专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010042637A3 BEAD INCUBATION AND WASHING ON A DROPLET ACTUATOR 审中-公开
标题翻译：喷嘴执行器上的珠子灌注和洗涤
公开(公告)号：WO2010042637A3
公开(公告)日：2010-07-22
申请号：PCT/US2009059868
申请日：2009-10-07
申请人： ADVANCED LIQUID LOGIC INC , SISTA RAMAKRISHNA , SUDARSAN ARJUN , PAMULA VAMSEE
发明人： SISTA RAMAKRISHNA , SUDARSAN ARJUN , PAMULA VAMSEE
IPC分类号： G01N33/543 , C12Q1/68 , G01N27/00
CPC分类号： G01N33/5308
摘要： The present invention relates to bead incubating and washing on a droplet actuator. Methods for incubating magnetically responsive beads that are labeled with primary antibody, a sample (i.e., analyte), and secondary reporter antibodies on a magnet, on and off a magnet, and completely off a magnet are provided. Also provided are methods for washing magnetically responsive beads using shape-assisted merging of droplets. Also provided are methods for shape-mediated splitting, transporting, and dispensing of a sample droplet that contains magnetically responsive beads. The apparatuses and methods of the invention provide for rapid time to result and optimum detection of an analyte in an immunoassay.
摘要翻译：本发明涉及在液滴致动器上的珠孵化和洗涤。提供用于将在一次抗体上标记的磁响应珠，样品（即分析物）和二次报告基因抗体孵育在磁体上，磁铁上和从磁体上离开并完全离开磁体的方法。还提供了使用形状辅助的液滴合并来洗涤磁响应珠的方法。还提供了用于形状介导的分离，输送和分配含有磁响应珠的样品液滴的方法。本发明的装置和方法提供了免疫测定中分析物的快速结果和最佳检测的时间。

2. 发明申请

WO2010009463A2 DROPLET OPERATIONS DEVICE 审中-公开
标题翻译： DROPLET操作设备
公开(公告)号：WO2010009463A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/051128
申请日：2009-07-20
申请人： ADVANCED LIQUID LOGIC, INC. , SRINIVASAN, Vijay , SUDARSAN, Arjun , PAMULA, Vamsee , POLLACK, Michael , SISTA, Ramakrishna , KOZIKOWSKI, Raymond , BELL, Nicole
发明人： SRINIVASAN, Vijay , SUDARSAN, Arjun , PAMULA, Vamsee , POLLACK, Michael , SISTA, Ramakrishna , KOZIKOWSKI, Raymond , BELL, Nicole
IPC分类号： G01N27/00 , G01N35/10 , B01J19/00 , B41J2/14 , B01L3/02
CPC分类号： G01N27/44756 , B01F13/0071 , B01F13/0076 , B01L3/502707 , B01L3/502792 , B01L2300/0816 , B01L2300/0819 , B01L2400/0427 , B01L2400/0688 , B01L2400/086 , B29C59/02 , B41J2/1601 , B81B7/0061 , B81B2201/058 , B81B2201/13 , F04B17/00 , F04B19/006
摘要： The invention provides droplet actuators with droplet operations surfaces for manipulating droplets, e.g., by conducting droplet operations. The droplet operations surfaces are typically exposed to a droplet operations gap. One or more regions of a droplet operation surface may include patterned topographic features. The invention also provides a droplet actuator in which one or both gap-facing droplet operations surfaces is formed using a removable film. The removable film may, in various embodiments, also include other components ordinarily associated with the droplet actuator substrate, such as the dielectric layer and the electrodes. Further, the invention provides droplet actuator devices and methods for coupling and/or sealing substrates of a droplet actuator, such as techniques for self-aligning assembly of droplet actuator substrates. The invention provides droplet actuators and methods of disassembling the droplet actuator in order to provide access for cleaning and/or recycling of droplet actuator surfaces.
摘要翻译：本发明提供液滴致动器，其具有用于操纵液滴的液滴操作表面，例如通过进行液滴操作。液滴操作表面通常暴露于液滴操作间隙。液滴操作表面的一个或多个区域可以包括图案化的地形特征。本发明还提供一种液滴致动器，其中使用可除去膜形成一个或两个面向间隙的液滴操作表面。在各种实施例中，可移除膜还可以包括通常与液滴致动器基底（例如介电层和电极）相关联的其它部件。此外，本发明提供了液滴致动器装置和用于联接和/或密封液滴致动器的基板的方法，例如用于液滴致动器基板的自对准组装的技术。本发明提供了液滴致动器和拆卸液滴致动器的方法，以提供用于清洁和/或再循环液滴致动器表面的通路。

