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1. 发明申请

WO2008023378A1 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO)CHLOROPHYLL PHOTOSYNTHESIZERS AND THEIR USES 审中-公开
标题翻译： RGD肽和卟啉或（细菌）叶绿素光合作用的偶联物及其用途
公开(公告)号：WO2008023378A1
公开(公告)日：2008-02-28
申请号：PCT/IL2007/001055
申请日：2007-08-23
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , SCHERZ, Avigdor , SALOMON, Yoram , RUBINSTEIN, Efrat , BRANDIS, Alexander , EREN, Doron , NEIMANN, Karin
发明人： SCHERZ, Avigdor , SALOMON, Yoram , RUBINSTEIN, Efrat , BRANDIS, Alexander , EREN, Doron , NEIMANN, Karin
IPC分类号： A61K41/00 , A61K47/48 , C07K5/103 , C07K7/06 , C07K7/08
CPC分类号： C07K5/123 , A61K41/0071 , A61K47/64 , C07K5/0817 , C07K5/10 , C07K5/126 , C07K7/06 , C07K7/64
摘要： Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and nonneoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.
摘要翻译：提供了卟啉，叶绿素和细菌叶绿素光敏剂与含有RGD的肽或RGD拟肽的缀合物，其可用于光动力治疗（PDT），特别是血管靶向的PDT（VTP），肿瘤和非肿瘤血管疾病如年龄相关性黄斑变性，以及通过不同技术诊断肿瘤。

2. 发明申请

WO02073062B1 SYNTHETIC MOLECULAR SPRING DEVICE 审中-公开
标题翻译：合成分子弹簧装置
公开(公告)号：WO02073062B1
公开(公告)日：2003-12-11
申请号：PCT/US0207178
申请日：2002-03-12
申请人： YEDA RES & DEV , YERUSHALMI ROIE , SCHERZ AVIGDOR , SHEINBEIN SOL
发明人： YERUSHALMI ROIE , SCHERZ AVIGDOR
IPC分类号： B82B1/00 , C07D487/22 , C07K14/00 , F03G7/00 , F16F1/00 , F16F1/36 , F16F3/00
CPC分类号： F16F1/3605 , F16F1/00 , F16F3/00
摘要： Synthetic molecular spring device featuring: (a) a synthetic molecular assembly, SMA, each scalable chemical module including; (i) at least one atom, M, (ii) at least one complexing group, CG, complexed to an atom, M, (iii) at least one axial ligand, AL, reversibly physicochemically paired with at least one atom, M complexed to a complexing group, CG, (iv) at least one substantially elastic molecular linker, ML, having body and two ends with at least one chemically bonded to another component of SMA; (b) activating mechanism, AM, operatively directed to an atom-axial ligand pair, whereby following activating mechanism, AM, sending activating signal, AS/AS', to an atom-axial ligand pair for physicochemically modifying the atom-axial ligand pair, there is activating at least one cycle of spring-type elastic reversible transitions between contracted and expanded linear conformational states of molecular linker, ML. Optionally includes (v) chemical connectors, CC, and/or, (vi) binding sites, BS.
摘要翻译：合成分子弹簧装置，其特征在于：（a）合成分子组件，SMA，每个可扩展化学模块包括：（i）至少一个原子M，（ii）至少一个络合基团CG，与原子M络合，（iii）至少一个轴向配体AL，可逆地与至少一个原子物理化学配对，M络合（iv）至少一种基本上弹性的分子连接体ML，其具有主体和两个末端，并且至少一个化学连接到SMA的另一个组分; （b）激活机制AM，其操作性地指向原子 - 轴向配体对，由此以下激活机制AM将激活信号AS / AS'发送至原子 - 轴向配体对以物理修饰原子 - 轴向配体对，在分子接头ML的收缩和扩展线性构象状态之间激活至少一个春季型弹性可逆转变的循环。任选地包括（v）化学连接体，CC和/或（vi）结合位点BS。

