专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09393221B2 Methods and compounds for reducing intracellular lipid storage 有权
标题翻译：减少细胞内脂质储存的方法和化合物
公开(公告)号：US09393221B2
公开(公告)日：2016-07-19
申请号：US13552975
申请日：2012-07-19
申请人： Sean Wu
发明人： Sean Wu
IPC分类号： C12N5/00 , C12N5/02 , A61K31/137 , A61K31/215 , A61K31/4375 , A61K31/439 , A61K31/4458 , A61K31/4709 , A61K31/706 , C40B30/06 , G01N33/50 , G01N33/92
CPC分类号： A61K31/137 , A61K31/215 , A61K31/4375 , A61K31/439 , A61K31/4458 , A61K31/4709 , A61K31/706 , C40B30/06 , G01N33/5061 , G01N33/5073 , G01N33/92
摘要： Compounds and compositions for reducing intracellular lipid accumulation in a cell are described herein. These compounds are useful for the treatment and prevention of lipid/glycogen disorders, as well as for the treatment and prevention of obesity. A high throughput screen for identifying compounds that reduce intracellular lipid accumulation in cells is also provided.
摘要翻译：本文描述了用于减少细胞中细胞内脂质积聚的化合物和组合物。这些化合物可用于治疗和预防脂质/糖原紊乱，以及用于治疗和预防肥胖症。还提供了用于鉴定减少细胞中细胞内脂质积累的化合物的高通量筛选。

2. 发明申请

US20140288077A1 SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY 审中-公开
标题翻译：取代的4-苯氧基酚类似物作为增殖细胞核抗原活性的调节剂
公开(公告)号：US20140288077A1
公开(公告)日：2014-09-25
申请号：US14130885
申请日：2012-07-05
申请人： Naoaki Fujii , Marcelo Actis , Chandanamali Punchihewa , Michele Connelly , Sean Wu
发明人： Naoaki Fujii , Marcelo Actis , Chandanamali Punchihewa , Michele Connelly , Sean Wu
IPC分类号： C07C235/46 , C07F15/00 , C07D241/08 , C07D295/16 , C07C275/24 , C07C311/04
CPC分类号： C07C235/46 , A61K31/282 , A61K31/535 , C07C275/24 , C07C311/04 , C07D233/34 , C07D235/08 , C07D241/08 , C07D241/36 , C07D261/10 , C07D295/16 , C07D295/185 , C07D295/26 , C07D307/14 , C07D413/00 , C07F15/0093
摘要： In one aspect, the invention relates to substituted 4-phenoxyphenol analogs, derivatives thereof, and related compounds, which are useful as inhibitors of proliferating cell nuclear antigen (PCNA); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating hyperproliferative disorders associated with PCNA using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：一方面，本发明涉及可用作增殖细胞核抗原（PCNA）抑制剂的取代的4-苯氧基苯酚类似物，其衍生物和相关化合物。制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与PCNA相关的过度增殖性疾病的方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

3. 发明申请

US20130023488A1 METHODS AND COMPOUNDS FOR REDUCING INTRACELLULAR LIPID STORAGE 有权
标题翻译：减少细胞内脂质储存的方法和化合物
公开(公告)号：US20130023488A1
公开(公告)日：2013-01-24
申请号：US13552975
申请日：2012-07-19
申请人： Sean Wu
发明人： Sean Wu
IPC分类号： A61K31/4458 , C12N5/071 , C12N5/077 , C12N5/079 , C12N5/078 , A61K31/137 , A61K31/4375 , A61K31/4709 , A61K31/215 , A61K31/706 , A61K31/439 , A61P3/06 , A61P9/00 , A61P3/04 , A61P21/00 , C40B30/06
CPC分类号： A61K31/137 , A61K31/215 , A61K31/4375 , A61K31/439 , A61K31/4458 , A61K31/4709 , A61K31/706 , C40B30/06 , G01N33/5061 , G01N33/5073 , G01N33/92
摘要： Compounds and compositions for reducing intracellular lipid accumulation in a cell are described herein. These compounds are useful for the treatment and prevention of lipid/glycogen disorders, as well as for the treatment and prevention of obesity. A high throughput screen for identifying compounds that reduce intracellular lipid accumulation in cells is also provided.
摘要翻译：本文描述了用于减少细胞中细胞内脂质积聚的化合物和组合物。这些化合物可用于治疗和预防脂质/糖原紊乱，以及用于治疗和预防肥胖症。还提供了用于鉴定减少细胞中细胞内脂质积累的化合物的高通量筛选。

