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1. 发明申请

WO2006127167A3 PROTEOLIPID MEMBRANE & LIPID MEMBRANE BIOSENSOR 审中-公开
标题翻译： PROTEOLIPID膜和脂膜生物传感器
公开(公告)号：WO2006127167A3
公开(公告)日：2007-03-22
申请号：PCT/US2006013926
申请日：2006-04-12
申请人： SRU BIOSYSTEMS INC , BAIRD CHERYL L , WANG GUO BIN , LAING LANCE , JOGIKALMATH GANGADHAR , GERSTENMAIER JOHN
发明人： BAIRD CHERYL L , WANG GUO BIN , LAING LANCE , JOGIKALMATH GANGADHAR , GERSTENMAIER JOHN
IPC分类号： G01N33/543 , G01N33/92
CPC分类号： G01N33/5432 , G01N33/54373 , G01N33/551 , G01N33/92
摘要： The invention provides label-free methods for performing an assay by using a colorimetric resonant biosensor comprising at least one surface to which is immobilized one or more non-polar molecules.
摘要翻译：本发明提供了通过使用包含固定有一个或多个非极性分子的至少一个表面的比色共振生物传感器来进行测定的无标记方法。

2. 发明申请

WO2006085958A3 INTEGRATION OF DIRECT BINDING SENSORS WITH MASS SPECTROMETRY FOR FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF MOLECULES 审中-公开
标题翻译：直接结合传感器与质谱分析的功能和结构特征的整合
公开(公告)号：WO2006085958A3
公开(公告)日：2006-09-14
申请号：PCT/US2005022719
申请日：2005-06-28
申请人： SRU BIOSYSTEMS INC , LI PETER , LIN BO , WILLIAMS CHRIS , LAING LANCE
发明人： LI PETER , LIN BO , WILLIAMS CHRIS , LAING LANCE
IPC分类号： G01N21/27 , G01N33/487 , G01N33/543
CPC分类号： G01N33/6848 , G01N21/27 , G01N33/542 , G01N33/543 , G01N33/54373
摘要： The invention provides methods for the detection, quantification, identification and structural analysis of one or more molecules. Mass spectrometry (MS) is not a universal detector as all molecules do not ionize equally well leading to poor signal to quantity information. MS can be optimized to identify the specific mass of a binding component when the presence of a material is known. Colorimetric resonant reflectance optical sensors provide a universal mass detector in that nearly all biological masses give equally proportional signals. The combined methods allow selection and or detection with quantification of all masses binding to the sensor with the ability to identify specific molecules by their individual masses and structure analyses.
摘要翻译：本发明提供了一种或多种分子的检测，定量，鉴定和结构分析的方法。质谱（MS）不是一个通用的检测器，因为所有的分子都不会很好地电离，导致信号与数量信息的差。当材料的存在已知时，可优化MS以鉴定结合组分的特定质量。比色共振反射光学传感器提供了通用的质量检测器，因为几乎所有的生物质量都产生等比例的信号。组合的方法允许通过定量结合传感器的所有质量的选择和/或检测，其具有通过其各自的质量和结构分析鉴定特定分子的能力。

3. 发明专利

AU2006249657B2 Proteolipid membrane & lipid membrane biosensor 未知
公开(公告)号：AU2006249657B2
公开(公告)日：2011-02-10
申请号：AU2006249657
申请日：2006-04-12
申请人： SRU BIOSYSTEMS INC
发明人： GERSTENMAIER JOHN , JOGIKALMATH GANGADHAR , LAING LANCE , WANG GUO BIN , BAIRD CHERYL L
IPC分类号： G01N33/543 , G01N33/92

4. 发明专利

AT475886T 未知
公开(公告)号：AT475886T
公开(公告)日：2010-08-15
申请号：AT06784359
申请日：2006-04-12
申请人： SRU BIOSYSTEMS INC
发明人： BAIRD CHERYL , WANG GUO , LAING LANCE , JOGIKALMATH GANGADHAR , GERSTENMAIER JOHN
IPC分类号： G01N33/543

5. 发明专利

AT470849T 未知
公开(公告)号：AT470849T
公开(公告)日：2010-06-15
申请号：AT06824773
申请日：2006-07-20
申请人： SRU BIOSYSTEMS INC
发明人： SCHULZ STEPHEN , CUNNINGHAM BRIAN , LAING LANCE , LI PETER , BINDER BRANT , JOGIKALMATH GANGADHAR , BORSODY ALEX
IPC分类号： G01N21/55 , G01N21/64
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label - free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.

