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1. 发明申请

US20110263025A1 BIODEGRADABLE POLYDISULFIDE AMINES FOR GENE DELIVERY 审中-公开
标题翻译：用于基因交付的生物可降解聚氨酯
公开(公告)号：US20110263025A1
公开(公告)日：2011-10-27
申请号：US13132210
申请日：2009-12-02
申请人： Mei Ou , Sung Wan Kim
发明人： Mei Ou , Sung Wan Kim
IPC分类号： C12N15/85 , C07H21/02 , C07H21/00 , C12N15/63 , C12N5/071 , C07C323/41
CPC分类号： C08L79/02 , A61K47/59 , A61K47/595 , C08G73/028 , C12N15/87
摘要： Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(N,N′-cystaminebisacrylamide-spermine), poly(N,N′-cystaminebisaciylamide-N,N′-bis(3-aminopropyl)1,3-propanediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(3-amino-propyl)ethylenediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(2-aminoethyl)-1,3-propanediamine), and poly(N,N′-cystaminebisacrylamide-triethylenetetramine). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and protected oligoamine monomers, followed by deprotection. Complexes are formed by mixing the poly(disulfide amine)s with a nucleic acid. Delivery of the nucleic acid into cells is carried out by contacting the cells with the nucleic acid/poly(disulfide amine) complexes.
摘要翻译：描述了聚（二硫化物胺），制备方法和使用方法。聚（二硫化物胺）的说明性实施方案包括聚（N，N'-胱胺胺双丙烯酰胺 - 精胺），聚（N，N'-胱氨酸双缩水甘油酰胺-N，N'-双（3-氨基丙基）1,3-丙二胺），聚（N，N'-半胱氨酸二丙烯酰胺-N，N'-双（3-氨基 - 丙基）乙二胺），聚（N，N'-胱胺胺双丙烯酰胺-N，N'-双（2-氨基乙基）丙二胺）和聚（N，N'-半胱氨酸二丙烯酰胺 - 三亚乙基四胺）。这些组合物通过在N，N-半胱氨酸二亚甲基丙烯酰胺和被保护的低聚单体之间加入Michael，然后脱保护来制备。通过将聚（二硫化物胺）与核酸混合形成络合物。通过使细胞与核酸/聚（二硫化物胺）络合物接触来进行将细胞递送到细胞中。

2. 发明申请

US20090130752A1 BIODEGRADABLE POLY(DISULFIDE AMINE)S FOR GENE DELIVERY 审中-公开
标题翻译：生物可降解聚（氨基磺酸）S用于基因交付
公开(公告)号：US20090130752A1
公开(公告)日：2009-05-21
申请号：US12267015
申请日：2008-11-07
申请人： Sung Wan Kim , Mei Ou
发明人： Sung Wan Kim , Mei Ou
IPC分类号： C12N15/00 , C07C233/00 , C07H21/00 , C12N15/63 , C07H21/02
CPC分类号： C07C323/41 , C07H21/00 , C07H21/02 , C12N15/87
摘要： Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(CBA-DAE), poly(CBA-DAB), and poly(CBA-DAH). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and N-Boc-protected diamine monomers, followed by N-Boc deprotection. Complexes are formed by mixing the poly(disulfide amine)s with nucleic acid. Delivery of the nucleic acid into cells is carried out by contacting the cells with the nucleic acid/poly(disulfide amine) complexes.
摘要翻译：描述了聚（二硫化物胺），制备方法和使用方法。聚（二硫化物胺）的说明性实施方案包括聚（CBA-DAE），聚（CBA-DAB）和聚（CBA-DAH）。这些组合物是通过在N，N-半胱氨酸二亚甲基丙烯酰胺和N-Boc-保护的二胺单体之间加入Michael，然后进行N-Boc去保护来制备的。通过将聚（二硫化物胺）与核酸混合形成络合物。通过使细胞与核酸/聚（二硫化物胺）络合物接触来进行将细胞递送到细胞中。

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