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1. 发明授权

US09733171B2 Acoustic concentration of particles in fluid flow 有权
公开(公告)号：US09733171B2
公开(公告)日：2017-08-15
申请号：US12903042
申请日：2010-10-12
申请人： Michael W. Ward , Gregory Kaduchak
发明人： Michael W. Ward , Gregory Kaduchak
IPC分类号： B07C5/00 , G01N1/40 , C12M1/00
CPC分类号： G01N1/4077 , C12M47/02 , G01N2001/4094
摘要： Disclosed herein is a acoustic concentration of particles in a fluid flow that includes a substantially acoustically transparent membrane and a vibration generator that define a fluid flow path therebetween. The fluid flow path is in fluid communication with a fluid source and a fluid outlet and the vibration generator is disposed adjacent the fluid flow path and is capable of producing an acoustic field in the fluid flow path. The acoustic field produces at least one pressure minima in the fluid flow path at a predetermined location within the fluid flow path and forces predetermined particles in the fluid flow path to the at least one pressure minima.

2. 发明授权

US09134271B2 Particle quantifying systems and methods using acoustic radiation pressure 有权
标题翻译：使用声辐射压力的粒子量化系统和方法
公开(公告)号：US09134271B2
公开(公告)日：2015-09-15
申请号：US13614956
申请日：2012-09-13
申请人： Michael D. Ward , Gregory Kaduchak
发明人： Michael D. Ward , Gregory Kaduchak
IPC分类号： G01N21/00 , G01N27/447 , G01N15/14 , G01N29/22 , G01N15/12 , G01N21/17 , G01N21/64
CPC分类号： G01N15/1404 , A61M1/3678 , G01N15/12 , G01N15/147 , G01N21/1702 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N27/447 , G01N29/222 , G01N33/56966 , G01N2015/1409 , G01N2015/1415 , G01N2015/142 , G01N2291/02416 , G01N2291/02809 , G01N2291/02836 , Y10T436/101666 , Y10T436/25 , Y10T436/25375 , Y10T436/25625 , Y10T436/2575
摘要： The present invention comprises methods and systems that use acoustic radiation pressure.
摘要翻译：本发明包括使用声辐射压力的方法和系统。

3. 发明授权

US09074979B2 Ultrasonic analyte concentration and application in flow cytometry 有权
标题翻译：超声波分析物浓度和流式细胞术中的应用
公开(公告)号：US09074979B2
公开(公告)日：2015-07-07
申请号：US13618237
申请日：2012-09-14
申请人： Gregory Kaduchak , Greg Goddard , Gary Salzman , Dipen Sinha , John C. Martin , Christopher Kwiatkowski , Steven Graves
发明人： Gregory Kaduchak , Greg Goddard , Gary Salzman , Dipen Sinha , John C. Martin , Christopher Kwiatkowski , Steven Graves
IPC分类号： G01H17/00 , G01N15/14 , G01N15/06 , G01N1/40
CPC分类号： B01D21/28 , G01N15/1459 , G01N2001/4094 , G01N2015/1413 , G01N2015/142 , Y10T137/0324 , Y10T137/206
摘要： The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.
摘要翻译：本发明包括用于使用声辐射压力将分析物浓缩在流过管的流体内的装置和相应方法。该装置包括功能发生器，其将射频电信号输出到将射频电信号变换成声信号的换能器，并将声信号耦合到管。声信号在管内被转换为将分析物浓缩在流体内的声压。

4. 发明授权

US08783109B2 Ultrasonic analyte concentration and application in flow cytometry 有权
标题翻译：超声波分析物浓度和流式细胞术中的应用
公开(公告)号：US08783109B2
公开(公告)日：2014-07-22
申请号：US11982042
申请日：2007-10-31
申请人： Gregory Kaduchak , Greg Goddard , Gary Salzman , Dipen Sinha , John C. Martin , Christopher Kwiatkowski , Steven Graves
发明人： Gregory Kaduchak , Greg Goddard , Gary Salzman , Dipen Sinha , John C. Martin , Christopher Kwiatkowski , Steven Graves
IPC分类号： G01H17/00 , G01N15/06
CPC分类号： B01D21/28 , G01N15/1459 , G01N2001/4094 , G01N2015/1413 , G01N2015/142 , Y10T137/0324 , Y10T137/206
摘要： The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.
摘要翻译：本发明包括用于使用声辐射压力将分析物浓缩在流过管的流体内的装置和相应方法。该装置包括功能发生器，其将射频电信号输出到将射频电信号变换成声信号的换能器，并将声信号耦合到管。声信号在管内被转换为将分析物浓集在流体内的声压。

