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1. 发明授权

US11295348B2 On-line advertisement method using advertisement website 有权
公开(公告)号：US11295348B2
公开(公告)日：2022-04-05
申请号：US15874339
申请日：2018-01-18
申请人： Sung Wan Kim
发明人： Sung Wan Kim
IPC分类号： G06Q30/02
摘要： Disclosed is an on-line advertisement method using an advertisement website. An on-line advertisement method according to an embodiment of the present invention provides an advertisement available to a user terminal at a current position of a user terminal which accesses an advertisement website.

2. 发明申请

US20130123624A1 VENTRICULAR ASSIST DEVICE CAPABLE OF IMPLANTATION OF STEM CELLS 审中-公开
标题翻译：能够植入干细胞的血管辅助装置
公开(公告)号：US20130123624A1
公开(公告)日：2013-05-16
申请号：US13523334
申请日：2012-06-14
申请人： David A. Bull , Rafe C. Connors , Harold M. Erickson , James Yockman , Sung Wan Kim
发明人： David A. Bull , Rafe C. Connors , Harold M. Erickson , James Yockman , Sung Wan Kim
IPC分类号： A61K35/34 , C12N5/071
CPC分类号： A61K35/34 , A61B8/12 , A61M1/1001 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/127 , A61M1/3472 , A61M1/3618 , A61M1/3621 , A61M1/3667 , A61M1/3689 , C12N5/0662
摘要： A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber for culturing the captured stem cells. The cultured stem cells can be delivered back to the heart by an electro-mechanical or ultrasound/echocardiographic delivery system that runs through the external path back into the ventricular assist device and allows for the delivery of the stem cells, or other therapeutic biologic or pharmacologic agents, directly into the internal chambers of the heart. Administering the stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, either alone or in combination, to the heart allows the myocardium to regenerate and repair itself even while the heart is attached to the ventricular assist device, ultimately allowing the heart to regenerate, recover and allow the VAD to be removed.
摘要翻译：一种生物心室辅助装置，其还具有捕获，生长和施用干细胞以再生和恢复心脏中损伤的心肌的能力。该装置与传统的心室辅助装置一起工作，并且具有与心室辅助装置的路径一致的额外的外部路径或管。外部途径允许施用干细胞，基因，遗传修饰的细胞或其他治疗生物或药理学剂，以及导致捕获循环干细胞的干细胞收集附件。干细胞收集附件还与用于培养所捕获的干细胞的室相关联。培养的干细胞可以通过机电或超声/超声心动图输送系统递送回心脏，该系统通过外部路径返回到心室辅助装置，并允许输送干细胞或其他治疗性生物学或药理学代理人，直接进入内心的内心。将心脏单独或组合的干细胞，基因，遗传修饰的细胞或其他治疗性生物或药理学剂施用于心脏，即使在心脏附着于心室辅助装置时也能使心肌再生和修复自身，最终允许心脏再生，恢复并允许VAD被去除。

3. 发明申请

US20110286588A1 METHOD FOR PROVIDING PERSONALIZED INTERNET TELEPHONE SERVICE AND TERMINAL USING THE SAME 审中-公开
公开(公告)号：US20110286588A1
公开(公告)日：2011-11-24
申请号：US13145923
申请日：2010-01-21
申请人： Sung Wan Kim
发明人： Sung Wan Kim
IPC分类号： H04W4/24 , H04M11/00
CPC分类号： H04M1/274508 , G06F16/972 , H04L67/306 , H04M1/2535 , H04M1/72583 , H04M3/42153 , H04M3/4931 , H04M15/55 , H04M2203/554 , H04M2207/20 , H04W8/20 , H04W12/06 , H04W12/08 , H04W80/04
摘要： Provided are a method for providing a personalized internet phone, and a terminal using the same. The method includes operations: (S10) of a user (20) using a terminal capable of internet connection to connect to a personalized internet phone service web server (10) and register for service, and store and set personal information in databases (11 and 12) of the personalized internet phone service web server (10); (S20) of the user (20) using a wired/wireless internet phone terminal (21) of an internet phone service provider being used, to connect to the personalized internet phone service web server (10); (S30) of using the wired/wireless internet phone terminal (21) to perform personal authentication and select a billing method, on a displayed screen provided by the personalized internet phone service web server (10); (S40) of, following the personal authentication and billing method selection, using the wired/wireless internet phone terminal (21) to call a phone number from a personally set phone number directory stored in the personal phone number directory storage database (12) of the personalized internet phone service web server (10) and make a phone call to a counterpart (30), or make a phone call using a phone number additionally provided by the personalized internet phone service web server (10); and (S50) of, when a call is made to a new phone number not stored in the personal phone number directory storage database (12), storing call details and the new phone number in the personal phone number directory storage database (12), and then ending the use of the wired/wireless internet phone terminal (21). Accordingly, an internet connecting member provided on a terminal may be used to connect to the personalized internet phone service web server and call a phone number list stored in the user's mobile phone terminal directly from a personal phone number directory storage database, or a list of phone numbers may be received from an additionally provided phone number directory storage database by business type in an area of interest or the current area which is provided by the web server, and the called or provided phone number may be used to make a call. Therefore, a wired/wireless internet phone terminal capable of being used for internet calling with an existing internet phone service provider may be used to connect to the personalized internet phone service web server and make the searching and calling of a phone number to be called as easy as when using the user's own mobile phone terminal, such that wired/wireless internet phone terminals may be popularized.

