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    • 2. 发明申请
    • BEAD MANIPULATION TECHNIQUES
    • BEAD操作技术
    • WO2010006166A3
    • 2010-04-29
    • PCT/US2009050101
    • 2009-07-09
    • ADVANCED LIQUID LOGIC INCPAMULA VAMSEETHWAR PRASANNASUDARSAN ARJUNSISTA RAMAKRISHNASULLIVAN MICHAELNORTON SCOTT
    • PAMULA VAMSEETHWAR PRASANNASUDARSAN ARJUNSISTA RAMAKRISHNASULLIVAN MICHAELNORTON SCOTT
    • G01N33/543G01N27/00
    • B03C5/028B03C5/005
    • The invention provides a method of redistributing magnetically responsive beads in a droplet. The method may include providing a droplet including magnetically responsive beads. The droplet may be provided within a region of a magnetic field having sufficient strength to attract the magnetically responsive beads to an edge of the droplet or towards an edge of the droplet, or otherwise regionalize or aggregate beads within the droplet. The method may also include conducting on a droplet operations surface one or more droplet operations using the droplet without removing the magnetically responsive beads from the region of the magnetic field. The droplet operations may in some cases be electrode -mediated. The droplet operations may redistribute and/or circulate the magnetically responsive beads within the droplet. In some cases, the droplet may include a sample droplet may include a target analyte. The redistributing of the magnetically responsive beads may cause target analyte to bind to the magnetically responsive beads. In some cases, the droplet may include unbound substances in a wash buffer. The redistributing of the magnetically responsive beads causes unbound substances to be freed from interstices of an aggregated set or subset of the magnetically responsive beads.
    • 本发明提供了在液滴中重新分布磁响应珠的方法。 该方法可以包括提供包括磁响应珠的液滴。 可以在具有足够强度的磁场的区域内提供液滴,以将磁响应珠吸引到液滴的边缘或朝向液滴的边缘,或以其他方式使液滴区域化或聚集在液滴内。 该方法还可以包括使用液滴在液滴操作表面上进行一个或多个液滴操作,而不从磁场的区域移除磁响应珠。 液滴操作在某些情况下可能是电极介导的。 液滴操作可以重新分配和/或循环液滴内的磁响应珠。 在一些情况下,液滴可以包括样品液滴可以包括目标分析物。 磁响应珠粒的重新分布可以使目标分析物结合到磁响应珠粒上。 在一些情况下,液滴可以包含洗涤缓冲液中的未结合物质。 磁响应珠粒的重新分布导致未结合的物质从磁性响应珠粒的聚集组或亚组的空隙释放。