3. 发明申请

WO2011002957A3 DROPLET ACTUATOR DEVICES AND METHODS 审中-公开
标题翻译：液滴驱动器装置和方法
公开(公告)号：WO2011002957A3
公开(公告)日：2011-08-04
申请号：PCT/US2010040705
申请日：2010-07-01
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL G , SRINIVASAN VIJAY , PAMULA VAMSEE K , BRACKETT GEORGE , BRAFFORD KEITH R , CLARK DARIUS , HUA ZHISHAN , NORTON SCOTT , SISTA RAMAKRISHNA , SMITH GREGORY F , STURMER RYAN A , SUDARSAN ARJUN , THWAR PRASANNA , WANG TIH-HONG , WINGER THEODORE
发明人： POLLACK MICHAEL G , SRINIVASAN VIJAY , PAMULA VAMSEE K , BRACKETT GEORGE , BRAFFORD KEITH R , CLARK DARIUS , HUA ZHISHAN , NORTON SCOTT , SISTA RAMAKRISHNA , SMITH GREGORY F , STURMER RYAN A , SUDARSAN ARJUN , THWAR PRASANNA , WANG TIH-HONG , WINGER THEODORE
IPC分类号： B41J2/06 , B41J2/175 , B41J29/38
CPC分类号： B01L3/502707 , B01F13/0071 , B01F13/0076 , B01L3/0241 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L3/502792 , B01L2200/0673 , B01L2200/0689 , B01L2300/0819 , B01L2300/0861 , B01L2300/087 , B01L2300/0874 , B01L2300/088 , B01L2300/0883 , B01L2400/0415 , B01L2400/0427 , B01L2400/0442 , B01L2400/0457 , B01L2400/0469 , B01L2400/0622 , B01L2400/0688 , B01L2400/088
摘要： The invention provides droplet actuator devices for facilitating certain droplet actuated molecular techniques. In one embodiment, the invention provides droplet actuators that facilitate droplet operations in three dimensions. In another embodiment, the invention provides for cost-effective production of droplet actuators. In another embodiment, the invention provides for replacing one or more components of a droplet actuator. In another embodiment, the invention provides droplet actuators using printed conductive inks to form electrodes and/or ground planes. In another embodiment, the invention provides a magnetic clamping fixture for assembling droplet actuators. In another embodiment, the invention provides simple, low cost power sources for use in combination with microfluidic systems. In another embodiment, the invention provides an immunoassay multiplexing platform that uses digital microfluidics and real-time imaging of flash-based chemiluminescent signals. In still another embodiment, the invention provides droplet actuator devices that are fabricated using a plasma treatment process to raise substrate surface energy.
摘要翻译：本发明提供了用于促进某些液滴致动分子技术的液滴致动器装置。在一个实施例中，本发明提供了促进三维液滴操作的液滴致动器。在另一个实施例中，本发明提供了液滴致动器的成本有效的生产。在另一个实施例中，本发明提供了替换液滴致动器的一个或多个部件。在另一个实施例中，本发明提供使用印刷导电油墨形成电极和/或接地平面的液滴致动器。在另一个实施例中，本发明提供了一种用于组装液滴致动器的磁性夹具。在另一个实施例中，本发明提供了与微流体系统结合使用的简单，低成本的电源。在另一个实施方案中，本发明提供了使用数字微流体和基于闪光的化学发光信号的实时成像的免疫测定多路复用平台。在又一个实施例中，本发明提供了使用等离子体处理工艺制造以提高衬底表面能量的液滴致动器装置。

