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1. 发明授权

US10221446B1 Signal propagation biomolecules, devices and methods 有权
公开(公告)号：US10221446B1
公开(公告)日：2019-03-05
申请号：US15283594
申请日：2016-10-03
申请人： Carl Brown, III , Steven Wayde Graves , Darko Stefanovic , Matthew Richard Lakin
发明人： Carl Brown, III , Steven Wayde Graves , Darko Stefanovic , Matthew Richard Lakin
IPC分类号： C12Q1/68 , C12Q1/6818 , C07H21/02 , C07H21/04
摘要： This disclosure describes a structured polynucleotide, devices that include the structured polynucleotide, and methods involving the structured polynucleotide and/or devices. Generally, the structured polynucleotide includes five domains. A first domain acts as a toehold for an input DNA logic gate to initiate binding to an SCS biomolecule. A second domain acts as a substrate recognition sequence for an upstream DNA logic gate. A third domain acts as a toehold for a output DNA logic gate to initiate binding of the SCS biomolecule to the gate. A fourth domain acts as an effector sequence to alter the state of the output logic gate. A fifth domain acts as a cage sequence to lock the effector sequence in an inactive state until an input gate binds to the structured polynucleotide.

2. 发明授权

US09274042B2 Spatially correlated light collection from multiple sample streams excited with a line focused light source 有权
标题翻译：用线聚焦光源激发的多个样品流的空间相关光收集
公开(公告)号：US09274042B2
公开(公告)日：2016-03-01
申请号：US13835108
申请日：2013-03-15
申请人： Steven Wayde Graves , Pearlson Prashanth Austin Suthanthiraraj , Andrew P. Shreve , Gabriel P Lopez
发明人： Steven Wayde Graves , Pearlson Prashanth Austin Suthanthiraraj , Andrew P. Shreve , Gabriel P Lopez
IPC分类号： G01N21/00 , G01N15/14 , G01N21/64
CPC分类号： G01N15/14 , G01N15/1404 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/64 , G01N2015/142
摘要： An affordable flow cytometry system with a significantly increased analytical rate, volumetric sample delivery and usable particle size including a light beam that interrogates multiple flow streams so as to provide excitation across all of the streams, and an optical objective configured to collect light from the sample streams and image the light onto an array detector.
摘要翻译：具有显着增加的分析速率，体积样品递送和可用粒度的可负担的流式细胞计量系统，其包括询问多个流动流的光束，以便在所有流中提供激发;以及光学物镜，被配置为收集来自样品的光流并将光成像到阵列检测器上。

3. 发明申请

US20090107241A1 METHOD FOR NON-CONTACT PARTICLE MANIPULATION AND CONTROL OF PARTICLE SPACING ALONG AN AXIS 有权
标题翻译：非接触粒子操纵的方法和颗粒间距的控制
公开(公告)号：US20090107241A1
公开(公告)日：2009-04-30
申请号：US11923403
申请日：2007-10-24
申请人： Gregory Russ GODDARD , Gregory KADUCHAK , James Hubert JETT , Steven Wayde GRAVES
发明人： Gregory Russ GODDARD , Gregory KADUCHAK , James Hubert JETT , Steven Wayde GRAVES
IPC分类号： G01H17/00
CPC分类号： G01N15/1404 , G01N2015/142
摘要： One or more of the embodiments of the present invention provide for a method of non-contact particle manipulation and control of particle spacing along an axis which includes axial and radial acoustic standing wave fields. Particles are suspended in an aqueous solution, and this solution then flows into the cylindrical flow channel. While the solution flows through the flow channel, the outer structure of the flow channel is vibrated at a resonant frequency, causing a radial acoustic standing wave field to form inside the flow channel in the solution. These radial acoustic standing waves focus the particles suspended in the solution to the center axis of the cylindrical flow channel.At the same time, a transducer is used to create an axial acoustic standing wave field in the flow channel parallel to the axis of the flow channel. This drives the particles, which are already being focused to the center axis of the flow channel, to nodes or anti-nodes of the axial standing wave at half-wavelength intervals, depending on whether the particles are more or less dense and more or less compressible than the surrounding fluid.
摘要翻译：本发明的一个或多个实施例提供了一种非接触式粒子操纵和沿着包括轴向和径向声驻波的轴的颗粒间隔的控制的方法。将颗粒悬浮在水溶液中，然后将该溶液流入圆柱形流动通道。当溶液流过流动通道时，流动通道的外部结构以共振频率振动，导致在溶液中的流动通道内形成径向声驻波。这些径向声驻波将悬浮在溶液中的颗粒聚焦到圆柱形流动通道的中心轴线上。同时，传感器用于在平行于流动通道的轴线的流动通道中产生轴向声波驻波场。这些粒子已经被聚焦到流动通道的中心轴线，以半波长间隔的轴向驻波的节点或反节点驱动，这取决于粒子是多或少密集还是多或少可压缩比周围的液体。

