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1. 发明申请

WO2008076973A2 BIOPSY MARKER WITH IN SITU-GENERATED IMAGING PROPERTIES 审中-公开
标题翻译：具有原位成像特性的生物标记物
公开(公告)号：WO2008076973A2
公开(公告)日：2008-06-26
申请号：PCT/US2007/087768
申请日：2007-12-17
申请人： C.R.BARD INC. , TALPADE, Dnyanesh, A. , PATHAK, Chandrashekhar, P.
发明人： TALPADE, Dnyanesh, A. , PATHAK, Chandrashekhar, P.
IPC分类号： A61K49/00
CPC分类号： A61B19/54 , A61B5/055 , A61B5/062 , A61B5/064 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/3966 , A61B2090/3995 , A61F2250/0098 , A61K49/0002 , A61K49/0409 , A61K49/18 , A61K49/222
摘要： A biopsy marker having radio-opaque properties that are derived in situ, based on a natural a biological response, such as for example, calcification, accumulation or tissue- concentration of a chemical agent so as to provide an imaging contrast. A biodegradable foam such as collagen foam or gelatin foam is embedded with a biological tissue that is susceptible to the calcification. Initially the marker can be imaged using ultrasound, but over time, the embedded material calcifies causing it to become visible under radiation imaging.
摘要翻译：根据天然生物学反应，例如化学试剂的钙化，积聚或组织浓度，提供原位衍生的具有不透射线性质的活检标记，以提供成像对比度。诸如胶原蛋白泡沫或明胶泡沫的生物可降解泡沫嵌入对钙化敏感的生物组织。最初，可以使用超声波对标记进行成像，但随着时间的推移，嵌入材料钙化，使其在辐射成像下变得可见。

2. 发明申请

WO2009043000A1 CARTRIDGE FOR POWDER AND LIQUID DRUG 审中-公开
标题翻译：粉剂和液体药盒
公开(公告)号：WO2009043000A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/078113
申请日：2008-09-29
申请人： BECTON, DICKINSON AND COMPANY , VEDRINE, Lionel , GROSKOPF, Roger, W. , SWEENEY, Matthew , TALPADE, Dnyanesh, A. , WEI, Min , JETER, Ruane
发明人： VEDRINE, Lionel , GROSKOPF, Roger, W. , SWEENEY, Matthew , TALPADE, Dnyanesh, A. , WEI, Min , JETER, Ruane
IPC分类号： A61M5/28 , A61M5/31
CPC分类号： A61M5/284 , A61M5/2448 , A61M5/288 , A61M5/3134 , A61M5/31513 , A61M5/345 , A61M5/347 , A61M5/348 , A61M2005/3104 , A61M2005/31516 , B65B3/003
摘要： A cartridge or injector (10) for holding and mixing a medical product is provided herein including a tubular body (16) having a cylindrical wall (26) having first (28) and second (30) opposing ends. The wall includes inner (34) and outer (36) surfaces with the inner surface having a generally constant cross-section along at least a drug mixing area. A first stopper (18) is slidably disposed within the wall between the first and second ends, the first stopper defining a liquid-light seal with the inner surface. A second stopper (20) is slidably disposed within the wall between the first stopper and the first end, the second stopper defining a liquid-tight seal with the inner surface. A flexible insert (22) is disposed at or in proximity to the second end, the insert forming a liquid-tight seal with the wall, the insert being pierceable by a medical needle or other piercing instrument. A rigid retainer (24) is fixed to the wall having an opening therein for providing access to the insert for piercing by a medical needle. The insert extends into the retainer and forms a liquid-tight seal across the opening.
摘要翻译：本文提供了用于保持和混合医疗产品的药筒或注射器（10），其包括具有具有第一（28）和第二（30）相对端的圆柱形壁（26）的管状体（16）。该壁包括内部（34）和外部（36）表面，其中内表面沿着至少一个药物混合区域具有大致恒定的横截面。第一止动件（18）可滑动地设置在第一和第二端之间的壁内，第一止动件限定与内表面的液体光密封。第二止动件（20）可滑动地设置在第一止挡件和第一端之间的壁内，第二止动件限定与内表面的液密密封。柔性插入件（22）设置在第二端处或附近，插入件与壁形成液密密封，插入件可被医用针或其它穿刺器械刺穿。刚性的保持器（24）固定在其上具有开口的壁上，用于提供通过医用针穿刺插入物的通路。插入件延伸到保持器中并且跨越开口形成液密密封。

3. 发明申请

WO2008073965A2 MULTIPLE IMAGING MODE TISSUE MARKER 审中-公开
标题翻译：多成像模式组织标记
公开(公告)号：WO2008073965A2
公开(公告)日：2008-06-19
申请号：PCT/US2007087211
申请日：2007-12-12
申请人： BARD INC C R , CASANOVA R MICHAEL , PATHAK CHANDRASHEKHAR P , TALPADE DNYANESH A
发明人： CASANOVA R MICHAEL , PATHAK CHANDRASHEKHAR P , TALPADE DNYANESH A
IPC分类号： A61K49/00
CPC分类号： A61B90/39 , A61B6/481 , A61B8/481 , A61B2090/376 , A61B2090/3908 , A61B2090/3925 , A61B2090/3954 , A61B2090/3966 , A61B2090/3995
摘要： An intracorporeal marker for marking a site within living tissue of a host having a body of porous hydroxyapatite whose physical properties permit the body to be distinguished from human soft tissue under visualization using ultrasonic and radiation imaging modalities.
摘要翻译：用于标记具有多孔羟基磷灰石体的主体的活体组织内的位点的体内标记，其物理性质允许使用超声波和放射成像模式将身体与可视化下的人类软组织区分开。

