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1. 发明申请

WO2003026556A2 BREATH-ENHANCED ULTRASONIC NEBULIZER AND DEDICATED UNIT DOSE AMPOULE 审中-公开
标题翻译：增强超声波净化器和专用单位剂量
公开(公告)号：WO2003026556A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/027712
申请日：2002-08-30
申请人： IVAX CORPORATION , IVAX U.K., LTD. , BARNEY, Brian , CHEW, Sophia , FAIRBURN, Paul , O'LEARY, David , STRIEBIG, Rachel , STRIEBIG, Rachel
发明人： BARNEY, Brian , CHEW, Sophia , FAIRBURN, Paul , O'LEARY, David , STRIEBIG, Rachel , STRIEBIG, Rachel
IPC分类号： A61J
CPC分类号： A61M15/0028 , A61M15/0016 , A61M15/0018 , A61M15/0033 , A61M15/0085 , A61M16/208 , A61M2205/14
摘要： A medicament delivery system comprises a nebulizer device, an open-faced mist chamber-defining element having a tubular input/output port, a tubular inhalation port connecting to the output port of the mist chamber-defining element, and a sealed unit dose ampoule adapted to fit within the mist chamber-defining element. The nebulizer device includes an ultrasonic transducer responsive to applied electrical energy to generate ultrasonic energy, an ultrasonic transmission horn between an input energy surface at an input end and an energy delivery surface at an output end. The sealed unit dose ampoule can be placed directly into the nebulizer device and acts as both the dose cup and baffle, so that the chance of spillage of drug and the number of components to be cleaned are minimized. The unit dose ampoule has a conical base to allow ultrasonic energy conducted from the ultrasonic system to be concentrated at the base of the ampoule. The inhalation port includes an inhalation valve and an exhalation valve.
摘要翻译：药物输送系统包括雾化器装置，具有管状输入/输出端口的开放式雾室限定元件，连接到雾室限定元件的输出端口的管状吸入口，以及适于以配合在雾室限定元件内。喷雾器装置包括响应于所施加的电能以产生超声能量的超声换能器，在输入端的输入能量表面与输出端的能量输送表面之间的超声波传播喇叭。密封单位剂量安瓿可以直接放置在雾化器装置中并充当剂量杯和挡板，使得药物溢出的可能性和待清洁的组分数量最小化。单位剂量安瓿具有锥形基底，以允许从超声系统传导的超声能量集中在安瓿的底部。吸入口包括吸入阀和呼气阀。

2. 发明申请

WO2011133740A1 DRY POWDER INHALER ASSEMBLY AND CONTAINERS 审中-公开
标题翻译：干粉收集器和集装箱
公开(公告)号：WO2011133740A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/033373
申请日：2011-04-21
申请人： CAMBRIDGE CONSULTANTS LIMITED , HARRIS, David S. , ALLEN, Matthew D. , FULLER, Amanda J. , HARRISON, Nicholas , HEWSON, Karl J. , HODSON, Peter D. , LEWIS, Scott A. , OAKLEY, Tom A. , PATTERSON, Samantha A. , SMITH, Simon J. , STRIEBIG, Rachel V. , STUART, Adam J. , MERRILL, Bryon A.
发明人： HARRIS, David S. , ALLEN, Matthew D. , FULLER, Amanda J. , HARRISON, Nicholas , HEWSON, Karl J. , HODSON, Peter D. , LEWIS, Scott A. , OAKLEY, Tom A. , PATTERSON, Samantha A. , SMITH, Simon J. , STRIEBIG, Rachel V. , STUART, Adam J. , MERRILL, Bryon A.
IPC分类号： A61M15/00 , A61M11/00
CPC分类号： A61M15/0028 , A61M15/0021 , A61M15/0026 , A61M15/0036 , A61M15/0041 , A61M15/0043 , A61M2202/064 , A61M2205/6045 , A61M2206/16
摘要： The present disclosure provides dry powder inhalers, containers for carrying a dose of dry powder medicament particles for dry powder inhalers, and a hinge that, while enjoying broader applicability, may be used in such inhalers.
摘要翻译：本公开提供干粉吸入器，用于携带用于干粉吸入器的干粉药物颗粒剂量的容器，以及在这种吸入器中可以使用更广泛适用性的铰链。

