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1. 发明申请

WO2007120241A3 DROPLET-BASED BIOCHEMISTRY 审中-公开
标题翻译：基于滴灌的生物化学
公开(公告)号：WO2007120241A3
公开(公告)日：2008-08-28
申请号：PCT/US2006047486
申请日：2006-12-11
申请人： ADVANCED LIQUID LOGIC INC , UNIV DUKE , POLLACK MICHAEL G , PAMULA VAMSEE K , SRINIVASAN VIJAY , PAIK PHILIP Y , ECKHARDT ALLEN E , FAIR RICHARD B
发明人： POLLACK MICHAEL G , PAMULA VAMSEE K , SRINIVASAN VIJAY , PAIK PHILIP Y , ECKHARDT ALLEN E , FAIR RICHARD B
IPC分类号： C07K1/26 , B41J2/01 , C12M1/34 , C12Q1/68 , G01N27/26
CPC分类号： B01L3/502792 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , C12Q1/6869 , G01N33/49 , C12Q2565/629 , C12Q2565/301
摘要： The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using discrete droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting biochemical reactions, such as the reagents described for use in nucleic acid amplification protocols, affinity-based assay protocols, sequencing protocols, and protocols for analyses of biological fluids.
摘要翻译：液滴微致动器技术领域本发明涉及液滴微致动器以及采用液滴微致动器来使用离散液滴执行各种协议的系统，装置和方法。本发明包括具有负载用于进行生物化学反应的试剂的一个或多个输入储存器的液滴微致动器或液滴微致动器系统，例如用于核酸扩增方案的所述试剂，基于亲和性的测定方案，测序方案和用于分析的方案的生物液体。

2. 发明申请

WO2008051310A2 DROPLET MANIPULATION SYSTEMS 审中-公开
标题翻译： DROPLET操作系统
公开(公告)号：WO2008051310A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/011298
申请日：2007-05-09
申请人： ADVANCED LIQUID LOGIC, INC. , DUKE UNIVERSITY , PAIK, Philip, Y. , BRAFFORD, Keith, R. , STURMER, Ryan, A. , SMITH, Gregory, F. , POLLACK, Michael, G. , PAMULA, Vamsee, K. , WEST, Richard, M. , SRINIVASAN, Vijay
发明人： PAIK, Philip, Y. , BRAFFORD, Keith, R. , STURMER, Ryan, A. , SMITH, Gregory, F. , POLLACK, Michael, G. , PAMULA, Vamsee, K. , WEST, Richard, M. , SRINIVASAN, Vijay
IPC分类号： B01D57/00
CPC分类号： B01F13/0076 , B01F13/0071 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L7/54 , B01L2200/0673 , B01L2200/14 , B01L2200/143 , B01L2200/16 , B01L2300/027 , B01L2300/0819 , B01L2300/089 , B01L2300/1827 , B01L2400/0421 , B01L2400/0427 , B01L2400/0448 , G01N33/49 , G01N2035/1034
摘要： The present invention relates to systems and methods for controlling droplet movements on a droplet microactuator and a droplet microactuator device, system and method for processing and/or analyzing samples. According to one aspect, a system is provided and includes a controller, a droplet microactuator electronically coupled to the controller, and a display device displaying a user interface electronically coupled to the controller, wherein the system is programmed and configured to permit a user to effect a droplet manipulation by interacting with the user interface. According to another aspect, a sample analyzer is provided and includes an analyzer unit comprising electronic or optical receiving means, a cartridge comprising self-contained droplet handling capabilities, and a means for coupling the cartridge to the analyzer unit which aligns electronic and/or optical outputs from the cartridge with electronic or optical receiving means on the analyzer unit.
摘要翻译：本发明涉及用于控制液滴微致动器上的液滴运动的系统和方法以及液滴微致动器装置，用于处理和/或分析样品的系统和方法。根据一个方面，提供了一种系统，其包括控制器，电子耦合到控制器的液滴微致动器以及显示电子耦合到控制器的用户界面的显示设备，其中系统被编程和配置为允许用户实现通过与用户界面交互来进行液滴操作。根据另一方面，提供一种样品分析器，其包括分析器单元，其包括电子或光学接收装置，包括独立液滴处理能力的盒，以及用于将盒耦合到分析器单元的装置，其将电子和/或光学对准在分析器单元上从带有电子或光学接收装置的墨盒输出。