4. 发明申请

WO2010006166A3 BEAD MANIPULATION TECHNIQUES 审中-公开
标题翻译： BEAD操作技术
公开(公告)号：WO2010006166A3
公开(公告)日：2010-04-29
申请号：PCT/US2009050101
申请日：2009-07-09
申请人： ADVANCED LIQUID LOGIC INC , PAMULA VAMSEE , THWAR PRASANNA , SUDARSAN ARJUN , SISTA RAMAKRISHNA , SULLIVAN MICHAEL , NORTON SCOTT
发明人： PAMULA VAMSEE , THWAR PRASANNA , SUDARSAN ARJUN , SISTA RAMAKRISHNA , SULLIVAN MICHAEL , NORTON SCOTT
IPC分类号： G01N33/543 , G01N27/00
CPC分类号： B03C5/028 , B03C5/005
摘要： The invention provides a method of redistributing magnetically responsive beads in a droplet. The method may include providing a droplet including magnetically responsive beads. The droplet may be provided within a region of a magnetic field having sufficient strength to attract the magnetically responsive beads to an edge of the droplet or towards an edge of the droplet, or otherwise regionalize or aggregate beads within the droplet. The method may also include conducting on a droplet operations surface one or more droplet operations using the droplet without removing the magnetically responsive beads from the region of the magnetic field. The droplet operations may in some cases be electrode -mediated. The droplet operations may redistribute and/or circulate the magnetically responsive beads within the droplet. In some cases, the droplet may include a sample droplet may include a target analyte. The redistributing of the magnetically responsive beads may cause target analyte to bind to the magnetically responsive beads. In some cases, the droplet may include unbound substances in a wash buffer. The redistributing of the magnetically responsive beads causes unbound substances to be freed from interstices of an aggregated set or subset of the magnetically responsive beads.
摘要翻译：本发明提供了在液滴中重新分布磁响应珠的方法。该方法可以包括提供包括磁响应珠的液滴。可以在具有足够强度的磁场的区域内提供液滴，以将磁响应珠吸引到液滴的边缘或朝向液滴的边缘，或以其他方式使液滴区域化或聚集在液滴内。该方法还可以包括使用液滴在液滴操作表面上进行一个或多个液滴操作，而不从磁场的区域移除磁响应珠。液滴操作在某些情况下可能是电极介导的。液滴操作可以重新分配和/或循环液滴内的磁响应珠。在一些情况下，液滴可以包括样品液滴可以包括目标分析物。磁响应珠粒的重新分布可以使目标分析物结合到磁响应珠粒上。在一些情况下，液滴可以包含洗涤缓冲液中的未结合物质。磁响应珠粒的重新分布导致未结合的物质从磁性响应珠粒的聚集组或亚组的空隙释放。

5. 发明申请

WO2008098236A2 DROPLET ACTUATOR DEVICES AND METHODS EMPLOYING MAGNETIC BEADS 审中-公开
标题翻译：刮刀致动器装置和使用磁珠的方法
公开(公告)号：WO2008098236A2
公开(公告)日：2008-08-14
申请号：PCT/US2008/053545
申请日：2008-02-11
申请人： ADVANCED LIQUID LOGIC, INC. , SISTA, Ramakrishna , PAMULA, Vamsee K. , POLLACK, Michael G. , SRINIVASAN, Vijay , ECKHARDT, Allen E.
发明人： SISTA, Ramakrishna , PAMULA, Vamsee K. , POLLACK, Michael G. , SRINIVASAN, Vijay , ECKHARDT, Allen E.
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L2200/025 , B01L2200/028 , B01L2200/0647 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0427 , B01L2400/043 , C12M25/01 , C12M25/16 , G01N27/44717 , G01N27/44786 , G01N33/54386 , G01N35/0098 , G01N2035/1046
摘要： A method of providing a droplet in contact with a magnetically responsive bead and having a reduced quantity of a substance. The method generally includes the steps of (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged for conducting droplet operations on a surface; (ii) a starting droplet comprising: (1) one or more magnetically responsive beads; (2) a starting quantity of the substance; and (3) a starting volume; (b) magnetically immobilizing the one or more magnetically responsive beads at a location which is at a distance from a target droplet splitting zone; (c) conducting one or more droplet operations comprising droplet dividing operations selected to divide the combined droplet to yield a set of droplets comprising: (i) a droplet comprising substantially all of the one or more magnetically responsive beads and having a decreased quantity of the substance relative to the starting concentration; and (ii) a droplet substantially lacking the magnetically responsive beads.
摘要翻译：提供与磁响应珠接触并具有减少的物质量的液滴的方法。该方法通常包括以下步骤：（a）提供液滴致动器，其包括：（i）包括布置用于在表面上进行液滴操作的电极的基板; （ii）起始液滴，包括：（1）一个或多个磁响应珠; （2）物质的起始量; 和（3）起始体积; （b）将一个或多个磁响应珠磁性地固定在距离目标液滴分裂区一定距离的位置; （c）进行一个或多个液滴操作，其包括液滴分割操作，所述液滴分割操作被选择以分开所述组合的液滴以产生一组液滴，所述液滴包括：（i）包含基本上所有所述一个或多个磁响应珠粒并且具有减少量物质相对于起始浓度; 和（ii）基本上不含磁响应珠的液滴。

