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1. 发明申请

WO2010051429A1 SYSTEM AND METHOD FOR DELIVERY OF BIOLOGIC AGENTS 审中-公开
标题翻译：用于递送生物代理的系统和方法
公开(公告)号：WO2010051429A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/062725
申请日：2009-10-30
申请人： MEDTRONIC, INC. , HINIDUMA-LOKUGE, Prasanga, D. , SIGG, Daniel, C.
发明人： HINIDUMA-LOKUGE, Prasanga, D. , SIGG, Daniel, C.
IPC分类号： A61M5/28 , A61M25/00 , A61M5/00
CPC分类号： A61M5/286 , A61M5/282 , A61M5/284 , A61M25/0068 , A61M25/0082
摘要： A container (200) for housing a therapeutic agent includes a body member (210), a sealing (220) element, and a rupturable membrane (250). The body member has a proximal end and a distal end and a lumen that extends from the proximal end to the distal end. The sealing element is slidably disposable in the lumen. The sealing element is configured to sealingly engage the body member as the element is slid within the lumen. The rupturable membrane is disposed across the lumen in proximity to the distal end of the body member.
摘要翻译：用于容纳治疗剂的容器（200）包括主体部件（210），密封件（220）和可破裂膜（250）。主体构件具有近端和远端以及从近端延伸到远端的内腔。密封元件在内腔中可滑动地一次性使用。密封元件构造成当元件在管腔内滑动时密封地接合主体构件。可破裂膜跨过内腔设置在主体构件的远端附近。

2. 发明申请

WO2010051369A1 SYSTEM AND METHOD FOR DELIVERY OF BIOLOGIC AGENTS 审中-公开
标题翻译：用于递送生物代理的系统和方法
公开(公告)号：WO2010051369A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/062552
申请日：2009-10-29
申请人： MEDTRONIC, INC. , HINIDUMA-LOKUGE, Prasanga D. , SIGG, Daniel C. , QIU, Xiachong
发明人： HINIDUMA-LOKUGE, Prasanga D. , SIGG, Daniel C. , QIU, Xiachong
IPC分类号： A61M25/00 , A61M5/145
CPC分类号： A61M5/1408 , A61M5/1413 , A61M5/1452 , A61M5/14566 , A61M5/165 , A61M5/2425 , A61M5/2466 , A61M37/0069
摘要： A delivery system for delivering a therapeutic agent to a patient includes a catheter, a stop feature, a container and a bar. The catheter has a proximal end and a distal end and includes a body defining a lumen that extends to the distal end of the catheter. The stop feature is in proximity to the distal end of the catheter. The container is configured to house the therapeutic agent and is insertable and slidably disposable in the lumen of the catheter. The container is also configured to engage the stop feature of the catheter. The bar is slidably disposable in the lumen of the catheter. Sliding of the bar distally in the lumen forces the therapeutic agent out of the container and out of the lumen when the container is engaged with the stop feature. The stop feature is configured to inhibit the container from exiting the lumen.
摘要翻译：用于将治疗剂递送到患者的递送系统包括导管，停止特征，容器和棒。导管具有近端和远端，并且包括限定延伸到导管的远端的腔的主体。停止特征靠近导管的远端。容器构造成容纳治疗剂并且可插入并可滑动地一次性地置于导管的内腔中。容器还构造成接合导管的停止特征。该杆在导管的内腔中可滑动地一次性使用。当容器与停止部件接合时，将管子向远侧方向滑动，迫使治疗剂离开容器并离开管腔。停止特征被配置成禁止容器离开管腔。

3. 发明申请

WO2008067279A2 BIOLOGICAL PACEMAKERS INCLUDING MUTATED HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) CHANNELS 审中-公开
标题翻译：生物制剂包括突变的高效催化循环核糖核酸（HCN）通道
公开(公告)号：WO2008067279A2
公开(公告)日：2008-06-05
申请号：PCT/US2007085576
申请日：2007-11-27
申请人： MEDTRONIC INC , SIGG DANIEL C , SHARMA VINOD , XIAO YONG-FU
发明人： SIGG DANIEL C , SHARMA VINOD , XIAO YONG-FU
CPC分类号： A61K48/005 , A61K38/00 , C07K14/705
摘要： A composition for implantation into cardiac tissue includes a biological pacemaker that, when implanted, expresses an effective amount of a mutated hyperpolarization-activated and cyclic nucleotide-gated (HCN) isoform to modify I h when compared with wild-type HCN. Methods for implementing each of the biological pacemakers include implanting each of biological pacemakers into cardiac tissue.
摘要翻译：用于植入心脏组织的组合物包括生物起搏器，当植入时，与野生型相比，表达有效量的突变的超极化激活和环状核苷酸门控（HCN）同种型以修饰I H 型HCN。实施每个生物起搏器的方法包括将每个生物起搏器植入心脏组织。

