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2. 发明专利

IL267239B Novel phenyl propionic acid derivatives and uses thereof 未知
公开(公告)号：IL267239B
公开(公告)日：2022-07-01
申请号：IL26723919
申请日：2019-06-11
申请人： IL DONG PHARMA , JAE HOON KANG , HONG SUB LEE , KYUNG MI AN , CHANG HEE HONG , HYUN JUNG KWAK , SHUO LIN CUI , HYO JUNG SONG
发明人： JAE-HOON KANG , HONG-SUB LEE , KYUNG-MI AN , CHANG-HEE HONG , HYUN-JUNG KWAK , SHUO-LIN CUI , HYO-JUNG SONG
IPC分类号： A61K31/541
摘要： Compounds of Formula (I), racemates, enantiomers, diastereomers thereof or pharmaceutical acceptable salts thereof, or pharmaceutical compositions containing the compounds, racemates, enantiomers, diastereomers thereof are disclosed. These compounds have GPR40 agonist activity and are capable of modulating blood glucose levels and glucose-dependent insulin secretion mechanism, and, thus, exhibit excellent glucose lowering efficacy without the risk of hypoglycemia. These compounds could be used in preventing and/or treating type 2 diabetes through adequate control of blood glucose.

3. 发明专利

IL267239D0 Novel phenyl propionic acid derivatives and uses thereof 未知
公开(公告)号：IL267239D0
公开(公告)日：2019-08-29
申请号：IL26723919
申请日：2019-06-11
申请人： IL DONG PHARMA , JAE HOON KANG , HONG SUB LEE , KYUNG MI AN , CHANG HEE HONG , HYUN JUNG KWAK , SHUO LIN CUI , HYO JUNG SONG
发明人： JAE-HOON KANG , HONG-SUB LEE , KYUNG-MI AN , CHANG-HEE HONG , HYUN-JUNG KWAK , SHUO-LIN CUI , HYO-JUNG SONG
IPC分类号： C07D20060101
摘要： Compounds of Formula (I), racemates, enantiomers, diastereomers thereof or pharmaceutical acceptable salts thereof, or pharmaceutical compositions containing the compounds, racemates, enantiomers, diastereomers thereof are disclosed. These compounds have GPR40 agonist activity and are capable of modulating blood glucose levels and glucose-dependent insulin secretion mechanism, and, thus, exhibit excellent glucose lowering efficacy without the risk of hypoglycemia. These compounds could be used in preventing and/or treating type 2 diabetes through adequate control of blood glucose.

4. 发明专利

IL244548D0 A novel phtalazinone derivatives and manufacturing process thereof 未知
公开(公告)号：IL244548D0
公开(公告)日：2016-04-21
申请号：IL24454816
申请日：2016-03-11
申请人： ILDONG PHARM CO LTD , JAE HOON KANG , HONG SUB LEE , YOON SUK LEE , JOON TAE PARK , KYUNG MI AN , JIN AH JEONG , KYUNG SUN KIM , JEONG GEUN KIM , CHANG HEE HONG , SUN YOUNG PARK , DONG KEUN SONG , YONG DON YUN
IPC分类号： C07D20060101

5. 发明申请

US20080039438A1 1B-Methylcarbapenem Derivative and Process for the Preparation Thereof 审中-公开
标题翻译： 1B-甲基碳青霉烯衍生物及其制备方法
公开(公告)号：US20080039438A1
公开(公告)日：2008-02-14
申请号：US11570468
申请日：2005-06-14
申请人： Kyung Ho Yoo , Dong Jin Kim , Yong Koo Kang , Kyung Seok Lee , Gwan Lee , Maeng Sup Kim , Jae Hoon Kang
发明人： Kyung Ho Yoo , Dong Jin Kim , Yong Koo Kang , Kyung Seok Lee , Gwan Lee , Maeng Sup Kim , Jae Hoon Kang
IPC分类号： A61K31/397 , A61P31/04 , C07D205/12 , C07D261/18
CPC分类号： C07D477/20
摘要： The present invention relates to a novel 1β-methylcarbapenem derivative, a process for the preparation thereof and a pharmaceutical composition comprising the 1β-methylcarbapenem derivative or a pharmaceutically acceptable salt thereof as an active antibacterial ingredient.
摘要翻译：本发明涉及一种新型的β-甲基碳青霉烯类衍生物，其制备方法和药物组合物，其包含作为活性抗菌成分的β-甲基碳青霉烯衍生物或其药学上可接受的盐。

