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1. 发明公开

EP1552207A1 AIR CONDITIONER ACCESS AND SERVICE FITTINGS 审中-公开
标题翻译： KLIMAANLAGEZUGANGS-仪器与维护
公开(公告)号：EP1552207A1
公开(公告)日：2005-07-13
申请号：EP03763269.2
申请日：2003-07-07
申请人： Gilbert, Major H. , Schultz, Jeffrey A.
发明人： Gilbert, Major H. , Schultz, Jeffrey A.
IPC分类号： F16L37/44 , F16K31/50
CPC分类号： F16K31/506 , B60H1/00485 , B60H1/00585 , F16K31/50 , F16L37/44 , F25B41/003 , F25B2345/006 , Y10T137/612
摘要： An air conditioner service fitting is provided and includes a valve body (12) comprising a threaded bore (20) and an annular valve seat (22) extending around the bore. The valve body is configured and the valve seat is positioned such that all fluid that passes through the bore crosses the valve seat. A twist-to-open valve (40) is disposed in the bore and threadedly engages with the valve body. The twist-to-open valve includes a valve element (44) configured to form a polymer-to-metal seal with the valve seat. The polymer-to-metal seat stops substantially all fluid flow through the bore and the flow path when the twist-to-open valve is closed. The valve body further includes an external connection feature (110) disposed around the bore. The valve body comprises an external sealing surface.

2. 发明专利

AU2003249732A1 AIR CONDITIONER ACCESS AND SERVICE FITTINGS 未知
公开(公告)号：AU2003249732A1
公开(公告)日：2004-01-23
申请号：AU2003249732
申请日：2003-07-07
申请人： GILBERT MAJOR H , SCHULTZ JEFFREY A
发明人： GILBERT MAJOR H , SCHULTZ JEFFREY A
IPC分类号： B60H1/00 , F16K31/50 , F16L37/44 , F25B41/00
摘要： An air conditioner service fitting is provided and includes a valve body comprising a threaded bore and an annular valve seat extending around the bore. The valve body is configured and the valve seat is positioned such that all fluid that passes through the bore crosses the valve seat. A twist-to-open valve is disposed in the bore and threadedly engages with the valve body. The twist-to-open valve includes a valve element configured to form a polymer-to-metal seal with the valve seat. The polymer-to-metal seal stops substantially all fluid flow through the bore and the flow path when the twist-to-open valve is closed. The valve body further includes an external connection feature disposed around the bore. The valve body comprises an external sealing surface.

3. 发明申请

WO2006065600A2 N-BIARYL AND N-ARYLHETEROARYL PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为治疗与相关疾病有关的5HT2C受体有效的调节剂的N-二异丙基和N-芳基乙酰胆碱衍生物
公开(公告)号：WO2006065600A2
公开(公告)日：2006-06-22
申请号：PCT/US2005/044293
申请日：2005-12-09
申请人： ARENA PHARMACEUTICALS, INC. , SMITH, Brian, M. , SANTORA, Vincent, J. , HAYASHI, Rena , IBARRA, Jason, B. , SCHULTZ, Jeffrey, A. , ESTRADA, Scott, A.
发明人： SMITH, Brian, M. , SANTORA, Vincent, J. , HAYASHI, Rena , IBARRA, Jason, B. , SCHULTZ, Jeffrey, A. , ESTRADA, Scott, A.
IPC分类号： C07D295/06 , C07D295/08 , A61K31/496 , A61P3/00 , C07D213/38 , C07D307/52 , C07D333/20
CPC分类号： C07D295/073 , C07D213/38 , C07D295/096 , C07D307/52 , C07D333/20
摘要： The present invention relates to certain biarylz and arylheteroaryl piperazine derivatives of Formula (Ia) that are modulators of the 5HT 2c receptor. Accordingly, compounds of the present invention are useful for the treatment of 5HT 2c receptor associated diseases or disorders, such as, obesity, Alzheimer Disease, erectile dysfunction and related disorders.
摘要翻译：本发明涉及式（Ia）的某些二芳基和芳基杂芳基哌嗪衍生物，其为5HT 2C受体的调节剂