4. 发明申请

US20110263025A1 BIODEGRADABLE POLYDISULFIDE AMINES FOR GENE DELIVERY 审中-公开
标题翻译：用于基因交付的生物可降解聚氨酯
公开(公告)号：US20110263025A1
公开(公告)日：2011-10-27
申请号：US13132210
申请日：2009-12-02
申请人： Mei Ou , Sung Wan Kim
发明人： Mei Ou , Sung Wan Kim
IPC分类号： C12N15/85 , C07H21/02 , C07H21/00 , C12N15/63 , C12N5/071 , C07C323/41
CPC分类号： C08L79/02 , A61K47/59 , A61K47/595 , C08G73/028 , C12N15/87
摘要： Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(N,N′-cystaminebisacrylamide-spermine), poly(N,N′-cystaminebisaciylamide-N,N′-bis(3-aminopropyl)1,3-propanediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(3-amino-propyl)ethylenediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(2-aminoethyl)-1,3-propanediamine), and poly(N,N′-cystaminebisacrylamide-triethylenetetramine). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and protected oligoamine monomers, followed by deprotection. Complexes are formed by mixing the poly(disulfide amine)s with a nucleic acid. Delivery of the nucleic acid into cells is carried out by contacting the cells with the nucleic acid/poly(disulfide amine) complexes.
摘要翻译：描述了聚（二硫化物胺），制备方法和使用方法。聚（二硫化物胺）的说明性实施方案包括聚（N，N'-胱胺胺双丙烯酰胺 - 精胺），聚（N，N'-胱氨酸双缩水甘油酰胺-N，N'-双（3-氨基丙基）1,3-丙二胺），聚（N，N'-半胱氨酸二丙烯酰胺-N，N'-双（3-氨基 - 丙基）乙二胺），聚（N，N'-胱胺胺双丙烯酰胺-N，N'-双（2-氨基乙基）丙二胺）和聚（N，N'-半胱氨酸二丙烯酰胺 - 三亚乙基四胺）。这些组合物通过在N，N-半胱氨酸二亚甲基丙烯酰胺和被保护的低聚单体之间加入Michael，然后脱保护来制备。通过将聚（二硫化物胺）与核酸混合形成络合物。通过使细胞与核酸/聚（二硫化物胺）络合物接触来进行将细胞递送到细胞中。

5. 发明授权

US07952501B2 Demodulator capable of compensating offset voltage of RF signal and method thereof 有权
标题翻译：能够补偿RF信号的失调电压的解调器及其方法
公开(公告)号：US07952501B2
公开(公告)日：2011-05-31
申请号：US12282605
申请日：2007-09-19
申请人： Sung Wan Kim , Pyeong Han Lee , Sung Hun Chun
发明人： Sung Wan Kim , Pyeong Han Lee , Sung Hun Chun
IPC分类号： H03M1/06
CPC分类号： H04B1/30
摘要： A demodulator capable of compensating for an offset voltage of a radio frequency (RF) signal, and a method of compensating for the offset voltage of the RF signal are provided. The demodulator includes an analog-to-digital conversion (ADC) unit for converting a first analog signal corresponding to a difference between the RF signal comprising the offset voltage and an analog reference signal into a first digital signal, and a compensation voltage generation unit for converting the first digital signal into an offset compensation voltage. The ADC unit converts a second analog signal corresponding to a difference between the RF signal comprising the offset voltage and the offset compensation voltage into a second digital signal. Accordingly, the offset voltage included in the RF signal is compensated for, and thus distortion and a signal-to-noise ratio (SNR) of the RF signal are reduced. This leads to an improvement of the reception sensitivity of an RF receiver.
摘要翻译：提供能够补偿射频（RF）信号的偏移电压的解调器，以及补偿RF信号的偏移电压的方法。解调器包括用于将与包括偏移电压的RF信号和模拟参考信号之间的差相对应的第一模拟信号转换为第一数字信号的模数转换（ADC）单元，以及用于将第一数字信号转换成偏移补偿电压。 ADC单元将与包括偏移电压的RF信号和偏移补偿电压之间的差相对应的第二模拟信号转换为第二数字信号。因此，包括在RF信号中的偏移电压被补偿，因此RF信号的失真和信噪比（SNR）降低。这导致RF接收机的接收灵敏度的提高。

