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1. 发明申请

US20130123624A1 VENTRICULAR ASSIST DEVICE CAPABLE OF IMPLANTATION OF STEM CELLS 审中-公开
标题翻译：能够植入干细胞的血管辅助装置
公开(公告)号：US20130123624A1
公开(公告)日：2013-05-16
申请号：US13523334
申请日：2012-06-14
申请人： David A. Bull , Rafe C. Connors , Harold M. Erickson , James Yockman , Sung Wan Kim
发明人： David A. Bull , Rafe C. Connors , Harold M. Erickson , James Yockman , Sung Wan Kim
IPC分类号： A61K35/34 , C12N5/071
CPC分类号： A61K35/34 , A61B8/12 , A61M1/1001 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/127 , A61M1/3472 , A61M1/3618 , A61M1/3621 , A61M1/3667 , A61M1/3689 , C12N5/0662
摘要： A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber for culturing the captured stem cells. The cultured stem cells can be delivered back to the heart by an electro-mechanical or ultrasound/echocardiographic delivery system that runs through the external path back into the ventricular assist device and allows for the delivery of the stem cells, or other therapeutic biologic or pharmacologic agents, directly into the internal chambers of the heart. Administering the stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, either alone or in combination, to the heart allows the myocardium to regenerate and repair itself even while the heart is attached to the ventricular assist device, ultimately allowing the heart to regenerate, recover and allow the VAD to be removed.
摘要翻译：一种生物心室辅助装置，其还具有捕获，生长和施用干细胞以再生和恢复心脏中损伤的心肌的能力。该装置与传统的心室辅助装置一起工作，并且具有与心室辅助装置的路径一致的额外的外部路径或管。外部途径允许施用干细胞，基因，遗传修饰的细胞或其他治疗生物或药理学剂，以及导致捕获循环干细胞的干细胞收集附件。干细胞收集附件还与用于培养所捕获的干细胞的室相关联。培养的干细胞可以通过机电或超声/超声心动图输送系统递送回心脏，该系统通过外部路径返回到心室辅助装置，并允许输送干细胞或其他治疗性生物学或药理学代理人，直接进入内心的内心。将心脏单独或组合的干细胞，基因，遗传修饰的细胞或其他治疗性生物或药理学剂施用于心脏，即使在心脏附着于心室辅助装置时也能使心肌再生和修复自身，最终允许心脏再生，恢复并允许VAD被去除。

2. 发明授权

US08241198B2 Ventricular assist device capable of implantation of stem cells 有权
标题翻译：能够植入干细胞的心室辅助装置
公开(公告)号：US08241198B2
公开(公告)日：2012-08-14
申请号：US12513310
申请日：2007-11-05
申请人： David A. Bull , Rafe C. Connors , Harold M. Erickson , James Yockman , Sung Wan Kim
发明人： David A. Bull , Rafe C. Connors , Harold M. Erickson , James Yockman , Sung Wan Kim
IPC分类号： A61M1/12
CPC分类号： A61K35/34 , A61B8/12 , A61M1/1001 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/127 , A61M1/3472 , A61M1/3618 , A61M1/3621 , A61M1/3667 , A61M1/3689 , C12N5/0662
摘要： A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory (14) that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber (39) for culturing the captured stem cells. The cultured stem cells can be delivered back to the heart by an electro-mechanical or ultrasound/echocardiographic delivery system that runs through the external path back into the ventricular assist device and allows for the delivery of the stem cells, or other therapeutic biologic or pharmacologic agents, directly into the internal chambers of the heart. Administering the stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, either alone or in combination, to the heart allows the myocardium to regenerate and repair itself even while the heart is attached to the ventricular assist device, ultimately allowing the heart to regenerate, recover and allow the VAD to be removed.
摘要翻译：一种生物心室辅助装置，其还具有捕获，生长和施用干细胞以再生和恢复心脏中损伤的心肌的能力。该装置与传统的心室辅助装置一起工作，并且具有与心室辅助装置的路径一致的额外的外部路径或管。外部途径允许施用干细胞，基因，遗传修饰的细胞或其他治疗生物或药理学试剂，以及导致捕获循环干细胞的干细胞收集附件（14）。干细胞收集附件还与用于培养所捕获的干细胞的室（39）相关联。培养的干细胞可以通过机电或超声/超声心动图输送系统递送回心脏，该系统通过外部路径返回到心室辅助装置，并允许输送干细胞或其他治疗性生物学或药理学代理人，直接进入内心的内心。将心脏单独或组合的干细胞，基因，遗传修饰的细胞或其他治疗性生物或药理学剂施用于心脏，即使在心脏附着于心室辅助装置时也能使心肌再生和修复自身，最终允许心脏再生，恢复并允许VAD被去除。

3. 发明申请

US20100145442A1 VENTRICULAR ASSIST DEVICE CAPABLE OF IMPLANTATION OF STEM CELLS 有权
标题翻译：能够植入干细胞的血管辅助装置
公开(公告)号：US20100145442A1
公开(公告)日：2010-06-10
申请号：US12513310
申请日：2007-11-05
申请人： David A. Bull , Rafe C. Connors , Harold M. Erickson , James Yockman , Sung Kim
发明人： David A. Bull , Rafe C. Connors , Harold M. Erickson , James Yockman , Sung Kim
IPC分类号： A61M1/10 , A61M37/00
CPC分类号： A61K35/34 , A61B8/12 , A61M1/1001 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/127 , A61M1/3472 , A61M1/3618 , A61M1/3621 , A61M1/3667 , A61M1/3689 , C12N5/0662
摘要： A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory (14) that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber (39) for culturing the captured stem cells. The cultured stem cells can be delivered back to the heart by an electro-mechanical or ultrasound/echocardiographic delivery system that runs through the external path back into the ventricular assist device and allows for the delivery of the stem cells, or other therapeutic biologic or pharmacologic agents, directly into the internal chambers of the heart. Administering the stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, either alone or in combination, to the heart allows the myocardium to regenerate and repair itself even while the heart is attached to the ventricular assist device, ultimately allowing the heart to regenerate, recover and allow the VAD to be removed.
摘要翻译：一种生物心室辅助装置，其还具有捕获，生长和施用干细胞以再生和恢复心脏中损伤的心肌的能力。该装置与传统的心室辅助装置一起工作，并且具有与心室辅助装置的路径一致的额外的外部路径或管。外部途径允许施用干细胞，基因，遗传修饰的细胞或其他治疗生物或药理学试剂，以及导致捕获循环干细胞的干细胞收集附件（14）。干细胞收集附件还与用于培养所捕获的干细胞的室（39）相关联。培养的干细胞可以通过机电或超声/超声心动图输送系统递送回心脏，该系统通过外部路径返回到心室辅助装置，并允许输送干细胞或其他治疗性生物学或药理学代理人，直接进入内心的内心。将心脏单独或组合的干细胞，基因，遗传修饰的细胞或其他治疗性生物或药理学剂施用于心脏，即使在心脏附着于心室辅助装置时也能使心肌再生和修复自身，最终允许心脏再生，恢复并允许VAD被去除。

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