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1. 发明申请

WO2006060760A3 HIGH IMPEDANCE ACTIVE FIXATION ELECTRODE OF AN ELECTRICAL MEDICAL LEAD 审中-公开
标题翻译：医用电极的高阻抗主动固定电极
公开(公告)号：WO2006060760A3
公开(公告)日：2006-08-17
申请号：PCT/US2005043887
申请日：2005-12-05
申请人： MEDTRONIC INC , COLES JAMES A JR , SOMMER JOHN L , SIGG DANIEL C
发明人： COLES JAMES A JR , SOMMER JOHN L , SIGG DANIEL C
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： Electrical medical leads having active fixation electrodes, particularly helix electrodes intended to be screwed into body tissue, e.g., the heart, are disclosed having selectively applied insulation to optimize exposed electrode surface area and dispose the exposed electrode surface area toward tissue that is less traumatized by injury caused by screwing in the fixation helix. In a preferred fabrication method, an outer helical surface is masked by contact with a masking tube while a dielectric coating is applied to the inner helical surface of the coil turns of the helix, and the masking tube is removed when the dielectric coating has set. In one variation, at least one aperture is formed through the masking tube sidewall exposing an area of the outer helical surface thereby interrupting the uninsulated outer helical electrode.
摘要翻译：公开了具有主动固定电极的电医疗引线，特别是旨在拧入人体组织（例如心脏）中的螺旋电极，其具有选择性施加的绝缘以优化暴露的电极表面区域并且将暴露的电极表面区域朝向组织拧入固定螺旋引起的损伤。在优选的制造方法中，通过与屏蔽管接触而屏蔽外螺旋表面，同时将介电涂层施加到螺旋的线圈匝的内螺旋表面上，并且当介电涂层凝固时去除掩蔽管。在一个变型中，穿过掩蔽管侧壁形成至少一个孔，从而暴露外部螺旋形表面的区域，从而中断未绝缘的外部螺旋形电极。

2. 发明专利

CA2594480A1 METHOD FOR FABRICATION OF LOW-POLARIZATION IMPLANTABLE STIMULATION ELECTRODE 未知
公开(公告)号：CA2594480A1
公开(公告)日：2006-08-03
申请号：CA2594480
申请日：2006-01-25
申请人： MEDTRONIC INC
发明人： BRABEC SCOTT J , ROSE RANDY G , COLES JAMES A JR , NYGREN LEA A
IPC分类号： A61N1/05

3. 发明专利

CA2589409A1 HIGH IMPEDANCE ACTIVE FIXATION ELECTRODE OF AN ELECTRICAL MEDICAL LEAD 未知
公开(公告)号：CA2589409A1
公开(公告)日：2006-06-08
申请号：CA2589409
申请日：2005-12-05
申请人： MEDTRONIC INC
发明人： SOMMER JOHN L , COLES JAMES A JR , SIGG DANIEL C
IPC分类号： A61N1/05
摘要： Electrical medical leads having active fixation electrodes, particularly helix electrodes intended to be screwed into body tissue, e.g., the heart, are disclosed having selectively applied insulation to optimize exposed electrode surface area and dispose the exposed electrode surface area toward tissue that is less traumatized by injury caused by screwing in the fixation helix. In a preferred fabrication method, an outer helical surface is masked by contact with a masking tube while a dielectric coating is applied to the inner helical surface of the coil turns of the helix, and the masking tube is removed when the dielectric coating has set. In one variation, at least one aperture is formed through the masking tube sidewall exposing an area of the outer helical surface thereby interrupting the uninsulated outer helical electrode.

4. 发明专利

DE602006010664D1 未知
公开(公告)号：DE602006010664D1
公开(公告)日：2010-01-07
申请号：DE602006010664
申请日：2006-01-25
申请人： MEDTRONIC INC
发明人： BRABEC SCOTT J , ROSE RANDY G , NYGREN LEA A , COLES JAMES A JR
IPC分类号： A61N1/05

5. 发明申请

WO2005062890A2 METHODS OF TREATING CARDIAC DISORDERS BY SUPPRESSING THE EXPRESSION OF THE POTASSIUM INWARDLY-RECTIFYING CHANNEL 审中-公开
标题翻译：通过抑制钾稳定通道的表达来治疗心脏病的方法
公开(公告)号：WO2005062890A2
公开(公告)日：2005-07-14
申请号：PCT/US2004043134
申请日：2004-12-23
申请人： MEDTRONIC INC
发明人： SIGG DANIEL , COLES JAMES A JR , UJHELYI MICHAEL , PADUA RUDY , KAEMMERER WILLIAM F
IPC分类号： A61K48/00 , C12N15/113 , C12N15/86
CPC分类号： C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention is directed toward methods for regulating biological pacemaking activity and devices used in such regulation. Such regulation can be accomplished by introducing genetic material to the heart by transfecting heart cells of the atrium or ventricle with an oligonucleotide, small interfering RNA, that silence KCNJ2, and suppress the IK1 current. Suppression (or silencing) of KCNJ2 subsequently induces pacemaker-like activities in previously regular myocytes. This invention provides for methods of targeted delivery using a fluid delivery catheter. Such a catheter allows the targeting of a specific area in the atrium or the ventricle of the heart. Also, combination methods of treating arrhythmia with traditional device-based therapies (e.g., pacemakers and defibrillators) and an oligonucleotide of the subject invention.
摘要翻译：本发明涉及用于调节生物起搏活性的方法和用于这种调节的装置。通过使用寡核苷酸，小干扰RNA，沉默KCNJ2和抑制IK1电流的寡核苷酸转染心房或心室的心脏细胞，将遗传物质引入心脏可以实现这种调节。 KCNJ2的抑制（或沉默）随后在以前的正常心肌细胞中诱导起搏器样活性。本发明提供了使用流体输送导管进行靶向递送的方法。这样的导管允许靶向心房的心房或心室的特定区域。此外，用传统的基于装置的疗法（例如起搏器和除颤器）治疗心律失常的组合方法和本发明的寡核苷酸。