3. 发明申请

WO2010036839A3 INHALERS WITH AIRWAY DISKS HAVING DISCRETE AIRWAY CHANNELS AND RELATED DISKS AND METHODS 审中-公开
标题翻译：带有离散气道通道的气道盘的吸入器及相关的盘和方法
公开(公告)号：WO2010036839A3
公开(公告)日：2010-06-03
申请号：PCT/US2009058285
申请日：2009-09-25
申请人： ORIEL THERAPEUTICS INC , STRIEBIG RACHEL , ALLEN MATTHEW , RUCKDESCHEL THOMAS W , BUCKNER CHARLES
发明人： STRIEBIG RACHEL , ALLEN MATTHEW , RUCKDESCHEL THOMAS W , BUCKNER CHARLES
IPC分类号： A61M15/00
CPC分类号： A61M15/0048 , A61M15/0021 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0075 , A61M2202/064 , Y10T29/49826
摘要： Dry powder inhalers include radially-extending discrete, typically dose- specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder in an inhaler.
摘要翻译：干粉吸入器包括径向延伸的离散的，通常剂量特定的气道通道，其连续地形成吸入通道的一部分以在吸入器中递送干粉。

4. 发明申请

WO2007144607A3 DRY POWDER INHALERS 审中-公开
标题翻译：干粉吸入器
公开(公告)号：WO2007144607A3
公开(公告)日：2008-02-21
申请号：PCT/GB2007002190
申请日：2007-06-13
申请人： CAMBRIDGE CONSULTANTS , SMITH SIMON JAMES , HARRIS DAVID STUART , STRIEBIG RACHEL VICTORIA , PEARL JULIE SUZANNE
发明人： SMITH SIMON JAMES , HARRIS DAVID STUART , STRIEBIG RACHEL VICTORIA , PEARL JULIE SUZANNE
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0008 , A61M15/002 , A61M15/0021 , A61M15/0026 , A61M15/0036 , A61M15/0043 , A61M15/0045 , A61M15/0065 , A61M2202/064 , A61M2205/195 , A61M2205/197 , A61M2206/16
摘要： A dry powder inhaler comprises: a cyclone chamber having a cyclone chamber outlet (20) extending substantially axially therefrom; a mouthpiece channel (26) having a central axis; and a plenum portion (58) connecting said cyclone chamber outlet (20) and said mouthpiece channel, the mouthpiece channel axis A m being offset from, and making a non-parallel angle with, the axis of the cyclone outlet A c such that in use air exits the cyclone outlet (20) at least partly tangentially into the mouthpiece (28). Also disclosed is a blister pack (200) for use with a dry powder inhaler and including a dose of powder for inhalation, the blister comprising: a base part (202) comprising at least one chamber (204,206); a grommet cover (208) extending partly over said chamber and defining an aperture (212, 214) above the chamber; and a protective layer (210) covering at least said aperture, wherein the edge of the grommet cover (208) defining the aperture (212, 214) is compliant so as in use to form a seal around a tube passing through the aperture.
摘要翻译：干粉吸入器包括：旋风室，其具有从其基本轴向延伸的旋风室出口（20）; 具有中心轴线的接口通道（26）; 以及连接所述旋风室出口（20）和所述接口通道的增压室（58），所述接口通道轴线A M m从所述旋转室出口（20）和所述接口通道的轴线偏移，并且与旋风出口A ，使得在使用中，空气至少部分切向地离开旋风出口（20）进入吹口（28）。还公开了一种与干粉吸入器一起使用并且包括一定剂量的用于吸入的粉末的泡罩包装（200），所述泡罩包括：包括至少一个室（204,206）的基部（202）; 在所述腔室上部分地延伸并且在所述腔室上方限定孔（212,214）的垫圈盖（208）以及覆盖至少所述孔的保护层（210），其中限定孔（212,214）的索环盖（208）的边缘是柔顺的，以便在使用中形成围绕穿过孔的管的密封。