4. 发明申请

WO2006065600A3 N-BIARYL AND N-ARYLHETEROARYL PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为治疗与相关疾病有关的5HT2C受体有效的调节剂的N-二异丙基和N-芳基乙酰胆碱衍生物
公开(公告)号：WO2006065600A3
公开(公告)日：2006-08-03
申请号：PCT/US2005044293
申请日：2005-12-09
申请人： ARENA PHARM INC , SMITH BRIAN M , SANTORA VINCENT J , HAYASHI RENA , IBARRA JASON B , SCHULTZ JEFFREY A , ESTRADA SCOTT A
发明人： SMITH BRIAN M , SANTORA VINCENT J , HAYASHI RENA , IBARRA JASON B , SCHULTZ JEFFREY A , ESTRADA SCOTT A
IPC分类号： C07D295/06 , A61K31/496 , A61P3/00 , C07D213/38 , C07D295/08 , C07D307/52 , C07D333/20
CPC分类号： C07D295/073 , C07D213/38 , C07D295/096 , C07D307/52 , C07D333/20
摘要： The present invention relates to certain biarylz and arylheteroaryl piperazine derivatives of Formula (Ia) that are modulators of the 5HT 2c
摘要翻译：本发明涉及式（Ia）的某些二芳基和芳基杂芳基哌嗪衍生物，其是5HT 2C的调节剂，

5. 发明申请

WO2006065706A1 N-BIARYL AND N-ARYLHETEROARYL 2-SUBSTITUTED PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗相关疾病的5HT2C受体的调节剂的N-取代二氮杂双环衍生物哌嗪衍生物
公开(公告)号：WO2006065706A1
公开(公告)日：2006-06-22
申请号：PCT/US2005/044815
申请日：2005-12-09
申请人： ARENA PHARMACEUTICALS, INC. , SMITH, Brian M. , SANTORA, Vincent J. , HAYASHI, Rena , IBARRA, Jason B. , SCHULTZ, Jeffrey A. , ESTRADA, Scott A.
发明人： SMITH, Brian M. , SANTORA, Vincent J. , HAYASHI, Rena , IBARRA, Jason B. , SCHULTZ, Jeffrey A. , ESTRADA, Scott A.
IPC分类号： C07D295/06 , C07D213/38 , C07D213/74 , C07D307/52 , C07D333/20 , A61K31/495 , A61K31/501 , A61K31/506 , A61P3/04 , A61P15/10 , A61P25/28 , A61P25/00
CPC分类号： C07D213/38 , C07D213/74 , C07D295/033 , C07D295/073 , C07D307/52 , C07D333/20
摘要： The present invention relates to certain N-biaryl and N-arylheteroaryl 2-substituted piperazine derivatives of Formula (Ia) that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the treatment of 5HT2C receptor associated diseases or disorders, such as, obesity, Alzheimer Disease, erectile dysfunction and related disorders.
摘要翻译：本发明涉及作为5HT 2C受体的调节剂的式（Ia）的某些N-联芳基和N-芳基杂芳基2-取代的哌嗪衍生物。因此，本发明的化合物可用于治疗5HT 2C受体相关疾病或障碍，如肥胖，阿尔茨海默病，勃起功能障碍和相关疾病。

6. 发明申请

WO2004005788A1 AIR CONDITIONER ACCESS AND SERVICE FITTINGS 审中-公开
标题翻译：空调接入和维修配件
公开(公告)号：WO2004005788A1
公开(公告)日：2004-01-15
申请号：PCT/US2003/021162
申请日：2003-07-07
申请人： GILBERT, Major, H. , SCHULTZ, Jeffrey, A.
发明人： GILBERT, Major, H. , SCHULTZ, Jeffrey, A.
IPC分类号： F16L37/44
CPC分类号： F16K31/506 , B60H1/00485 , B60H1/00585 , F16K31/50 , F16L37/44 , F25B41/003 , F25B2345/006 , Y10T137/612
摘要： An air conditioner service fitting is provided and includes a valve body (12) comprising a threaded bore (20) and an annular valve seat (22) extending around the bore. The valve body is configured and the valve seat is positioned such that all fluid that passes through the bore crosses the valve seat. A twist-to-open valve (40) is disposed in the bore and threadedly engages with the valve body. The twist-to-open valve includes a valve element (44) configured to form a polymer-to-metal seal with the valve seat. The polymer-to-metal seat stops substantially all fluid flow through the bore and the flow path when the twist-to-open valve is closed. The valve body further includes an external connection feature (110) disposed around the bore. The valve body comprises an external sealing surface.
摘要翻译：提供了一种空调器维修配件，并且包括阀体（12），阀体（12）包括螺纹孔（20）和围绕孔延伸的环形阀座（22）。阀体被构造并且阀座被定位成使得通过孔的所有流体与阀座交叉。旋转开启阀（40）设置在孔中并与阀体螺纹接合。扭转打开阀包括构造成与阀座形成聚合物与金属密封件的阀元件（44）。当扭转打开的阀关闭时，聚合物 - 金属阀座基本上阻止通过孔和流动路径的所有流体流动。阀体还包括设置在孔周围的外部连接特征（110）。阀体包括外部密封表面。