3. 发明申请

WO2009095912A1 ENDOSCOPIC IMAGING PHOTODYNAMIC THERAPY SYSTEM AND METHODS OF USE 审中-公开
标题翻译：内窥镜成像光化疗治疗系统及其使用方法
公开(公告)号：WO2009095912A1
公开(公告)日：2009-08-06
申请号：PCT/IL2009/000108
申请日：2009-01-28
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , GEVA, Eli , SALOMON, Yoram , SCHERZ, Avigdor , GLINERT, Itai
发明人： GEVA, Eli , SALOMON, Yoram , SCHERZ, Avigdor , GLINERT, Itai
IPC分类号： A61N5/06 , A61B18/22 , A61B18/20
CPC分类号： A61B18/22 , A61B10/0233 , A61B90/37 , A61B2018/2266 , A61B2090/3782 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N2005/0611 , A61N2005/063 , A61N2005/0651 , A61N2005/067
摘要： The invention provides an endoscopic imaging photodynamic therapy system (EIPS) for focused tissue ablation by illumination of a photosensitizer drug in a target tissue, said system comprising an endoscopic assembly, a real-time imaging component for locating the target tissue and monitoring the ablation intervention, a therapeutic light system and, optionally, a drug delivery module, wherein said imaging component comprises a flexible transducer with an operative channel for insertion of a flexible light guide of the therapeutic light system and, optionally, a flexible drug delivery catheter of the drug delivery module. This EIPS may be used in various medical applications where tissue ablation is required and photodynamic therapy may be applied, in particular, in the treatment of extrauterine pregnancy (EUP).
摘要翻译：本发明提供一种内窥镜成像光动力治疗系统（EIPS），用于通过照射目标组织中的光敏药物来聚焦组织消融，所述系统包括内窥镜组件，用于定位靶组织的实时成像组件和监测消融干预，治疗光系统和任选的药物递送模块，其中所述成像部件包括具有用于插入治疗光系统的柔性光导的可操作通道的柔性换能器，以及可选地，药物的柔性药物输送导管交货模块该EIPS可以用于需要组织消融的各种医疗应用，并且可以应用光动力学治疗，特别是在宫外孕（EUP）的治疗中。

4. 发明申请

WO2010004565A3 FORECASTING OF TREATED SKIN COLORS 审中-公开
标题翻译：预测处理过的皮肤颜色
公开(公告)号：WO2010004565A3
公开(公告)日：2010-06-03
申请号：PCT/IL2009000688
申请日：2009-07-09
申请人： SEETHROUGH LTD , GROSSINGER ISRAEL , MERCIER MICHEL , LUSTIG SAGIV , GROSSINGER NADAV , BENNY ELI , ISHKOV ELENA , SCHERZ AVIGDOR , LANDA BENZION
发明人： GROSSINGER ISRAEL , MERCIER MICHEL , LUSTIG SAGIV , GROSSINGER NADAV , BENNY ELI , ISHKOV ELENA , SCHERZ AVIGDOR , LANDA BENZION
IPC分类号： A61B5/103
CPC分类号： A45D44/005 , A61B5/0059 , A61B5/411
摘要： A method of selecting a substance for use in a cosmetic skin treatment comprises, measuring a reflectance spectrum of the skin to which said treatment is to be applied, said reflectance spectrum defining an original skin tone; modifying the measured reflectance spectrum in accordance with the absorbance spectrum of a substance proposed for said cosmetic skin treatment to provide a modified skin reflectance spectrum defining a modified skin tone; and matching such that if said modified skin tone appears to match said original skin tone then indicating said proposed substance in said cosmetic skin treatment, and otherwise repeating said modifying with a new proposed substance until a match is found.
摘要翻译：选择用于美容皮肤处理的物质的方法包括：测量要施加所述处理的皮肤的反射光谱，所述反射光谱限定原始肤色; 根据针对所述美容皮肤处理提议的物质的吸收光谱来修改测量的反射光谱，以提供定义修改的肤色的修改的皮肤反射光谱; 并且如此匹配，使得如果所述修改后的肤色看起来与所述原始肤色相匹配，则在所述美容皮肤处理中指示所述建议的物质，否则用新建议的物质重复所述修饰直至找到匹配。

5. 发明申请

WO2010004565A2 FORECASTING OF TREATED SKIN COLORS 审中-公开
标题翻译：预处理皮肤颜色
公开(公告)号：WO2010004565A2
公开(公告)日：2010-01-14
申请号：PCT/IL2009/000688
申请日：2009-07-09
申请人： SEETHROUGH LTD. , GROSSINGER, Israel , MERCIER, Michel , LUSTIG, Sagiv , GROSSINGER, Nadav , BENNY, Eli , ISHKOV, Elena , SCHERZ, Avigdor , LANDA, Benzion
发明人： GROSSINGER, Israel , MERCIER, Michel , LUSTIG, Sagiv , GROSSINGER, Nadav , BENNY, Eli , ISHKOV, Elena , SCHERZ, Avigdor , LANDA, Benzion
IPC分类号： A45D44/00 , A45D34/00
CPC分类号： A45D44/005 , A61B5/0059 , A61B5/411
摘要： A method of selecting a substance for use in a cosmetic skin treatment comprises, measuring a reflectance spectrum of the skin to which said treatment is to be applied, said reflectance spectrum defining an original skin tone; modifying the measured reflectance spectrum in accordance with the absorbance spectrum of a substance proposed for said cosmetic skin treatment to provide a modified skin reflectance spectrum defining a modified skin tone; and matching such that if said modified skin tone appears to match said original skin tone then indicating said proposed substance in said cosmetic skin treatment, and otherwise repeating said modifying with a new proposed substance until a match is found.
摘要翻译：选择用于化妆品皮肤治疗的物质的方法包括：测量所述治疗所应用的皮肤的反射光谱，所述反射光谱定义原始肤色; 根据提出用于所述化妆品皮肤处理的物质的吸收光谱修改测量的反射光谱，以提供限定修饰的皮肤色调的修饰的皮肤反射光谱; 并且匹配使得如果所述修改的肤色看起来与所述原始肤色匹配，然后在所述化妆品皮肤处理中指示所述提出的物质，并且否则重复所述修饰用新的提出的物质直到发现匹配。