4. 发明申请

WO2006060514A9 METHODS AND SYSTEMS FOR PROVIDING THERAPIES INTO THE PERICARDIAL SPACE 审中-公开
标题翻译：将治疗提供给心脏空间的方法和系统
公开(公告)号：WO2006060514A9
公开(公告)日：2006-07-20
申请号：PCT/US2005043374
申请日：2005-11-30
申请人： MEDTRONIC INC , SIGG DANIEL C , UJHELYI MICHAEL R , MORRIS MARY M
发明人： SIGG DANIEL C , UJHELYI MICHAEL R , MORRIS MARY M
IPC分类号： A61B5/02 , A61B5/00 , A61B17/00 , A61B17/22 , A61B17/34 , A61B18/14 , A61M5/142 , A61M5/172
CPC分类号： A61M5/14276 , A61B17/00234 , A61B17/3417 , A61B17/3478 , A61B18/1492 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/3484 , A61B2017/3488 , A61B2017/349 , A61B2018/00291 , A61B2018/00357 , A61B2018/00392 , A61M5/1723 , A61M2005/1405 , A61M2205/3523
摘要： Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.
摘要翻译：公开了通过血管系统和心房壁，特别是通过上腔静脉和右心房壁经心脏进入心包空间的方法和系统，以向心脏递送药理学特别是NO供体药物。输注导管的近端连接器联接到输注泵，并且具有远端输注导管腔端部开口的远侧导管段设置在心包空间中。可植入输注泵可与可植入缺血监测器结合操作以监测缺血状态并触发递送或调节药理学剂的周期性递送以最佳地治疗缺血。患者可以操作患者活化剂，当感觉到缺血症状时患者传递由可植入输液泵接收的信号并触发推注和/或连续输注的传递。

5. 发明申请

WO2006044890A2 SELF-FIXATING SCAFFOLDS 审中-公开
标题翻译：自我修复
公开(公告)号：WO2006044890A2
公开(公告)日：2006-04-27
申请号：PCT/US2005/037430
申请日：2005-10-13
申请人： MEDTRONIC, INC. , SIGG, Daniel, C. , HINIDUMA-LOKUGE, Prasanga , D. , SHARMA, Vinrod , SOMMER, John, L.
发明人： SIGG, Daniel, C. , HINIDUMA-LOKUGE, Prasanga , D. , SHARMA, Vinrod , SOMMER, John, L.
IPC分类号： A61N1/05 , A61N1/30
CPC分类号： A61L27/50 , A61F2/2493 , A61F2/848 , A61L27/54 , A61L2300/252 , A61L2300/604 , A61M37/0069
摘要： A self-fixating scaffold delivers therapeutic material to tissue for treating various diseases/conditions. A scaffold holds the therapeutic material and is implanted into the tissue. A fixation element anchors the scaffold in the tissue making the scaffold less likely to become dislodged.
摘要翻译：自固定支架将治疗材料递送至组织以治疗各种疾病/病症。支架固定治疗材料并植入组织。固定元件将支架锚定在组织中，使得支架不太可能脱落。

6. 发明申请

WO2010105081A1 METHOD OF TREATING HEART FAILURE 审中-公开
标题翻译：治疗心力衰竭的方法
公开(公告)号：WO2010105081A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/027020
申请日：2010-03-11
申请人： MEDTRONIC, INC. , SIGG, Daniel, C. , SCHWARTZMAN, David , WARMAN, Eduardo, N. , KATRA, Rodolphe, Pierre
发明人： SIGG, Daniel, C. , SCHWARTZMAN, David , WARMAN, Eduardo, N. , KATRA, Rodolphe, Pierre
IPC分类号： A61K38/22 , A61P9/10
CPC分类号： A61K38/2221
摘要： The present invention includes methods, systems, uses, and means for the delivery of one or more anti-fibrotic agents into the pericardial space for the treatment and prevention of heart failure (HF).
摘要翻译：本发明包括用于将一种或多种抗纤维化剂递送到心包空间中用于治疗和预防心力衰竭（HF）的方法，系统，用途和方法。

7. 发明申请

WO2008043099A3 HYBRID PACING SYSTEM 审中-公开
公开(公告)号：WO2008043099A3
公开(公告)日：2008-04-10
申请号：PCT/US2007/080718
申请日：2007-10-08
申请人： MEDTRONIC, INC. , SOYKAN, Orhan , SIGG, Daniel, C. , LASKE, Timothy, G.
发明人： SOYKAN, Orhan , SIGG, Daniel, C. , LASKE, Timothy, G.
IPC分类号： A61N1/362 , A61K48/00 , C12N5/06 , A61N1/368
摘要： A hybrid pacing system includes an implanted biological pacemaker and an implantable medical device providing pacing stimuli to one or more chambers of the heart. The IMD senses activity produced by the biological pacemaker, and coordinates the pacing stimuli provided by the IMD with the pacing delivered by the biological pacemaker.