4. 发明授权

US07373277B1 Methods and systems for detection of selected defects particularly in relatively noisy inspection data 有权
标题翻译：用于检测选定缺陷的方法和系统，特别是在相对嘈杂的检查数据中
公开(公告)号：US07373277B1
公开(公告)日：2008-05-13
申请号：US10858420
申请日：2004-06-01
申请人： Sean Wu , Haiguang Chen , Michael D. Kirk
发明人： Sean Wu , Haiguang Chen , Michael D. Kirk
IPC分类号： G06F11/30
CPC分类号： G06T7/0006 , G01N21/8851 , G01N21/9501 , G06T2207/10056 , G06T2207/20061 , G06T2207/30148
摘要： Various methods and systems for detection of selected defects particularly in relatively noisy inspection data are provided. One method includes applying a spatial filter algorithm to raw inspection data acquired across an area on a substrate to determine a first portion of the raw inspection data that has a higher probability of being a selected type of defect than a second portion of the raw inspection data. The selected type of defect includes a non-point defect. The method also includes generating a raw two-dimensional map illustrating the first portion of the raw inspection data. In addition, the method includes searching the raw two-dimensional map for an event that has spatial characteristics that approximately match spatial characteristics of the selected type of defect. The method further includes determining if the event corresponds to a defect having the selected type.
摘要翻译：提供用于检测所选缺陷的各种方法和系统，特别是在相对嘈杂的检查数据中。一种方法包括将空间滤波器算法应用于跨越衬底上的区域获取的原始检查数据，以确定原始检查数据的第一部分与原始检查数据的第二部分相比具有较高选择类型的缺陷概率。所选择的缺陷类型包括非点缺陷。该方法还包括生成示出原始检查数据的第一部分的原始二维映射。此外，该方法包括搜索原始二维地图中具有与所选择的缺陷类型的空间特征近似匹配的空间特征的事件。该方法还包括确定事件是否对应于具有所选类型的缺陷。

5. 发明申请

US20050150299A1 Reconstruction of transient acoustic radiation from a finite object subject to arbitrarily time-dependent excitation 有权
标题翻译：从有限的物体重新构造瞬态声辐射，经受任意时间依赖的激发
公开(公告)号：US20050150299A1
公开(公告)日：2005-07-14
申请号：US10754036
申请日：2004-01-08
申请人： Sean Wu
发明人： Sean Wu
IPC分类号： G06F17/50 , G01N29/00
CPC分类号： G06F17/5018
摘要： General algorithms are developed for reconstructing the acoustic field generated by an arbitrary object subject to an arbitrarily time-dependent excitation. These algorithms enable one to visualize a time-domain acoustic pressure wave as it travels through three-dimensional space. Such a tool can be used to diagnose general noise sources and transmission since in engineering applications most structures are subject to arbitrarily time-dependent excitations. To facilitate the derivations of the temporal solutions, we make use of Laplace transform and expand the acoustic pressure in terms of the spherical Hankel functions and the spherical harmonics. The expansion coefficients are settled by solving an over-determined system of equations obtained by matching the assumed-form solutions to the measured acoustic pressures. To obtain a general expression for a temporal kernel, we replace the spherical Hankel functions by polynomials in s, recast the infinite integral in the inverse Laplace transform as a contour integral in the complex s-plane, and evaluate it via residue theorem. Once this is done, the transient acoustic quantities anywhere including a source surface can be obtained by convoluting the temporal kernels with respect to measured acoustic pressures.
摘要翻译：开发了用于重建由任意时间依赖激励的任意对象产生的声场的通用算法。这些算法使得人们可以在时域声压波行进三维空间时可视化。这种工具可用于诊断通用噪声源和传输，因为在工程应用中，大多数结构都受到任意时间相关的激励。为了促进时间解的推导，我们利用拉普拉斯变换，并根据球面汉克尔函数和球谐函数扩展声压。扩展系数通过求解通过将假定形式解与匹配的声压获得的方程式的过度确定系统来确定。为了获得时间核的一般表达式，我们用s中的多项式代替球面汉克尔函数，将反拉普拉斯变换中的无限积分重写为复S平面中的轮廓积分，并通过残差定理进行评估。一旦这样做，包括源表面在内的任何地方的瞬态声量可以通过相对于测量的声压卷积时间核来获得。

