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1. 发明申请

WO2003082007A2 METHOD AND APPARATUS FOR USING AN ELECTROMAGNETIC FIELD IN CELLULAR TRANSPLANTATION 审中-公开
标题翻译：在细胞移植中使用电磁场的方法和装置
公开(公告)号：WO2003082007A2
公开(公告)日：2003-10-09
申请号：PCT/US2003/009057
申请日：2003-03-24
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA , SEN, Luyi , CUI, Guanggen , LAKS, Hillel
发明人： SEN, Luyi , CUI, Guanggen , LAKS, Hillel
IPC分类号： A01N
CPC分类号： A61N2/02 , A61N1/325 , A61N1/326 , A61N1/327 , A61N1/40
摘要： An electromagnetic field is applied to transplanted cells during their transplantation culturing to achieve confluence and alignment of transplanted cells into damaged tissue and organs, therefore improving the synchronization of electrical and mechanical tissue or organ functions. The electromagnetic field may be applied by catheter based to a selected portion of tissue or to the entire surface of a hollow body cavity or organ, such as heart chamber. The electromagnetic field is provided by an expansible net or array from a catheter or on an inflatable balloon or stent. The electromagnetic field is also provided by an implantable net or array of electrodes which may either be hardwired to a pulse generator or coupled by means of wireless or inductive transmission.
摘要翻译：在移植培养期间将电磁场施加到移植细胞上，以将移植细胞汇合并排列到损伤的组织和器官中，从而改善电和机械组织或器官功能的同步。电磁场可以通过导管基于组织的选定部分或中空体腔或器官（例如心室）的整个表面施加。电磁场由可膨胀的网或阵列从导管或可膨胀气球或支架提供。电磁场还由可植入网或电极阵列提供，其可以硬连线到脉冲发生器或通过无线或电感传输耦合。

2. 发明申请

WO2008024857A3 AN APPARATUS AND METHOD FOR OPTIMIZATION OF CARDIAC RESYNCHRONIZATION THERAPY 审中-公开
公开(公告)号：WO2008024857A3
公开(公告)日：2008-02-28
申请号：PCT/US2007/076543
申请日：2007-08-22
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CUI, Guanggen , SEN, Luyi
发明人： CUI, Guanggen , SEN, Luyi
IPC分类号： A61N1/368
摘要： An apparatus ( 10) and method for biventricular pacing comprises means and steps for i) evidence-based, 11) optimized, in) simultaneously evidence-based and optimized endomyocardium and ιv) optimized epimyocardium pacing in cardiac resynchronization Monophasic action potential is mapped by evidence-based and individualized optimization of cardiac resynchronization, pacing and implantable cardioverter defibrillators in percutaneous procedures, thoracoscopic procedures or open chest surgeries The optimized electrode sites are identified without MAP mapping without use of an electrophysiologic system for optimι/ed cardiac resynchronization, pacing and an implantable cardioverter defibrillator in percutaneous procedures, thoracoscopic procedures or open chest surgeries The effectiveness of this therapy is optimized in a majority of patients with heart failure, IeIt ventricular (LV) or right ventricular (RV) dysfunction, cardiomyopathies, arrhythmias, congenital heart diseases, heart transplantations, and/or in patients immediately after open heart surgeries for fast recovery.

3. 发明申请

WO2008024857A2 AN APPARATUS AND METHOD FOR OPTIMIZATION OF CARDIAC RESYNCHRONIZATION THERAPY 审中-公开
标题翻译：用于优化心脏再生治疗的装置和方法
公开(公告)号：WO2008024857A2
公开(公告)日：2008-02-28
申请号：PCT/US2007076543
申请日：2007-08-22
申请人： UNIV CALIFORNIA , CUI GUANGGEN , SEN LUYI
发明人： CUI GUANGGEN , SEN LUYI
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61B5/0422 , A61N1/3627
摘要： An apparatus and method for biventricular pacing comprises means and steps for i) evidence-based, ii) optimized, iii) simultaneously evidence-based and optimized endomyocardium and iv) optimized epimyocardium pacing in cardiac resynchronization. Monophasic action potential is mapped by evidence-based and individualized optimization of cardiac resynchronization, pacing and implantable cardioverter defibrillators in percutaneous procedures, thoracoscopic procedures or open chest surgeries. The optimized electrode sites are identified without MAP mapping without use of an electrophysiologic system for optimized cardiac resynchronization, pacing and an implantable cardioverter defibrillator in percutaneous procedures, thoracoscopic procedures or open chest surgeries. The effectiveness of this therapy is optimized in a majority of patients with heart failure, left ventricular (LV) or right ventricular (RV) dysfunction, cardiomyopathies, arrhythmias, congenital heart diseases, heart transplantations, and/or in patients immediately after open heart surgeries for fast recovery.
摘要翻译：用于双心室起搏的装置和方法包括以下步骤：i）基于证据，ii）优化，iii）同时基于证据和优化的心内膜，以及iv）心脏再同步中优化的心外膜起搏。通过基于证据和个体化优化的心脏再同步，起搏和植入式心律转复除颤器在经皮手术，胸腔镜手术或胸部手术中的单相动作电位。在经皮程序，胸腔镜手术或开放性胸部手术中，不使用电生理系统来优化电极位点，无需使用电生理系统优化心脏再同步，起搏和植入式心律转复除颤器。在大多数心力衰竭，左心室（LV）或右心室（RV）功能障碍，心肌病，心律失常，先天性心脏病，心脏移植和/或在开心手术后立即进行的患者中，该疗法的有效性被优化为快速恢复。

4. 发明申请

WO2003082007A3 METHOD AND APPARATUS FOR USING AN ELECTROMAGNETIC FIELD IN CELLULAR TRANSPLANTATION 审中-公开
公开(公告)号：WO2003082007A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/009057
申请日：2003-03-24
申请人： THE REGENT OF THE UNIVERSITY OF CALIFORNIA , SEN, Luyi , CUI, Guanggen , LAKS, Hillel
发明人： SEN, Luyi , CUI, Guanggen , LAKS, Hillel
IPC分类号： A61K48/00
摘要： An electromagnetic field is applied to transplanted cells during their transplantation culturing to achieve confluence and alignment of transplanted cells into damaged tissue and organs, therefore improving the synchronization of electrical and mechanical tissue or organ functions. The electromagnetic field may be applied by catheter based to a selected portion of tissue or to the entire surface of a hollow body cavity or organ, such as heart chamber. The electromagnetic field is provided by an expansible net or array from a catheter or on an inflatable balloon or stent. The electromagnetic field is also provided by an implantable net or array of electrodes which may either be hardwired to a pulse generator or coupled by means of wireless or inductive transmission.

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