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1. 发明专利

DE29621819U1 未知
公开(公告)号：DE29621819U1
公开(公告)日：1997-02-13
申请号：DE29621819
申请日：1996-12-16
申请人： SCHMITT MARKUS , WERNER KLAUS , WIRTH CHRISTOPH PROF DR
IPC分类号： B62K5/007 , B62K21/00 , B62K5/00

2. 发明申请

WO2011138234A3 DIAGNOSTIC TRANSCRIPT AND SPLICE PATTERNS OF HR-HPV IN DIFFERENT CERVICAL LESIONS 审中-公开
标题翻译：人乳头瘤病毒在不同宫颈癌中的诊断性病例和病理特征
公开(公告)号：WO2011138234A3
公开(公告)日：2013-11-07
申请号：PCT/EP2011056787
申请日：2011-04-28
申请人： DEUTSCHES KREBSFORSCH , SCHMITT MARKUS , GISSMANN LUTZ , PAWLITA MICHAEL , HOEFLER DANIELA
发明人： SCHMITT MARKUS , GISSMANN LUTZ , PAWLITA MICHAEL , HOEFLER DANIELA
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q1/6883
摘要： The present invention relates to a method for differentiating in a subject with HR-HPV between a severe form of HR-HPV infection and a mild form of HR-HPV infection. It further is concerned with a composition comprising a probe oligonucleotide mixture, a device, and a kit for use in conjunction with the method of the invention.
摘要翻译：本发明涉及一种在严重形式的HR-HPV感染与轻度形式的HR-HPV感染之间区分HR-HPV的受试者的方法。它还涉及包含探针寡核苷酸混合物，装置和与本发明的方法结合使用的试剂盒的组合物。

3. 发明申请

WO2010052317A1 DIAGNOSTIC TRANSCRIPT AND SPLICE PATTERNS OF HPV16 IN DIFFERENT CERVICAL LESIONS 审中-公开
标题翻译： HPV16在不同宫颈癌中的诊断和病理特征
公开(公告)号：WO2010052317A1
公开(公告)日：2010-05-14
申请号：PCT/EP2009/064811
申请日：2009-11-09
申请人： DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM, STIFTUNG DES ÖFFENTLICHEN RECHTS , SCHMITT, Markus , GISSMANN, Lutz , PAWLITA, Michael
发明人： SCHMITT, Markus , GISSMANN, Lutz , PAWLITA, Michael
IPC分类号： C12Q1/68
CPC分类号： C12Q1/708 , C12Q2545/113
摘要： The present invention relates to a method for differentiating in a subject with HPV 16 between (i) a severe form of HPV16 infection and (ii) a mild form of HPV16 infection based on determining the amount of a first gene product and a second gene product in a sample of a subject and calculating a ratio of the amount of said first gene product and the amount of said second gene product. Further envisaged by the present invention is a composition comprising an oligonucleotide mixture. Also envisaged by the present invention are a kit and a device adapted to carry out the method of the present invention.
摘要翻译：本发明涉及一种用于在（i）严重形式的HPV16感染和（ii）基于确定第一基因产物和第二基因产物的量的温和形式的HPV16感染之间的HPV16区分受试者的方法并且计算所述第一基因产物的量和所述第二基因产物的量的比例。本发明进一步设想的是包含寡核苷酸混合物的组合物。本发明还设想了适用于实施本发明方法的试剂盒和装置。