4. 发明申请

US20140349276A1 SIGNAL PROPAGATION BIOMOLECULES, DEVICES AND METHODS 有权
标题翻译：信号传播生物分子，设备和方法
公开(公告)号：US20140349276A1
公开(公告)日：2014-11-27
申请号：US14283993
申请日：2014-05-21
申请人： CARL BROWN III , STEVEN WAYDE GRAVES , DARKO STEFANOVIC , MATTHEW RICHARD LAKIN
发明人： CARL BROWN III , STEVEN WAYDE GRAVES , DARKO STEFANOVIC , MATTHEW RICHARD LAKIN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2521/345 , C12Q2525/301 , C12Q2565/1015
摘要： This disclosure describes a structured polynucleotide, devices that include the structured polynucleotide, and methods involving the structured polynucleotide and/or devices. Generally, the structured polynucleotide includes five domains. A first domain acts as a toehold for an input DNA logic gate to initiate binding to an SCS biomolecule. A second domain acts as a substrate recognition sequence for an upstream DNA logic gate. A third domain acts as a toehold for a output DNA logic gate to initiate binding of the SCS biomolecule to the gate. A fourth domain acts as an effector sequence to alter the state of the output logic gate. A fifth domain acts as a cage sequence to lock the effector sequence in an inactive state until an input gate binds to the structured polynucleotide.
摘要翻译：本公开描述了结构化多核苷酸，包括结构化多核苷酸的装置和涉及结构化多核苷酸和/或装置的方法。通常，结构化多核苷酸包括五个结构域。第一个域用作输入DNA逻辑门的始发点，以启动与SCS生物分子的结合。第二个域用作上游DNA逻辑门的底物识别序列。第三个域用作输出DNA逻辑门的脚注，以启动SCS生物分子与门的结合。第四个域用作效应序列来改变输出逻辑门的状态。第五结构域充当笼状序列，以将效应序列锁定在无活性状态，直到输入门结合结构化多核苷酸。

5. 发明申请

US20120298236A1 Method for Non-Contact Particle Manipulation and Control of Particle Spacing Along an Axis 有权
标题翻译：非接触式颗粒操作方法和沿轴的颗粒间距控制
公开(公告)号：US20120298236A1
公开(公告)日：2012-11-29
申请号：US13570605
申请日：2012-08-09
申请人： Gregory Russ Goddard , Gregory Kaduchak , James Hubert Jett , Steven Wayde Graves
发明人： Gregory Russ Goddard , Gregory Kaduchak , James Hubert Jett , Steven Wayde Graves
IPC分类号： F03B11/00
CPC分类号： G01N15/1404 , G01N15/1484 , G01N2015/142 , G01N2015/149 , Y10T137/206
摘要： Method and system for uniformly spacing particles in a flowing system comprising suspending particles in an elongated fluid filled cavity; exposing said cavity to an axial acoustic standing wave field, wherein said axial acoustic standing wave field drives said particles to nodal and anti-nodal positions along the center axis of said cavity to result in uniformly spaced particles; and focusing said particles to the center axis of said cavity.
摘要翻译：用于在流动系统中均匀间隔颗粒的方法和系统，包括将颗粒悬浮在细长的流体填充空腔中; 将所述空腔暴露于轴向声驻波场，其中所述轴向声驻波场沿着所述空腔的中心轴线将所述颗粒驱动到节点和反节点位置，以产生均匀间隔的颗粒; 并将所述颗粒聚焦到所述空腔的中心轴线上。

