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1. 发明授权

US07544472B2 Apparatus for detecting biomolecular bonding and a method thereof 有权
标题翻译：用于检测生物分子结合的装置及其方法
公开(公告)号：US07544472B2
公开(公告)日：2009-06-09
申请号：US11325056
申请日：2006-01-03
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
IPC分类号： C12Q1/68 , C12M1/36 , G01N15/06
CPC分类号： G01N33/542 , G01N29/036 , G01N33/54366 , G01N2291/0257
摘要： An apparatus and method for detecting biomolecular bonding are disclosed. The apparatus comprises a substrate; a rotation unit mounted on the substrate, a probe biomolecule immobilized on a surface of the rotation unit; an input port and an output port connected with the substrate. A frequency detector is connected with the output port to measure rotational frequency of the rotation unit. The presence or absence of molecular bonding is detected by measuring difference between the rotational frequencies before and after mixing the probe biomolecule with a sample biomolecule.
摘要翻译：公开了一种用于检测生物分子结合的装置和方法。该装置包括基板; 安装在所述基板上的旋转单元，固定在所述旋转单元的表面上的探针生物分子; 与基板连接的输入端口和输出端口。频率检测器与输出端口连接，以测量旋转单元的旋转频率。通过测量将探针生物分子与样品生物分子混合之前和之后的旋转频率之间的差异来检测分子键的存在或不存在。

2. 发明申请

US20080027088A1 Imidazole-Based Hmg-Coa Reductase Inhibitors 审中-公开
标题翻译：基于咪唑的Hmg-Coa还原酶抑制剂
公开(公告)号：US20080027088A1
公开(公告)日：2008-01-31
申请号：US10594348
申请日：2005-03-21
申请人： Reynold Homan , Sotirios K. Karathanasis , Robert L. Panek , Tae-Sik Park , Mark D. Rekhter
发明人： Reynold Homan , Sotirios K. Karathanasis , Robert L. Panek , Tae-Sik Park , Mark D. Rekhter
IPC分类号： A61K31/201 , A61K31/351 , A61K31/405 , A61K31/455 , A61K31/47 , A61K31/505 , A61P3/04 , A61P3/10
CPC分类号： A61K31/345 , A61K31/22 , A61K2300/00
摘要： The present invention relates to methods of treating atherosclerosis, dyslipidemia, other cardiovascular diseases and related diseases, such as diabetes, using a serine palmitoyltransferase (SPT) inhibitor. The present invention also relates to pharmaceutical compositions and kits that comprise a serine palmitoyltransferase (SPT) inhibitor, optionally with another pharmaceutical agent.
摘要翻译：本发明涉及使用丝氨酸棕榈酰转移酶（SPT）抑制剂治疗动脉粥样硬化，血脂异常，其它心血管疾病和相关疾病如糖尿病的方法。本发明还涉及包含丝氨酸棕榈酰转移酶（SPT）抑制剂，任选地与另一种药剂的药物组合物和试剂盒。

3. 发明申请

US20070273642A1 METHOD AND APPARATUS FOR SELECTING INFORMATION IN MULTI-DIMENSIONAL SPACE 审中-公开
标题翻译：用于选择多维空间信息的方法和装置
公开(公告)号：US20070273642A1
公开(公告)日：2007-11-29
申请号：US11697670
申请日：2007-04-06
申请人： Tae-Sik Park , Sang-Goog Lee , Kwang-Woon Lee
发明人： Tae-Sik Park , Sang-Goog Lee , Kwang-Woon Lee
IPC分类号： G09G5/00
CPC分类号： G06F3/016 , G06F3/011 , G06F3/014 , G06F3/0346 , G06F2203/0331
摘要： Method and apparatus for selecting information in a multi-dimensional space are provided. The method includes the steps of sensing the motion of a user intending to select information, and determining whether the sensed motion is an effective motion intended for information selection and returning to the sensing step if it is determined that the motion is not the effective one. Accordingly, difficulty in setting a predetermined threshold to a single value can be overcome. In addition, even a very slight motion can be accurately detected without being influenced by gravity and offsets. Moreover, it can be accurately determined whether a user's two- or three-dimensional motion is an effective motion for selecting information and which motion unit among at least two motion units has generated the effective motion, so that a high correct recognition rate for information and high reliability can be achieved, and a user is allowed to easily select information.
摘要翻译：提供了用于在多维空间中选择信息的方法和装置。该方法包括以下步骤：感测想要选择信息的用户的运动，以及确定所感测的运动是否是用于信息选择的有效运动，并且如果确定运动不是有效运动则返回到感测步骤。因此，可以克服将预定阈值设置为单个值的困难。此外，即使非常轻微的运动也能够被精确地检测而不受重力和偏移的影响。此外，可以准确地确定用户的二维或三维运动是否是用于选择信息的有效运动，以及至少两个运动单元中的哪个运动单元已经产生有效运动，使得用于信息的高正确识别率可以实现高可靠性，并且允许用户容易地选择信息。