3. 发明申请

WO2007120240A2 DROPLET-BASED PYROSEQUENCING 审中-公开
标题翻译：基于DROPLET的PYROSEQUENCING
公开(公告)号：WO2007120240A2
公开(公告)日：2007-10-25
申请号：PCT/US2006/047481
申请日：2006-12-11
申请人： ADVANCED LIQUID LOGIC, INC. , DUKE UNIVERSITY , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , POLLACK, Michael, G. , PAMULA, Vamsee, K. , ALLEN, Dwayne, J. , FAIR, Richard, B. , GRIFFIN, Peter
发明人： POLLACK, Michael, G. , PAMULA, Vamsee, K. , ALLEN, Dwayne, J. , FAIR, Richard, B. , GRIFFIN, Peter
IPC分类号： B01D57/00
CPC分类号： B01L3/502792 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , C12Q1/6869 , G01N33/49 , C12Q2565/629 , C12Q2565/301
摘要： The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting sequencing protocols, such as the reagents for conducting a pyrosequencing protocol. The invention also includes a droplet microactuator or droplet microactuator system, having one or more input reservoirs loaded with a sample for conducting a pyrosequencing protocol.
摘要翻译：液滴微致动器技术领域本发明涉及液滴微致动器以及采用液滴微致动器来使用液滴执行各种协议的系统，装置和方法。本发明包括液滴微致动器或液滴微致动器系统，其具有一个或多个输入储存器，其中装载有用于进行测序方案的试剂，例如用于进行焦磷酸测序方案的试剂。本发明还包括液滴微致动器或液滴微致动器系统，其具有装载有用于进行焦磷酸测序方案的样品的一个或多个输入储存器。

4. 发明申请

WO2004029585A1 METHODS AND APPARATUS FOR MANIPULATING DROPLETS BY ELECTROWETTING-BASED TECHNIQUES 审中-公开
标题翻译：通过电镀技术控制滴定液的方法和装置
公开(公告)号：WO2004029585A1
公开(公告)日：2004-04-08
申请号：PCT/US2003/012753
申请日：2003-04-24
申请人： DUKE UNIVERSITY , PAMULA, Vamsee, K. , POLLACK, Michael, G. , PAIK, Philip, Y. , REN, Hong , FAIR, Richard, B.
发明人： PAMULA, Vamsee, K. , POLLACK, Michael, G. , PAIK, Philip, Y. , REN, Hong , FAIR, Richard, B.
IPC分类号： G01N1/00
CPC分类号： B01F13/0071 , B01F13/0076 , B01F13/0084 , B01J2219/00479 , B01J2219/00653 , B01L3/502792 , B01L2300/089 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , C40B60/14 , G01N15/14 , G01N2035/1046 , G02B26/005 , Y10T436/11 , Y10T436/113332 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： In a method for sampling a continuous liquid flow, the liquid flow is supplied to a surface along an input flow path. The liquid flow is sampled by forming a sample droplet from a portion of the liquid flow. The sample droplet is moved along an analysis flow path to a processing area of the surface, where the sample droplet is processed. Discrete sample droplets are formed and moved using an electrowetting technique. A binary mixing apparatus and method are also provided. The apparatus comprises an array of electrodes, an electronic controller communicating with the electrodes, a sample droplet supply area communicating with the array, and an additive droplet supply area communicating with the array. The electronic controller alternately energizes and de-energizes selected electrodes to carry out droplet-to-droplet binary mixing operations to obtain one or more droplets having a target mixing ratio.
摘要翻译：在对连续液体流进行取样的方法中，液体流被输送到沿输入流路的表面。通过从液体流的一部分形成样品液滴来取样液体流。样品液滴沿着分析流动路径移动到表面的处理区域，在该处理区域处理样品液滴。使用电润湿技术形成和移动离散样品液滴。还提供了二元混合装置和方法。该装置包括电极阵列，与电极连通的电子控制器，与该阵列连通的样品液滴供应区域以及与该阵列连通的附加液滴供应区域。电子控制器交替地激励和去激活所选择的电极以进行液滴到液滴的二进制混合操作以获得具有目标混合比的一个或多个液滴。

