号：US11915043
申请日：2006-03-16
申请人： Haruhiko Kusaka , Hiroko Takahashi , Yuji Ohgomori , Kaoru Hamashima , Gan Wen , Taketoshi Naito
发明人： Haruhiko Kusaka , Hiroko Takahashi , Yuji Ohgomori , Kaoru Hamashima , Gan Wen , Taketoshi Naito
IPC分类号： C08K5/1535 , C07D307/12 , C09K3/00
CPC分类号： C07D307/20 , C08F220/28
摘要： The present invention provides a (meth)acrylate containing a heterocyclic ring, which is a structure necessary for achieving physical properties required in many fields, and a hydrophilic group in the same monomer molecule and further provides a process for producing the same from industrially easily-available starting materials by industrially feasible reactions.A (meth)acryloyloxytetrahydrofuran having a structure represented by the following general formula (1): wherein R1 and R2 each is a hydrogen atom or a (meth)acryloyl group represented by the following general formula (2) and at least one of R1 and R2 is a (meth)acryloyl group represented by the general formula (2).
摘要翻译：本发明提供了含有杂环的（甲基）丙烯酸酯，其为实现许多领域所需的物理性能所必需的结构，并且在同一单体分子中提供亲水基团，并进一步提供其工业上容易制备的方法，可用的原料通过工业上可行的反应。具有由以下通式（1）表示的结构的（甲基）丙烯酰氧基四氢呋喃：其中R1和R2各自为氢原子或由以下通式（2）表示的（甲基）丙烯酰基，R1和 R2是由通式（2）表示的（甲基）丙烯酰基。

2. 发明授权

US06018048A Noble metal Raney catalysts and preparation of hydrogenated compounds therewith 失效
标题翻译：贵金属阮内催化剂及其氢化化合物的制备
公开(公告)号：US06018048A
公开(公告)日：2000-01-25
申请号：US989157
申请日：1997-12-11
申请人： Kouhei Morikawa , Shuuji Hirayama , Yoshimasa Ishimura , Yuseki Suyama , Tsutomu Nozawa , Hiroyuki Monzen , Motoo Miura , Kuniomi Marumo , Taketoshi Naito
发明人： Kouhei Morikawa , Shuuji Hirayama , Yoshimasa Ishimura , Yuseki Suyama , Tsutomu Nozawa , Hiroyuki Monzen , Motoo Miura , Kuniomi Marumo , Taketoshi Naito
IPC分类号： C07D251/04 , B01J25/00 , C07B61/00 , C07C5/10 , C07C29/19 , C07C29/20 , C07C31/13 , C07C31/27 , C07C35/21 , C07C51/36 , C07C51/367 , C07C61/09 , C07C67/31 , C07C209/48 , C07C209/72 , C07C211/46 , C07C211/50 , C07D211/02 , C07D215/02 , C07D217/02 , C07D237/30 , C07D239/74 , C07D241/42 , C07D295/02 , C07D475/00 , C07C5/02
CPC分类号： C07C29/20 , B01J25/00 , C07C209/48 , C07C51/36 , C07C51/367 , C07C67/31 , C07D211/02 , C07C2101/14 , C07C2102/28
摘要： Noble metal, particularly ruthenium, Raney catalysts having the property of catalyzing the hydrogenation of (1) aromaticity-exhibiting ring portions of organic compounds, (2) carboxylic acids and their ester portions (carbonyl ester groups), (3) ring portions and carboxylic acid or their ester groups in compounds having such ring portions and carboxylic acid or their ester portions, and (4) ring portions and nitrile groups of aromatic nitrile compounds and methods for the preparation of corresponding hydrogenated compounds. The methods allow preparation of hydrogenated compounds having hydrogenated aromatic ring portions, hydrogenated carbonyl ester groups, hydrogenated aromatic ring and carbonyl ester groups, or hydrogenated aromatic rings and nitrile groups under milder hydrogen pressure and temperature conditions than the conventional catalysts.
摘要翻译：贵金属，特别是钌，具有催化（1）有机化合物的芳香性显示环部分的氢化的性质的阮内催化剂，（2）羧酸及其酯部分（羰基酯基），（3）环部分和羧基酸或其酯基，以及（4）芳族腈化合物的环部分和腈基以及制备相应的氢化化合物的方法。该方法允许在比常规催化剂更温和的氢气压力和温度条件下，制备具有氢化芳环部分，氢化羰基酯基，氢化芳环和羰基酯基，或氢化芳环和腈基的氢化化合物。

