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    • 4. 发明申请
    • Method for manufacturing of polymer micro needle array with liga process
    • 聚合物微针阵列制造方法
    • US20060055090A1
    • 2006-03-16
    • US10542613
    • 2004-01-16
    • Seung-seob LeeSang-Joon Moon
    • Seung-seob LeeSang-Joon Moon
    • B29C35/08
    • B81C99/0085A61B5/14514A61M37/0015A61M2037/0053B81B2201/055B81C2201/032G03F7/00G03F7/0035
    • The present invention relates to a method for manufacturing a micro needle array with an X-ray process. The present invention provides a method for manufacturing a micro needle array, comprising the steps of preparing an X-ray mask by forming an absorber having a configuration of the micro needle array on a substrate; preparing a PMMA cast for the micro needle array by exposing PMMA to vertical and inclined X-rays using the X-ray mask; preparing a flexible PDMS mold having a configuration opposite to that of the PMMA cast by pouring PDMS on the PMMA cast; filling an upper surface of the PDMS mold with a gel type of polymer to obtain a desired thickness of the polymer; patterning a desired configuration of a hole by irradiating UV rays on the polymer; and separating the PDMS mold to complete the polymer micro needle array. The micro needle array of the present invention is made of a polymer material and can be used for drawing blood from or injecting a medicine into the skin.
    • 本发明涉及一种利用X射线处理制造微针阵列的方法。 本发明提供一种微针阵列的制造方法,其特征在于,包括以下步骤:在基板上形成具有微针阵列构造的吸收体,制作X射线掩模; 通过使用X射线掩模将PMMA暴露于垂直和倾斜的X射线,为微针阵列制备PMMA铸件; 通过将PDMS浇注在PMMA铸件上,制备具有与PMMA铸件相反的构型的柔性PDMS模具; 用凝胶型聚合物填充PDMS模具的上表面以获得所需的聚合物厚度; 通过在聚合物上照射紫外线来图案化所需的孔构型; 并分离PDMS模具以完成聚合物微针阵列。 本发明的微针阵列由聚合物材料制成,可用于将血液从药物中吸取或注入皮肤。