5. 发明申请

WO2011002957A2 DROPLET ACTUATOR DEVICES AND METHODS 审中-公开
标题翻译： DROPLET执行器装置和方法
公开(公告)号：WO2011002957A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040705
申请日：2010-07-01
申请人： ADVANCED LIQUID LOGIC, INC. , POLLACK, Michael G. , SRINIVASAN, Vijay , PAMULA, Vamsee K. , BRACKETT, George , BRAFFORD, Keith R. , CLARK, Darius , HUA, Zhishan , NORTON, Scott , SISTA, Ramakrishna , SMITH, Gregory F. , STURMER, Ryan A. , SUDARSAN, Arjun , THWAR, Prasanna , WANG, Tih-Hong , WINGER, Theodore
发明人： POLLACK, Michael G. , SRINIVASAN, Vijay , PAMULA, Vamsee K. , BRACKETT, George , BRAFFORD, Keith R. , CLARK, Darius , HUA, Zhishan , NORTON, Scott , SISTA, Ramakrishna , SMITH, Gregory F. , STURMER, Ryan A. , SUDARSAN, Arjun , THWAR, Prasanna , WANG, Tih-Hong , WINGER, Theodore
IPC分类号： B41J2/06 , B41J2/175 , B41J29/38
CPC分类号： B01L3/502707 , B01F13/0071 , B01F13/0076 , B01L3/0241 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L3/502792 , B01L2200/0673 , B01L2200/0689 , B01L2300/0819 , B01L2300/0861 , B01L2300/087 , B01L2300/0874 , B01L2300/088 , B01L2300/0883 , B01L2400/0415 , B01L2400/0427 , B01L2400/0442 , B01L2400/0457 , B01L2400/0469 , B01L2400/0622 , B01L2400/0688 , B01L2400/088
摘要： The invention provides droplet actuator devices for facilitating certain droplet actuated molecular techniques. In one embodiment, the invention provides droplet actuators that facilitate droplet operations in three dimensions. In another embodiment, the invention provides for cost-effective production of droplet actuators. In another embodiment, the invention provides for replacing one or more components of a droplet actuator. In another embodiment, the invention provides droplet actuators using printed conductive inks to form electrodes and/or ground planes. In another embodiment, the invention provides a magnetic clamping fixture for assembling droplet actuators. In another embodiment, the invention provides simple, low cost power sources for use in combination with microfluidic systems. In another embodiment, the invention provides an immunoassay multiplexing platform that uses digital microfluidics and real-time imaging of flash-based chemiluminescent signals. In still another embodiment, the invention provides droplet actuator devices that are fabricated using a plasma treatment process to raise substrate surface energy.
摘要翻译：本发明提供了用于促进某些液滴致动分子技术的液滴致动器装置。在一个实施例中，本发明提供了有助于三维液滴操作的液滴致动器。在另一个实施例中，本发明提供了液滴致动器的成本有效的生产。在另一个实施例中，本发明提供了替换液滴致动器的一个或多个部件。在另一个实施例中，本发明提供使用印刷导电油墨形成电极和/或接地平面的液滴致动器。在另一个实施例中，本发明提供一种用于组装液滴致动器的磁性夹紧夹具。在另一个实施例中，本发明提供了用于与微流体系统组合使用的简单的低成本电源。在另一个实施方案中，本发明提供了使用数字微流体和基于闪光的化学发光信号的实时成像的免疫测定多路复用平台。在另一个实施例中，本发明提供使用等离子体处理工艺制造以提高衬底表面能的液滴致动器装置。

6. 发明申请

WO2008091848A3 SURFACE ASSISTED FLUID LOADING AND DROPLET DISPENSING 审中-公开
标题翻译：表面辅助流体加载和液滴分配
公开(公告)号：WO2008091848A3
公开(公告)日：2008-09-12
申请号：PCT/US2008051627
申请日：2008-01-22
申请人： ADVANCED LIQUID LOGIC INC , SUDARSAN ARJUN , POLLACK MICHAEL G , PAMULA VAMSEE K , SRINIVASAN VIJAY
发明人： SUDARSAN ARJUN , POLLACK MICHAEL G , PAMULA VAMSEE K , SRINIVASAN VIJAY
IPC分类号： B05B5/00
CPC分类号： B01L3/0241 , B01F13/0071 , B01F13/0076 , B01L3/502792 , B01L2300/0819 , B01L2300/089 , B01L2300/165 , B01L2400/0415 , B01L2400/0427
摘要： The present invention relates to surface assisted fluid loading and droplet dispensing on a droplet micro actuator. A droplet actuator is provided and includes one or more electrodes configured for conducting one or more droplet operations on a droplet operations surface of the substrate. The droplet actuator further includes a wettable surface defining a path from a fluid reservoir into a locus which is sufficiently near to one or more of the electrodes that activation of the one or more electrodes results in a droplet operation. Methods and systems are also provided.
摘要翻译：本发明涉及表面辅助流体加载和液滴微致动器上的液滴分配。提供液滴致动器并且包括一个或多个电极，该一个或多个电极被配置用于在衬底的液滴操作表面上进行一个或多个液滴操作。液滴致动器还包括可润湿表面，该可润湿表面限定从流体储存器到轨迹的路径，该轨迹与一个或多个电极充分接近，以致一个或多个电极的激活导致液滴操作。还提供了方法和系统。

