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1. 发明申请

US20160290805A1 SYSTEMS AND METHODS FOR GNSS SNR PROBABILISTIC LOCALIZATION AND 3-D MAPPING 审中-公开
标题翻译： GNSS信噪比概率定位和三维映射的系统与方法
公开(公告)号：US20160290805A1
公开(公告)日：2016-10-06
申请号：US15038702
申请日：2014-12-02
申请人： THE REGENTS OF UNIVERSITY OF CALIFORNIA
发明人： Andrew T. Irish , Jason T. Isaacs , Francois Quitin , Joao P. Hespanha , Upamanyu Madhow
IPC分类号： G01C21/00 , G01S19/22
CPC分类号： G01C21/005 , G01S19/22
摘要： Various embodiments each include at least one of systems, methods, devices, and software for GNSS simultaneous localization and mapping (SLAM). The disclosed techniques demonstrate that simultaneous localization and mapping (SLAM) can be performed using only GNSS SNR and geo-location data, collectively termed GNSS data henceforth. A principled Bayesian approach for doing so is disclosed. A 3-D environment map is decomposed into a grid of binary-state cells (occupancy grid) and the receiver locations are approximated by sets of particles. Using a large number of sparsely sampled GNSS SNR measurements and receiver/satellite coordinates (all available from off-the-shelf GNSS receivers), likelihoods of blockage are associated with every receiver-to-satellite beam. Loopy Belief Propagation is used to estimate the probabilities of each cell being occupied or empty, along with the probability of the particles for each receiver location.
摘要翻译：各种实施例各自包括用于GNSS同时定位和映射（SLAM）的系统，方法，设备和软件中的至少一个。所公开的技术表明，可以仅使用GNSS SNR和地理位置数据（以下统称为GNSS数据）来执行同时定位和映射（SLAM）。披露了一项原则性的贝叶斯方法。 3-D环境图被分解成二进制状态单元格（占用网格），并且接收器位置由一组粒子近似。使用大量稀疏采样的GNSS SNR测量和接收机/卫星坐标（全部可从现成的GNSS接收机获得），阻塞的可能性与每个接收机到卫星的波束相关联。 Loopy信仰传播用于估计每个被占用或空的单元的概率，以及每个接收器位置的粒子的概率。

2. 发明申请

US20140243244A1 MICRO-BUBBLE PLATE FOR PATTERNING BIOLOGICAL AND NON-BIOLOGICAL MATERIALS 审中-公开
标题翻译：用于绘制生物和非生物材料的微孔板
公开(公告)号：US20140243244A1
公开(公告)日：2014-08-28
申请号：US13777949
申请日：2013-02-26
申请人： The Regents of University of California
发明人： Yuli Wang , Mark Bachman , Christopher E. Sims , Guann-Pyng Li , Nancy Allbritton
IPC分类号： C12M1/12
CPC分类号： C12M25/06 , B01L3/5085 , B01L3/5088 , B01L2200/0647 , B01L2300/0829 , B01L2300/161 , C12M25/00
摘要： Systems and methods are provided for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate with regions that will trap gas, usually in the form of bubbles, when the plate is submerged in liquid. Other embodiment of the present invention include a method for placing materials on the plate at pre-determined locations through the use of trapped gas to prevent materials from collecting at unwanted regions. The plate has great utility for plating cells and tissues at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate with coatings at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micromechanical structures—where the structures may be formed from living or non-living material, tissue or non-tissue, organic or inorganic, and the like.
摘要翻译：提供了系统和方法，用于在板上的特定位置图案化生物和非生物材料，以及生长三维结构。优选实施例包括具有区域的板，当板被浸没在液体中时，其具有通常以气泡形式捕获气体的区域。本发明的其它实施方案包括通过使用捕获的气体将材料放置在预定位置处的材料的方法，以防止材料在不需要的区域收集。该板对于在特定位置（例如阵列）上的电镀细胞和组织具有很大的用途。所公开的方法还可以用于在具有特定位置的涂层涂覆板的表面以用于图案化涂布应用，并且建立材料以产生三维结构，包括微机械结构，其中结构可以由活的或非活的材料，组织或非组织，有机或无机等。

