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1. 发明申请

WO2008112787A3 METHOD AND APPARATUS OF LOW STRENGTH ELECTRIC FIELD NETWORK-MEDIATED DELIVERY OF THERAPEUTICS IN SOLID ORGANS 审中-公开
标题翻译：低强度电场网络介导的固体治疗药物传递方法与装置
公开(公告)号：WO2008112787A3
公开(公告)日：2008-11-06
申请号：PCT/US2008056693
申请日：2008-03-12
申请人： UNIV CALIFORNIA , SEN LUYI
发明人： SEN LUYI
IPC分类号： C12N15/01 , A61K48/00 , C12M1/42 , C12Q1/02 , C12Q1/68
CPC分类号： C12N15/87
摘要： A methodology and apparatus for drug, gene, siRNA, shRNA shRNA peptide, protein, antibody or any other biomedical therapeutic reagents targeting in various of solid organs of large animals and humans ex vivo and in vivo is described. The delivery is assisted with the application of a low strength electric field network (LSEN). A low strength electric field network (LSEN) system is used for ex vivo or in vivo delivery of any therapeutic gene, siRNA, shRNA shRNA protein or drugs into a lung, pleura, breast, liver, spleen, pancreas, kidney, adrenal, prostate, testicle, ovary and tumors in chest, abdominal and pelvic cavity.
摘要翻译：描述了在体内和体内靶向大动物和人的各种固体器官中的药物，基因，siRNA，shRNA shRNA肽，蛋白质，抗体或任何其它生物医学治疗试剂的方法和装置。通过应用低强度电场网络（LSEN）协助交货。使用低强度电场网络（LSEN）系统将任何治疗基因，siRNA，shRNA shRNA蛋白或药物离体或体内递送至肺，胸膜，乳腺，肝脏，脾脏，胰腺，肾脏，肾上腺，前列腺，睾丸，卵巢和肿瘤在胸部，腹部和盆腔。

2. 发明申请

WO2007109335A3 A METHOD FOR NONINVASIVELY AND QUANTITATIVELY MONITORING THERAPEUTIC AND DIAGNOSTIC TRANSGENE EXPRESSION INDUCED BY EX VIVO AND IN VIVO GENE TARGETING IN ORGANS, TISSUES AND CELLS 审中-公开
标题翻译：一种无创和定量监测EXVIVO和VIVO基因指导在器官，组织和细胞中诱导的诊断和诊断转移表达的方法
公开(公告)号：WO2007109335A3
公开(公告)日：2008-10-09
申请号：PCT/US2007007048
申请日：2007-03-20
申请人： UNIV CALIFORNIA , SEN LUYI , GAMBHIR SANJIV S
发明人： SEN LUYI , GAMBHIR SANJIV S
IPC分类号： C12Q1/68 , A61K49/00 , G21H5/02
CPC分类号： C12Q1/6897
摘要： An composition in a method for noninvasively monitoring the expression of therapeutic transgene delivered ex vivo and in vivo for the treatment of diseases includes the step of quantitatively imaging a reporter gene expression which is coupled to a therapeutic gene on a plasmid vector to infer levels, location, or duration of the therapeutic gene expression in the targeted tissues or organs. The reporter gene is imaged using a radiopharmaceutical for scintigraphic imaging of the gene expression interactions with the reporter gene, namely positron emission tomography, gamma camera or single-photon emission computed tomography. The genes are delivered with a liposome encapsulated reporter-therapeutic linked transgene vector with balanced reporter/therapeutic transgene expression. A transgene composition includes the reporter gene linked to the therapeutic gene or genes incorporated in and delivered by a liposome encapsulated reporter-therapeutic linked transgene vector.
摘要翻译：用于非侵入性监测离体和体内递送的用于治疗疾病的治疗性转基因表达的方法中的组合物包括定量成像与质粒载体上的治疗基因偶联的报告基因表达以推断水平，位置或靶向组织或器官中治疗性基因表达的持续时间。使用放射性药物对报告基因进行成像，用于与报告基因的基因表达相互作用的闪烁照相成像，即正电子发射断层扫描，γ照相机或单光子发射计算机断层摄影。基因与具有平衡的报告基因/治疗性转基因表达的脂质体封装的报告基因治疗连接的转基因载体递送。转基因组合物包括与治疗基因连接的报告基因或掺入脂质体封装的报告基因 - 治疗连锁的转基因载体并递送的基因。