6. 发明申请

WO2009107139A1 RGD-(BACTERIO)CHLOROPHYLL CONJUGATES FOR PHOTODYNAMIC THERAPY AND IMAGING OF NECROTIC TUMORS 审中-公开
标题翻译： RGD-（BACTERIO）氯吡格雷配合物用于光动力治疗和成像肿瘤
公开(公告)号：WO2009107139A1
公开(公告)日：2009-09-03
申请号：PCT/IL2009/000228
申请日：2009-03-01
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , SCHERZ, Avigdor , GOLDSHAID, Liat , SALOMON, Yoram
发明人： SCHERZ, Avigdor , GOLDSHAID, Liat , SALOMON, Yoram
IPC分类号： A61K41/00 , A61P35/00 , A61K49/00 , A61K49/08 , A61K49/14 , A61K51/08 , A61K51/04
CPC分类号： A61K51/0485 , A61K41/0057 , A61K41/0071 , A61K49/0036 , A61K49/0056 , A61K49/085 , A61K49/14 , A61K51/044 , A61K51/0446 , A61K51/0451 , A61K51/082 , A61K51/088 , C07D257/04
摘要： RGD-chlorophyll and RGD-bacteriochlorophyll conjugates that home and accumulate in necrotic tumor domains much longer than in tumor non-necrotic domains are provided for use in minimally invasive tumor-targeted imaging, tumor-targeted photodynamic therapy, and/or on-line prognosis of necrotic tumors.
摘要翻译：家庭和积累在坏死肿瘤域中的RGD-叶绿素和RGD-细菌叶绿素缀合物比在肿瘤非坏死区域中长得多的时间被提供用于微创肿瘤靶向成像，肿瘤靶向光动力学治疗和/或在线预后的坏死性肿瘤。

7. 发明申请

WO2004011821A2 METHOD USING A SYNTHETIC MOLECULAR SPRING DEVICE IN A SYSTEM FOR DYNAMICALLY CONTROLLING A SYSTEM PROPERTY AND A CORRESPONDING SYSTEM THEREOF 审中-公开
标题翻译：使用合成分子弹簧装置在系统中动态控制系统属性的方法及其相关系统
公开(公告)号：WO2004011821A2
公开(公告)日：2004-02-05
申请号：PCT/IL2003/000612
申请日：2003-07-24
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , SCHERZ, Avigdor , YERUSHALMI, Roie
发明人： SCHERZ, Avigdor , YERUSHALMI, Roie
IPC分类号： F16F
CPC分类号： F16F1/00 , F16F3/00 , G02F2001/01791
摘要： Using a synthetic molecular spring device in a system for dynamically controlling a system property, such as momentum, topography, and electronic behavior. System features (a) the synthetic molecular spring device having (i) at least one synthetic molecular assembly each featuring at least one chemical unit including at least one: (1) atom; (2) complexing group complexed to at least one atom; (3) axial ligand reversibly physicochemically paired with at least one complexed atom; and (4) substantially elastic molecular linker; and, (ii) an activating mechanism directed to at least one atom-axial ligand pair; and, (b) a selected unit operatively coupled to synthetic molecular assembly, and exhibiting the system property. Activating mechanism sends an activating signal to atom-axial ligand pairs, for physicochemically modifying atom-axial ligand pairs, thereby activating at least one cycle of spring-type elastic reversible transitions between contracted and expanded linear conformational states of substantially elastic molecular linkers, causing dynamically controllable change in the system property.
摘要翻译：在系统中使用合成分子弹簧装置来动态地控制系统属性，例如动量，地形和电子行为。系统特征（a）合成分子弹簧装置，其具有（i）至少一个合成分子组合，每个合成分子组合具有包含至少一个：（1）原子的至少一个化学单元; （2）与至少一个原子络合的络合基团; （3）轴向配体与至少一个复合原子可逆地物理化学配对; 和（4）基本上弹性的分子接头; 和（ii）针对至少一个原子 - 轴配体对的激活机制; 和（b）选择的单元，其可操作地耦合到合成分子组件，并显示出系统性质。激活机制将激活信号发送到原子 - 轴配体对，用于物理化学修饰原子 - 轴配体对，由此激活基本上弹性的分子接头的收缩和扩展的线性构象状态之间的弹簧型弹性可逆转换的至少一个循环，系统性能的可控变化。