6. 发明授权

US07740877B2 Aliphatically modified biodegradable block copolymers as thermogelling polymers 有权
标题翻译：脂肪族改性的生物可降解嵌段共聚物作为热凝胶聚合物
公开(公告)号：US07740877B2
公开(公告)日：2010-06-22
申请号：US11784528
申请日：2007-04-06
申请人： Sung Wan Kim , Seongbong Jo , Jin Kim
发明人： Sung Wan Kim , Seongbong Jo , Jin Kim
IPC分类号： A61F2/02 , C08G63/08
CPC分类号： C08L67/04 , A61K9/0024 , A61K9/06 , A61K47/34 , C08G63/664
摘要： A thermogelling, aliphatically modified polymer for use in drug delivery is described. Illustrative embodiments include poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) hexanoate and poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) laurate. Another illustrative embodiment includes a composition having a thermogelling amount of an aliphatically modified poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) and an effective amount of a drug. The thermogelling polymers are made by bonding an aliphatic group to poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone). A method of use includes injecting a warm-blooded individual with a thermogelling amount of the aliphatically modified polymer and a drug.
摘要翻译：描述了用于药物递送的耐热凝胶，脂质改性聚合物。说明性实施方案包括聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）己酸酯和聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）月桂酸酯。另一个说明性实施方案包括具有热凝胶量的脂族改性聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）和有效量的药物。热胶凝聚合物通过将脂族基团与聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）结合而制备。一种使用方法包括用热胶凝量的脂质改性聚合物和药物注射温血个体。

7. 发明申请

US20100010067A1 ARGININE-CONJUGATED BIOREDUCIBLE POLY(DISULFIDE AMINE) POLYMERS FOR GENE DELIVERY SYSTEM 有权
标题翻译：用于基因输送系统的ARGININE-CONJUGATED BIOREDUCIBLE POLY（DISANCED AMINE）POLYMERS FOR GENE DELIVERY SYSTEM
公开(公告)号：US20100010067A1
公开(公告)日：2010-01-14
申请号：US12496568
申请日：2009-07-01
申请人： Sun Hwa Kim , Ji Hoon Jeong , Tae-il Kim , Sung Wan Kim , David A. Bull
发明人： Sun Hwa Kim , Ji Hoon Jeong , Tae-il Kim , Sung Wan Kim , David A. Bull
IPC分类号： A61K48/00 , C08G75/14 , C12N15/09
CPC分类号： A61K9/5146 , A61K47/34 , A61K47/59 , A61K47/595 , A61K47/6455 , A61K48/0041 , C12N15/111 , C12N2320/32
摘要： An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with siRNA. ABP is biodegraded under reducing conditions, such as in the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity. ABP is an effective delivery vehicle for gene silencing with siRNA and may be used for treating cancer.
摘要翻译：描述了精氨酸接枝的可生物还原的聚（二硫化胺）（“ABP”）作为有效和无毒的基因递送的试剂。 ABP用siRNA形成小于200nm的带正电荷的纳米颗粒。 ABP在还原条件下如细胞质中生物降解。与哺乳动物细胞中的聚乙烯亚胺相比，ABP的转染效率高得多，不显示细胞毒性。 ABP是用于siRNA基因沉默的有效递送载体，可用于治疗癌症。

8. 发明申请

US20090130752A1 BIODEGRADABLE POLY(DISULFIDE AMINE)S FOR GENE DELIVERY 审中-公开
标题翻译：生物可降解聚（氨基磺酸）S用于基因交付
公开(公告)号：US20090130752A1
公开(公告)日：2009-05-21
申请号：US12267015
申请日：2008-11-07
申请人： Sung Wan Kim , Mei Ou
发明人： Sung Wan Kim , Mei Ou
IPC分类号： C12N15/00 , C07C233/00 , C07H21/00 , C12N15/63 , C07H21/02
CPC分类号： C07C323/41 , C07H21/00 , C07H21/02 , C12N15/87
摘要： Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(CBA-DAE), poly(CBA-DAB), and poly(CBA-DAH). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and N-Boc-protected diamine monomers, followed by N-Boc deprotection. Complexes are formed by mixing the poly(disulfide amine)s with nucleic acid. Delivery of the nucleic acid into cells is carried out by contacting the cells with the nucleic acid/poly(disulfide amine) complexes.
摘要翻译：描述了聚（二硫化物胺），制备方法和使用方法。聚（二硫化物胺）的说明性实施方案包括聚（CBA-DAE），聚（CBA-DAB）和聚（CBA-DAH）。这些组合物是通过在N，N-半胱氨酸二亚甲基丙烯酰胺和N-Boc-保护的二胺单体之间加入Michael，然后进行N-Boc去保护来制备的。通过将聚（二硫化物胺）与核酸混合形成络合物。通过使细胞与核酸/聚（二硫化物胺）络合物接触来进行将细胞递送到细胞中。