6. 发明授权

US5663331A Cephalosporin compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US5663331A
公开(公告)日：1997-09-02
申请号：US256348
申请日：1995-01-23
申请人： Kee Won Kim , Jae Hoon Kang , Cheon Ho Park
发明人： Kee Won Kim , Jae Hoon Kang , Cheon Ho Park
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/36
CPC分类号： C07D501/00
摘要： The present invention relates to new cephalosporin compounds of the formula (I), particularly 3-position of cephem rings thereof substituted with new thione compounds and pharmaceutically acceptable salts thereof, which have broad antibacterial activities against both Gram-positive and Gram-negative bacteria, and the said compounds can be prepared by reacting the compounds of the formula (II) with the new thione compounds of the formula (III). ##STR1## wherein R.sub.1 is a C.sub.1-4 alkyl(preferably methyl or ethyl), C.sub.3-4 alkenyl(preferably allyl), C.sub.3-4 alkynyl (preferably propargyl) group or --C(R.sup.a) (R.sup.b)CO.sub.2 H(preferably --C(CH.sub.3).sub.2 CO.sub.2 H or --CH.sub.2 CO.sub.2 H), wherein R.sup.1 and R.sup.b, same or different, are a hydrogen atom or a C.sub.1-4 alkyl group;R.sub.2 is a C.sub.1-4 alkyl(preferably methyl or ethyl), C.sub.3-4 alkenyl(preferably allyl), C.sub.3-4 cycloalkyl(preferably cyclopropyl) group or carboxyalkyl(preferably --CH.sub.2 CO.sub.2 H) group;R.sub.3 is a 5- or 6-membered heterocyclic compound-containing 1 or 2 nitrogen atom(s) (preferably piperazine, alkylpiperazine-substituted with C.sub.1-4 alkyl at N-- or 2-position of piperazine, imidazole-substituted or unsubstituted with C.sub.1-4 alkyl); R.sub.4 is hydrogen or a carboxylic acid.
摘要翻译： PCT No.PCT / KR93 / 00005 Sec。 371日期1995年1月24日 102（e）1995年1月24日PCT PCT 1993年1月16日PCT公布。公开号WO93 / 15084 日期：1993年8月5日本发明涉及式（I）的新型头孢菌素化合物，特别是用新的硫酮化合物及其药学上可接受的盐取代的头孢烯环的3-位，其具有对革兰氏阳性和革兰氏阴性细菌，所述化合物可以通过使式（II）化合物与式（III）的新型硫酮化合物反应来制备。（II）甲基或乙基），C3-4烯基（优选烯丙基），C3-4炔基（优选炔丙基）或-C（Ra）（Rb）CO2H（优选-C（CH 3）2 CO 2 H或-CH 2 CO 2 H），其中R 1和R b相同或不同，为氢原子或C 1-4烷基; R2是C1-4烷基（优选甲基或乙基），C3-4烯基（优选烯丙基），C3-4环烷基（优选环丙基）或羧基烷基（优选-CH2CO2H）基团; R3是含有1或2个氮原子的5或6元杂环化合物（优选哌嗪，哌嗪，被哌嗪的N-或2-位上的C 1-4烷基取代的烷基哌嗪，咪唑取代或未取代的C1 -4烷基）; R4是氢或羧酸。