6. 发明专利

NZ562794A Proteolipid membrane & lipid membrane biosensor using a titanium surface 未知
公开(公告)号：NZ562794A
公开(公告)日：2010-07-30
申请号：NZ56279406
申请日：2006-04-12
申请人： SRU BIOSYSTEMS INC
发明人： BAIRD CHERYL L , WANG GUO BIN , LAING LANCE , JOGIKALMATH GANGADHAR , GERSTENMAIER JOHN
IPC分类号： G01N33/543 , G01N33/92
摘要： Disclosed is a colorimetric resonant biosensor or a grating-based waveguide biosensor, wherein the surface of the biosensor is titanium oxide, titanium dioxide, or titanium phosphate, wherein the surface is coated with silane to form a titanium oxide-silane, titanium dioxide-silane, or titanium phosphate-silane surface, and wherein a lipid bilayer or lipid monolayer is immobilized on the surface. Also disclosed is a method of analyzing a chemical or physical interaction in a lipid bilayer or lipid monolayer using a colorimetric resonant biosensor or a grating-based waveguide biosensor, wherein the biosensor comprises a titanium oxide-silane, titanium dioxide-silane, or titanium phosphate-silane surface, and wherein a lipid bilayer comprising contacting the lipid layer with a species and analyzing the interaction of the lipid layer and the species by (a) detecting a maxima in reflected wavelength or a minima in transmitted wavelength of light used to illuminate the biosensor, wherein if the wavelength of light is shifted the species has interacted with the lipid layer; or (b) detecting a change in refractive index of light used to illuminate the biosensor, wherein a change in refractive index indicated that the species has interacted with the lipid layer.

7. 发明专利

CA2683082A1 METHOD FOR EMPLOYING A BIOSENSOR TO DETECT SMALL MOLECULES THAT BIND DIRECTLY TO IMMOBILIZED TARGETS 未知
公开(公告)号：CA2683082A1
公开(公告)日：2008-10-30
申请号：CA2683082
申请日：2008-04-19
申请人： SRU BIOSYSTEMS INC
发明人： LOWE PETER , WAGNER RICK , LAING LANCE
IPC分类号： G01N21/00 , G01N33/50
摘要： Method for Employing a Biosensor to Detect Small Molecules that Bind Dire ctly to Immobilized Targets. The invention provides method of detecting inte ractions of small molecules with target molecules.

8. 发明专利

HK1109804A1 PROTEOLIPID MEMBRANE AND LIPID MEMBRANE BIOSENSOR 未知
公开(公告)号：HK1109804A1
公开(公告)日：2008-06-20
申请号：HK08103821
申请日：2008-04-07
申请人： SRU BIOSYSTEMS INC
发明人： BAIRD CHERYL , WANG GUO BIN , LAING LANCE , JOGIKALMATH GANGADHAR , GERSTENMAIER JOHN
IPC分类号： G01N20060101

9. 发明专利

CA2604099C PROTEOLIPID MEMBRANE & LIPID MEMBRANE BIOSENSOR 未知
公开(公告)号：CA2604099C
公开(公告)日：2011-02-15
申请号：CA2604099
申请日：2006-04-12
申请人： SRU BIOSYSTEMS INC
发明人： BAIRD CHERYL L , WANG GUO BIN , LAING LANCE , JOGIKALMATH GANGADHAR , GERSTENMAIER JOHN
IPC分类号： G01N33/543 , G01N33/92
摘要： The invention provides label-free methods for performing an assay by using a colorimetric resonant biosensor comprising at least one surface to which is immobilized one or more non-polar molecules.

10. 发明专利

CA2746452A1 METHODS OF DETECTION OF CHANGES IN CELLS 未知
公开(公告)号：CA2746452A1
公开(公告)日：2010-07-01
申请号：CA2746452
申请日：2009-12-14
申请人： SRU BIOSYSTEMS INC
发明人： WAGNER RICK , FERNANDEZ RAFAEL , CUNNINGHAM BRIAN T , LAING LANCE
IPC分类号： G01N33/567 , C12Q1/02 , C12Q1/68 , G01N1/28 , G01N21/78
摘要： Methods are provided to detect changes in cells without the use of detection labels In one embodiment, detection of responses of cells to stimuli comprises immobilizing one or more extracellular matrix ligands to a surface of a colopmetric resonant reflectance biosensor or a grating-based waveguide biosensor, and adding the cells having cell surface receptors specific for the one or more extracellular matrix ligands to the biosensor Changes in cells are then detected by the biosensor before and after introduction of stimuli to the biosensor.

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