3. 发明申请

WO2006102684A2 ULTRA LOW STRENGTH ELECTRIC FIELD NETWORK-MEDIATED EX VIVO GENE, PROTEIN AND DRUG DELIVERY IN CELLS 审中-公开
标题翻译：超低强度电场网络介导EX体外基因，蛋白质和药物在细胞中的传递
公开(公告)号：WO2006102684A2
公开(公告)日：2006-09-28
申请号：PCT/US2006011355
申请日：2006-03-16
申请人： UNIV CALIFORNIA , SEN LUYI , GUANGGEN CUI
发明人： SEN LUYI , GUANGGEN CUI
IPC分类号： C12N15/09
CPC分类号： C12N15/87 , C12M35/02
摘要： Ex vivo gene, protein or drug delivery to macroscopic quantities of various types of cells, cell clusters, or tissues using ultra low strength LSEFN strategies is disclosed in which the bioengineered cells and tissues are then systemically transfused, delivered or implanted into the various organs or tissue for the treatment of diseases. An LSEFN chamber is used which is shaped and sized to intimately contain the cells, cell clusters, or tissues in a transfusion chamber between opposing membrane encapsulated electrode arrays across which LSEFN pulses are applied.
摘要翻译：公开了使用超低强度LSEFN策略将体外基因，蛋白质或药物递送至宏观量的各种类型的细胞，细胞簇或组织，其中然后将生物工程化的细胞和组织系统地输注，递送或植入各种器官或用于治疗疾病的组织。使用LSEFN腔室，其形状和尺寸被设定为在施加LSEFN脉冲的相对膜封装电极阵列之间的输液室中密切地容纳细胞，细胞簇或组织。

4. 发明申请

WO2008112730A1 A METHOD FOR USING LOWSTRENGTH ELECTRIC FIELD NETWORK (LSEN) AND IMMUNOSUPPRESSIVE STRATEGIES TO MEDIATE IMMUNE RESPONSES 审中-公开
标题翻译：一种使用低电压电场网络（LSEN）和免疫抑制策略来介绍免疫应答的方法
公开(公告)号：WO2008112730A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056603
申请日：2008-03-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SEN, Luyi
发明人： SEN, Luyi
IPC分类号： A61K48/00 , C07H21/04 , A01N1/02
CPC分类号： A61K48/0083 , A61N1/205
摘要： Application to an allograft or xenograft of a low strength electric field network (LSEN) together with an immunosuppressive drug, gene and siRNA or other gene-based therapy is used to mediate the immune responses within an donor organ, tissue or cells, to prevent the acute and chronic rejection and to induce true tolerance, The gene(s) is locally transferred ex vivo in the time interval between harvest and implantation of allografts or xenografts before the implantation to introduce the long- term over expression of immunosuppressive and/or modulative molecules, or for down regulating alloreactive molecules in the donor organ, tissue or cells only and not in the recipient's whole body system.
摘要翻译：使用低强度电场网络（LSEN）的同种异体移植物或异种移植物以及免疫抑制药物，基因和siRNA或其他基于基因的治疗来介导供体器官，组织或细胞内的免疫应答，以防止急性和慢性排斥反应并诱导真正的耐受性。在植入之前，在收获和植入同种异体移植物或异种移植物之间的时间间隔内，将基因局部转移基因以引入免疫抑制和/或调节分子的长期过表达，或仅用于下调供体器官，组织或细胞中的同种异体反应性分子，而不是在接受者的全身系统中。

