发明申请
WO2008005338A1 MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
审中-公开
基本信息:
- 专利标题： MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
- 专利标题（中）：用于治疗相关疾病的组胺H3受体的调节剂
- 申请号：PCT/US2007/015139 申请日：2007-06-28
- 公开(公告)号：WO2008005338A1 公开(公告)日：2008-01-10
- 发明人： SANTORA, Vincent, J. , COVEL, Jonathan, A. , IBARRA, Jason, B. , SEMPLE, Graeme , SMITH, Brian , SMITH, Jeffrey , WEINHOUSE, Michael, I. , SCHULTZ, Jeffrey, A.
- 申请人： ARENA PHARMACEUTICALS, INC. , PARK, Douglas, M. , SANTORA, Vincent, J. , COVEL, Jonathan, A. , IBARRA, Jason, B. , SEMPLE, Graeme , SMITH, Brian , SMITH, Jeffrey , WEINHOUSE, Michael, I. , SCHULTZ, Jeffrey, A.
- 申请人地址： 6166 Nancy Ridge Drive San Diego, 5 92121-3223 US
- 专利权人： ARENA PHARMACEUTICALS, INC.,PARK, Douglas, M.,SANTORA, Vincent, J.,COVEL, Jonathan, A.,IBARRA, Jason, B.,SEMPLE, Graeme,SMITH, Brian,SMITH, Jeffrey,WEINHOUSE, Michael, I.,SCHULTZ, Jeffrey, A.
- 当前专利权人： ARENA PHARMACEUTICALS, INC.,PARK, Douglas, M.,SANTORA, Vincent, J.,COVEL, Jonathan, A.,IBARRA, Jason, B.,SEMPLE, Graeme,SMITH, Brian,SMITH, Jeffrey,WEINHOUSE, Michael, I.,SCHULTZ, Jeffrey, A.
- 当前专利权人地址： 6166 Nancy Ridge Drive San Diego, 5 92121-3223 US
- 代理机构： DUFFIELD, Jonathan, J. et al.
- 优先权： US60/817,459 20060629
- 主分类号： C07D207/06
- IPC分类号： C07D207/06 ; C07D207/12 ; C07D207/48 ; C07D401/12 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; C07D417/12 ; C07D419/10 ; A61K31/4025 ; A61K31/4439 ; A61K31/40 ; A61K31/541 ; A61K31/4409 ; A61K31/5377
摘要：
The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3-receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-receptor associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as narcolepsy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.
摘要（中）：
本发明涉及式（Ia）的某些联苯磺酰胺衍生物及其药物组合物，其调节组胺H3受体的活性。 化合物及其药物组合物涉及可用于治疗组胺H3-受体相关疾病的方法，例如认知障碍，癫痫症，脑外伤，抑郁症，肥胖症，睡眠障碍和觉醒症，例如发作性睡病，睡眠不足，嗜睡症， 射精滞后，睡眠呼吸暂停等，注意缺陷多动障碍（ADHD），精神分裂症，过敏，上呼吸道过敏反应，过敏性鼻炎，鼻塞，痴呆，阿尔茨海默氏病等。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D207/00 | 杂环化合物，含五元环，不与其他环稠合，带1个氮原子作为惟一的环杂原 |
| --------C07D207/02 | .只有氧或碳原子直接连在环氮原子上 |
| ----------C07D207/04 | ..环原子间或环原子与非环原子间无双键 |
| ------------C07D207/06 | ...带有只含氢和碳原子的基，连在环碳原子上 |