7. 发明申请

WO2011059893A1 PRESSURE REGULATOR VALVE SEALS, SYSTEMS AND METHODS 审中-公开
标题翻译：压力调节阀密封，系统和方法
公开(公告)号：WO2011059893A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/055633
申请日：2010-11-05
申请人： SCHRADER BRIDGEPORT INTERNATIONAL, INC. , SCHULTZ, Jeffrey, A. , RIELEY, Benjamin, R.
发明人： SCHULTZ, Jeffrey, A. , RIELEY, Benjamin, R.
IPC分类号： F16K15/02
CPC分类号： F16K17/06 , F02M37/0029 , Y10T137/0396
摘要： A pressure regulator valve has a housing (105) that defines a fluid passage and a flat seat (107) disposed around an opening of the fluid passage and exit ports. A pin (110) with a raised conforming elastomeric embossment (101) that contacts the seat (107) when the valve is closed is axially disposed in the housing. The pin (110) is biased to maintain the elastomeric embossment (101) in contact with the seat to maintain the valve closed and control an opening pressure of the valve. Flow of fluid through and out of the pressure regulator valve housing (105) is controlled through adjustment of a level of this biasing. The fluid flows across the flat seat and between the flat seat and the embossment when the valve is open in such a manner that the flow is generally laminar and such that the valve minimizes pressure gain at the onset of flow.
摘要翻译：压力调节阀具有限定流体通道的壳体（105）和围绕流体通道和出口的开口设置的平坦座（107）。具有凸起的符合弹性体压纹（101）的销（110）在阀关闭时与座（107）接触，轴向地设置在壳体中。销（110）被偏置以保持弹性体压花（101）与座接触，以保持阀关闭并控制阀的打开压力。流经压力调节阀壳体（105）的流体的流动通过调整该偏置的水平来控制。当阀门以这样的方式打开时，流体流过平坦座椅并且在平坦座椅和压花部之间流动，使得流体通常是层流的，并且使得阀门在流动开始时使压力增益最小化。

8. 发明申请

WO2011112257A1 APPLICATOR FOR SELF-ADHESIVE PRODUCTS 审中-公开
标题翻译：自粘产品的应用者
公开(公告)号：WO2011112257A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/000448
申请日：2011-03-10
申请人： S. C. JOHNSON & SON, INC. , SCHULTZ, Jeffrey, A. , KLINKHAMMER, Michael, E. , ZACH, Steven, A. , WORTLEY, Russell, B. , RICE, William, J. , JAICHANDRA, Doraiswami , DUENNES, Mark, D. , KRISTIANSEN, Keith, C. , BUTLER, Jeffrey, E., Jr. , VAN DYK, Thomas , DEMAR, David, A. , CHARRIEZ, Roland , KIELY, John , ANASTASIADIS, John
发明人： SCHULTZ, Jeffrey, A. , KLINKHAMMER, Michael, E. , ZACH, Steven, A. , WORTLEY, Russell, B. , RICE, William, J. , JAICHANDRA, Doraiswami , DUENNES, Mark, D. , KRISTIANSEN, Keith, C. , BUTLER, Jeffrey, E., Jr. , VAN DYK, Thomas , DEMAR, David, A. , CHARRIEZ, Roland , KIELY, John , ANASTASIADIS, John
IPC分类号： B65D83/00
CPC分类号： C11D17/0056 , B65D83/0005 , C11D17/003
摘要： A device for application of a self-adhesive product, wherein the device operates with at least a first step and a second step. The first step and second step being temporally separate.
摘要翻译：一种用于施加自粘性产品的装置，其中所述装置至少具有第一步骤和第二步骤。第一步和第二步在时间上是分开的。

