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    • 3. 发明申请
    • IMIDAZOLIDINE DERIVATIVE AND USE THEREOF
    • 咪唑啉衍生物及其用途
    • WO1996004248A1
    • 1996-02-15
    • PCT/JP1995001485
    • 1995-07-26
    • SUNTORY LIMITEDFUKAMI, HarukazuSUMIDA, MotooNIWATA, ShinjiroKAKUTANI, SakiSAITOH, MasayukiSHIBATA, HiroshiKISO, Yoshinobu
    • SUNTORY LIMITED
    • C07D233/80
    • C07D401/04C07D233/80C07D233/86C07D403/04C07D405/12
    • An imidazolidine derivative represented by general formula (1) and medicines containing the derivative as the active ingredient, representative examples of which include a chymase inhibitor and a preventive or remedy for cardiac and circulatory diseases caused by abnormal palpitation induced by angiotensin II, wherein A and B represent each an aromatic hydrocarbon group which may be substituted by one to three substituents selected from among halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylenedioxy, phenoxy, nitro, cyano, phenyl, C2-C5 alkanoylamino, carboxyl which may be esterified with C1-C4 alkyl or alkenyl, carboxyalkyl which may be esterified with C1-C4 alkyl or alkenyl, carboxyalkyloxy which may be esterified with C1-C4 alkyl or alkenyl, N-alkylpiperazinylcarbonyl, N-alkylpiperazinylcarbonylalkyl, N-alkyl-piperazinylcarbonylalkyloxy and morpholinocarbonyl; X represents sulfonyl or carbonyl; and Y represents oxygen or sulfur.
    • 由通式(1)表示的咪唑烷衍生物和含有该衍生物作为活性成分的药物,其代表性实例包括胃促胰酶抑制剂和由血管紧张素II诱导的异常心悸引起的心脏和循环系统疾病的预防或治疗,其中A和 B表示各自为可被一至三个选自卤素,C 1 -C 4烷基,C 1 -C 4烷氧基,C 1 -C 4亚烷基二氧基,苯氧基,硝基,氰基,苯基,C 2 -C 5烷酰基氨基,羧基 其可以被C 1 -C 4烷基或链烯基酯化,可被C 1 -C 4烷基或链烯基酯化的羧基烷基,可被C 1 -C 4烷基或链烯基酯化的羧基烷氧基,N-烷基哌嗪基羰基,N-烷基哌嗪基羰基烷基, 哌嗪基羰基烷氧基和吗啉代羰基; X表示磺酰基或羰基; Y表示氧或硫。