6. 发明申请

WO2012151192A2 MOLECULAR DIAGNOSTICS PLATFORM 审中-公开
标题翻译：分子诊断平台
公开(公告)号：WO2012151192A2
公开(公告)日：2012-11-08
申请号：PCT/US2012/035963
申请日：2012-05-01
申请人： ADVANCED LIQUID LOGIC, INC. , BORT, Donovan , GRAHAM, Carrie , PAMULA, Vamsee , POLLACK, Michael , SISTA, Ramakrishna , SRINIVASAN, Vijay
发明人： BORT, Donovan , GRAHAM, Carrie , PAMULA, Vamsee , POLLACK, Michael , SISTA, Ramakrishna , SRINIVASAN, Vijay
CPC分类号： G01N27/44791 , B01F1/0027 , B01F13/0071 , B01F13/0076 , B01F2001/0055 , B01F2215/0037 , B01L3/502761 , B01L3/502792 , B01L2200/0605 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/089 , B01L2400/0406 , B01L2400/0418 , B01L2400/0427 , B01L2400/043 , B01L2400/0487 , B81B1/004
摘要： A method of mixing a droplet, the method comprising providing a droplet on a surface, forming the droplet into a first "U" shape having a bottom region and two terminal ends, and simultaneously merging the terminal ends and splitting the droplet at the bottom region to form a second "U" shape which is substantially opposite the first "U" shape.
摘要翻译：一种混合液滴的方法，所述方法包括在表面上提供液滴，将所述液滴形成为具有底部区域和两个末端的第一“U”形状，并同时合并末端并在底部区域分离液滴以形成与第一“U”形大致相反的第二“U”形。

7. 发明申请

WO2011084703A3 ENZYME ASSAYS ON A DROPLET ACTUATOR 审中-公开
标题翻译：在液滴驱动器上的酶分析
公开(公告)号：WO2011084703A3
公开(公告)日：2011-12-08
申请号：PCT/US2010061118
申请日：2010-12-17
申请人： ADVANCED LIQUID LOGIC INC , ECKHARDT ALLEN E , GRAHAM CARRIE , SISTA RAMAKRISHNA , PAMULA VAMSEE K , WINGER THEODORE , WANG TONG , XIONG YALIN , WU NING , SAHA SANJAY , RAOLJI GAJENDRASINH BALVANTSINH , DAYAM RAVEENDRA
发明人： ECKHARDT ALLEN E , GRAHAM CARRIE , SISTA RAMAKRISHNA , PAMULA VAMSEE K , WINGER THEODORE , WANG TONG , XIONG YALIN , WU NING , SAHA SANJAY , RAOLJI GAJENDRASINH BALVANTSINH , DAYAM RAVEENDRA
IPC分类号： C12Q1/34 , C07D311/06 , C07D311/18 , C12M1/34 , C12Q1/25 , G01N33/52
CPC分类号： C12Q1/40 , B01L3/502784 , B01L2300/0654 , B01L2300/0816 , B01L2300/18 , B01L2400/0427 , B01L2400/043 , C07D311/16 , C07D311/18 , C07D311/20 , C07D405/12 , C07D413/12 , C07H15/203 , C07H17/075 , C12Q1/25 , C12Q1/34 , C12Q1/44 , C12Q1/54 , C12Y302/01023 , G01N21/6452 , G01N33/5438 , G01N2333/916 , G01N2333/926 , G01N2333/938 , G01N2800/04
摘要： The invention is directed to droplet actuator devices and assay methods for multiplexed newborn testing for metabolic disorders. The methods include, among other things, droplet-based enzymatic assays and immunoassays for testing for metabolic disorders. The invention includes methods and devices for conducting multiple assays for different metabolic disorders on a single droplet actuator, as well as multiple assays for the same metabolic disorder using samples from different subjects and/or multiple samples from the same subject on a single droplet actuator. In various embodiments, the invention includes methods for conducting enzymatic activity assays and/or immunoassays in a single fresh blood and/or plasma samples and dried blood and/or plasma samples.
摘要翻译：本发明涉及用于代谢紊乱的多路复用新生儿测试的液滴致动器装置和测定方法。除其他之外，所述方法包括基于液滴的酶测定和用于测试代谢紊乱的免疫测定。本发明包括用于在单一液滴致动器上针对不同代谢病症进行多种测定的方法和装置，以及使用来自不同受试者的样品和/或来自单个液滴致动器上的来自相同受试者的多个样品的相同代谢病症的多种测定。在各种实施方式中，本发明包括用于在单个新鲜血液和/或血浆样品以及干燥的血液和/或血浆样品中进行酶活性测定和/或免疫测定的方法。