5. 发明申请

US20100000325A1 Ultrasonic analyte concentration and application in flow cytometry 有权
标题翻译：超声波分析物浓度和流式细胞术中的应用
公开(公告)号：US20100000325A1
公开(公告)日：2010-01-07
申请号：US11982042
申请日：2007-10-31
申请人： Gregory Kaduchak , Greg Goddard , Gary Salzman , Dipen Sinha , John C. Martin , Christopher Kwiatkowski , Steven Graves
发明人： Gregory Kaduchak , Greg Goddard , Gary Salzman , Dipen Sinha , John C. Martin , Christopher Kwiatkowski , Steven Graves
IPC分类号： G01H17/00
CPC分类号： B01D21/28 , G01N15/1459 , G01N2001/4094 , G01N2015/1413 , G01N2015/142 , Y10T137/0324 , Y10T137/206
摘要： The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.
摘要翻译：本发明包括用于使用声辐射压力将分析物浓缩在流过管的流体内的装置和相应方法。该装置包括功能发生器，其将射频电信号输出到将射频电信号变换成声信号的换能器，并将声信号耦合到管。声信号在管内被转换为将分析物浓缩在流体内的声压。

6. 发明申请

US20090178716A1 System and Method for Acoustic Focusing Hardware and Implementations 有权
标题翻译：声学聚焦硬件和实现的系统和方法
公开(公告)号：US20090178716A1
公开(公告)日：2009-07-16
申请号：US12209084
申请日：2008-09-11
申请人： Gregory Kaduchak , Michael D. Ward
发明人： Gregory Kaduchak , Michael D. Ward
IPC分类号： F17D1/16 , B01D19/00 , G01N21/00 , B65D83/00 , F15C1/00 , H04R17/00
CPC分类号： G01N15/1404 , G01N2015/1413 , G01N2015/1415 , G01N2015/142 , Y10T29/42 , Y10T137/0391 , Y10T137/206 , Y10T137/2196
摘要： The present invention is a method and apparatus for acoustic focusing hardware and implementations.
摘要翻译：本发明是用于声学聚焦硬件和实现的方法和装置。

7. 发明申请

US20090053686A1 Particle Switching Systems and Methods Using Acoustic Radiation Pressure 有权
标题翻译：使用声辐射压力的粒子切换系统和方法
公开(公告)号：US20090053686A1
公开(公告)日：2009-02-26
申请号：US12239410
申请日：2008-09-26
申请人： Michael D. Ward , Carleton C. Stewart , Gregory Kaduchak
发明人： Michael D. Ward , Carleton C. Stewart , Gregory Kaduchak
IPC分类号： A01N1/02 , C12N13/00 , C40B30/10
CPC分类号： G01N15/1404 , A61M1/3678 , G01N15/12 , G01N15/147 , G01N21/1702 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N27/447 , G01N29/222 , G01N33/56966 , G01N2015/1409 , G01N2015/1415 , G01N2015/142 , G01N2291/02416 , G01N2291/02809 , G01N2291/02836 , Y10T436/101666 , Y10T436/25 , Y10T436/25375 , Y10T436/25625 , Y10T436/2575
摘要： The present invention comprises methods and systems that use acoustic radiation pressure.
摘要翻译：本发明包括使用声辐射压力的方法和系统。

8. 发明申请

US20060024206A1 Non-invasive acoustic technique for mixing and segregation of fluid suspensions in microfluidic applications 审中-公开
标题翻译：用于在微流体应用中混合和分离流体悬浮液的非侵入性声学技术
公开(公告)号：US20060024206A1
公开(公告)日：2006-02-02
申请号：US10958886
申请日：2004-10-05
申请人： Naveen Sinha , Gregory Kaduchak , Dipen Sinha , Peter Adcock
发明人： Naveen Sinha , Gregory Kaduchak , Dipen Sinha , Peter Adcock
IPC分类号： B01L3/00
CPC分类号： F04B19/006 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/5027 , F04F7/00 , Y10T436/2575
摘要： The present invention includes an apparatus and corresponding method for fluid flow control in microfluidic applications. A microchamber, filled with a fluid, is in fluid contact with a flexible plate. A transducer is acoustically coupled to the flexible plate. A function generator outputs a signal to excite the transducer, which in turn induces drumhead vibration of the flexible plate, creating a flow pattern within the fluid filled microchamber.
摘要翻译：本发明包括用于微流体应用中的流体流动控制的装置和相应的方法。充满流体的微室与柔性板流体接触。换能器声学耦合到柔性板。函数发生器输出信号以激励换能器，这又引起柔性板的鼓头振动，在流体填充的微型仓内产生流动模式。