6. 发明申请

US20130214176A1 Spatially Correlated Light Collection from Multiple Sample Streams Excited with a Line Focused Light Source 有权
标题翻译：使用线聚焦光源激发的多个样品流的空间相关光收集
公开(公告)号：US20130214176A1
公开(公告)日：2013-08-22
申请号：US13835108
申请日：2013-03-15
申请人： Steven Wayde Graves , Pearlson Prashanth Austin Suthanthiraraj , Andrew P. Shreve , Gabriel P. Lopez
发明人： Steven Wayde Graves , Pearlson Prashanth Austin Suthanthiraraj , Andrew P. Shreve , Gabriel P. Lopez
IPC分类号： G01N15/14 , G01N21/64
CPC分类号： G01N15/14 , G01N15/1404 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/64 , G01N2015/142
摘要： An affordable flow cytometry system with a significantly increased analytical rate, volumetric sample delivery and usable particle size including a light beam that interrogates multiple flow streams so as to provide excitation across all of the streams, and an optical objective configured to collect light from the sample streams and image the light onto an array detector.
摘要翻译：具有显着增加的分析速率，体积样品递送和可用粒度的可负担的流式细胞计量系统，其包括询问多个流动流的光束，以便在所有流中提供激发;以及光学物镜，被配置为收集来自样品的光流并将光成像到阵列检测器上。

7. 发明授权

US08830451B1 Multinode acoustic focusing for parallel flow cytometry analysis applications 有权
公开(公告)号：US08830451B1
公开(公告)日：2014-09-09
申请号：US13103756
申请日：2011-05-09
申请人： Steven Wayde Graves , Robert W. Applegate, Jr. , Gabriel Lopez , Menake Eranda Piyasena
发明人： Steven Wayde Graves , Robert W. Applegate, Jr. , Gabriel Lopez , Menake Eranda Piyasena
IPC分类号： G01N21/00 , G01N15/02 , G01N15/14
CPC分类号： G01N15/1459 , G01N15/0205 , G01N15/1404 , G01N15/1484 , G01N2015/142
摘要： An analytical device such as a flow cytometer is provided in which a fluid sample flowing through a channel is focused into multiple, parallel particle streams by an acoustic wave field extending across the channel. Each stream is then presented to an individual detector to allow for simultaneous interrogation of the multiple streams and thus, high-throughput analysis of the fluid sample.

8. 发明授权

US08528406B2 Method for non-contact particle manipulation and control of particle spacing along an axis 有权
标题翻译：非接触式颗粒操纵和沿着轴线控制颗粒间距的方法
公开(公告)号：US08528406B2
公开(公告)日：2013-09-10
申请号：US11923403
申请日：2007-10-24
申请人： Gregory Russ Goddard , Gregory Kaduchak , James Hubert Jett , Steven Wayde Graves
发明人： Gregory Russ Goddard , Gregory Kaduchak , James Hubert Jett , Steven Wayde Graves
IPC分类号： G01H17/00
CPC分类号： G01N15/1404 , G01N2015/142
摘要： One or more of the embodiments of the present invention provide for a method of non-contact particle manipulation and control of particle spacing along an axis which includes axial and radial acoustic standing wave fields. Particles are suspended in an aqueous solution, and this solution then flows into the cylindrical flow channel. While the solution flows through the flow channel, the outer structure of the flow channel is vibrated at a resonant frequency, causing a radial acoustic standing wave field to form inside the flow channel in the solution. These radial acoustic standing waves focus the particles suspended in the solution to the center axis of the cylindrical flow channel.At the same time, a transducer is used to create an axial acoustic standing wave field in the flow channel parallel to the axis of the flow channel. This drives the particles, which are already being focused to the center axis of the flow channel, to nodes or anti-nodes of the axial standing wave at half-wavelength intervals, depending on whether the particles are more or less dense and more or less compressible than the surrounding fluid.
摘要翻译：本发明的一个或多个实施例提供了一种非接触式粒子操纵和沿着包括轴向和径向声驻波的轴的颗粒间隔的控制的方法。将颗粒悬浮在水溶液中，然后将该溶液流入圆柱形流动通道。当溶液流过流动通道时，流动通道的外部结构以共振频率振动，导致在溶液中的流动通道内形成径向声驻波。这些径向声驻波将悬浮在溶液中的颗粒聚焦到圆柱形流动通道的中心轴线上。同时，传感器用于在平行于流动通道的轴线的流动通道中产生轴向声波驻波场。这些粒子已经被聚焦到流动通道的中心轴线，以半波长间隔的轴向驻波的节点或反节点驱动，这取决于粒子是多或少密集还是多或少可压缩比周围的液体。

