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    • 10. 发明申请
    • Monoacetyldiacylglycerol Derivative for the Treatment of Sepsis
    • 单乙酰二酰基甘油衍生物治疗脓毒症
    • US20100137435A1
    • 2010-06-03
    • US12640875
    • 2009-12-17
    • Sang-Hee Kim
    • Sang-Hee Kim
    • A61K31/22A61P35/00
    • A61K31/22A21D2/16A23G1/32A23G1/42A23G3/36A23G3/364A23G4/06A23G4/12A23G9/32A23G9/36A23L2/52A23L33/105A23L33/12A23V2002/00A61K9/0019A61K9/0056A61K9/0058A61K9/2018A61K9/4858A61K9/4875A23V2200/308A23V2200/324A23V2250/186A23V2250/641A23V2250/704
    • The uses of mono acetyl diacyl glycerol derivatives extracted from deer antler for immunomodulating agent disclosed. Medical supplies and health foods containing the same as an effective ingredient also disclosed. Mono acetyl diacyl glycerol derivatives shows significantly effect for immuno modulation including immune enhancing. In the case of inducing cancer in a hamster by injecting cancer cell line, cancer development was delayed by activating lymphocytes, monocytes, and dendritic cells that are important factors to promote immunity and apoptosis of cancer cell was induced by promoting cytotoxicity of immune cell against caner cell. Also in the case of mouse induced septic shock, it shows 100% survival rate even after lapse of 120 hours by control of immune function and suppression effect of apoptosis. Therefore, mono acetyl diacyl glycerol derivatives according to the present invention can be effectively used for an immunomodulating agent, a sepsis treatment, a cancer treatment, and a health food for an immune modulation or the prevention of cancer.
    • 公开了从鹿鹿茸提取的单乙酰二酰基甘油衍生物用于免疫调节剂的用途。 含有与有效成分相同的医疗用品和保健食品也披露。 单乙酰二酰基甘油衍生物显示出对包括免疫增强在内的免疫调节的显着影响。 在通过注射癌细胞系在仓鼠中诱导癌症的情况下,通过激活作为促进免疫的重要因素的淋巴细胞,单核细胞和树突状细胞来延缓癌症发展,并通过促进免疫细胞对细胞的细胞毒性诱导癌细胞的细胞毒性 细胞。 在小鼠诱发的败血性休克的情况下,即使经过120小时后,通过控制免疫功能和凋亡的抑制效果也显示出100%的存活率。 因此,根据本发明的单乙酰二酰基甘油衍生物可以有效地用于免疫调节剂,败血症治疗,癌症治疗和用于免疫调节或预防癌症的保健食品。