7. 发明申请

WO2011084703A3 ENZYME ASSAYS ON A DROPLET ACTUATOR 审中-公开
标题翻译：在液滴驱动器上的酶分析
公开(公告)号：WO2011084703A3
公开(公告)日：2011-12-08
申请号：PCT/US2010061118
申请日：2010-12-17
申请人： ADVANCED LIQUID LOGIC INC , ECKHARDT ALLEN E , GRAHAM CARRIE , SISTA RAMAKRISHNA , PAMULA VAMSEE K , WINGER THEODORE , WANG TONG , XIONG YALIN , WU NING , SAHA SANJAY , RAOLJI GAJENDRASINH BALVANTSINH , DAYAM RAVEENDRA
发明人： ECKHARDT ALLEN E , GRAHAM CARRIE , SISTA RAMAKRISHNA , PAMULA VAMSEE K , WINGER THEODORE , WANG TONG , XIONG YALIN , WU NING , SAHA SANJAY , RAOLJI GAJENDRASINH BALVANTSINH , DAYAM RAVEENDRA
IPC分类号： C12Q1/34 , C07D311/06 , C07D311/18 , C12M1/34 , C12Q1/25 , G01N33/52
CPC分类号： C12Q1/40 , B01L3/502784 , B01L2300/0654 , B01L2300/0816 , B01L2300/18 , B01L2400/0427 , B01L2400/043 , C07D311/16 , C07D311/18 , C07D311/20 , C07D405/12 , C07D413/12 , C07H15/203 , C07H17/075 , C12Q1/25 , C12Q1/34 , C12Q1/44 , C12Q1/54 , C12Y302/01023 , G01N21/6452 , G01N33/5438 , G01N2333/916 , G01N2333/926 , G01N2333/938 , G01N2800/04
摘要： The invention is directed to droplet actuator devices and assay methods for multiplexed newborn testing for metabolic disorders. The methods include, among other things, droplet-based enzymatic assays and immunoassays for testing for metabolic disorders. The invention includes methods and devices for conducting multiple assays for different metabolic disorders on a single droplet actuator, as well as multiple assays for the same metabolic disorder using samples from different subjects and/or multiple samples from the same subject on a single droplet actuator. In various embodiments, the invention includes methods for conducting enzymatic activity assays and/or immunoassays in a single fresh blood and/or plasma samples and dried blood and/or plasma samples.
摘要翻译：本发明涉及用于代谢紊乱的多路复用新生儿测试的液滴致动器装置和测定方法。除其他之外，所述方法包括基于液滴的酶测定和用于测试代谢紊乱的免疫测定。本发明包括用于在单一液滴致动器上针对不同代谢病症进行多种测定的方法和装置，以及使用来自不同受试者的样品和/或来自单个液滴致动器上的来自相同受试者的多个样品的相同代谢病症的多种测定。在各种实施方式中，本发明包括用于在单个新鲜血液和/或血浆样品以及干燥的血液和/或血浆样品中进行酶活性测定和/或免疫测定的方法。

8. 发明申请

WO2009135205A3 DROPLET ACTUATOR TECHNIQUES USING COAGULATABLE SAMPLES 审中-公开
公开(公告)号：WO2009135205A3
公开(公告)日：2009-11-05
申请号：PCT/US2009/042699
申请日：2009-05-04
申请人： ADVANCED LIQUID LOGIC, INC. , CHILDREN'S MEDICAL CENTER CORPORATION , PAMULA, Vamsee, K. , EMANI, Sitaram , ECKHARDT, Allen
发明人： PAMULA, Vamsee, K. , EMANI, Sitaram , ECKHARDT, Allen
IPC分类号： G01N33/48 , G01N33/49 , G01N33/53 , G01N27/26
摘要： The invention provides techniques for coagulating blood on a droplet actuator. The invention also provides methods of manipulating the coagulated blood including a variety of droplet operations that may be conducted using the coagulated blood. Further, the invention provides a variety of assays that make use of the coagulated blood or various blood samples as input.