8. 发明申请

WO2010027894A2 DROPLET ACTUATORS, MODIFIED FLUIDS AND METHODS 审中-公开
标题翻译：滴落执行器，改性流体和方法
公开(公告)号：WO2010027894A2
公开(公告)日：2010-03-11
申请号：PCT/US2009/055139
申请日：2009-08-27
申请人： ADVANCED LIQUID LOGIC, INC. , SRINIVASAN, Vijay , PAMULA, Vamsee , SISTA, Ramakrishna , SUDARSAN, Arjun , THWAR, Prasanna
发明人： SRINIVASAN, Vijay , PAMULA, Vamsee , SISTA, Ramakrishna , SUDARSAN, Arjun , THWAR, Prasanna
IPC分类号： B01J19/00 , B01L3/00 , G01N1/28
CPC分类号： B01L3/502792 , B01L3/502715 , B01L3/502746 , B01L7/52 , B01L7/525 , B01L9/52 , B01L2300/0819 , B01L2300/1827 , B01L2400/0427 , B01L2400/0677 , B01L2400/086
摘要： The present invention provides droplet actuators, modified fluids and methods relating to droplet operations. An aspect includes a droplet actuator including a substrate comprising electrodes arranged for conducting droplet operations on a droplet operations surface of the substrate; a filler fluid phase in contact with the droplet operations surface at least partially surrounding a droplet phase including a droplet arranged on one or more of the electrodes, the filler fluid phase being divided by one or more physical barriers into zones; and an opening in the one or more physical barriers for transporting the droplet phase from one zone to another. Still other aspects are provided.
摘要翻译：本发明提供了与液滴操作有关的液滴致动器，改进的流体和方法。一个方面包括一种液滴致动器，其包括：衬底，其包括被布置用于在衬底的液滴操作表面上进行液滴操作的电极; 与所述液滴操作表面接触的填充液相，其至少部分围绕包括布置在所述一个或多个电极上的液滴的液滴相，所述填充液相被一个或多个物理屏障分成区域; 以及用于将液滴相从一个区域输送到另一个区域的一个或多个物理屏障中的开口。还提供了其他方面。