6. 发明授权

US5974066A Low cost, efficient vertical cavity surface emitting laser package, method, bar code scanner and optical storage unit 失效
标题翻译：低成本，高效的垂直腔表面发射激光封装，方法，条码扫描器和光存储单元
公开(公告)号：US5974066A
公开(公告)日：1999-10-26
申请号：US853606
申请日：1997-05-09
申请人： Sean Wu , Chao-pin Yeh , Karl Wyatt , Jang-Hun (James) Yeh , James Morikuni
发明人： Sean Wu , Chao-pin Yeh , Karl Wyatt , Jang-Hun (James) Yeh , James Morikuni
IPC分类号： H01S5/022 , H01S5/183 , H01S3/18
CPC分类号： H01S5/02296 , H01S5/02212 , H01S5/02228 , H01S5/0683 , H01S5/183
摘要： The present invention provides a low cost, efficient vertical cavity surface emitting laser package (300) and manufacturing method, the package having a head assembly having at least three leads, a vertical cavity surface emitting laser die bonded to a top surface of the head assembly, for generating a beam of light, and a photodiode, die bonded to the top surface of the head assembly proximate to the vertical cavity surface emitting laser for receiving at least a portion of the beam of light, and generating feedback for adjusting an electrical input current to the vertical cavity surface emitting laser based on a received optical power of the portion of the beam of light received. The vertical cavity surface emitting laser and the photodiode are injection molded in a predetermined shape with a recessed area for placement of a partially reflective holographic optical element/reflector.
摘要翻译：本发明提供了一种低成本，高效的垂直腔表面发射激光器封装（300）和制造方法，该封装具有具有至少三个引线的头部组件，垂直腔表面发射激光裸片结合到头部组件的顶表面，用于产生光束，以及光电二极管，其芯片接合到靠近垂直腔表面发射激光器的头部组件的顶表面，用于接收光束的至少一部分，并产生用于调整电输入的反馈基于所接收的光束的部分的接收光功率，电流到垂直腔表面发射激光器。垂直腔表面发射激光器和光电二极管被注塑成具有用于放置部分反射全息光学元件/反射器的凹陷区域的预定形状。

7. 发明授权

US07711521B1 Methods and systems for detection of selected defects particularly in relatively noisy inspection data 有权
标题翻译：用于检测选定缺陷的方法和系统，特别是在相对嘈杂的检查数据中
公开(公告)号：US07711521B1
公开(公告)日：2010-05-04
申请号：US12119179
申请日：2008-05-12
申请人： Sean Wu , Haiguang Chen , Michael D. Kirk
发明人： Sean Wu , Haiguang Chen , Michael D. Kirk
IPC分类号： G06F11/30
CPC分类号： G06T7/0006 , G01N21/8851 , G01N21/9501 , G06T2207/10056 , G06T2207/20061 , G06T2207/30148
摘要： Various methods and systems for detection of selected defects particularly in relatively noisy inspection data are provided. One method includes applying a spatial filter algorithm to raw inspection data acquired across an area on a substrate to determine a first portion of the raw inspection data that has a higher probability of being a selected type of defect than a second portion of the raw inspection data. The selected type of defect includes a non-point defect. The method also includes generating a raw two-dimensional map illustrating the first portion of the raw inspection data. In addition, the method includes searching the raw two-dimensional map for an event that has spatial characteristics that approximately match spatial characteristics of the selected type of defect. The method further includes determining if the event corresponds to a defect having the selected type.
摘要翻译：提供用于检测所选缺陷的各种方法和系统，特别是在相对嘈杂的检查数据中。一种方法包括将空间滤波器算法应用于跨越衬底上的区域获取的原始检查数据，以确定原始检查数据的第一部分与原始检查数据的第二部分相比具有较高选择类型的缺陷概率。所选择的缺陷类型包括非点缺陷。该方法还包括生成示出原始检查数据的第一部分的原始二维映射。此外，该方法包括搜索原始二维地图中具有与所选择的缺陷类型的空间特征近似匹配的空间特征的事件。该方法还包括确定事件是否对应于具有所选类型的缺陷。