4. 发明申请

WO2008051987A3 LARGE SAMPLE LOW ASPECT RATIO BIOPSY NEEDLE 审中-公开
标题翻译：大样本低比例生物针
公开(公告)号：WO2008051987A3
公开(公告)日：2008-08-28
申请号：PCT/US2007082259
申请日：2007-10-23
申请人： BARD INC C R , TALPADE DNYANESH A , ANDERSON TYSON D , ALMAZAN DANIEL O
发明人： TALPADE DNYANESH A , ANDERSON TYSON D , ALMAZAN DANIEL O
IPC分类号： A61B10/00
CPC分类号： A61B10/0275 , A61B10/0283
摘要： A high aspect ratio biopsy needle achieves reliable performance with large solid sample size by means of a variety of features and combinations thereof, including support to prevent bending, reinforcement of the needle, and cutting edges arranged to resist deformation.
摘要翻译：高长宽比活检针通过各种特征和组合实现了大的固体样品尺寸的可靠性能，包括用于防止弯曲，针刺的支撑和设置成抵抗变形的切割边缘的支撑。

5. 发明申请

WO2008076973A3 BIOPSY MARKER WITH IN SITU-GENERATED IMAGING PROPERTIES 审中-公开
标题翻译：具有生成成像特性的生物标记
公开(公告)号：WO2008076973A3
公开(公告)日：2008-08-14
申请号：PCT/US2007087768
申请日：2007-12-17
申请人： BARD INC C R , TALPADE DNYANESH A , PATHAK CHANDRASHEKHAR P
发明人： TALPADE DNYANESH A , PATHAK CHANDRASHEKHAR P
IPC分类号： A61B19/00 , A61B17/00 , A61D1/04
CPC分类号： A61B19/54 , A61B5/055 , A61B5/062 , A61B5/064 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/3966 , A61B2090/3995 , A61F2250/0098 , A61K49/0002 , A61K49/0409 , A61K49/18 , A61K49/222
摘要： A biopsy marker having radio-opaque properties that are derived in situ, based on a natural a biological response, such as for example, calcification, accumulation or tissue- concentration of a chemical agent so as to provide an imaging contrast. A biodegradable foam such as collagen foam or gelatin foam is embedded with a biological tissue that is susceptible to the calcification. Initially the marker can be imaged using ultrasound, but over time, the embedded material calcifies causing it to become visible under radiation imaging.
摘要翻译：基于自然的生物反应，例如化学药剂的钙化，积聚或组织浓度，原位衍生的具有不透射线特性的活组织检查标记，以便提供成像对比度。可生物降解的泡沫如胶原蛋白泡沫或明胶泡沫包埋有易于钙化的生物组织。最初可以使用超声波对标记物进行成像，但随着时间的推移，嵌入材料会钙化，导致其在辐射成像下变得可见。

6. 发明申请

WO2008073965A3 MULTIPLE IMAGING MODE TISSUE MARKER 审中-公开
公开(公告)号：WO2008073965A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/087211
申请日：2007-12-12
申请人： C.R. BARD INC. , CASANOVA, R., Michael , PATHAK, Chandrashekhar, P. , TALPADE, Dnyanesh, A.
发明人： CASANOVA, R., Michael , PATHAK, Chandrashekhar, P. , TALPADE, Dnyanesh, A.
IPC分类号： A61B19/00 , A61B17/00 , A61D1/04
摘要： An intracorporeal marker for marking a site within living tissue of a host having a body of porous hydroxyapatite whose physical properties permit the body to be distinguished from human soft tissue under visualization using ultrasonic and radiation imaging modalities.

7. 发明申请

WO2008051987A2 LARGE SAMPLE LOW ASPECT RATIO BIOPSY NEEDLE 审中-公开
标题翻译：大样本低纵横比生物针头
公开(公告)号：WO2008051987A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/082259
申请日：2007-10-23
申请人： C.R. BARD INC. , TALPADE, Dnyanesh, A. , ANDERSON, Tyson, D. , ALMAZAN, Daniel, O.
发明人： TALPADE, Dnyanesh, A. , ANDERSON, Tyson, D. , ALMAZAN, Daniel, O.
IPC分类号： A61B5/151
CPC分类号： A61B10/0275 , A61B10/0283
摘要： A high aspect ratio biopsy needle achieves reliable performance with large solid sample size by means of a variety of features and combinations thereof, including support to prevent bending, reinforcement of the needle, and cutting edges arranged to resist deformation.
摘要翻译：高纵横比活检针通过各种特征及其组合实现可靠的性能，其具有大的固体样本尺寸，包括防止弯曲的支撑，针的加强以及布置为抵抗变形。

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