7. 发明授权

US08530205B2 Buffer composition for catalyzing the preparation of calcitriol or calcifediol and method for preparing calcitriol or calcifediol using same 有权
标题翻译：用于催化骨化三醇或钙二十二醇的制备的缓冲液组合物及使用其制备骨化三醇或钙非二醇的方法
公开(公告)号：US08530205B2
公开(公告)日：2013-09-10
申请号：US13162246
申请日：2011-06-16
申请人： Dae-Jung Kang , Jong-Hyuk Im , Hyun-Jung Jung , Jae-Hoon Kang
发明人： Dae-Jung Kang , Jong-Hyuk Im , Hyun-Jung Jung , Jae-Hoon Kang
IPC分类号： C12P15/00 , C12N9/52
CPC分类号： C12P7/22 , C12N1/38
摘要： The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly, the present invention relates to a buffer composition for promoting production of calcitriol or calcifediol comprising a metallic compound, an organic solvent, cyclodextrin, tris(hydroxymethyl)aminomethane, sodium succinate, sodium chloride, magnesium chloride, and water, and a method for producing calcitriol or calcifediol using the same. In the method for producing calcitiriol or calcifediol, the production yield of calcitriol or calcifediol is high, and the bioconversion is carried out in an enzyme reaction system instead of in a microorganism culture system. Thus, it is not required to maintain a sterile state. Also, the separation/purification following the completion of a biocatalytic reaction can be carried out in a cleaner state than the microorganism culture method. Accordingly, there is an advantage in that a cost required for separation is low and the quality is improved. Furthermore, the buffer composition for promoting production of calcitriol or calcifediol can provide a high productivity of calcitriol or calcifediol.
摘要翻译：本发明涉及一种用于促进骨化三醇或钙二十二醇的生产的缓冲组合物，以及使用该缓冲组合物生产骨化三醇或钙二十二醇的方法。更具体地说，本发明涉及一种用于促进骨化三醇或钙非二醇的生产的缓冲组合物，其包含金属化合物，有机溶剂，环糊精，三（羟甲基）氨基甲烷，琥珀酸钠，氯化钠，氯化镁和水）用于使用其生产骨化三醇或calcifediol。在生产calcitiriol或calcifediol的方法中，骨化三醇或calcifediol的产量高，生物转化在酶反应体系中而不是在微生物培养系统中进行。因此，不需要保持无菌状态。此外，生物催化反应完成后的分离/纯化可以比微生物培养方法更清洁的状态进行。因此，存在分离所需的成本低，质量提高的优点。此外，用于促进骨化三醇或calcifediol的生产的缓冲组合物可以提供高三氧化三萜或calcifediol的生产率。

8. 发明申请

US20120309750A1 5-MEMBERED HETEROCYCLE DERIVATIVES AND MANUFACTURING PROCESS THEREOF 审中-公开
标题翻译： 5成员的异构体衍生物及其制造方法
公开(公告)号：US20120309750A1
公开(公告)日：2012-12-06
申请号：US13579507
申请日：2011-02-17
申请人： Jae-Hoon Kang , Hong-Sub Lee , Jin-Sun Kwon , Joon-Tae Park , Chang-Sung Hong , Dong-Hyung Sin , Soo-Jung Hong , An-Na Moon , Jin-Ah Jeong , Sung-Wook Kwon
发明人： Jae-Hoon Kang , Hong-Sub Lee , Jin-Sun Kwon , Joon-Tae Park , Chang-Sung Hong , Dong-Hyung Sin , Soo-Jung Hong , An-Na Moon , Jin-Ah Jeong , Sung-Wook Kwon
IPC分类号： C07D413/14 , C07D413/04 , A61P35/00 , C07D417/14 , A61K31/541 , A61K31/5377 , A61K31/422
CPC分类号： C07D261/18 , A61K31/422 , A61K31/5377 , C07D403/04 , C07D409/04 , C07D413/04 , C07D413/14
摘要： Disclosed are a novel 5-membered heterocycle derivatives of Formula I, a tautomer, pharmaceutically acceptable salt, prodrug thereof and a pharmaceutical use thereof. The 5-membered heterocycle derivatives of Formula I, a tautomer, pharmaceutically acceptable salt, prodrug thereof and compositions containing them are useful for treating a tumor.
摘要翻译：公开了式I的新的5元杂环衍生物，其互变异构体，药学上可接受的盐，前药及其药学用途。式I的5元杂环衍生物，互变异构体，药学上可接受的盐，前药以及含有它们的组合物可用于治疗肿瘤。