9. 发明授权

US08263407B2 Method for non-contact particle manipulation and control of particle spacing along an axis 有权
标题翻译：非接触式颗粒操纵和沿着轴线控制颗粒间距的方法
公开(公告)号：US08263407B2
公开(公告)日：2012-09-11
申请号：US12288896
申请日：2008-10-23
申请人： Gregory Russ Goddard , Gregory Kaduchak , James Hubert Jett , Steven Wayde Graves
发明人： Gregory Russ Goddard , Gregory Kaduchak , James Hubert Jett , Steven Wayde Graves
IPC分类号： G01N33/48
CPC分类号： G01N15/1404 , G01N15/1484 , G01N2015/142 , G01N2015/149 , Y10T137/206
摘要： Method and system for uniformly spacing particles in a flowing system comprising suspending particles in an elongated fluid filled cavity; exposing said cavity to an axial acoustic standing wave field, wherein said axial acoustic standing wave field drives said particles to nodal and anti-nodal positions along the center axis of said cavity to result in uniformly spaced particles; and focusing said particles to the center axis of said cavity.
摘要翻译：用于在流动系统中均匀间隔颗粒的方法和系统，包括将颗粒悬浮在细长的流体填充空腔中; 将所述空腔暴露于轴向声驻波场，其中所述轴向声驻波场沿着所述空腔的中心轴线将所述颗粒驱动到节点和反节点位置，以产生均匀间隔的颗粒; 并将所述颗粒聚焦到所述空腔的中心轴线上。

10. 发明申请

US20090139332A1 Method for non-contact particle manipulation and control of particle spacing along an axis 有权
标题翻译：非接触式颗粒操纵和沿着轴线控制颗粒间距的方法
公开(公告)号：US20090139332A1
公开(公告)日：2009-06-04
申请号：US12288896
申请日：2008-10-23
申请人： Gregory Russ Goddard , Gregory Kaduchak , James Hubert Jett , Steven Wayde Graves
发明人： Gregory Russ Goddard , Gregory Kaduchak , James Hubert Jett , Steven Wayde Graves
IPC分类号： G01H17/00
CPC分类号： G01N15/1404 , G01N15/1484 , G01N2015/142 , G01N2015/149 , Y10T137/206
摘要： Method and system for uniformly spacing particles in a flowing system comprising suspending particles in an elongated fluid filled cavity; exposing said cavity to an axial acoustic standing wave field, wherein said axial acoustic standing wave field drives said particles to nodal and anti-nodal positions along the center axis of said cavity to result in uniformly spaced particles; and focusing said particles to the center axis of said cavity.
摘要翻译：用于在流动系统中均匀间隔颗粒的方法和系统，包括将颗粒悬浮在细长的流体填充空腔中; 将所述空腔暴露于轴向声驻波场，其中所述轴向声驻波场沿着所述空腔的中心轴线将所述颗粒驱动到节点和反节点位置，以产生均匀间隔的颗粒; 并将所述颗粒聚焦到所述空腔的中心轴线上。

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