3. 发明授权

US4954512A Anti-ulcer composition 失效
标题翻译：抗溃疡组成
公开(公告)号：US4954512A
公开(公告)日：1990-09-04
申请号：US275193
申请日：1988-11-23
申请人： Katsunori Oguro , Hiroshi Nojima , Nobuyuki Hashizume , Norio Ohno , Taketoshi Naito
发明人： Katsunori Oguro , Hiroshi Nojima , Nobuyuki Hashizume , Norio Ohno , Taketoshi Naito
IPC分类号： A61K31/235 , A61K31/165 , A61K31/215 , A61K31/44 , A61K31/4406 , A61P1/04 , A61P43/00 , C07D211/62 , C07D213/75
CPC分类号： C07D213/75 , C07D211/62 , Y10S514/925 , Y10S514/926 , Y10S514/927
摘要： An anti-peptic ulcer composition containing, as an active ingredient, a therapeutically effective amount of a compound having the formula (I): ##STR1## wherein A represents H.sub.2 NCH.sub.2 --, ##STR2## B represents ##STR3## D and E each independently represent H, R,--R'CO.sub.2 R,--R'(OH)CO.sub.2 R, ##STR4## wherein X represents H, CONR.sub.2, CONHR, CONH.sub.2, CO.sub.2 H, CO.sub.2 R, or COR or --R'(CO.sub.2 R)--; R' represents a lower alkylene group and R represents a lower alkyl group; F represents H, ##STR5## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