9. 发明申请

WO2008051310A3 DROPLET MANIPULATION SYSTEMS 审中-公开
标题翻译： DROPLET操作系统
公开(公告)号：WO2008051310A3
公开(公告)日：2009-04-16
申请号：PCT/US2007011298
申请日：2007-05-09
申请人： ADVANCED LIQUID LOGIC INC , UNIV DUKE , PAIK PHILIP Y , BRAFFORD KEITH R , STURMER RYAN A , SMITH GREGORY F , POLLACK MICHAEL G , PAMULA VAMSEE K , WEST RICHARD M , SRINIVASAN VIJAY
发明人： PAIK PHILIP Y , BRAFFORD KEITH R , STURMER RYAN A , SMITH GREGORY F , POLLACK MICHAEL G , PAMULA VAMSEE K , WEST RICHARD M , SRINIVASAN VIJAY
IPC分类号： B01D57/00
CPC分类号： B01F13/0076 , B01F13/0071 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L7/54 , B01L2200/0673 , B01L2200/14 , B01L2200/143 , B01L2200/16 , B01L2300/027 , B01L2300/0819 , B01L2300/089 , B01L2300/1827 , B01L2400/0421 , B01L2400/0427 , B01L2400/0448 , G01N33/49 , G01N2035/1034
摘要： The present invention relates to systems and methods for controlling droplet movements on a droplet microactuator and a droplet microactuator device, system and method for processing and/or analyzing samples. According to one aspect, a system is provided and includes a controller, a droplet microactuator electronically coupled to the controller, and a display device displaying a user interface electronically coupled to the controller, wherein the system is programmed and configured to permit a user to effect a droplet manipulation by interacting with the user interface. According to another aspect, a sample analyzer is provided and includes an analyzer unit comprising electronic or optical receiving means, a cartridge comprising self-contained droplet handling capabilities, and a means for coupling the cartridge to the analyzer unit which aligns electronic and/or optical outputs from the cartridge with electronic or optical receiving means on the analyzer unit.
摘要翻译：本发明涉及用于控制液滴微致动器上的液滴运动的系统和方法以及液滴微致动器装置，用于处理和/或分析样品的系统和方法。根据一个方面，提供了一种系统，其包括控制器，电子耦合到控制器的液滴微致动器以及显示电子耦合到控制器的用户界面的显示设备，其中系统被编程和配置为允许用户实现通过与用户界面交互来进行液滴操作。根据另一方面，提供一种样品分析器，其包括分析器单元，其包括电子或光学接收装置，包括独立液滴处理能力的盒，以及用于将盒耦合到分析器单元的装置，其将电子和/或光学对准在分析器单元上从带有电子或光学接收装置的墨盒输出。

10. 发明申请

WO2008106678A1 DROPLET ACTUATOR STRUCTURES 审中-公开
标题翻译： DROPLET执行机构结构
公开(公告)号：WO2008106678A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/055648
申请日：2008-03-03
申请人： ADVANCED LIQUID LOGIC, INC. , PAMULA, Vamsee, K. , POLLACK, Michael, G. , SRINIVASAN, Vijay , PAIK, Phil
发明人： PAMULA, Vamsee, K. , POLLACK, Michael, G. , SRINIVASAN, Vijay , PAIK, Phil
IPC分类号： B41J2/045
CPC分类号： B01L3/502792 , B01L3/0241 , B01L3/50273 , B01L2200/06 , B01L2300/06 , B01L2400/0427 , B41J2/14
摘要： Approaches to configuring and wiring electrodes in a droplet actuator are provided. Droplet actuators employing the designs of the invention are useful for conducting a variety of droplet operations. In one set of embodiments, the droplet actuator of the invention includes various single-layer wiring configurations for mitigating the constraints and drawbacks that are associated with single-layer designs, such as wireability constraints, limited mechanisms for performing droplet operations, electrostatic interference from wires, and any combinations thereof. In another set of embodiments, the droplet actuator of the invention includes a reference electrode that is situated on one substrate that is separated by a gap from a second substrate and one or more control electrodes that are situated on the second substrate. The control electrodes may be placed such that the second substrate is interposed between the control electrodes and the first substrate.
摘要翻译：提供了在液滴致动器中配置和布线电极的方法。采用本发明设计的液滴致动器可用于进行各种液滴操作。在一组实施例中，本发明的液滴致动器包括用于减轻与单层设计相关联的约束和缺点的各种单层布线配置，例如线性约束，用于执行液滴操作的有限机构，来自线的静电干扰，及其任何组合。在另一组实施例中，本发明的液滴致动器包括参考电极，该参考电极位于一个衬底上，其间隔开第二衬底的间隙和位于第二衬底上的一个或多个控制电极。控制电极可以被放置成使得第二衬底插入在控制电极和第一衬底之间。

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