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1. 发明申请

US20150335258A1 SILICON MICROSYSTEMS FOR HIGH-THROUGHPUT ANALYSIS OF NEURAL CIRCUIT ACTIVITY, METHOD AND PROCESS FOR MAKING THE SAME 审中-公开
标题翻译：用于神经电路活动的高通量分析的硅微结构，其制造方法和方法
公开(公告)号：US20150335258A1
公开(公告)日：2015-11-26
申请号：US14648244
申请日：2013-11-30
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA
发明人： Sotiris MASMANIDIS
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61B5/04001 , A61B5/4064 , A61B5/6868 , A61B2562/125 , Y10T29/49119
摘要： Provided herein are multi-electrode probe/microsystem designs that readily allow recording with multiple electrodes simultaneously, and of two spatially distinct brain regions at the same time. Also provide are methods and processes for manufacturing the probes.
摘要翻译：本文提供了容易允许同时记录多个电极的多电极探针/微系统设计，以及同时存在两个空间不同的脑区域的多电极探针/微系统设计。还提供用于制造探针的方法和方法。

2. 发明授权

US11124830B2 Single cell genomic sequencing using hydrogel based droplets 有权
公开(公告)号：US11124830B2
公开(公告)日：2021-09-21
申请号：US16849344
申请日：2020-04-15
申请人： The Regent of the University of California
发明人： Freeman Lan , Benjamin Demaree , Iain Clark , Adam R. Abate
IPC分类号： C12Q1/6869 , C12Q1/6806
摘要： The present disclosure provides ultrahigh-throughput single cell genomic sequencing methods, referred to herein as “SiC-seq”, which methods include encapsulating single cells in molten gel droplets to facilitate bulk cell lysis and purification of genomic DNA in microgels. Systems and devices for practicing the subject methods are also provided.

3. 发明申请

US20160285090A1 SILICON OXIDE NANOTUBE ELECTRODE AND METHOD 审中-公开
标题翻译：氧化硅纳米管电极和方法
公开(公告)号：US20160285090A1
公开(公告)日：2016-09-29
申请号：US15034052
申请日：2014-11-14
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA
发明人： Cengiz S Ozkan , Mihrimah Ozkan , Zachary Favors , Wei Wang
IPC分类号： H01M4/48 , H01M4/139 , H01M4/13 , H01M10/0525
CPC分类号： H01M4/483 , H01M4/02 , H01M4/13 , H01M4/139 , H01M4/366 , H01M10/0525 , H01M2004/027
摘要： A silicon oxide nanotube electrode and methods are shown, that are fabricated via single step hard-template growth method and evaluated as an anode for Li-ion batteries. SiOx nanotubes exhibit a highly stable reversible capacity with no capacity fading. Devices such as lithium ion batteries are shown incorporating silicon oxide nanotube electrodes.
摘要翻译：示出了通过单步硬模板生长方法制造的氧化硅纳米管电极和方法，并且将其评价为用于锂离子电池的阳极。 SiOx纳米管表现出高度稳定的可逆容量，没有容量衰减。显示了诸如锂离子电池的装置，其中并入有氧化硅纳米管电极。

4. 发明申请

US20140205009A1 METHOD AND APPARATUS FOR SPATIALLY SCALABLE VIDEO COMPRESSION AND TRANSMISSION 有权
标题翻译：用于空间可缩放视频压缩和传输的方法和装置
公开(公告)号：US20140205009A1
公开(公告)日：2014-07-24
申请号：US14160405
申请日：2014-01-21
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA
发明人： Kenneth Rose , Jingning Han , Vinay Melkote
IPC分类号： H04N19/61 , H04N19/593
CPC分类号： H04N19/33 , H04N19/124 , H04N19/13 , H04N19/187 , H04N19/196 , H04N19/48 , H04N19/503 , H04N19/547 , H04N19/59 , H04N19/61
摘要： A method and apparatus provide the ability to resample video frame into various resolutions, and to predict, quantize, and entropy code the video signal for spatially scalable compression and networking applications. The solution involves a unified re-sampling and estimation-theoretic prediction, quantization, and entropy coding framework, which by design is tailored to allow base layer coding information to be fully accessible and usable by enhancement layers; and for the enhancement layer to account for all available information from both layers for superior compression performance. Specialization may include specific techniques for coding and networking scenarios, where the potential of the unified resampling and estimation-theoretic framework is realized to considerably improve the overall system performance over existing schemes.
摘要翻译：一种方法和装置提供将视频帧重新取样成各种分辨率的能力，并且可以对视频信号进行预测，量化和熵编码以用于空间可缩放的压缩和联网应用。该解决方案涉及统一的重采样和估计理论预测，量化和熵编码框架，其设计被定制为允许基层编码信息被增强层完全可访问和可用; 并且增强层可以考虑来自两个层的所有可用信息以获得出色的压缩性能。专业化可能包括编码和联网方案的具体技术，其中实现了统一的重采样和估计理论框架的潜力，以显着提高现有方案的整体系统性能。