4. 发明授权

US4873253A Phenylalanine derivative and proteinase inhibitor 失效
标题翻译：苯丙氨酸衍生物和蛋白酶抑制剂
公开(公告)号：US4873253A
公开(公告)日：1989-10-10
申请号：US31738
申请日：1987-03-30
申请人： Shosuke Okamoto , Yoshio Okada , Akiko Okunomiya , Taketoshi Naito , Yoshio Kimura , Morihiko Yamada , Norio Ohno , Yasuhiro Katsuura , Hiroshi Nojima , Takashi Shishikura
发明人： Shosuke Okamoto , Yoshio Okada , Akiko Okunomiya , Taketoshi Naito , Yoshio Kimura , Morihiko Yamada , Norio Ohno , Yasuhiro Katsuura , Hiroshi Nojima , Takashi Shishikura
IPC分类号： C07D211/60 , C07D211/62 , C07D213/64 , C07D213/643 , C07D213/75 , C07D213/80 , C07D233/88 , C07D239/42 , C07D257/06 , C07D277/46 , C07D295/185
CPC分类号： C07D213/643 , C07D211/60 , C07D211/62 , C07D213/75 , C07D213/80 , C07D233/88 , C07D239/42 , C07D257/06 , C07D277/46 , C07D295/185
摘要： A phenylalanine derivative having the formula (I): ##STR1## wherein A represents ##STR2## B represents ##STR3## wherein m is 0, 1, or 2 and n is 3, 4, or 5; X represents (a) hydroxy, (b) nitro, (c) amino, (d) phenoxy which may be substituted with (i) halogen or (ii) nitro, (e) c.sub.1 -C.sub.4 alkyloxy which may be substituted wit (i) phenyl or (ii) benzoyl, (f) benzoyl, (g) pyridyloxy which may be substituted with (i) halogen or (ii) nitro, or (h) c.sub.1 -C.sub.4 alkyl which may by substituted with halogen;Y represents ##STR4## or --OR.sup.3 wherein R.sup.1 R.sup.2 are independently (a) hydrogen, (b) phenyl which may be substituted with (i) benzoyl, (ii) C.sub.1 -C.sub.4 alkylcarbonyl, (iii) C.sub.1 -C.sub.4 alkyl which may be further substituted with C.sub.1 -C.sub.4 alkoxycarbonyl or hydroxycarbonyl, (iv) C.sub.2 -C.sub.5 alkenyl which may be further substituted with hydroxycarbonyl or C.sub.1 -C.sub.4 alkoxycarbonyl, (v) C.sub.1 -C.sub.4 alkoxycarbonyl, or (vi) amidino, (c) pyridyl which may be substituted with halogen or carboxyl (d) imidazolyl, (e) pyrimidyl, (f) tetrazolyl, (g) thiazolyl which may be substituted with C.sub.1 -C.sub.4 alkyl which may be further substituted with C.sub.1 -C.sub.4 alkoxycarbonyl, (h) C.sub.1 -C.sub.6 alkyl which may be substituted with C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkoxycarbonyl, phenyl, or benzoyl, (i) C.sub.5 -C.sub.7 cycloalkyl which may be substituted with C.sub.1 -C.sub.4 alkoxycarbonyl or (j) R.sup.1 and R.sup.2 may form, with the nitrogen atom attached thereto, (i) pyperazyl which may be substituted on the nitrogen atom with C.sub.1 -C.sub.4 alkyl which may be further substituted with phenyl, (ii) piperidino which may be substituted with carboxyl or C.sub.1 -C.sub.4 alkoxycarbonyl, (iii) pyrrolidyl which may be substituted with C.sub.1 -C.sub.4 alkoxycarbonyl, or (iv) morpholyl; andR.sup.3 represents (a) hydrogen, (b) C.sub.1 -C.sub.6 alkyl which may be substituted with (i) C.sub.1 -C.sub.4 alkoxy, (ii) pehnyl, or (iii) pyridyl, or (c) pyridyl; or a pharmaceutically acceptable acid salt thereof.This phenylalanine derivative is effective as a proteinase.

5. 发明授权

US06245920B1 Metal raney catalysts and preparation of hydrogenated compounds therewith 失效
标题翻译：金属催化剂和氢化化合物的制备
公开(公告)号：US06245920B1
公开(公告)日：2001-06-12
申请号：US09451145
申请日：1999-11-30
申请人： Kouhei Morikawa , Shuuji Hirayama , Yoshimasa Ishimura , Yuseki Suyama , Tsutomu Nozawa , Hiroyuki Monzen , Motoo Miura , Kuniomi Marumo , Taketoshi Naito
发明人： Kouhei Morikawa , Shuuji Hirayama , Yoshimasa Ishimura , Yuseki Suyama , Tsutomu Nozawa , Hiroyuki Monzen , Motoo Miura , Kuniomi Marumo , Taketoshi Naito
IPC分类号： C07D30702
CPC分类号： B01J25/00
摘要： Noble metal, particularly ruthenium, Raney catalysts which can hydrogenate (1) aromaticity-exhibiting ring portions of organic compounds, (2) carboxylic acids and their ester portions (carbonyl ester groups), (3) ring portions and carboxylic acid or their ester groups in compounds having such ring portions and carboxylic acid or their ester portions, and (4) ring portions and nitrile groups of aromatic nitrile compounds and methods for the preparation of corresponding hydrogenated compounds. The methods allow preparation of hydrogenated compounds having hydrogenated aromatic ring portions, hydrogenated carbonyl ester groups, hydrogenated aromatic ring and carbonyl ester groups, or hydrogenated aromatic rings and nitrile groups under milder hydrogen pressure and temperature conditions than the conventional catalysts.
摘要翻译：贵金属，特别是钌，可加氢氢化（1）芳香性显示有机化合物的环部分的阮内催化剂，（2）羧酸及其酯部分（羰基酯基），（3）环部分和羧酸或其酯基在具有这种环部分的化合物和羧酸或其酯部分中，和（4）芳族腈化合物的环部分和腈基以及制备相应的氢化化合物的方法。该方法允许在比常规催化剂更温和的氢气压力和温度条件下，制备具有氢化芳环部分，氢化羰基酯基，氢化芳环和羰基酯基，或氢化芳环和腈基的氢化化合物。