9. 发明申请

US20080187764A1 NANO- OR MICRO-SCALE ORGANIC-INORGANIC COMPOSITE DEVICE AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：纳米或微尺度有机无机复合材料及其制造方法
公开(公告)号：US20080187764A1
公开(公告)日：2008-08-07
申请号：US11859406
申请日：2007-09-21
申请人： Won Cheol JUNG , Seok Gwang DOO , Sung Ho PARK , Sang Cheol PARK , Sang Hoon YOO , Sung Wan KIM
发明人： Won Cheol JUNG , Seok Gwang DOO , Sung Ho PARK , Sang Cheol PARK , Sang Hoon YOO , Sung Wan KIM
IPC分类号： B32B15/08 , C25D1/00
CPC分类号： C25D1/04 , C23C28/00 , H01L51/4253 , H01L51/441 , Y02E10/549 , Y02P70/521 , Y10T428/31533 , Y10T428/31678 , Y10T428/31855
摘要： Disclosed herein is a nano- or micro-scale organic-inorganic composite device and a method for producing the same. The nano- or micro-scale organic-inorganic composite device includes a first electrode, a second electrode, and a photoactive layer formed of a fullerene-conducting polymer composite interposed between opposing surfaces of the first electrode and the second electrode, and a method of producing a nano- or micro-scale organic-inorganic composite device capable of mass production of the nano- or micro-scale organic-inorganic composite device, by producing an integrated structure of nano- or micro-scale organic-inorganic composite devices of a uniform size and quality using a porous template, where each device includes a first and second electrode, and a photoactive layer.
摘要翻译：本文公开了一种纳米级或微尺度有机 - 无机复合器件及其制造方法。纳米级或微尺度有机 - 无机复合器件包括第一电极，第二电极和介于第一电极和第二电极的相对表面之间的富勒烯导电聚合物复合材料形成的光活性层，以及生产能够大规模生产纳米或微尺度有机 - 无机复合器件的纳米或微尺度有机 - 无机复合器件，通过生产纳米级或微尺度有机 - 无机复合器件的整合结构使用多孔模板的均匀尺寸和质量，其中每个装置包括第一和第二电极以及光活性层。

10. 发明授权

US5853723A Targeting of peg antibody conjugates to islet cells 失效
标题翻译：将peg抗体缀合物靶向胰岛细胞
公开(公告)号：US5853723A
公开(公告)日：1998-12-29
申请号：US710653
申请日：1996-09-20
申请人： Harvey Jacobs , Sung Wan Kim , Virginie Menard
发明人： Harvey Jacobs , Sung Wan Kim , Virginie Menard
IPC分类号： A61K39/395 , A61K31/00 , A61K38/00 , A61K39/44 , A61K47/48 , A61P3/00 , A61P3/10 , C07K16/40 , A61K47/00
CPC分类号： A61K47/48215 , A61K39/44 , A61K47/48646 , C07K16/40 , A61K38/00 , C07K2317/55
摘要： A method for delaying onset of insulin dependent diabetes mellitus (IDDM) in an individual predisposed to developing the disease is disclosed. The method comprises administering a composition comprising an immunologically effective monoclonal antibody or fragment thereof against glutamic acid decarboxylase (GAD) coupled to a nonimmunogenic hydrophilic polymer that provides a hydration shell around the monoclonal antibody for inhibiting immune recognition thereof. Poly(ethylene glycol) is a preferred polymer. A method of reducing insulitis in an IDDM patient and a composition therefor are also described.
摘要翻译：公开了一种在发生该疾病的个体中延缓胰岛素依赖性糖尿病（IDDM）发病的方法。该方法包括施用包含免疫有效的单克隆抗体或其片段的组合物，其抗体与非免疫原性亲水性聚合物偶联的谷氨酸脱羧酶（GAD），所述非免疫原性亲水性聚合物在单克隆抗体周围提供水合壳以抑制其免疫识别。聚（乙二醇）是优选的聚合物。还描述了减少IDDM患者的胰岛炎的方法及其组合物。

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