3. 发明申请

US20150194606A1 HIGH MOBILITY POLYMER THIN-FILM TRANSISTORS WITH CAPILLARITY-MEDIATED SELF-ASSEMBLY 有权
标题翻译：高移动聚合物薄膜晶体管，具有介电自组装
公开(公告)号：US20150194606A1
公开(公告)日：2015-07-09
申请号：US14585653
申请日：2014-12-30
申请人： THE REGENTS OF UNIVERSITY OF CALIFORNIA
发明人： Chan Luo , Alan Heeger
IPC分类号： H01L51/00 , B05C9/02
CPC分类号： B05C9/02 , H01L51/0012 , H01L51/0036 , H01L51/0043
摘要： Embodiments of the invention include methods and materials for preparing organic semiconducting layers, for example one used in an organic semiconductor device including a substrate with a nanostructured surface and a polymeric semiconductor film overlying the nanostructured surface. Aspects of the invention use capillary action to modulate polymer chain self-assembly on a surface and unidirectional alignment at a critical buried interface where charge carriers migrate between a dielectric and the polymer. By controlling the properties of the surfaces upon which polymers are disposed, artisans can enhance the transistor saturated mobilities of conjugated polymers.
摘要翻译：本发明的实施例包括用于制备有机半导体层的方法和材料，例如用于包括具有纳米结构表面的衬底和覆盖纳米结构化表面的聚合物半导体膜的有机半导体器件中的一种。本发明的方面使用毛细作用来调节表面上的聚合物链自组装和在电荷载体在电介质和聚合物之间迁移的关键掩埋界面处的单向取向。通过控制配置聚合物的表面的性质，技术人员可以增强共轭聚合物的晶体管饱和迁移率。

4. 发明申请

US20030211080A1 Method for in vivo regulation of cardiac muscle contractility 有权
标题翻译：心肌收缩力体内调节方法
公开(公告)号：US20030211080A1
公开(公告)日：2003-11-13
申请号：US10342120
申请日：2003-01-13
申请人： The Regents of University of California
发明人： Wolfgang H. Dillmann , Frank Giordano , Ruben Mestril
IPC分类号： A61K048/00 , C12N015/861
CPC分类号： C12N9/14 , A01K2267/0375 , A61K38/00 , A61K48/00 , C12N15/86 , C12N2710/10343 , C12N2750/14143 , C12Y306/03008
摘要： A method for regulating in vivo calcium transport in cardiac muscle of animals suffering from congestive heart failure is disclosed. According to the method, calcium ATPase activity (which decreases as congestive heart failure develops) and cardiac muscle contractility augmented by delivering a gene which operatively encodes the enzyme into the heart. Delivery systems, including but not limited to using adeno-associated viral vectors are provided. Methods for monitoring the expression and effect of the gene product on cardiac performance are also provided.
摘要翻译：公开了一种用于调节患有充血性心力衰竭的动物心肌肌体内钙转运的方法。根据该方法，通过将可操作地编码酶的基因递送到心脏中，钙ATP酶活性（其随着充血性心力衰竭发展而减少）和心肌收缩力增加。提供递送系统，包括但不限于使用腺相关病毒载体。还提供了监测基因产物对心脏性能的表达和作用的方法。

5. 发明公开

US20240127910A1 METHODS AND SYSTEMS OF PREDICTING AGENT INDUCED EFFECTS IN SILICO 审中-公开
公开(公告)号：US20240127910A1
公开(公告)日：2024-04-18
申请号：US18204912
申请日：2023-06-01
申请人： The Regents of University of California
发明人： Colleen Clancy , Pei-Chi Yang , Kevin DeMarco , Igor V. Vorobyov
IPC分类号： G16C20/50 , G06N20/00 , G16C20/30 , G16C20/70 , G16H50/50
CPC分类号： G16C20/50 , G06N20/00 , G16C20/30 , G16C20/70 , G16H50/50
摘要： The disclosure presents a new computer based model framework to predict drug effects over multiple time and spatial scales from the drug chemistry to the cardiac rhythm. The disclosure presents a new computer based model framework to predict drug effects from the level of the receptor interaction to the cardiac rhythm.