4. 发明申请

WO2011073183A1 PROBES FOR GENOTYPING LOW-RISK-HPV 审中-公开
标题翻译：用于基因型低风险HPV的探针
公开(公告)号：WO2011073183A1
公开(公告)日：2011-06-23
申请号：PCT/EP2010/069614
申请日：2010-12-14
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM , SCHMITT, Markus , PAWLITA, Michael
发明人： SCHMITT, Markus , PAWLITA, Michael
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708
摘要： The current invention is concerned with a composition comprising at least one probe oligonucleotide each for the nucleotide sequences of the invention, said probe oligonucleotides specifically hybridizing to the sense strand or the antisense strand of said nucleotide sequences. Moreover, the present invention relates to a method for the identification of low-risk HPV types in a sample comprising the steps of a) contacting a sample with an amplification composition allowing amplification of at least one region of the HPV genome specifically hybridizing to at least one of the probe oligonucleotides of the current invention under conditions which allow for the amplification of polynucleotides and b) identifying low-risk HPV genotypes in said sample based on the amplified polynucleotides obtained in step a) by hybridizing the amplified polynucleotides with at least one labelled probe oligonucleotide of the current invention while said amplified polynucleotides are present in the same reaction container. The invention also relates to the use of a composition of the current invention for identifying low-risk HPV hi a sample and to a kit comprising the composition of the invention and / or adopted for carrying out the method of the invention and an instruction manual.
摘要翻译：本发明涉及包含本发明核苷酸序列的至少一种探针寡核苷酸的组合物，所述探针寡核苷酸与所述核苷酸序列的有义链或反义链特异性杂交。此外，本发明涉及一种用于鉴定样品中低风险HPV类型的方法，包括以下步骤：a）使样品与扩增组合物接触，所述扩增组合物允许至少一个HPV基因区域的扩增，特别是至少与本发明的探针寡核苷酸之一在允许扩增多核苷酸的条件下，以及b）基于步骤a）中获得的扩增多核苷酸鉴定所述样品中的低风险HPV基因型，通过将扩增的多核苷酸与至少一个标记的而所述扩增的多核苷酸存在于相同的反应容器中的本发明的探针寡核苷酸。本发明还涉及本发明的组合物在样品中鉴定低风险HPV的用途，以及包含本发明组合物和/或用于实施本发明方法和使用说明书的试剂盒的用途。

5. 发明申请

WO2012136712A1 MEANS AND METHODS FOR QUANTIFYING NUCLEIC ACIDS 审中-公开
标题翻译：用于定量核酸的方法和方法
公开(公告)号：WO2012136712A1
公开(公告)日：2012-10-11
申请号：PCT/EP2012/056178
申请日：2012-04-04
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM , PAWLITA, Michael , SCHMITT, Markus
发明人： PAWLITA, Michael , SCHMITT, Markus
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6851 , C12Q1/6806 , C12Q1/708 , C12Q2545/114 , C12Q2600/16 , C12Q2527/143 , C12Q2537/143
摘要： The present invention relates to a method for comparing the amounts of a first and a second polynucleotide comprised in a sample, said method comprising the steps of a) amplifying said first and said second test polynucleotide in a test sample and a first and a second control polynucleotide in a reference sample, wherein said first and said second control polynucleotide is present in the reference sample in amounts sufficient to allow for generation of maximal amounts of amplification products of the said control polynucleotides, b) determining the amounts of the first and the second test amplification product of said first and said second polynucleotide and the first and the second control amplification product of said first and said second control polynucleotide, c) calculating (i) the ratio of the amounts of the first test amplification product and the first control amplification product and (ii) the ratio of the second test amplification product and the second control amplification product; and, d) comparing the ratios calculated in c) (i) and (ii), whereby the amount of the first test polynucleotide and the amount second test polynucleotide comprised in the test sample are compared. Furthermore, the present invention relates to a device for comparing the amounts of a first and a second polynucleotide comprised in a sample by the method of the present invention.
摘要翻译：本发明涉及一种用于比较样品中包含的第一和第二多核苷酸的量的方法，所述方法包括以下步骤：a）在测试样品中扩增所述第一和第二测试多核苷酸，以及第一和第二对照参考样品中的多核苷酸，其中所述第一和第二对照多核苷酸以足以允许产生所述对照多核苷酸的最大量的扩增产物的量存在于参照样品中，b）确定第一和第二所述第一和第二多核苷酸的测试扩增产物和所述第一和第二对照多核苷酸的第一和第二对照扩增产物，c）计算（i）第一测试扩增产物和第一对照扩增产物的量的比例产物和（ii）第二测试扩增产物和第二对照扩增的比率产品; 和d）比较在c）（i）和（ii）中计算的比例，由此比较测试样品中包含的第一测试多核苷酸和第二测试多核苷酸的量。此外，本发明涉及通过本发明的方法比较样品中包含的第一和第二多核苷酸的量的装置。