5. 发明申请

US20200277672A1 Single Cell Genomic Sequencing Using Hydrogel Based Droplets 审中-公开
公开(公告)号：US20200277672A1
公开(公告)日：2020-09-03
申请号：US16849344
申请日：2020-04-15
申请人： The Regent of the University of California
发明人： Freeman Lan , Benjamin Demaree , Iain Clark , Adam R. Abate
IPC分类号： C12Q1/6869 , C12Q1/6806
摘要： The present disclosure provides ultrahigh-throughput single cell genomic sequencing methods, referred to herein as “SiC-seq”, which methods include encapsulating single cells in molten gel droplets to facilitate bulk cell lysis and purification of genomic DNA in microgels. Systems and devices for practicing the subject methods are also provided.

6. 发明申请

US20160083698A1 LONE STAR VIRUS 审中-公开
标题翻译：孤星星病毒
公开(公告)号：US20160083698A1
公开(公告)日：2016-03-24
申请号：US14785268
申请日：2014-04-18
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN . . .
发明人： Charles Chiu , Andrea Swei , Barbara J.B. Johnson
IPC分类号： C12N7/00 , A61K39/12 , C07K14/005 , C07K16/10 , G01N33/569 , C12Q1/70
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C07K14/005 , C07K16/10 , C07K2317/24 , C12N2760/12221 , C12N2760/12234 , C12N2760/12251 , C12Q1/701 , G01N33/56983 , G01N2333/175 , G01N2469/10
摘要： This disclosure concerns the isolation, identification and sequencing of a unique Phlebovirus, the Lone Star Virus. Lone Star Virus nucleic acid molecules, proteins and antibodies are disclosed. Methods are also disclosed for the detection, diagnostic and treatment of the Lone Star Virus.
摘要翻译：本公开涉及独特的疫苗病毒，孤星病毒的分离，鉴定和测序。公开了孤星病毒核酸分子，蛋白质和抗体。还公开了用于孤星病毒的检测，诊断和治疗的方法。

7. 发明申请

WO2010033196A2 SIMPLIFIED ONE-POT SYNTHESIS OF [18F]SFB FOR RADIOLABELING 审中-公开
标题翻译： [18F] SFB用于放射性标签的简化单点合成
公开(公告)号：WO2010033196A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/005176
申请日：2009-09-16
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA , OLMA, Sebastian , SHEN, Clifton, Kwang-Fu
发明人： OLMA, Sebastian , SHEN, Clifton, Kwang-Fu
IPC分类号： C07D207/444 , C07D207/26 , A61K31/4166 , A61P35/00
CPC分类号： C07K1/13 , C07D207/26 , C07D207/444 , C07D207/46
摘要： A non-aqueous single pot synthesis of [18F]SFB is set forth. The [18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.
摘要翻译：阐述了[18F] SFB的非水单锅合成。然后使用以该方法制备的[18F] SFB，例如以标记化合物作为可注射组合物的代表性实例来标记靶向人表皮生长因子受体2（HER2）的肽或工程改造的抗体片段（双抗体）使用PET扫描来定位异常组织，特别是动物或人体内的肿瘤。