9. 发明申请

US20120064584A1 BUFFER COMPOSITION FOR CATALYZING THE PREPARATION OF CALCITRIOL OR CALCIFEDIOL AND METHOD FOR PREPARING CALCITRIOL OR CALCIFEDIOL USING SAME 有权
标题翻译：用于催化制备计算机或计算机的缓冲剂组合物及其制备计算机或计算机的方法
公开(公告)号：US20120064584A1
公开(公告)日：2012-03-15
申请号：US13162246
申请日：2011-06-16
申请人： Dae-Jung Kang , Jong-Hyuk Im , Hyun-Jung Jung , Jae-Hoon Kang
发明人： Dae-Jung Kang , Jong-Hyuk Im , Hyun-Jung Jung , Jae-Hoon Kang
IPC分类号： B01J31/32 , C12P15/00 , B01J31/26 , B01J31/30 , B01J31/28
CPC分类号： C12P7/22 , C12N1/38
摘要： The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly, the present invention relates to a buffer composition for promoting production of calcitriol or calcifediol comprising a metallic compound, an organic solvent, cyclodextrin, tris(hydroxymethyl)aminomethane, sodium succinate, sodium chloride, magnesium chloride, and water, and a method for producing calcitriol or calcifediol using the same. In the method for producing calcitiriol or calcifediol, the production yield of calcitriol or calcifediol is high, and the bioconversion is carried out in an enzyme reaction system instead of in a microorganism culture system. Thus, it is not required to maintain a sterile state. Also, the separation/purification following the completion of a biocatalytic reaction can be carried out in a cleaner state than the microorganism culture method. Accordingly, there is an advantage in that a cost required for separation is low and the quality is improved. Furthermore, the buffer composition for promoting production of calcitriol or calcifediol can provide a high productivity of calcitriol or calcifediol.
摘要翻译：本发明涉及一种用于促进骨化三醇或钙二十二醇的生产的缓冲组合物，以及使用该缓冲组合物生产骨化三醇或钙二十二醇的方法。更具体地说，本发明涉及一种用于促进骨化三醇或钙非二醇的生产的缓冲组合物，其包含金属化合物，有机溶剂，环糊精，三（羟甲基）氨基甲烷，琥珀酸钠，氯化钠，氯化镁和水）用于使用其生产骨化三醇或calcifediol。在生产calcitiriol或calcifediol的方法中，骨化三醇或calcifediol的产量高，生物转化在酶反应体系中而不是在微生物培养系统中进行。因此，不需要保持无菌状态。此外，生物催化反应完成后的分离/纯化可以比微生物培养方法更清洁的状态进行。因此，存在分离所需的成本低，质量提高的优点。此外，用于促进骨化三醇或calcifediol的生产的缓冲组合物可以提供高三氧化三萜或calcifediol的生产率。

10. 发明申请

US20100168421A1 A NEW PEPTIDE DEFORMYLASE INHIBITOR COMPOUND AND MANUFACTURING PROCESS THEREOF 审中-公开
标题翻译：新型抗坏血酸酶抑制剂化合物及其制备方法
公开(公告)号：US20100168421A1
公开(公告)日：2010-07-01
申请号：US12663316
申请日：2008-06-04
申请人： Jae Hoon KANG , Seung Woo YU , Hee Yeol LEE , Kyung Mi AN , Bong Hwan CHO
发明人： Jae Hoon KANG , Seung Woo YU , Hee Yeol LEE , Kyung Mi AN , Bong Hwan CHO
IPC分类号： C07D413/12 , C07D401/12 , C07D405/12 , C07D211/60
CPC分类号： C07D211/58 , C07D401/12 , C07D405/12
摘要： The present invention relates to the novel antibacterial compounds having potent antibacterial activity as inhibitors of peptide deformylase. This invention further relates to pharmaceutically acceptable salts thereof, to processes for their preparation, and to pharmaceutical compositions containing them as an active ingredient.
摘要翻译：本发明涉及具有作为肽变性酶抑制剂的有效抗菌活性的新型抗菌化合物。本发明还涉及其药学上可接受的盐，其制备方法以及含有它们作为活性成分的药物组合物。

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