9. 发明授权

US06186004B1 Apparatus and method for remote, noninvasive characterization of structures and fluids inside containers 有权
标题翻译：用于远程，无损地表征容器内结构和流体的装置和方法
公开(公告)号：US06186004B1
公开(公告)日：2001-02-13
申请号：US09323175
申请日：1999-05-27
申请人： Gregory Kaduchak , Dipen N. Sinha
发明人： Gregory Kaduchak , Dipen N. Sinha
IPC分类号： G01N2904
CPC分类号： G01N29/348 , G01N29/036 , G01N29/2418 , G01N29/346 , G01N2291/014 , G01N2291/02836 , G01N2291/0423 , G01N2291/0427 , G01N2291/106 , G01N2291/2634
摘要： An apparatus and method for the remote, noncontact evaluation of structures and containers at large distances (on the order of several meters) in air is described. The invention utilizes an air-coupled, parametric acoustic array to excite resonance vibrations of elastic, fluid-filled vessels and structural members. A nonlinear mixing process in the air medium transforms highly directional, narrow beamwidth higher acoustic frequencies into lower acoustic frequencies suitable for vibrational excitation of common structures. The parametric array also has an advantage for nondestructive evaluation applications in that it is capable of producing a broader bandwidth than typical linear devices, such as speakers and ultrasonic transducers. Typical carrier frequencies are in the 200 kHz range, and the sound field 3 m from the array has been demonstrated to have a bandwidth of greater than 25 kHz at a center frequency of 15 kHz. Vibrations have been excited in a fluid-filled, steel container at distances greater than 3 m from the array which are readily detected using a laser vibrometer in a fixed position relative to the acoustic array. It is demonstrated that the fluid contained within the steel vessel may be classified by analyzing the change in the response of the generated lowest-order, antisymmetric Lamb wave to changes in the interior fluid loading.
摘要翻译：描述了一种在空中远距离（几米左右）的结构和容器进行远程，非接触式评估的装置和方法。本发明利用空气耦合的参数声阵列来激发弹性流体填充的容器和结构构件的共振振动。空气介质中的非线性混合过程将高度方向性，窄波束宽度更高的声频转换成适合于共同结构的振动激励的较低声频。参数阵列还具有非破坏性评估应用的优点，因为它能够产生比典型的线性器件（如扬声器和超声换能器）更宽的带宽。典型的载波频率在200 kHz范围内，阵列3 m的声场在15 kHz的中心频率处具有大于25 kHz的带宽。振动已经在流体填充的钢容器中被激发，该容器距离阵列大于3m的距离，其使用激光测振仪在相对于声阵列的固定位置容易地检测。通过分析生成的最低阶，反对称兰姆波对内部流体负载变化的响应的变化，可以对钢容器中所含的流体进行分类。

10. 发明授权

US08932520B2 Method for non-contact particle manipulation and control of particle spacing along an axis 有权
公开(公告)号：US08932520B2
公开(公告)日：2015-01-13
申请号：US13570605
申请日：2012-08-09
申请人： Gregory R Goddard , Gregory Kaduchak , James H Jett , Steven W Graves
发明人： Gregory R Goddard , Gregory Kaduchak , James H Jett , Steven W Graves
IPC分类号： A61L2/00 , G01N15/14
CPC分类号： G01N15/1404 , G01N15/1484 , G01N2015/142 , G01N2015/149 , Y10T137/206
摘要： Method and system for uniformly spacing particles in a flowing system comprising suspending particles in an elongated fluid filled cavity; exposing said cavity to an axial acoustic standing wave field, wherein said axial acoustic standing wave field drives said particles to nodal and anti-nodal positions along the center axis of said cavity to result in uniformly spaced particles; and focusing said particles to the center axis of said cavity.

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