8. 发明申请

WO2003072093A1 METHOD OF TREATMENT OF HYPERTENSION USING SELECTIVE SEROTONIN RE-UPTAKE INHIBITORS (SSRIs) 审中-公开
标题翻译：使用选择性丝氨酸重新吸收抑制剂（SSRI）治疗高血压的方法
公开(公告)号：WO2003072093A1
公开(公告)日：2003-09-04
申请号：PCT/US2003/005393
申请日：2003-02-21
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA , MONTEJO-PERNAS, Maria, Julia , BALLESTEROS, Juan
发明人： MONTEJO-PERNAS, Maria, Julia , BALLESTEROS, Juan
IPC分类号： A61K31/135
CPC分类号： A61K31/343 , A61K31/136 , A61K31/15 , A61K31/443
摘要： The present application provides a method for treating and/or preventing hypertension in an individual comprising the administration of hypotensive amounts of at least one SSRI, alone or in combination with at least one anti-hypertensive drug. The present invention also relates to the use of at least one SSRI, alone or in combination with at least one anti-hypertensive drug, for the preparation of medicaments for the prevention and/or treatment of hyertension. In both cases, the SSRI is selected from the group consisting of citalopram, fluvoxamine, paroxetine and sertraline. The present invention also relates to methods for preventing and/or treating conditions in which hypertension is a risk factor or a complication. There is a need for new anti-hypertensive therapies, specially if they treat the neurobiological substrate of hypertension such as the present invention. The present invention also relates to methods for preventing and/or of treating hypertension when the subject has also one or more psychiatric condition(s), or non-psychiatric conditions, susceptible to be treated by an SSRI.
摘要翻译：本申请提供了治疗和/或预防个体的高血压的方法，包括施用低血压量的至少一种SSRI，单独或与至少一种抗高血压药物组合。本发明还涉及至少一种SSRI，单独或与至少一种抗高血压药组合用于制备用于预防和/或治疗感染的药物的用途。在这两种情况下，SSRI选自西酞普兰，氟伏沙明，帕罗西汀和舍曲林。本发明还涉及预防和/或治疗高血压是危险因素或并发症的病症的方法。需要新的抗高血压疗法，特别是如果它们治疗高血压的神经生物底物如本发明。本发明还涉及当受试者还具有易受SSRI治疗的一种或多种精神病症状或非精神病症状时，用于预防和/或治疗高血压的方法。

9. 发明申请

WO2002100244A3 MICROFABRICATED SURGICAL DEVICE 审中-公开
公开(公告)号：WO2002100244A3
公开(公告)日：2002-12-19
申请号：PCT/US2002/018203
申请日：2002-06-05
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA , SEWARD, Kirk, Patrick , PISANO, Albert, P. , STUPAR, Philip, Anthony
发明人： SEWARD, Kirk, Patrick , PISANO, Albert, P. , STUPAR, Philip, Anthony
IPC分类号： A61M5/32
摘要： This invention relates to microfabricated surgical devices (10, 50, 52, 54, 60, 70, 80) made of conformally coated polymer (28).

10. 发明申请

WO2002077179A2 LEINAMYCIN BIOSYNTHESIS GENE CLUSTER AND ITS COMPONENTS AND THEIR USES 审中-公开
标题翻译： LEINAMYCIN BIOSYNTHESIS基因组及其组分及其用途
公开(公告)号：WO2002077179A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/008937
申请日：2002-03-22
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA , KYOWA HAKKO KOGYO CO, LTD. , SHEN, Ben , CHENG, Yi-qiang , TANG, Gong-li
发明人： SHEN, Ben , CHENG, Yi-qiang , TANG, Gong-li
IPC分类号： C12N
CPC分类号： C12N15/52 , C12P17/185
摘要： This invention provides detailed sequence analysis and characterization of the gene cluster responsible for the synthesis of leinamycin in Streptomyces atroolivaceus . The leinamycin gene cluster provides a hybrid polyketide synthase/nonribosomal peptide synthetase pathway. Elucidation of the various modules and enzymatic domains characterizing the pathway provides convenient synthetic routes for leinamycins, leinamycin analogs, and various other polyketides, peptides, and hybrid peptide-polyketide natural products.
摘要翻译：本发明提供了负责合成链霉菌（Streptomyces atroolivaceus）中的莱茵霉素的基因簇的详细序列分析和表征。 leinamycin基因簇提供了一种杂合聚酮化合物合酶/非核糖体肽合成酶途径。阐明该途径表征的各种模块和酶结构域为莱米霉素，莱茵霉素类似物和各种其他聚酮化合物，肽和杂合肽 - 聚酮化合物天然产物提供了方便的合成途径。

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