4. 发明申请

US20060147972A1 Apparatus for detecting biomolecular bonding and a method thereof 有权
公开(公告)号：US20060147972A1
公开(公告)日：2006-07-06
申请号：US11325056
申请日：2006-01-03
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N33/542 , G01N29/036 , G01N33/54366 , G01N2291/0257
摘要： An apparatus and method for detecting biomolecular bonding are disclosed. The apparatus comprises a substrate; a rotation unit mounted on the substrate, a probe biomolecule immobilized on a surface of the rotation unit; an input port and an output port connected with the substrate. A frequency detector is connected with the output port to measure rotational frequency of the rotation unit. The presence or absence of molecular bonding is detected by measuring difference between the rotational frequencies before and after mixing the probe biomolecule with a sample biomolecule.

5. 发明申请

US20060017125A1 Vibration type MEMS switch and fabricating method thereof 有权
公开(公告)号：US20060017125A1
公开(公告)日：2006-01-26
申请号：US11182775
申请日：2005-07-18
申请人： Moon-chul Lee , Tae-sik Park , Hee-moon Jeong
发明人： Moon-chul Lee , Tae-sik Park , Hee-moon Jeong
IPC分类号： H01L29/84
CPC分类号： H01H59/0009 , H01H2059/0036 , H01H2059/0063
摘要： A vibration type MEMS switch and a method of fabricating the vibration type MEMS switch. The vibration type MEMS switch includes a vibrating body supplied with an alternating current voltage of a predetermined frequency to vibrate in a predetermined direction; and a stationary contact point spaced apart from the vibrating body along a vibration direction of the vibrating body. When a direct current voltage with a predetermined magnitude is applied to the stationary contact point, a vibration margin of the vibrating body is increased, the vibrating body contacts the stationary contact point and the vibration type MEMS switch is turned on. A first substrate is bonded to a second substrate to isolate the vibrating body in a sealed vacuum space. The vibration type MEMS switch is turned on and/off by a resonance.

6. 发明申请

US20050262941A1 Gyro-sensor comprising a plurality of component units, and fabricating method thereof 有权
标题翻译：包括多个部件单元的陀螺传感器及其制造方法
公开(公告)号：US20050262941A1
公开(公告)日：2005-12-01
申请号：US11141054
申请日：2005-06-01
申请人： Tae-sik Park , Moon-chul Lee , Chang-youl Moon
发明人： Tae-sik Park , Moon-chul Lee , Chang-youl Moon
IPC分类号： G01C19/56 , B81B3/00 , B81B7/00 , B81C3/00 , G01C19/00 , G01C19/5769 , G01P15/08
CPC分类号： B81C1/0023 , B81B2207/07 , G01C19/56 , H01L2224/16225
摘要： Provided are a gyro-sensor including a plurality of component units and a method of fabricating the gyro-sensor. The gyro-sensor includes: a substrate; a micro electro mechanical system structure including a surface including a predetermined area in which a cavity is formed and connected to an upper surface of the substrate to output a vibration signal proportional to an external rotation force; and a circuit unit positioned in the cavity, converting the vibration signal into a predetermined electric signal proportional to a circular angular velocity, and outputting the predetermined electric signal.
摘要翻译：提供了包括多个部件单元的陀螺仪传感器和制造陀螺仪传感器的方法。陀螺传感器包括：基板; 微电子机械系统结构，其包括包括形成空腔的预定区域的表面并且连接到所述基板的上表面以输出与外部旋转力成比例的振动信号; 以及位于所述空腔中的电路单元，将所述振动信号转换为与圆形角速度成比例的预定电信号，并输出所述预定电信号。

7. 发明申请

US20050239120A1 Bio molecular detection apparatus and method thereof 失效
标题翻译：生物分子检测装置及其方法
公开(公告)号：US20050239120A1
公开(公告)日：2005-10-27
申请号：US11114070
申请日：2005-04-26
申请人： Tae-sik Park , Jung-ho Kang , Jong-hwa Won , Young-il Kim , Moon-chul Lee
发明人： Tae-sik Park , Jung-ho Kang , Jong-hwa Won , Young-il Kim , Moon-chul Lee
IPC分类号： G01N22/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N27/02 , G01N27/22 , G01N27/327 , G01N33/543 , G01R33/00
CPC分类号： G01N27/3275 , G01N33/48792
摘要： An apparatus and method of detecting bio molecular by measuring a variation of an electrical characteristic of a circuit having an inductance device and a capacitance device. The bio molecular detection method comprises providing a signal converting unit having at least one inductance device and at least one capacitance device connected with each other, disposing a biochip, which has capturing probe biomolecules attached to a substrate, at a location in the signal converting unit, and measuring an electrical characteristic of the signal converting unit, performing a coupling reaction of the biochip and a sample to be analyzed; and measuring an electrical characteristic of the signal converting unit after the coupling reaction.
摘要翻译：通过测量具有电感器件和电容器件的电路的电特性的变化来检测生物分子的装置和方法。所述生物分子检测方法包括提供信号转换单元，所述信号转换单元具有至少一个电感器件和至少一个电容器件，所述至少一个电容器件彼此连接，在所述信号转换单元中的位置处设置生物芯片，所述生物芯片具有连接到衬底的捕获探针生物分子测量信号转换单元的电特性，进行生物芯片与待分析样品的偶联反应; 并测量耦合反应后的信号转换单元的电特性。

