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1. 发明专利

IL267239B Novel phenyl propionic acid derivatives and uses thereof 未知
公开(公告)号：IL267239B
公开(公告)日：2022-07-01
申请号：IL26723919
申请日：2019-06-11
申请人： IL DONG PHARMA , JAE HOON KANG , HONG SUB LEE , KYUNG MI AN , CHANG HEE HONG , HYUN JUNG KWAK , SHUO LIN CUI , HYO JUNG SONG
发明人： JAE-HOON KANG , HONG-SUB LEE , KYUNG-MI AN , CHANG-HEE HONG , HYUN-JUNG KWAK , SHUO-LIN CUI , HYO-JUNG SONG
IPC分类号： A61K31/541
摘要： Compounds of Formula (I), racemates, enantiomers, diastereomers thereof or pharmaceutical acceptable salts thereof, or pharmaceutical compositions containing the compounds, racemates, enantiomers, diastereomers thereof are disclosed. These compounds have GPR40 agonist activity and are capable of modulating blood glucose levels and glucose-dependent insulin secretion mechanism, and, thus, exhibit excellent glucose lowering efficacy without the risk of hypoglycemia. These compounds could be used in preventing and/or treating type 2 diabetes through adequate control of blood glucose.

2. 发明专利

IL267239D0 Novel phenyl propionic acid derivatives and uses thereof 未知
公开(公告)号：IL267239D0
公开(公告)日：2019-08-29
申请号：IL26723919
申请日：2019-06-11
申请人： IL DONG PHARMA , JAE HOON KANG , HONG SUB LEE , KYUNG MI AN , CHANG HEE HONG , HYUN JUNG KWAK , SHUO LIN CUI , HYO JUNG SONG
发明人： JAE-HOON KANG , HONG-SUB LEE , KYUNG-MI AN , CHANG-HEE HONG , HYUN-JUNG KWAK , SHUO-LIN CUI , HYO-JUNG SONG
IPC分类号： C07D20060101
摘要： Compounds of Formula (I), racemates, enantiomers, diastereomers thereof or pharmaceutical acceptable salts thereof, or pharmaceutical compositions containing the compounds, racemates, enantiomers, diastereomers thereof are disclosed. These compounds have GPR40 agonist activity and are capable of modulating blood glucose levels and glucose-dependent insulin secretion mechanism, and, thus, exhibit excellent glucose lowering efficacy without the risk of hypoglycemia. These compounds could be used in preventing and/or treating type 2 diabetes through adequate control of blood glucose.

3. 发明申请

US20100212038A1 TRANSGENIC FISH WITH TISSUE-SPECIFIC EXPRESSION 审中-公开
标题翻译：具有组织特异性表达的转基因鱼
公开(公告)号：US20100212038A1
公开(公告)日：2010-08-19
申请号：US12355700
申请日：2009-01-16
申请人： Shuo Lin
发明人： Shuo Lin
IPC分类号： A01K67/027 , C12N5/10 , C12N15/63 , C12Q1/68 , A01K67/02
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/40 , A01K2267/03 , C07K14/461 , C12N15/8509 , C12N2830/008
摘要： Disclosed are transgenic fish, and a method of making transgenic fish, which express transgenes in stable and predictable tissue- or developmentally-specific patterns. The transgenic fish contain transgene constructs with homologous expression sequences. Also disclosed are methods of using such transgenic fish. Such expression of transgenes allow the study of developmental processes, the relationship of cell lineages, the assessment of the effect of specific genes and compounds on the development or maintenance of specific tissues or cell lineages, and the maintenance of lines of fish bearing mutant genes.
摘要翻译：公开了转基因鱼，以及制备转基因鱼的方法，其表达稳定且可预测的组织或发育特异性模式中的转基因。转基因鱼含有具有同源表达序列的转基因构建体。还公开了使用这种转基因鱼的方法。转基因的这种表达允许研究发育过程，细胞谱系的关系，特定基因和化合物对特定组织或细胞谱系的发育或维持的影响的评估，以及维持带有突变基因的鱼系。

4. 发明申请

US20100048637A1 CYCLOHEXYLAMINES, PHENYLAMINES AND USES THEREOF 失效
标题翻译：环己基胺，苯乙烯及其用途
公开(公告)号：US20100048637A1
公开(公告)日：2010-02-25
申请号：US12543480
申请日：2009-08-18
申请人： Shuo Lin , Zhen Yang
发明人： Shuo Lin , Zhen Yang
IPC分类号： A61K31/4436 , C07D409/02 , C07K14/00 , A61P35/00
CPC分类号： C07D409/04
摘要： Compounds having the formula I, their methods of synthesis, and pharmaceutically acceptable salts of certain of them are provided in which the variables have the definitions described herein. Compositions including the compounds having the formula I-A in which the variables have the definitions described herein, and methods of using the compositions for the treatment of certain diseases mediated by the up-regulation of Smo are also disclosed.
摘要翻译：提供了具有式I的化合物，其合成方法及其某些药学上可接受的盐，其中变量具有本文所述的定义。还公开了包括具有式I-A的化合物的组合物，其中变量具有本文所述的定义，以及使用该组合物治疗由上调Smo介导的某些疾病的方法。