6. 发明申请

US20170066747A1 MCL-1 ANTAGONISTS 审中-公开
标题翻译： MCL-1拮抗剂
公开(公告)号：US20170066747A1
公开(公告)日：2017-03-09
申请号：US15123232
申请日：2015-03-03
申请人： The Regents of University of California , The Royal Institution for the Advancement of Learning/McGill University
发明人： Patrick Harran , James H. Frederich , Gordon Shore , Mai Nguyen
IPC分类号： C07D405/04 , C07D405/14
CPC分类号： C07D405/04 , C07D401/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D471/04
摘要： Provided herein are Mcl-1 antagonist compositions and methods of treating g the compositions described herein.
摘要翻译：本文提供了Mcl-1拮抗剂组合物和治疗本文所述组合物的方法。

7. 发明申请

US20040091578A1 Stabilization of hypoallergenic, hyperdigestible previously reduced proteins 审中-公开
公开(公告)号：US20040091578A1
公开(公告)日：2004-05-13
申请号：US10698824
申请日：2003-10-30
申请人： The Regents of University of California
发明人： Bob B. Buchanan , Susumu Morigasaki , Gregorio del Val , Oscar L. Frick
IPC分类号： C12P021/06 , A23B007/10
CPC分类号： A21D2/26 , A21D2/264 , A21D2/265 , A21D2/266 , A21D2/36 , A21D8/04 , A21D13/064 , A23C9/1209 , A23C9/1213 , A23C9/152 , A23J1/12 , A23J1/14 , A23J3/08 , A23J3/18 , A23K20/147 , A23L5/27 , A23L7/109 , A23L11/34 , A23L13/48 , A23L33/17 , A61K38/00 , A61K39/35 , A61K2035/122 , C07K1/1133 , C07K14/415 , C07K14/43504 , C07K14/46 , C07K14/76 , C07K14/811 , C12N9/0036 , C12N9/20 , C12P21/02 , C12Q1/26 , C12Q1/34 , C12Y108/01008 , C12Y108/01009
摘要： Disulfide proteins showed mitigated allergenicity and increased digestibility by pepsin following reduction by thioredoxin. The sulfhydryl groups newly formed on reduction by thioredoxin (at 4null C.) or dithiothreitol (DTT) (at 55null C.) were blocked with a physiological disulfide, such as cystamine or oxidized glutathione (GSSG) to obtain stable forms of the disarmed allergen. When derivatized with cystamine, BLG was separated from its oxidized and reduced forms on non-reducing SDS-PAGE and appeared to lack sulfhydryl groups. Although less effective GSSG, gave similar results. Allergenicity of the two derivatives was compared with that of the oxidized, reduced and reoxidized forms of BLG by skin testing dogs from a colony sensitized to cow's milk. Both the cystamine and GSSG derivatized BLG showed decreased allergenicity and increased sensitivity to pepsin as compared to controls. The reoxidized form resembled the derivatives in having lower allergenicity. The thioredoxin- and DTT-reduced forms showed hypoallergenic, hyperdigestible properties, most effectively when the reduced proteins were heated at 55null C. Whole milk subjected to these procedures showed results similar to those obtained with pure BLG. Other proteins are similarly stabilized. Stable forms of such disarmed, hypoallergenic and hyperdigestible disulfide protein allergens or just hypoallergenic or just hyperdigestible protein allergens are useful in foods as well as clinical preparations.

8. 发明申请

US20160200639A1 INTERMOLECULAR C-H SILYLATION OF UNACTIVATED ARENES 有权
标题翻译：活化胂的分子间C-H硅烷化
公开(公告)号：US20160200639A1
公开(公告)日：2016-07-14
申请号：US14916787
申请日：2014-09-08
申请人： THE REGENTS OF UNIVERSITY OF CALIFORNIA
发明人： John F. HARTWIG , Chen CHENG , Tyler WILSON
IPC分类号： C07B47/00 , C07F7/08 , C07F7/18
CPC分类号： C07B47/00 , C07F7/0807 , C07F7/0829 , C07F7/0838 , C07F7/0878 , C07F7/1804 , C07F7/1876 , C07F7/188
摘要： Reaction mixtures for silvlating arene substrates and methods of using such reaction mixtures to silyiate the arene substrates are provided. Exemplary reaction mixtures include the arene substrate, a liganded metal catalyst, a hydrogen acceptor and an organic solvent. The reaction conditions allow for diverse substituents on the arene substrate.
摘要翻译：提供用于硅烷化芳烃底物的反应混合物和使用这种反应混合物来使芳烃基团进行硅烷化的方法。示例性的反应混合物包括芳烃底物，配体金属催化剂，氢受体和有机溶剂。反应条件允许芳烃底物上的不同取代基。