6. 发明授权

US06777570B2 Process for producing norbornene derivative having organosilyl group 失效
标题翻译：制备具有有机甲硅烷基的降冰片烯衍生物的方法
公开(公告)号：US06777570B2
公开(公告)日：2004-08-17
申请号：US10670515
申请日：2003-09-26
申请人： Hiroko Takahashi , Takako Takahashi , Taketoshi Naito , Shuji Ichikawa
发明人： Hiroko Takahashi , Takako Takahashi , Taketoshi Naito , Shuji Ichikawa
IPC分类号： C07F708
CPC分类号： C07F7/0827
摘要： A process for producing a norbornene derivative having an organosilyl group suitable as a synthetic intermediate for pesticides and medicaments and for production of polyolefin polymers, particularly polyolefin polymers having a good adhesiveness with metals or insulating inorganic materials in high yields with a satisfactory purity. A process for producing a norbornene derivative having an organosilyl group represented by the general formula (3): wherein R each represents an alkyl group or an aryl group, R′ represents an alkyl group or an aryl group, n represents an integer of 0 to 2 and m represents an integer of 0 or more, which comprises reacting a compound represented by the general formula (1): wherein R, n and m have the same meanings as above, and X represents a halogen atom, with a Grignard agent represented by the general formula (2): R′MgCl (2) wherein R′ has the same meaning as above.
摘要翻译：具有适合作为农药和药物的合成中间体的有机甲硅烷基的降冰片烯衍生物的制造方法以及用于生产聚烯烃聚合物的方法，特别是具有与金属或绝缘无机材料的良好粘合性的聚烯烃聚合物，其产率高，具有令人满意的纯度。一种具有由通式（3）表示的有机甲硅烷基的降冰片烯衍生物的方法：其中R各自表示烷基或芳基，R'表示烷基或芳基，n表示0〜 2和m表示0或更大的整数，其包括使通式（1）表示的化合物：其中R，n和m具有与上述相同的含义，X表示卤素原子，表示为格列酮由通式（2）表示：其中R'具有与上述相同的含义。

7. 发明授权

US06215030B1 Noble metal raney catalysts and preparation of hydrogenated compounds therewith 失效
标题翻译：贵金属催化剂和氢化化合物的制备
公开(公告)号：US06215030B1
公开(公告)日：2001-04-10
申请号：US09451146
申请日：1999-11-30
申请人： Kouhei Morikawa , Shuuji Hirayama , Yoshimasa Ishimura , Yuseki Suyama , Tsutomu Nozawa , Hiroyuki Monzen , Motoo Miura , Kuniomi Marumo , Taketoshi Naito
发明人： Kouhei Morikawa , Shuuji Hirayama , Yoshimasa Ishimura , Yuseki Suyama , Tsutomu Nozawa , Hiroyuki Monzen , Motoo Miura , Kuniomi Marumo , Taketoshi Naito
IPC分类号： C07C2704
CPC分类号： C07C29/20 , B01J25/00 , C07C51/36 , C07C51/367 , C07C67/31 , C07C209/48 , C07C2601/14 , C07C2602/28 , C07D211/02 , C07C35/21 , C07C31/276 , C07C31/20 , C07C35/08 , C07C31/1355 , C07C61/08 , C07C59/01 , C07C69/675
摘要： Noble metal, particularly ruthenium, Raney catalysts which can hydrogenate (1) aromaticity-exhibiting ring portions of organic compounds, (2) carboxylic acids and their ester portions (carbonyl ester groups), (3) ring portions and carboxylic acid or their ester groups in compounds having such ring portions and carboxylic acid or their ester portions, and (4) ring portions and nitrile groups of aromatic nitrile compounds and methods for the preparation of corresponding hydrogenated compounds. The methods allow preparation of hydrogenated compounds having hydrogenated aromatic ring portions, hydrogenated carbonyl ester groups, hydrogenated aromatic ring and carbonyl ester groups, or hydrogenated aromatic rings and nitrile groups under milder hydrogen pressure and temperature conditions than the conventional catalysts.
摘要翻译：贵金属，特别是钌，可加氢氢化（1）芳香性显示有机化合物的环部分的阮内催化剂，（2）羧酸及其酯部分（羰基酯基），（3）环部分和羧酸或其酯基在具有这种环部分的化合物和羧酸或其酯部分中，和（4）芳族腈化合物的环部分和腈基以及制备相应的氢化化合物的方法。该方法允许在比常规催化剂更温和的氢气压力和温度条件下，制备具有氢化芳环部分，氢化羰基酯基，氢化芳环和羰基酯基，或氢化芳环和腈基的氢化化合物。