5. 发明申请

WO2008086064A2 AN APPARATUS AND METHOD FOR IN VIVO INTRACELLULAR TRANSFECTION OF GENE, SIRNA, SHRNA VECTORS, AND OTHER BIOMEDICAL DIAGNOSTIC AND THERAPEUTIC DRUGS AND MOLECULES FOR THE TREATMENT OF ARTHRITIS AND OTHER ORTHOPEDIC DISEASEAS IN LARGE ANIMALS AND HUMAN 审中-公开
标题翻译：用于基因，SIRNA，SHRNA载体和其他生物医学诊断和治疗药物的体内细胞转染的装置和方法以及用于治疗大动物和人类中的ARTHRITIS和其他正常疾病的分子
公开(公告)号：WO2008086064A2
公开(公告)日：2008-07-17
申请号：PCT/US2008050059
申请日：2008-01-02
申请人： UNIV CALIFORNIA , SEN LUYI
发明人： SEN LUYI
IPC分类号： A61N1/30
CPC分类号： A61N1/327 , A61N1/325
摘要： An apparatus for in vivo intracellular transfection of gene, siRNA, shRNA vectors, and other biomedical diagnostic and therapeutic drugs and molecules for the treatment of arthritis and other orthopedic diseases in large animals and humans includes: a source of low voltage, short duration pulses in long duration bursts (LSEN); an electrode mesh system coupled to the source for generating distributed electric field network into a joint, including bones, cartilages, and related tissues; and means for transfecting the gene, siRNA, shRNA vectors, and other biomedical diagnostic and therapeutic drugs and molecules into a joint. The electrode mesh system includes alternatively arranged negative and positive electrodes in a first array which is capable of being inserted into a joint cavity, and either an alternatively arranged negative and positive or an all negative second electrode array which is positioned outside of the joint and in directly contact with overlying skin.
摘要翻译：用于体内细胞内转染基因，siRNA，shRNA载体和其他用于治疗大动物和人类中的关节炎和其他整形外科疾病的生物医学诊断和治疗药物和分子的装置包括：低电压，短持续脉冲源长时间突发（LSEN）; 耦合到所述源的电极网系统，用于将分布式电场网络发生到包括骨骼，软骨和相关组织在内的关节中; 以及将基因，siRNA，shRNA载体和其他生物医学诊断和治疗药物和分子转染到关节中的方法。电极网系统包括可排列的第一阵列中的负电极和正电极，该第一阵列能够插入到接合腔中，以及位于接头外侧的交替布置的负极和正极或全负极第二电极阵列直接接触上皮肤。

6. 发明申请

WO2008024857A2 AN APPARATUS AND METHOD FOR OPTIMIZATION OF CARDIAC RESYNCHRONIZATION THERAPY 审中-公开
标题翻译：用于优化心脏再生治疗的装置和方法
公开(公告)号：WO2008024857A2
公开(公告)日：2008-02-28
申请号：PCT/US2007076543
申请日：2007-08-22
申请人： UNIV CALIFORNIA , CUI GUANGGEN , SEN LUYI
发明人： CUI GUANGGEN , SEN LUYI
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61B5/0422 , A61N1/3627
摘要： An apparatus and method for biventricular pacing comprises means and steps for i) evidence-based, ii) optimized, iii) simultaneously evidence-based and optimized endomyocardium and iv) optimized epimyocardium pacing in cardiac resynchronization. Monophasic action potential is mapped by evidence-based and individualized optimization of cardiac resynchronization, pacing and implantable cardioverter defibrillators in percutaneous procedures, thoracoscopic procedures or open chest surgeries. The optimized electrode sites are identified without MAP mapping without use of an electrophysiologic system for optimized cardiac resynchronization, pacing and an implantable cardioverter defibrillator in percutaneous procedures, thoracoscopic procedures or open chest surgeries. The effectiveness of this therapy is optimized in a majority of patients with heart failure, left ventricular (LV) or right ventricular (RV) dysfunction, cardiomyopathies, arrhythmias, congenital heart diseases, heart transplantations, and/or in patients immediately after open heart surgeries for fast recovery.
摘要翻译：用于双心室起搏的装置和方法包括以下步骤：i）基于证据，ii）优化，iii）同时基于证据和优化的心内膜，以及iv）心脏再同步中优化的心外膜起搏。通过基于证据和个体化优化的心脏再同步，起搏和植入式心律转复除颤器在经皮手术，胸腔镜手术或胸部手术中的单相动作电位。在经皮程序，胸腔镜手术或开放性胸部手术中，不使用电生理系统来优化电极位点，无需使用电生理系统优化心脏再同步，起搏和植入式心律转复除颤器。在大多数心力衰竭，左心室（LV）或右心室（RV）功能障碍，心肌病，心律失常，先天性心脏病，心脏移植和/或在开心手术后立即进行的患者中，该疗法的有效性被优化为快速恢复。