8. 发明申请

WO2006060760A3 HIGH IMPEDANCE ACTIVE FIXATION ELECTRODE OF AN ELECTRICAL MEDICAL LEAD 审中-公开
标题翻译：医用电极的高阻抗主动固定电极
公开(公告)号：WO2006060760A3
公开(公告)日：2006-08-17
申请号：PCT/US2005043887
申请日：2005-12-05
申请人： MEDTRONIC INC , COLES JAMES A JR , SOMMER JOHN L , SIGG DANIEL C
发明人： COLES JAMES A JR , SOMMER JOHN L , SIGG DANIEL C
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： Electrical medical leads having active fixation electrodes, particularly helix electrodes intended to be screwed into body tissue, e.g., the heart, are disclosed having selectively applied insulation to optimize exposed electrode surface area and dispose the exposed electrode surface area toward tissue that is less traumatized by injury caused by screwing in the fixation helix. In a preferred fabrication method, an outer helical surface is masked by contact with a masking tube while a dielectric coating is applied to the inner helical surface of the coil turns of the helix, and the masking tube is removed when the dielectric coating has set. In one variation, at least one aperture is formed through the masking tube sidewall exposing an area of the outer helical surface thereby interrupting the uninsulated outer helical electrode.
摘要翻译：公开了具有主动固定电极的电医疗引线，特别是旨在拧入人体组织（例如心脏）中的螺旋电极，其具有选择性施加的绝缘以优化暴露的电极表面区域并且将暴露的电极表面区域朝向组织拧入固定螺旋引起的损伤。在优选的制造方法中，通过与屏蔽管接触而屏蔽外螺旋表面，同时将介电涂层施加到螺旋的线圈匝的内螺旋表面上，并且当介电涂层凝固时去除掩蔽管。在一个变型中，穿过掩蔽管侧壁形成至少一个孔，从而暴露外部螺旋形表面的区域，从而中断未绝缘的外部螺旋形电极。

9. 发明申请

WO2004093969A1 SYSTEM FOR THE DELIVERY OF A BIOLOGIC THERAPY WITH DEVICE MONITORING AND BACK-UP 审中-公开
标题翻译：用于设备监测和备份的生物治疗系统
公开(公告)号：WO2004093969A1
公开(公告)日：2004-11-04
申请号：PCT/US2004/011581
申请日：2004-04-15
申请人： MEDTRONIC, INC. , LASKE, Timothy, G. , SIGG, Daniel, C. , SOYKAN, Orhan
发明人： LASKE, Timothy, G. , SIGG, Daniel, C. , SOYKAN, Orhan
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61B5/042 , A61B5/0452 , A61B5/0464 , A61B5/076 , A61B5/4839 , A61B5/6882 , A61K48/00 , A61M5/1723 , A61M2205/04 , A61M2210/122 , A61M2210/125 , A61M2230/04 , A61N1/0568 , C12N2750/14143
摘要： An implantable medical device (IMD), such as a cardiac monitor and/or pulse generator is implanted during a procedure where a biologic is introduced into a targeted area of the heart. The IMD monitors cardiac performance to determine the efficacy of the biologic. Based on the achieved efficacy, the IMD will either take no action, provide device based therapy, and/or ablate the tissue to destroy the biologic and its effects if the biologic proves unsuccessful.
摘要翻译：在将生物体引入心脏的目标区域的过程中植入诸如心脏监测器和/或脉冲发生器的可植入医疗装置（IMD）。 IMD监测心脏功能以确定生物制剂的功效。基于实现的功效，如果生物学证明不成功，IMD将不采取行动，提供基于设备的治疗和/或消融组织以破坏生物及其影响。

10. 发明申请

WO2008073577A3 ELECTRONIC AND BIOLOGICAL PACEMAKER SYSTEMS 审中-公开
公开(公告)号：WO2008073577A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/082089
申请日：2007-10-22
申请人： MEDTRONIC, INC. , SIGG, Daniel, C. , LASKE, Timothy, G. , SHARMA, Vinrod , SOYKAN, Orhan
发明人： SIGG, Daniel, C. , LASKE, Timothy, G. , SHARMA, Vinrod , SOYKAN, Orhan
IPC分类号： A61N1/362 , A61K48/00 , C12N5/06
摘要： Heart pacing systems include at least one electronic or biological pacemaker as a primary pacemaker, and at least one electronic or biological pacemaker as a backup pacemaker. When implanted, the primary pacemaker(s) produce primary pacing stimuli that modulate cardiac function. The backup pacemaker(s) provide backup pacing stimuli when the electronic pacemaker is unable to modulate cardiac function at the predetermined pacing rate. The heart pacing systems are implemented by implantation in regions where they can provide pacing stimuli to cardiac tissue.

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