9. 发明申请

US20140042390A1 INTERPENETRATING NETWORKS OF CARBON NANOSTRUCTURES AND NANO-SCALE ELECTROACTIVE MATERIALS 审中-公开
标题翻译：碳纳米管和纳米尺度电化学材料的互连网络
公开(公告)号：US20140042390A1
公开(公告)日：2014-02-13
申请号：US13963973
申请日：2013-08-09
申请人： THE REGENTS OF UNIVERSITY OF CALIFORNIA
发明人： George Gruner , Xiangfeng Duan , Bruce S. Dunn , Veronica Augustyn
IPC分类号： H01M4/36 , H01M4/583 , H01L29/16 , H01G9/042 , H01G9/048 , H01L29/15 , H01M4/48 , H01M4/64
CPC分类号： H01M4/364 , B82Y10/00 , H01G9/042 , H01G9/048 , H01G11/24 , H01G11/30 , H01L29/0673 , H01L29/127 , H01L29/15 , H01L29/1606 , H01L29/775 , H01M4/131 , H01M4/48 , H01M4/481 , H01M4/485 , H01M4/502 , H01M4/505 , H01M4/523 , H01M4/5825 , H01M4/583 , H01M4/624 , H01M4/625 , H01M4/64 , Y02E60/13 , Y10T428/25
摘要： An interpenetrating network assembly with a network of connected flakes of nano-scale crystalline carbon and nano-scale particles of an electroactive material interconnected with the carbon flakes is provided. The network assemblies are particularly suited for energy storage applications that use metal oxide electroactive materials and a single charge collector or a source and drain. Interpenetrating networks of graphene flakes and metal oxide nanosheets can form independent pathways between source and drain. Nano-scale conductive materials such as metal nanowires, carbon nanotubes, activated carbon or carbon black can be included as part of the conductive network to improve charge transfer.
摘要翻译：提供了一种互穿网络组件，其具有纳米尺度结晶碳的连接薄片网络和与碳薄片互连的电活性材料的纳米级颗粒。网络组件特别适用于使用金属氧化物电活性材料和单个电荷收集器或源极和漏极的能量存储应用。石墨烯薄片和金属氧化物纳米片的互穿网络可以在源极和漏极之间形成独立的通路。作为导电网络的一部分，可以包括诸如金属纳米线，碳纳米管，活性炭或炭黑的纳米级导电材料以改善电荷转移。

10. 发明申请

US20030056247A1 Phytochrome regulated transcription factor for control of higher plant development 审中-公开
公开(公告)号：US20030056247A1
公开(公告)日：2003-03-20
申请号：US10084553
申请日：2002-02-25
申请人： The Regents of University of California
发明人： Elaine Tobin , Lin Sun , Zhi-Yong Wang
IPC分类号： A01H005/00 , C07H021/04 , C12N009/22
CPC分类号： C12N15/827 , C07K14/415 , C12N15/8261 , Y02A40/146
摘要： The present invention involves the isolation and characterization of the first discovered phytochrome-regulated transcriptional factor, a protein designated CCA1 which binds to the promoter region of the chlorophyll binding protein gene (Lhcb1*3) of Arabidopsis. The Lhcb1*3 gene of Arabidopsis is known to be regulated by phytochrome in etiolated seedlings where a brief illumination by red light results in a large increase in the level of mRNA from this gene. A DNA binding activity, designated CA-1, that interacts with the promoter region of Lhcb1*3 was previously discovered in cellular extracts. This binding activity was used to obtain a cDNA clone for a transcription factor that binds specifically to the Lhcb1*3 promoter. Modification of the expression of CCA1 using techniques of genetic engineering results in unexpected changes in the timing of plant flowering. When CCA1 is overexpressed, it appears that the normal circadian rhythms of the plant are disrupted. The plants take a significantly longer time to reach flowering even in the presence of day length conditions that normally induce flowering. Thus, a method of extending vegetative growth and delaying flowering is provided.

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