5. 发明申请

WO2007144607A2 DRY POWDER INHALERS 审中-公开
标题翻译：干粉吸入器
公开(公告)号：WO2007144607A2
公开(公告)日：2007-12-21
申请号：PCT/GB2007/002190
申请日：2007-06-13
申请人： CAMBRIDGE CONSULTANTS LIMITED , SMITH, Simon, James , HARRIS, David, Stuart , STRIEBIG, Rachel, Victoria , PEARL, Julie, Suzanne
发明人： SMITH, Simon, James , HARRIS, David, Stuart , STRIEBIG, Rachel, Victoria , PEARL, Julie, Suzanne
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0008 , A61M15/002 , A61M15/0021 , A61M15/0026 , A61M15/0036 , A61M15/0043 , A61M15/0045 , A61M15/0065 , A61M2202/064 , A61M2205/195 , A61M2205/197 , A61M2206/16
摘要： A dry powder inhaler comprises: a cyclone chamber having a cyclone chamber outlet (20) extending substantially axially therefrom; a mouthpiece channel (26) having a central axis; and a plenum portion (58) connecting said cyclone chamber outlet (20) and said mouthpiece channel, the mouthpiece channel axis A m being offset from, and making a non-parallel angle with, the axis of the cyclone outlet A c such that in use air exits the cyclone outlet (20) at least partly tangentially into the mouthpiece (28). Also disclosed is a blister pack (200) for use with a dry powder inhaler and including a dose of powder for inhalation, the blister comprising: a base part (202) comprising at least one chamber (204,206); a grommet cover (208) extending partly over said chamber and defining an aperture (212, 214) above the chamber; and a protective layer (210) covering at least said aperture, wherein the edge of the grommet cover (208) defining the aperture (212, 214) is compliant so as in use to form a seal around a tube passing through the aperture.
摘要翻译：干粉吸入器包括：旋风室，其具有从其基本轴向延伸的旋风室出口（20）; 具有中心轴线的接口通道（26）; 以及连接所述旋风室出口（20）和所述接口通道的增压室（58），所述接口通道轴线A M m从所述旋转室出口（20）和所述接口通道的轴线偏移并且与旋风出口A ，使得在使用中，空气至少部分切向地离开旋风出口（20）进入吹口（28）。还公开了一种与干粉吸入器一起使用并且包括一定剂量的用于吸入的粉末的泡罩包装（200），所述泡罩包括：包括至少一个室（204,206）的基部（202）; 在所述腔室上部分地延伸并且在所述腔室上方限定孔（212,214）的垫圈盖（208）以及覆盖至少所述孔的保护层（210），其中限定孔（212,214）的索环盖（208）的边缘是柔顺的，以便在使用中形成围绕穿过孔的管的密封。

6. 发明申请

WO2011023947A1 INHALERS 审中-公开
标题翻译：吸入器
公开(公告)号：WO2011023947A1
公开(公告)日：2011-03-03
申请号：PCT/GB2010/001598
申请日：2010-08-24
申请人： CAMBRIDGE CONSULTANTS LIMITED , STRIEBIG, Rachel , HODSON, Peter , HARRIS, David, Stuart , GREENLEAF, David , MYSZKO, Marek , FULLER, Amanda, Jane , ALLEN, Matthew
发明人： STRIEBIG, Rachel , HODSON, Peter , HARRIS, David, Stuart , GREENLEAF, David , MYSZKO, Marek , FULLER, Amanda, Jane , ALLEN, Matthew
IPC分类号： B04C5/103 , A61M15/00
CPC分类号： A61M15/00 , A61M11/002 , A61M15/0045 , A61M2202/064 , A61M2206/16 , B04C5/103
摘要： A dry powder inhaler incorporates a cyclone chamber (4) comprising at least one air inlet (6) and an outlet (10) wherein the configuration of the air inlet (6) and the shape of the chamber (4) is such that in use a reverse flow cyclone is set up in the chamber (4). The chamber (4) further comprises flow disrupter means, e.g. the upper surface (14) of a protrusion (12) from the base, disposed so as in use to restrict air flowing from the base of the chamber (4) in an axial direction.
摘要翻译：干粉吸入器包括旋风室（4），其包括至少一个空气入口（6）和出口（10），其中空气入口（6）的形状和室（4）的形状使得在使用中反应流旋流器设置在腔室（4）中。室（4）还包括流动破坏装置，例如，突出部（12）的上表面（14）从基部设置成在使用中以限制从腔室（4）的基部沿轴向流动的空气。

7. 发明申请

WO2010036839A2 INHALERS WITH AIRWAY DISKS HAVING DISCRETE AIRWAY CHANNELS AND RELATED DISKS AND METHODS 审中-公开
标题翻译：具有航空公司航空通道的航空器吸入器及相关的磁盘和方法
公开(公告)号：WO2010036839A2
公开(公告)日：2010-04-01
申请号：PCT/US2009/058285
申请日：2009-09-25
申请人： ORIEL THERAPEUTICS, INC. , STRIEBIG, Rachel , ALLEN, Matthew , RUCKDESCHEL, Thomas W. , BUCKNER, Charles
发明人： STRIEBIG, Rachel , ALLEN, Matthew , RUCKDESCHEL, Thomas W. , BUCKNER, Charles
IPC分类号： A61M15/00
CPC分类号： A61M15/0048 , A61M15/0021 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0075 , A61M2202/064 , Y10T29/49826
摘要： Dry powder inhalers include radially-extending discrete, typically dose- specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder in an inhaler.
摘要翻译：干粉吸入器包括径向延伸的离散的，通常为剂量特异性的气道通道，其顺序地形成吸入路径的一部分以将干粉输送到吸入器中。