8. 发明授权

US4224238A Process for preparing tertiary alkyl isocyanates 失效
标题翻译：叔烷基异氰酸酯的制备方法
公开(公告)号：US4224238A
公开(公告)日：1980-09-23
申请号：US30649
申请日：1979-04-16
申请人： Nobuyuki Nagato , Taketoshi Naito
发明人： Nobuyuki Nagato , Taketoshi Naito
IPC分类号： C07C265/04 , C07C67/00 , C07C241/00 , C07C263/02 , C07C118/00
CPC分类号： C07C263/00
摘要： Process for preparing an alkyl isocyanate having the isocyanate group bonded to the tertiary carbon atom of the alkyl group, which comprises reacting the corresponding alkyl halide in a substantially anhydrous condition in the presence of a specified catalyst with an alkali metal cyanate in an aprotic solvent which forms no salt with a hydrogen halide.
摘要翻译：用于制备具有与烷基的叔碳原子键合的异氰酸酯基的异氰酸烷基酯的方法，该方法包括在规定的催化剂存在下，在基本无水的条件下将相应的烷基卤与碱金属氰酸酯反应在非质子传递溶剂中与卤化氢不形成盐。

9. 发明授权

US4895842A Phenylalanine derivative and proteinase inhibitor 失效
公开(公告)号：US4895842A
公开(公告)日：1990-01-23
申请号：US912480
申请日：1986-09-29
申请人： Shosuke Okamoto , Yoshio Okada , Akiko Okunomiya , Taketoshi Naito , Yoshio Kimura , Morihiko Yamada , Norio Ohno , Yasuhiro Katsuura , Yumi Seki
发明人： Shosuke Okamoto , Yoshio Okada , Akiko Okunomiya , Taketoshi Naito , Yoshio Kimura , Morihiko Yamada , Norio Ohno , Yasuhiro Katsuura , Yumi Seki
IPC分类号： A61K38/00 , C07D211/16 , C07D211/32 , C07D211/62 , C07D213/30 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/75 , C07D239/42 , C07D295/185 , C07D307/14 , C07D401/12 , C07K5/065
CPC分类号： C07D213/30 , C07D211/16 , C07D211/32 , C07D211/62 , C07D213/40 , C07D213/643 , C07D213/75 , C07D239/42 , C07D295/185 , C07D307/14 , C07D401/12 , C07K5/06078 , A61K38/00
摘要： A phenylalanine derivative having the formula (I): ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen provided that both R.sup.1 and R.sup.2 are not hydrogen at the same time;C.sub.1 -C.sub.8 alkyl which may be substituted with hydroxy, hydroxycarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, C.sub.1 -C.sub.4 alkylmercapto, C.sub.1 -C.sub.4 alkoxy, carbamoyl, sulfamoyl, pyridyl, or phenyl which may further be substituted with nitro, C.sub.1 -C.sub.4 alkoxy, or halogen;C.sub.6 -C.sub.8 cycloalkyl which may be substituted with hydroxy, C.sub.1 -C.sub.4 alkoxy, hydroxylcarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, or C.sub.1 -C.sub.4 alkyl;phenyl which may be substituted with halogen, nitro, trifluoromethyl, C.sub.1 -C.sub.4 alkoxy C.sub.1 C.sub.4 alkylmercapto, C.sub.1 -C.sub.4 alkylcarbonyl, phenylcarbonyl, hydroxycarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, carbamoyl, sulfamoyl, amidino, pyridylcarbonyl, or