6. 发明申请

WO2011069957A1 VERFAHREN ZUR ISOMERISIERUNG EINES GESÄTTIGTEN, VERZWEIGTEN UND ZYKLISCHEN KOHLENWASSERSTOFFS 审中-公开
标题翻译：饱和异构化，方法和支环烃
公开(公告)号：WO2011069957A1
公开(公告)日：2011-06-16
申请号：PCT/EP2010/068958
申请日：2010-12-06
申请人： BASF SE , TSCHIRSCHWITZ, Steffen , DEUERLEIN, Stephan , BÜRKLE, Jochen , SCHMITT, Markus , SCHREIBER, Michael , OEHLENSCHLÄGER, Steffen
发明人： TSCHIRSCHWITZ, Steffen , DEUERLEIN, Stephan , BÜRKLE, Jochen , SCHMITT, Markus , SCHREIBER, Michael , OEHLENSCHLÄGER, Steffen
IPC分类号： C07C5/29 , C07C13/18
CPC分类号： C07C5/29 , C07C2523/72 , C07C2527/126 , C07C2531/02 , C07C13/18
摘要： Verfahren zur Isomerisierung eines gesättigten, verzweigten und zyklischen Kohlenwasserstoffs, wobei bei der Isomerisierung ein tertiäres C-Atom des Kohlenwasserstoffs in ein sekundäres C-Atom umgewandelt wird, indem man die Isomerisierung in Gegenwart einer super-sauren ionischen Flüssigkeit, umfassend ein organisches Kation und ein anorganisches Anion, wobei das Anion ein super-saures Aluminiumtrichlorid-Lewisbase-Addukt ist, und einer Kupfer(ll)-Verbindung durchführt.
摘要翻译：一种用于饱和的，支链和环状烃，其中所述烃的叔碳原子是通过在超酸性离子液体的存在下包含有机阳离子的异构化反应，并转化为仲碳原子在异构化的异构化过程无机阴离子，所述阴离子是一种超酸性铝 - 路易斯碱加合物，和铜（II）化合物进行。

7. 发明申请

WO2005045383A3 FORCE-SENSING DEVICE, AND METHOD FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：测力装置及其制造方法
公开(公告)号：WO2005045383A3
公开(公告)日：2005-07-14
申请号：PCT/EP2004012494
申请日：2004-11-04
申请人： HTW DRESDEN , MUENNICH MARTIN , SCHMITT MARKUS , SCHULTES GUENTER
发明人： MUENNICH MARTIN , SCHMITT MARKUS , SCHULTES GUENTER
IPC分类号： B25B23/14 , B25B23/142 , F16B31/02 , G01G3/14 , G01L1/22 , G01L3/10 , G01L5/00 , G01L5/24
CPC分类号： G01L1/2237 , B25B23/14 , B25B23/1425 , F16B31/02 , G01G3/141 , G01L3/108 , G01L5/0004 , G01L5/24
摘要： The invention relates to a device for measuring forces, especially weights, or force-dependent variables such as pressure and torque. Said device comprises a measuring element (1, 3) that deforms when force is applied and a sensor element (4) which is connected to the measuring element and deforms along with said measuring element so as to generate a measurement signal. Also disclosed is a method for producing such a device. According to the invention, a support element (3) which is welded to the remainder of the measuring element is provided for the sensor element (4). The sensor element is applied to the support element (3) before the support element (3) is welded to the remainder of the measuring element (1).
摘要翻译：本发明涉及一种设备，用于测量力，尤其是权重和非依赖变量，例如压力和扭矩与下力的变形测量体（1,3）和连接到所述测量体的一部分，该变形测量体，以产生测量信号传感器元件（4）以及用于制造这种装置的方法。根据本发明，为传感器元件（4）提供焊接到剩余测量体的载体元件（3）。在焊接载体元件（3）之前，将传感器元件与剩余的测量体（1）一起应用于载体元件（3）。