8. 发明申请

US20070189550A1 Panel acoustic contributions examination 审中-公开
标题翻译：小组声学贡献检查
公开(公告)号：US20070189550A1
公开(公告)日：2007-08-16
申请号：US11354214
申请日：2006-02-14
申请人： Sean Wu
发明人： Sean Wu
IPC分类号： H04B15/00
CPC分类号： H04R3/02 , G01H3/125 , H04R2499/13
摘要： A system for analyzing noise sources correlates the sound pressure level value at any field point to the acoustic energy directly flowing out of any individual panel of a vibrating structure. This acoustic energy flow or acoustic intensity depicts how sound radiates and in which direction a sound wave propagates in the field. Therefore, the result represents a true contribution of an individual panel to an acoustic field. The acoustic intensity on the surface of a vibrating object is reconstructed by the Helmholtz equation least squares (HELS) based nearfield acoustical holography (NAH). The acoustic intensity is utilized to establish correlations between user-designated panels and the SPL value at any field point. With this information users can rank the order of contributions from individual panels of any vibrating structure to an acoustic field. These order ranking and panel contribution analyses help engineers to come up the best strategy to tackle various noise issues in the most cost-effective manner. The method is applicable to both interior and exterior regions.
摘要翻译：用于分析噪声源的系统将任何场点处的声压级值与直接从振动结构的任何单独面板流出的声能相关联。这种声能流或声强描述了声波在声场中的辐射方向以及声波传播方向。因此，结果表明单个面板对声场的真正贡献。振动物体表面的声强度由基于亥姆霍兹方程最小二乘法（HELS）的近场声全息（NAH）重建。声强度用于建立用户指定面板与任何场点SPL值之间的相关性。有了这些信息，用户可以将任何振动结构的单个面板的贡献顺序排列到声场。这些订单排名和面板贡献分析帮助工程师以最具成本效益的方式制定出最佳策略来解决各种噪音问题。该方法适用于内外区域。

9. 发明申请

US20060125577A1 Acoustic resonator device and method for manufacturing the same 审中-公开
标题翻译：声谐振器装置及其制造方法
公开(公告)号：US20060125577A1
公开(公告)日：2006-06-15
申请号：US11008930
申请日：2004-12-13
申请人： Chin-Tang Hsieh , Ying-Chung Chen , Sean Wu , Chen-Kuei Chung , Kuo-Sheng Kao , Chin-Chi Chen
发明人： Chin-Tang Hsieh , Ying-Chung Chen , Sean Wu , Chen-Kuei Chung , Kuo-Sheng Kao , Chin-Chi Chen
IPC分类号： H03H9/56
CPC分类号： H03H9/174 , H03H3/02
摘要： An acoustic resonator device includes a semiconductor substrate, a FBAR (thin film bulk acoustic resonator) and a support plate. The FBAR is fabricated on the upper surface of the semiconductor substrate. The semiconductor substrate has a resonant cavity through the upper and the lower surfaces thereof. The support plate is attached to the lower surface of the semiconductor substrate to shelter the opening of the resonant cavity. Moreover, the support plate can provide a larger die-attaching area for the acoustic resonator device, for the protection of the resonant cavity from chipping during wafer sawing.
摘要翻译：声谐振器装置包括半导体衬底，FBAR（薄膜体声波谐振器）和支撑板。 FBAR制造在半导体衬底的上表面上。半导体衬底通过其上表面和下表面具有谐振腔。支撑板附接到半导体衬底的下表面以遮住谐振腔的开口。此外，支撑板可以为声谐振器装置提供更大的管芯附着区域，用于在晶片锯切期间保护谐振腔免于碎裂。

10. 发明申请

US20070163351A1 NON-INVASIVE VIBRO-ACOUSTIC ANALYSIS 有权
标题翻译：非入侵振动分析
公开(公告)号：US20070163351A1
公开(公告)日：2007-07-19
申请号：US11564945
申请日：2006-11-30
申请人： Sean Wu
发明人： Sean Wu
IPC分类号： G01H11/00
CPC分类号： G01H1/003 , G01H3/00 , G01H17/00
摘要： A system provides an in situ or non-invasive vibro-acosutic (VA) analysis of an arbitrary complex vibrating structure. The major advantages of this system are that: (1) it allows for an identification of the VA modes that are directly responsible for structural vibration and sound radiation; (2) it enables one to acquire a quantitative description of contributions from individual VA modes that are responsible for resultant structural vibration and sound radiation; and (3) it is non-invasive so that one can conduct an in situ analysis of a machine running under its natural working condition. With this information, one can tackle noise and vibration problems in the most cost-effective manner.
摘要翻译：系统提供任意复杂振动结构的原位或非侵入性振动 - 辅助（VA）分析。该系统的主要优点是：（1）允许识别直接负责结构振动和声辐射的VA模式; （2）它能够从负责结构振动和声辐射的各个VA模式获得定量描述; （3）非侵入性，可以对自然工作条件下运行的机器进行现场分析。通过这些信息，可以以最具成本效益的方式解决噪声和振动问题。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式