发明申请
WO2009058300A1 BIPHENYL DERIVATIVES AS MODULATORS OF THE HISTAMINE-H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
审中-公开
基本信息:
- 专利标题： BIPHENYL DERIVATIVES AS MODULATORS OF THE HISTAMINE-H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
- 专利标题（中）：作为用于治疗相关疾病的组胺H3受体的调节剂的联苯衍生物
- 申请号：PCT/US2008/012272 申请日：2008-10-29
- 公开(公告)号：WO2009058300A1 公开(公告)日：2009-05-07
- 发明人： SANTORA, Vincent J. , COVEL, Jonathan A. , ESTRADA, Scott A. , IBARRA, Jason B. , REN, Albert S. , SCHULTZ, Jeffrey A. , SEMPLE, Graeme , SMITH, Brian M. , SMITH, Jeffrey , WEINHOUSE, Michael I.
- 申请人： ARENA PHARMACEUTICALS, INC. , SANTORA, Vincent J. , COVEL, Jonathan A. , ESTRADA, Scott A. , IBARRA, Jason B. , REN, Albert S. , SCHULTZ, Jeffrey A. , SEMPLE, Graeme , SMITH, Brian M. , SMITH, Jeffrey , WEINHOUSE, Michael I.
- 申请人地址： 6166 Nancy Ridge Drive San Diego, 5 92121-3223 US
- 专利权人： ARENA PHARMACEUTICALS, INC.,SANTORA, Vincent J.,COVEL, Jonathan A.,ESTRADA, Scott A.,IBARRA, Jason B.,REN, Albert S.,SCHULTZ, Jeffrey A.,SEMPLE, Graeme,SMITH, Brian M.,SMITH, Jeffrey,WEINHOUSE, Michael I.
- 当前专利权人： ARENA PHARMACEUTICALS, INC.,SANTORA, Vincent J.,COVEL, Jonathan A.,ESTRADA, Scott A.,IBARRA, Jason B.,REN, Albert S.,SCHULTZ, Jeffrey A.,SEMPLE, Graeme,SMITH, Brian M.,SMITH, Jeffrey,WEINHOUSE, Michael I.
- 当前专利权人地址： 6166 Nancy Ridge Drive San Diego, 5 92121-3223 US
- 代理机构： GODDARD, Christine, A.
- 优先权： US61/001,017 20071030; US61/188,420 20080808
- 主分类号： C07D403/10
- IPC分类号： C07D403/10 ; C07D405/10 ; C07D413/10 ; A61K31/422 ; A61K31/4025 ; A61K31/5355 ; A61P37/08
摘要：
Biphenyl derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the H3 histamine receptor. (Ia) Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness, such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease, pain and the like.
摘要（中）：
式（Ia）的联苯衍生物及其药物组合物，其调节H3组胺受体的活性。 （Ia）本发明化合物及其药物组合物涉及可用于治疗组胺H3相关疾病如认知障碍，癫痫，脑外伤，抑郁症，肥胖症，睡眠障碍和觉醒症如发作性睡病的方法 注意力缺陷多动障碍（ADHD），偏头痛综合征，转移综合征，嗜睡作为药物的副作用，维持警惕以帮助完成任务等，猝死，睡眠过多，嗜睡症，时差，睡眠呼吸暂停等 ），精神分裂症，过敏，上呼吸道过敏反应，过敏性鼻炎，鼻塞，痴呆，阿尔茨海默病，疼痛等。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D403/00 | 杂环化合物，含有两个或更多的杂环，以氮原子作为仅有的杂环原子，C07D401/00组不包含的 |
| --------C07D403/02 | .含两个杂环 |
| ----------C07D403/10 | ..被含芳环的碳链连接的 |