9. 发明申请

WO2012151192A3 MOLECULAR DIAGNOSTICS PLATFORM 审中-公开
标题翻译：分子诊断平台
公开(公告)号：WO2012151192A3
公开(公告)日：2013-03-21
申请号：PCT/US2012035963
申请日：2012-05-01
申请人： ADVANCED LIQUID LOGIC INC , BORT DONOVAN , GRAHAM CARRIE , PAMULA VAMSEE , POLLACK MICHAEL , SISTA RAMAKRISHNA , SRINIVASAN VIJAY
发明人： BORT DONOVAN , GRAHAM CARRIE , PAMULA VAMSEE , POLLACK MICHAEL , SISTA RAMAKRISHNA , SRINIVASAN VIJAY
IPC分类号： G01N35/08 , B01F3/08 , C12Q1/68 , G01N21/00
CPC分类号： G01N27/44791 , B01F1/0027 , B01F13/0071 , B01F13/0076 , B01F2001/0055 , B01F2215/0037 , B01L3/502761 , B01L3/502792 , B01L2200/0605 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/089 , B01L2400/0406 , B01L2400/0418 , B01L2400/0427 , B01L2400/043 , B01L2400/0487 , B81B1/004
摘要： A method of mixing a droplet, the method comprising providing a droplet on a surface, forming the droplet into a first "U" shape having a bottom region and two terminal ends, and simultaneously merging the terminal ends and splitting the droplet at the bottom region to form a second "U" shape which is substantially opposite the first "U" shape.
摘要翻译：一种混合液滴的方法，所述方法包括在表面上提供液滴，将所述液滴形成为具有底部区域和两个末端的第一“U”形状，并同时合并末端并在底部区域分离液滴以形成与第一“U”形大体相反的第二“U”形状。

10. 发明申请

WO2011084703A2 ENZYME ASSAYS ON A DROPLET ACTUATOR 审中-公开
标题翻译：滴剂执行器上的酶测定
公开(公告)号：WO2011084703A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/061118
申请日：2010-12-17
申请人： ADVANCED LIQUID LOGIC, INC. , ECKHARDT, Allen, E. , GRAHAM, Carrie , SISTA, Ramakrishna , PAMULA, Vamsee, K. , WINGER, Theodore , WANG, Tong , XIONG, Yalin , WU, Ning , SAHA, Sanjay , RAOLJI, Gajendrasinh, Balvantsinh , DAYAM, Raveendra
发明人： ECKHARDT, Allen, E. , GRAHAM, Carrie , SISTA, Ramakrishna , PAMULA, Vamsee, K. , WINGER, Theodore , WANG, Tong , XIONG, Yalin , WU, Ning , SAHA, Sanjay , RAOLJI, Gajendrasinh, Balvantsinh , DAYAM, Raveendra
IPC分类号： C12Q1/34 , C12Q1/25 , C12M1/34 , G01N33/52 , C07D311/06 , C07D311/18
CPC分类号： C12Q1/40 , B01L3/502784 , B01L2300/0654 , B01L2300/0816 , B01L2300/18 , B01L2400/0427 , B01L2400/043 , C07D311/16 , C07D311/18 , C07D311/20 , C07D405/12 , C07D413/12 , C07H15/203 , C07H17/075 , C12Q1/25 , C12Q1/34 , C12Q1/44 , C12Q1/54 , C12Y302/01023 , G01N21/6452 , G01N33/5438 , G01N2333/916 , G01N2333/926 , G01N2333/938 , G01N2800/04
摘要： The invention is directed to droplet actuator devices and assay methods for multiplexed newborn testing for metabolic disorders. The methods include, among other things, droplet-based enzymatic assays and immunoassays for testing for metabolic disorders. The invention includes methods and devices for conducting multiple assays for different metabolic disorders on a single droplet actuator, as well as multiple assays for the same metabolic disorder using samples from different subjects and/or multiple samples from the same subject on a single droplet actuator. In various embodiments, the invention includes methods for conducting enzymatic activity assays and/or immunoassays in a single fresh blood and/or plasma samples and dried blood and/or plasma samples.
摘要翻译：本发明涉及液滴致动器装置和用于代谢紊乱的多重新生儿测试的测定方法。所述方法尤其包括用于测试代谢紊乱的基于液滴的酶测定和免疫测定。本发明包括用于在单个液滴致动器上对不同代谢紊乱进行多个测定的方法和装置，以及使用来自不同受试者的样品和/或来自相同受试者的单个液滴致动器的多个样品的相同代谢紊乱的多个测定。在各种实施方案中，本发明包括用于在单个新鲜血液和/或血浆样品和干血液和/或血浆样品中进行酶活性测定和/或免疫测定的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式