7. 发明申请

WO2003082007A3 METHOD AND APPARATUS FOR USING AN ELECTROMAGNETIC FIELD IN CELLULAR TRANSPLANTATION 审中-公开
公开(公告)号：WO2003082007A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/009057
申请日：2003-03-24
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA , SEN, Luyi , CUI, Guanggen , LAKS, Hillel
发明人： SEN, Luyi , CUI, Guanggen , LAKS, Hillel
IPC分类号： A61K48/00
摘要： An electromagnetic field is applied to transplanted cells during their transplantation culturing to achieve confluence and alignment of transplanted cells into damaged tissue and organs, therefore improving the synchronization of electrical and mechanical tissue or organ functions. The electromagnetic field may be applied by catheter based to a selected portion of tissue or to the entire surface of a hollow body cavity or organ, such as heart chamber. The electromagnetic field is provided by an expansible net or array from a catheter or on an inflatable balloon or stent. The electromagnetic field is also provided by an implantable net or array of electrodes which may either be hardwired to a pulse generator or coupled by means of wireless or inductive transmission.

8. 发明申请

WO2008112787A2 METHOD AND APPARATUS OF LOW STRENGTH ELECTRIC FIELD NETWORK-MEDIATED DELIVERY OF DRUG, GENE, SI-RNA, SH-RNA PROTEIN, PEPTIDE, ANTIBODY OR OTHER BIOMEDICAL AND THERAPEUTIC MOLECULES AND REAGENTS IN SOLID ORGANS 审中-公开
标题翻译：低强度电场网络介导传递药物，基因，SI-RNA，SH-RNA蛋白，肽，抗体或其他生物医学和治疗性分子和固体器官试剂的方法和装置
公开(公告)号：WO2008112787A2
公开(公告)日：2008-09-18
申请号：PCT/US2008/056693
申请日：2008-03-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SEN, Luyi
发明人： SEN, Luyi
IPC分类号： A61K48/00
CPC分类号： C12N15/87
摘要： A methodology and apparatus for drug, gene, siRNA, shRNA shRNA peptide, protein, antibody or any other biomedical therapeutic reagents targeting in various of solid organs of large animals and humans ex vivo and in vivo is described. The delivery is assisted with the application of a low strength electric field network (LSEN). A low strength electric field network (LSEN) system is used for ex vivo or in vivo delivery of any therapeutic gene, siRNA, shRNA shRNA protein or drugs into a lung, pleura, breast, liver, spleen, pancreas, kidney, adrenal, prostate, testicle, ovary and tumors in chest, abdominal and pelvic cavity.
摘要翻译：描述了药物，基因，siRNA，shRNA shRNA肽，蛋白质，抗体或靶向大型动物和人类的各种固体器官的任何其他生物医学治疗试剂的方法和装置。通过应用低强度电场网络（LSEN）协助交货。使用低强度电场网络（LSEN）系统将任何治疗基因，siRNA，shRNA shRNA蛋白或药物离体或体内递送至肺，胸膜，乳腺，肝脏，脾脏，胰腺，肾脏，肾上腺，前列腺，睾丸，卵巢和肿瘤在胸部，腹部和盆腔。