6. 发明申请

WO2005062958A3 METH0DS OF USING HCN GENES TO TREAT CARDIAC ARRHYTHMIAS 审中-公开
标题翻译：使用HCN基因治疗心脑血管病的药物
公开(公告)号：WO2005062958A3
公开(公告)日：2007-05-18
申请号：PCT/US2004043457
申请日：2004-12-23
申请人： MEDTRONIC INC
发明人： SIGG DANIEL , COLES JAMES A JR , TENBROEK ERICA
IPC分类号： A61K48/00 , A01N63/00
CPC分类号： C07K14/705 , A61K35/34 , A61K38/177 , A61K48/00 , A61K48/005 , C12N2750/14143 , C12N2840/203
摘要： The subject invention is directed to methods of treating cardiac pacing dysfunction by administering HCN genes, alone or in combination with other genes.
摘要翻译：本发明涉及通过单独或与其它基因组合施用HCN基因来治疗心脏起搏功能障碍的方法。

7. 发明申请

WO2005062942A3 NOVEL OLIGONUCLEOTIDES AND TREATING CARDIAC DISORDERS BY USING THE SAME 审中-公开
标题翻译：新的寡核苷酸和治疗心脏病患者使用它
公开(公告)号：WO2005062942A3
公开(公告)日：2006-10-05
申请号：PCT/US2004043379
申请日：2004-12-22
申请人： MEDTRONIC INC
发明人： SIGG DANIEL , UJHELYI MICHAEL , COLES JAMES A JR , PADUA RUDY
IPC分类号： C12Q1/68 , A01N43/04 , A61K31/04 , A61K48/00 , C07H21/04 , C07K14/705 , C12N15/113
CPC分类号： C07K14/705 , A61K48/00 , C12N15/1138 , C12N2830/006 , C12N2830/008 , C12N2840/203
摘要： Novel oligonucleotides and methods of treating a cardiac disease or disorder using the same are provided. The oligonucleotides are useful in modulating the expression of the connexin 43 protein and may be combined with other biologically active agents and compositions to treat cardiac disease. Methods of modulating connexin expression include the suppression of the expression of connexin 43 and the inducement of expression of connexin 45.
摘要翻译：提供了新的寡核苷酸和使用其治疗心脏病或病症的方法。寡核苷酸可用于调节连接蛋白43蛋白的表达，并且可以与其它生物活性剂和组合物组合以治疗心脏病。调节连接蛋白表达的方法包括抑制连接蛋白43的表达和诱导连接蛋白45的表达。

8. 发明公开

EP1697536A4 NOVEL OLIGONUCLEOTIDES AND TREATING CARDIAC DISORDERS BY USING THE SAME 审中-公开
标题翻译：新寡核苷酸和治疗心脏病使用THEREOF
公开(公告)号：EP1697536A4
公开(公告)日：2009-08-12
申请号：EP04815454
申请日：2004-12-22
申请人： MEDTRONIC INC
发明人： SIGG DANIEL , UJHELYI MICHAEL , COLES JAMES A JR , PADUA RUDY
IPC分类号： A61K31/713 , A01N43/04 , A61K31/04 , A61K48/00 , A61P9/06 , C07H21/04 , C07K14/705 , C12N15/113 , C12Q1/68
CPC分类号： C07K14/705 , A61K48/00 , C12N15/1138 , C12N2830/006 , C12N2830/008 , C12N2840/203

9. 发明公开

EP1697499A4 METHODS OF TREATING CARDIAC DISORDERS BY SUPPRESSING THE EXPRESSION OF THE POTASSIUM INWARDLY-RECTIFYING CHANNEL 审中-公开
标题翻译： METHOD FOR心脏疾病的治疗通过抑制内向整流钾离子通道的表达
公开(公告)号：EP1697499A4
公开(公告)日：2009-05-27
申请号：EP04815242
申请日：2004-12-23
申请人： MEDTRONIC INC
发明人： SIGG DANIEL , COLES JAMES A JR , UJHELYI MICHAEL , PADUA RUDY , KAEMMERER WILLIAM F
IPC分类号： A01N43/04 , A61K31/07 , A61K48/00 , C07H21/04 , C12N15/113 , C12N15/86 , C12Q1/68
CPC分类号： C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53

10. 发明公开

EP1696995A4 METH0DS OF USING HCN GENES TO TREAT CARDIAC ARRHYTHMIAS 审中-公开
标题翻译：使用HCN基因的，用于治疗心律失常的方法
公开(公告)号：EP1696995A4
公开(公告)日：2009-03-04
申请号：EP04815522
申请日：2004-12-23
申请人： MEDTRONIC INC
发明人： SIGG DANIEL , COLES JAMES A JR , TENBROEK ERICA
IPC分类号： A61K48/00 , A01N63/00
CPC分类号： C07K14/705 , A61K35/34 , A61K38/177 , A61K48/00 , A61K48/005 , C12N2750/14143 , C12N2840/203

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