8. 发明申请

WO2012136682A1 VIRAL LOAD ASSESSMENT IN MULTIPLE HPV INFECTIONS AS PREDICTOR FOR THE PRESENCE OF CERVICAL LESIONS 审中-公开
标题翻译：多发性HPV感染的病毒载量评估作为宫颈癌患者的预防因素
公开(公告)号：WO2012136682A1
公开(公告)日：2012-10-11
申请号：PCT/EP2012/056119
申请日：2012-04-04
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM , SCHMITT, Markus , PAWLITA, Michael
发明人： SCHMITT, Markus , PAWLITA, Michael
IPC分类号： C12Q1/68 , C12Q1/70 , B01L7/00
CPC分类号： C12Q1/708 , C12Q1/6851 , C12Q2600/112 , C12Q2537/143 , C12Q2537/16
摘要： The present invention is concerned with a method for differentiating in a subject infected with at least two high-risk (HR-) human papillomavirus (HPV) genotypes between a severe form of HPV infection and a mild form of HPV infection, comprising a) quantifying the genome numbers of each of said at least two HR-HPV-genotypes in a sample from said patient, b) comparing the genome number of the HR-HPV genotype with the highest genome number to at least one reference amount, and c) differentiating between (i) a severe form of HPV infection and (ii) a mild form of HPV infection. Furthermore, the current invention relates to a method for diagnosing a severe form of HPV infection in a subject comprising the method of the invention, as well as to oligonucleotides for use in said method for diagnosis and a device for use in said method.
摘要翻译：本发明涉及用于区分在严重形式的HPV感染和轻度形式的HPV感染之间感染至少两种高风险（HR））人乳头状瘤病毒（HPV）基因型的受试者的方法，其包括：a）量化所述患者的样品中所述至少两种HR-HPV基因型中的每一种的基因组数目，b）将HR-HPV基因型的基因组数目与最高基因组数目比较至至少一个参考量，以及c）区分在（i）严重形式的HPV感染和（ii）轻度形式的HPV感染之间。此外，本发明涉及用于诊断受试者中严重形式的HPV感染的方法，所述方法包括本发明的方法，以及用于所述诊断方法的寡核苷酸和用于所述方法的装置。

9. 发明申请

WO2010108831A1 GENOTYPING OF BOVINE PAPILLOMAVIRUS GENOTYPES 审中-公开
标题翻译：牛血清病毒基因组遗传学研究
公开(公告)号：WO2010108831A1
公开(公告)日：2010-09-30
申请号：PCT/EP2010/053456
申请日：2010-03-17
申请人： DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM , SCHMITT, Markus , MÜLLER, Martin
发明人： SCHMITT, Markus , MÜLLER, Martin
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708
摘要： The present invention is concerned with the provision of diagnostic means and methods. Specifically, it relates to a composition comprising oligonucleotides selected from at least two different groups of oligonucleotides, said groups comprising at least one pair of oligonucleotides being capable of specifically amplifying polynucleotides comprised by a Bovine Papillomavirus (BPV), said BPV being selected from the group consisting of BPV-1, BPV-2, BPV-3, BPV-4, BPV-5, BPV-6, BPV-7, BPV-8, BPV-9, BPV-10, and BAPV-11 as well as uses based on said composition and kits comprising it. Moreover, contemplated is a method for the simultaneous detection and / or identification of BPV types in a sample.
摘要翻译：本发明涉及提供诊断手段和方法。具体地，本发明涉及包含寡核苷酸的组合物，所述寡核苷酸选自至少两个不同的寡核苷酸组，所述组包含至少一对能够特异性扩增由牛乳头瘤病毒（BPV）组成的多核苷酸的寡核苷酸，所述BPV选自组由BPV-1，BPV-2，BPV-3，BPV-4，BPV-5，BPV-6，BPV-7，BPV-8，BPV-9，BPV-10和BAPV-11组成，基于所述组合物和包含它的试剂盒。此外，预期的是同时检测和/或识别样品中BPV类型的方法。

10. 发明申请

WO2009027403A1 COMPOSITION COMPRISING AN OLIGONUCLEOTIDE MIXTURE FOR IMPROVED DETECTION OF HUMAN PAPILLOMAVIRUS GENOTYPES 审中-公开
标题翻译：包含用于改善人类斑马鱼基因组检测的寡核苷酸混合物的组合物
公开(公告)号：WO2009027403A1
公开(公告)日：2009-03-05
申请号：PCT/EP2008/061156
申请日：2008-08-26
申请人： DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM , SCHMITT, Markus , WATERBOER, Tim , PAWLITA, Michael
发明人： SCHMITT, Markus , WATERBOER, Tim , PAWLITA, Michael
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q2537/143 , C12Q2549/119
摘要： The present invention relates to a composition comprising an oligonucleotide mixture. Moreover, the present invention relates to the use of said oligonucleotide mixture for diagnosing different HPV genotypes in a sample of a subject. Further encompassed is a method for diagnosing different HPV genotypes in a sample of a subject and a kit carrying out said method.
摘要翻译：本发明涉及包含寡核苷酸混合物的组合物。此外，本发明涉及用于诊断受试者样品中不同HPV基因型的所述寡核苷酸混合物的用途。进一步包括用于诊断受试者样品中不同HPV基因型的方法和进行所述方法的试剂盒。

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