5. 外观设计

USD579809S1 Gauge cover with visor 有权
标题翻译：带遮阳板的护盖
公开(公告)号：USD579809S1
公开(公告)日：2008-11-04
申请号：US29265768
申请日：2006-09-08
申请人： Jack Po-Shuo Lin
设计人： Jack Po-Shuo Lin

6. 外观设计

USD563815S1 Truck dashboard gauge cover without visor 有权
标题翻译：卡车仪表板盖没有遮阳板
公开(公告)号：USD563815S1
公开(公告)日：2008-03-11
申请号：US29265769
申请日：2006-09-08
申请人： Jack Po-Shuo Lin
设计人： Jack Po-Shuo Lin

7. 发明申请

US20050177889A1 Fish produced by nuclear transfer from cultured cells 有权
标题翻译：通过培养细胞的核转运产生的鱼
公开(公告)号：US20050177889A1
公开(公告)日：2005-08-11
申请号：US10517880
申请日：2003-06-11
申请人： Shuo Lin
发明人： Shuo Lin
IPC分类号： A01K20060101 , A01K67/027 , C12N15/00 , C12N15/873
CPC分类号： C12N15/873 , A01K2227/40
摘要： The disclosure provided herein teaches that fertile transgenic fish can be generated by nuclear transfer using cultured cells as embryonic fibroblasts.
摘要翻译：本文提供的公开内容指出，可以通过使用培养的细胞作为胚胎成纤维细胞的核转移产生可育转基因鱼。

8. 发明授权

US06797534B1 Method of integrating the fabrication process for integrated circuits and MEM devices 有权
标题翻译：集成电路和MEM器件制造工艺的集成方法
公开(公告)号：US06797534B1
公开(公告)日：2004-09-28
申请号：US10418121
申请日：2003-04-18
申请人： Shuo-Lin Tu , Lu-Shan Chiang , Shih-Lin Chu
发明人： Shuo-Lin Tu , Lu-Shan Chiang , Shih-Lin Chu
IPC分类号： H01L2100
CPC分类号： B81C1/00246 , B81C2203/0735
摘要： A method of forming a MEM device with an integrated circuit that includes providing a semiconductor substrate including a first region and a second region, forming an integrated circuit device on the first region, forming a first insulating layer on the semiconductor substrate, etching the first insulating layer to form a first dielectric layer on the first region and a second dielectric layer on the second region spaced apart from the first dielectric layer, forming a second insulating layer over the semiconductor substrate, the first dielectric layer and the second dielectric layer, etching the second insulating layer to expose the first dielectric layer, forming a third insulating layer over the semiconductor substrate, the second insulatng layer and the first dielectric layer, etching the third insulating layer to form a plurality of vias, and forming a metal layer over the semiconductor substrate to fill the vias.
摘要翻译：一种用集成电路形成MEM器件的方法，该集成电路包括提供包括第一区域和第二区域的半导体衬底，在第一区域上形成集成电路器件，在半导体衬底上形成第一绝缘层，蚀刻第一绝缘层层，以在第一区域上形成第一电介质层，并且在第二区域上与第一介电层隔开的第二电介质层，在半导体衬底，第一介电层和第二电介质层上形成第二绝缘层，蚀刻第二绝缘层以暴露第一介电层，在半导体衬底上形成第三绝缘层，第二绝缘层和第一介电层，蚀刻第三绝缘层以形成多个通孔，并在半导体上形成金属层底物填充通孔。

9. 发明授权

US06380458B1 Cell-lineage specific expression in transgenic zebrafish 失效
标题翻译：转基因斑马鱼中细胞谱系特异性表达
公开(公告)号：US06380458B1
公开(公告)日：2002-04-30
申请号：US08871755
申请日：1997-06-09
申请人： Shuo Lin
发明人： Shuo Lin
IPC分类号： A01K67027
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/40 , A01K2267/03 , C07K14/461 , C12N15/8509 , C12N2830/008
摘要： Disclosed are transgenic fish, and a method of making transgenic fish, which express transgenes in stable and predictable tissue- or developmentally-specific patterns. The transgenic fish contain transgene constructs with homologous expression sequences. Also disclosed are methods of using such transgenic fish. Such expression of transgenes allow the study of developmental processes, the relationship of cell lineages, the assessment of the effect of specific genes and compounds on the development or maintenance of specific tissues or cell lineages, and the maintenance of lines of fish bearing mutant genes.
摘要翻译：公开了转基因鱼，以及制备转基因鱼的方法，其表达稳定且可预测的组织或发育特异性模式中的转基因。转基因鱼含有具有同源表达序列的转基因构建体。还公开了使用这种转基因鱼的方法。转基因的这种表达允许研究发育过程，细胞谱系的关系，特定基因和化合物对特定组织或细胞谱系的发育或维持的影响的评估，以及维持带有突变基因的鱼系。

10. 外观设计

USD564862S1 Rocker switch bezel 有权
标题翻译：摇摆开关表圈
公开(公告)号：USD564862S1
公开(公告)日：2008-03-25
申请号：US29286214
申请日：2007-04-27
申请人： Jack Po-Shuo Lin
设计人： Jack Po-Shuo Lin

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