9. 发明申请

WO2009058300A1 BIPHENYL DERIVATIVES AS MODULATORS OF THE HISTAMINE-H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：作为用于治疗相关疾病的组胺H3受体的调节剂的联苯衍生物
公开(公告)号：WO2009058300A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/012272
申请日：2008-10-29
申请人： ARENA PHARMACEUTICALS, INC. , SANTORA, Vincent J. , COVEL, Jonathan A. , ESTRADA, Scott A. , IBARRA, Jason B. , REN, Albert S. , SCHULTZ, Jeffrey A. , SEMPLE, Graeme , SMITH, Brian M. , SMITH, Jeffrey , WEINHOUSE, Michael I.
发明人： SANTORA, Vincent J. , COVEL, Jonathan A. , ESTRADA, Scott A. , IBARRA, Jason B. , REN, Albert S. , SCHULTZ, Jeffrey A. , SEMPLE, Graeme , SMITH, Brian M. , SMITH, Jeffrey , WEINHOUSE, Michael I.
IPC分类号： C07D403/10 , C07D405/10 , C07D413/10 , A61K31/422 , A61K31/4025 , A61K31/5355 , A61P37/08
CPC分类号： C07D413/10 , C07D403/10 , C07D405/10
摘要： Biphenyl derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the H3 histamine receptor. (Ia) Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness, such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease, pain and the like.
摘要翻译：式（Ia）的联苯衍生物及其药物组合物，其调节H3组胺受体的活性。（Ia）本发明化合物及其药物组合物涉及可用于治疗组胺H3相关疾病如认知障碍，癫痫，脑外伤，抑郁症，肥胖症，睡眠障碍和觉醒症如发作性睡病的方法注意力缺陷多动障碍（ADHD），偏头痛综合征，转移综合征，嗜睡作为药物的副作用，维持警惕以帮助完成任务等，猝死，睡眠过多，嗜睡症，时差，睡眠呼吸暂停等），精神分裂症，过敏，上呼吸道过敏反应，过敏性鼻炎，鼻塞，痴呆，阿尔茨海默病，疼痛等。

10. 发明申请

WO2008005338A1 MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译：用于治疗相关疾病的组胺H3受体的调节剂
公开(公告)号：WO2008005338A1
公开(公告)日：2008-01-10
申请号：PCT/US2007/015139
申请日：2007-06-28
申请人： ARENA PHARMACEUTICALS, INC. , PARK, Douglas, M. , SANTORA, Vincent, J. , COVEL, Jonathan, A. , IBARRA, Jason, B. , SEMPLE, Graeme , SMITH, Brian , SMITH, Jeffrey , WEINHOUSE, Michael, I. , SCHULTZ, Jeffrey, A.
发明人： SANTORA, Vincent, J. , COVEL, Jonathan, A. , IBARRA, Jason, B. , SEMPLE, Graeme , SMITH, Brian , SMITH, Jeffrey , WEINHOUSE, Michael, I. , SCHULTZ, Jeffrey, A.
IPC分类号： C07D207/06 , C07D207/12 , C07D207/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D419/10 , A61K31/4025 , A61K31/4439 , A61K31/40 , A61K31/541 , A61K31/4409 , A61K31/5377
CPC分类号： C07D405/12 , C07D207/06 , C07D207/12 , C07D207/48 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D419/10
摘要： The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3-receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-receptor associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as narcolepsy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.
摘要翻译：本发明涉及式（Ia）的某些联苯磺酰胺衍生物及其药物组合物，其调节组胺H3受体的活性。化合物及其药物组合物涉及可用于治疗组胺H3-受体相关疾病的方法，例如认知障碍，癫痫症，脑外伤，抑郁症，肥胖症，睡眠障碍和觉醒症，例如发作性睡病，睡眠不足，嗜睡症，射精滞后，睡眠呼吸暂停等，注意缺陷多动障碍（ADHD），精神分裂症，过敏，上呼吸道过敏反应，过敏性鼻炎，鼻塞，痴呆，阿尔茨海默氏病等。

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