9. 发明申请

WO2007120557A2 METHOD AND APPARATUS OF LOW STRENGH ELECTRIC FIELD NETWORK-MEDIATED DELIVERY OF DRUG, GENE, SIRNA, SHRN, PROTEIN, PEPTIDE, ANTIBODY OR OTHER BIOMEDICAL AND THERAPEUTIC MOLECULES AND REAGENTS IN SKIN, SOFT TISSUE, JOINTS AND BONE 审中-公开
标题翻译：低强度电场网络介导的药物，基因，SIRNA，SHRN，蛋白质，肽，抗体或其他生物医学和治疗分子和皮肤，软组织，接头和骨骼中的试剂的方法和装置
公开(公告)号：WO2007120557A2
公开(公告)日：2007-10-25
申请号：PCT/US2007008445
申请日：2007-04-02
申请人： UNIV CALIFORNIA , SEN LUYI
发明人： SEN LUYI
IPC分类号： A61K48/00 , A61N1/44
CPC分类号： A61N1/0424 , A61K48/0075 , A61N1/0476 , A61N1/327 , C12M35/02
摘要： The illustrated embodiments of the invention include four preferred embodiments: 1) a method and apparatus for the joint and its related soft tissue for bone gene, protein and drug delivery; 2) a method and apparatus for gene, protein and drug delivery to an extremity; 3) a method and apparatus for delivery of gene, protein and drug delivery to skin and soft tissue; and/or 4) a method and apparatus for delivery of a gene, protein and drug to soft tissue tumor.
摘要翻译：本发明的所示实施例包括四个优选实施例：1）用于骨基因，蛋白质和药物递送的关节及其相关软组织的方法和装置; 2）将基因，蛋白质和药物递送至肢体的方法和装置; 3）用于将基因，蛋白质和药物递送递送至皮肤和软组织的方法和装置; 和/或4）用于将基因，蛋白质和药物递送到软组织肿瘤的方法和装置。

10. 发明申请

WO2003082007A2 METHOD AND APPARATUS FOR USING AN ELECTROMAGNETIC FIELD IN CELLULAR TRANSPLANTATION 审中-公开
标题翻译：在细胞移植中使用电磁场的方法和装置
公开(公告)号：WO2003082007A2
公开(公告)日：2003-10-09
申请号：PCT/US2003/009057
申请日：2003-03-24
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA , SEN, Luyi , CUI, Guanggen , LAKS, Hillel
发明人： SEN, Luyi , CUI, Guanggen , LAKS, Hillel
IPC分类号： A01N
CPC分类号： A61N2/02 , A61N1/325 , A61N1/326 , A61N1/327 , A61N1/40
摘要： An electromagnetic field is applied to transplanted cells during their transplantation culturing to achieve confluence and alignment of transplanted cells into damaged tissue and organs, therefore improving the synchronization of electrical and mechanical tissue or organ functions. The electromagnetic field may be applied by catheter based to a selected portion of tissue or to the entire surface of a hollow body cavity or organ, such as heart chamber. The electromagnetic field is provided by an expansible net or array from a catheter or on an inflatable balloon or stent. The electromagnetic field is also provided by an implantable net or array of electrodes which may either be hardwired to a pulse generator or coupled by means of wireless or inductive transmission.
摘要翻译：在移植培养期间将电磁场施加到移植细胞上，以将移植细胞汇合并排列到损伤的组织和器官中，从而改善电和机械组织或器官功能的同步。电磁场可以通过导管基于组织的选定部分或中空体腔或器官（例如心室）的整个表面施加。电磁场由可膨胀的网或阵列从导管或可膨胀气球或支架提供。电磁场还由可植入网或电极阵列提供，其可以硬连线到脉冲发生器或通过无线或电感传输耦合。

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