8. 发明申请

WO2005097243A1 SMALL ANIMAL MASK 审中-公开
标题翻译：小动物面膜
公开(公告)号：WO2005097243A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/011370
申请日：2005-04-01
申请人： IVAX CORPORATION , DVM PHARMACEUTICALS, INC. , BARNEY, Brian , STRIEBIG, Rachel , PYE, Siobhan
发明人： BARNEY, Brian , STRIEBIG, Rachel , PYE, Siobhan
IPC分类号： A61M15/00
CPC分类号： A61D7/04 , A61M15/0015 , A61M15/0086 , A61M15/009 , A61M16/06 , A61M16/0816
摘要： A spacer for connecting an inhaler device to a mask, including an elongated cylindrical first member extending along a central axis between a proximal end adapted to receive an inhaler device and a distal end having a particle reflecting surface, and wherein the first member has an inner channel extending along the central axis, and an elongated cylindrical second member extending along a central axis between a closed proximal end and a distal end adapted to connect to a mask, wherein the second member defines an inner channel extending along the central axis of the second member and wherein the first member and the second member are connected such that the inner channels of the members are joined lengthwise.
摘要翻译：一种用于将吸入器装置连接到掩模上的间隔件，包括在适于接收吸入器装置的近端和具有粒子反射表面的远端之间沿中心轴延伸的细长圆柱形第一构件，并且其中第一构件具有内部通道沿着中心轴线延伸，以及细长的圆柱形第二构件，其沿着适于连接到掩模的封闭近端和远端之间的中心轴线延伸，其中第二构件限定沿着第二构件的中心轴线延伸的内部通道并且其中所述第一构件和所述第二构件连接成使得所述构件的内部通道纵向地连接。

9. 发明申请

WO2005034833A3 DRY POWDER INHALATION APPARATUS 审中-公开
公开(公告)号：WO2005034833A3
公开(公告)日：2005-04-21
申请号：PCT/US2004/032160
申请日：2004-10-02
申请人： IVAX CORPORATION , NORTON HEALTHCARE LTD. , BARNEY, Brian , O'LEARY, David , STRIEBIG, Rachel
发明人： BARNEY, Brian , O'LEARY, David , STRIEBIG, Rachel
IPC分类号： A61M11/00
摘要： The invention relates to dry powder inhalation apparatus usually operable by breath of a user which provides for controlled and smooth transfer of medicament during multiple actuations by a user. A mechanism of the apparatus for achieving this controlled and smooth transfer includes a device (4) normally held adjacent a reservoir for receiving medicament in a cup or receptacle (15) and which is generally movable transversely of a longitudinal axis of the apparatus to delivery channels of the apparatus. This bodily shifting of the device (4) is achieved by a yoke acting on an abutment (16) thereof. Spillage of medicament in the apparatus is avoided.

10. 发明申请

WO2005034833A2 DRY POWDER INHALATION APPARATUS 审中-公开
标题翻译：干粉吸入装置
公开(公告)号：WO2005034833A2
公开(公告)日：2005-04-21
申请号：PCT/US2004032160
申请日：2004-10-02
申请人： IVAX CORP , NORTON HEALTHCARE LTD , BARNEY BRIAN , O'LEARY DAVID , STRIEBIG RACHEL
发明人： BARNEY BRIAN , O'LEARY DAVID , STRIEBIG RACHEL
IPC分类号： A61J20060101 , A61M15/00 , A61M16/00 , A61J
CPC分类号： A61M15/0091 , A61M15/0026 , A61M15/0065 , A61M15/0068 , A61M15/0096 , A61M2016/0024 , A61M2202/064 , A61M2205/583 , A61M2205/8206
摘要： The invention relates to dry powder inhalation apparatus usually operable by breath of a user which provides for controlled and smooth transfer of medicament during multiple actuations by a user. A mechanism of the apparatus for achieving this controlled and smooth transfer includes a device (4) normally held adjacent a reservoir for receiving medicament in a cup or receptacle (15) and which is generally movable transversely of a longitudinal axis of the apparatus to delivery channels of the apparatus. This bodily shifting of the device (4) is achieved by a yoke acting on an abutment (16) thereof. Spillage of medicament in the apparatus is avoided.
摘要翻译：本发明涉及通常由用户的呼吸操作的干粉吸入装置，其在用户的多次致动期间提供药物的受控和平滑的转移。用于实现这种受控和平稳转移的装置的机构包括通常保持在容器附近的装置（4），用于接收在杯子或容器（15）中的药物，并且其通常可以横向于装置的纵向轴线移动到输送通道的装置。设备（4）的这种身体移动通过作用在其基台（16）上的轭来实现。避免了药物在装置中的溢出。

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