8. 发明申请

US20110020140A1 MICRO PUMP 有权
标题翻译：微型泵
公开(公告)号：US20110020140A1
公开(公告)日：2011-01-27
申请号：US11266903
申请日：2005-11-04
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang , Moon-chul Lee
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang , Moon-chul Lee
IPC分类号： F04B37/02
CPC分类号： F04B19/006 , F04B43/043
摘要： Provided is a micro pump having a simple structure. The micro pump includes a pump chamber including inflow and outflow passages through which a drive fluid flows, a first valve configured to open or close the inflow passage, a second valve configured to open or close the outflow passage, and a pump chamber heating and cooling unit configured to heat or cool the pump chamber.
摘要翻译：提供一种结构简单的微型泵。微型泵包括泵室，其包括驱动流体流过的流入和流出通道，构造成打开或关闭流入通道的第一阀，构造成打开或关闭流出通道的第二阀，以及泵室加热和冷却单元被配置为加热或冷却泵室。

9. 发明申请

US20060018801A1 Sample processing apparatus and method using vacuum chamber 有权
标题翻译：使用真空室的样品处理设备和方法
公开(公告)号：US20060018801A1
公开(公告)日：2006-01-26
申请号：US11188000
申请日：2005-07-25
申请人： Tae-sik Park , Sung-hee Lee , Jung-ho Kang , Young-il Kim , Moon-chul Lee
发明人： Tae-sik Park , Sung-hee Lee , Jung-ho Kang , Young-il Kim , Moon-chul Lee
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L2200/10 , B01L2300/049 , B01L2400/049 , B01L2400/06
摘要： A bio sample processing apparatus and method using vacuum chambers in which a bio sample is injected into a first vacuum chamber connected with one end of a bio processor and, after processing, is ejected into a second vacuum chamber connected with the other end of the bio processor. The vacuum chambers and bio processor are connected with each other to form an environment with a pressure lower than atmospheric pressure, and the bio sample moves toward the second vacuum chamber due to the pressure difference created by the injection of the bio sample into the first vacuum chamber.
摘要翻译：一种使用真空室的生物样品处理装置和方法，其中将生物样品注入与生物处理器的一端连接的第一真空室中，并且在处理之后被喷射到与生物的另一端连接的第二真空室中处理器。真空室和生物处理器彼此连接以形成压力低于大气压的环境，并且生物样品由于将生物样品注入第一真空产生的压差而向第二真空室移动房间。

10. 发明授权

US06683095B2 CDK inhibitors having 3-hydroxychromen-4-one structure 失效
标题翻译：具有3-羟基色烯-4-酮结构的CDK抑制剂
公开(公告)号：US06683095B2
公开(公告)日：2004-01-27
申请号：US10275066
申请日：2002-11-01
申请人： Chang-Yong Hong , Jin-Ho Lee , Tae-Sik Park , Jong-Hyun Kim , Sei-Hyun Choi , Sook-Kyung Yoon , Hyun-Ho Chung , Ho-Sun Son , Eunice Eun-Kyeong Kim , Seong-Gu Ro , Shin-Wu Jeong , Dong-Myung Kim
发明人： Chang-Yong Hong , Jin-Ho Lee , Tae-Sik Park , Jong-Hyun Kim , Sei-Hyun Choi , Sook-Kyung Yoon , Hyun-Ho Chung , Ho-Sun Son , Eunice Eun-Kyeong Kim , Seong-Gu Ro , Shin-Wu Jeong , Dong-Myung Kim
IPC分类号： A61K31453
CPC分类号： C07D405/04 , C07D311/30 , C07D417/04 , C07D417/14
摘要： A novel 3-hydroxychromen-4-one derivative, pharmaceutically acceptable salt, hydrate, solvate or isomer thereof which is useful as an inhibitor for Cyclin Dependent Kinase (“CDK”) is disclosed. Further, a process for preparing the compound and a composition for suppression or treatment of cancer and diseases induced by cell proliferation such as inflammation, angiostenosis, angiogenesis, etc. is disclosed comprising the compound as an active component together with pharmaceutically acceptable carriers.
摘要翻译：公开了一种可用作细胞周期蛋白依赖性激酶（“CDK”）抑制剂的新型3-羟基色烯-4-酮衍生物，其药学上可接受的盐，水合物，溶剂合物或异构体。此外，公开了一种制备化合物的方法和用于抑制或治疗癌症的组合物以及由细胞增殖如炎症，血管狭窄症，血管发生等引起的疾病，其包括作为活性成分的化合物以及药学上可接受的载体。

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