C.sub.1 -C.sub.6 alkyl which may further be substituted with C.sub.1 -C.sub.4 alkylcarbonyl, hydroxycarbonyl, or C.sub.1 -C.sub.4 alkoxycarbonyl;pyridyl which may be substituted with halogen or C.sub.1 -C.sub.4 alkoxy;pyrimidyl;N-benzylazacyclohexyl; andR.sup.1 and R.sup.2 may form with the nitrogen atom attached thereto a ring structure as morpholino; thiomorpholino; piperazino which may be substituted with phenylcarbonyl, benzyl, or C.sub.1 -C.sub.4 alkyl;pyrrolidyl which may be substituted with hydroxycarbonyl or C.sub.1 -C.sub.4 alkoxycarbonyl; andpiperidino substituted with C.sub.1 -C.sub.4 alkyl, phenyl C.sub.1 -C.sub.4 alkyl, phenycarbonyl, or C.sub.1 -C.sub.4 alkoxycarbonyl;X is hydrogen; nitro; amino; or --OZ wherein Z is hydrogen; C.sub.1 -C.sub.4 alkyl; C.sub.2 -C.sub.4 alkenyl; benzyl which may be substituted with halogen, C.sub.1 -C.sub.4 alkyl, nitro, trifluoromethyl, hydroxycarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, or cyano; phenylcarbonylmethyl; pyridylmethyl; phenyl which may be substituted with nitro or halogen; pyridyl or pyrimidyl which may be substituted with nitro; phenylsulfonyl which may be substituted with C.sub.1 -C.sub.4 alkyl; or benzyloxycarbonyl which may be substituted with halogen;n is 4 to 10; andthe mark * indicates that the configuration of the carbon may be either one of D-configuration, L-configuration and DL-configuration or a pharmaceutical acceptable salt thereof.This phenylalanine derivative is effective as a proteinase inhibitor.

10. 发明授权

US4130577A Process for preparing .alpha., .alpha.-dimethylbenzyl isocyanates 失效
标题翻译：制备{60，{60-二甲基苄基异氰酸酯的方法
公开(公告)号：US4130577A
公开(公告)日：1978-12-19
申请号：US844815
申请日：1977-10-25
申请人： Nobuyuki Nagato , Taketoshi Naito
发明人： Nobuyuki Nagato , Taketoshi Naito
IPC分类号： C07B61/00 , B01J21/06 , B01J23/00 , B01J23/02 , B01J23/06 , B01J23/16 , B01J23/44 , B01J23/70 , B01J27/00 , B01J27/02 , B01J27/06 , B01J27/24 , B05D7/26 , C07C67/00 , C07C241/00 , C07C263/02 , C07C265/08 , C07C118/00
CPC分类号： C07C263/00
摘要： Process for preparing .alpha.,.alpha.-dimethylbenzyl isocyanate or its derivatives which comprises reacting the corresponding organic halide in an anhydrous condition in the presence of a specified catalyst with an alkali metal cyanate in an aprotic solvent which forms no salt with a hydrogen halide.
摘要翻译：制备α，α-二甲基苄基异氰酸酯或其衍生物的方法，其包括在规定的催化剂存在下，在无水条件下使碱金属氰酸酯与不与卤化氢形成盐的非质子溶剂中使相应的有机卤化物反应。

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