8. 发明申请

WO2002073062A3 SYNTHETIC MOLECULAR SPRING DEVICE 审中-公开
公开(公告)号：WO2002073062A3
公开(公告)日：2002-09-19
申请号：PCT/US2002/007178
申请日：2002-03-12
申请人： YEDA RESEARCH DEVELOPMENT CO. LTD. , SHEINBEIN, Sol , YERUSHALMI, Roie , SCHERZ, Avigdor
发明人： YERUSHALMI, Roie , SCHERZ, Avigdor
IPC分类号： F16F1/00
摘要： Synthetic molecular spring device featuring: (a) a synthetic molecular assembly, SMA, each scalable chemical module including; (i) at least one atom, M, (ii) at least one complexing group, CG, complexed to an atom, M, (iii) at least one axial ligand, AL, reversibly physicochemically paired with at least one atom, M complexed to a complexing group, CG, (iv) at least one substantially elastic molecular linker, ML, having body and two ends with at least one chemically bonded to another component of SMA; (b) activating mechanism, AM, operatively directed to an atom-axial ligand pair, whereby following activating mechanism, AM, sending activating signal, AS/AS', to an atom-axial ligand pair for physicochemically modifying the atom-axial ligand pair, there is activating at least one cycle of spring-type elastic reversible transitions between contracted and expanded linear conformational states of molecular linker, ML. Optionally includes (v) chemical connectors, CC, and/or, (vi) binding sites, BS.

9. 发明申请

WO1997019081A1 SYNTHETIC METAL-SUBSTITUTED BACTERIOCHLOROPHYLL DERIVATIVES AND USE THEREOF 审中-公开
标题翻译：合成金属取代的溴化胆碱衍生物及其用途
公开(公告)号：WO1997019081A1
公开(公告)日：1997-05-29
申请号：PCT/IL1996000161
申请日：1996-11-24
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , SCHERZ, Avigdor , SALOMON, Yoram , SCHEER, Hugo , HARTWICH, Gerhard , BRANDIS, Alexander
发明人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
IPC分类号： C07D487/22
CPC分类号： C07D487/22 , A61K41/0071 , C07D491/22
摘要： Metalated bacteriochlorophylls of the formula [M]-BChl, wherein M is a metal atom selected from divalent Pd, Co, Ni, Cu, Zn and Mn, trivalent Fe, Mn and Cr, and tetravalent Sn and Pt, and Bchl represents the residue of a demetalated natural or synthetic bacteriochlorophyll derivative, are prepared by transmetalation of the corresponding [Cd]-BChl derivatives carrying at position 17 a group COOR1, wherein R1 is a C1 - C25 hydrocarbyl residue, and further optional transesterification of the 17 -COOR1 of the obtained [M]-BChl. The compounds are for use in photodynamic therapy and diagnosis and for killing cells and infectious agents, e.g. bacteria and viruses, both in biological products and in living tissue. Preferred compounds are those of formula (I') wherein R'1 is a residue selected from (i) optionally substituted hydrocarbyl; (ii) hydroxy-containing amino acid or peptide or a derivative thereof; and (iii) hydroxy-containing peptide or a cell-specific ligand, e.g. peptide or protein, linked to the COO-group via a spacer as defined in (i).
摘要翻译：式[M] -BChl的金属化细菌叶绿素，其中M是选自二价Pd，Co，Ni，Cu，Zn和Mn，三价Fe，Mn和Cr的金属原子，四价Sn和Pt，Bchl表示残基脱甲基天然或合成细菌叶绿素衍生物的制备是通过将携带在17位的相应[Cd] -BCh1衍生物与COOR1基团（其中R1是C1-C25烃基残基）进一步任选的酯交换反式所得[M] -BChl的-COOR1。该化合物用于光动力学治疗和诊断以及用于杀死细胞和感染因子，例如，细菌和病毒，无论是生物制品还是活体组织。优选的化合物是式（I'）的化合物，其中R'1是选自（i）任选取代的烃基的残基; （ii）含羟基的氨基酸或肽或其衍生物; 和（iii）含羟基的肽或细胞特异性配体，例如。通过如（i）中定义的间隔物与COO-基团连接的肽或蛋白质。

10. 发明申请

WO2005120573A3 CATIONIC BACTERIOCHLOROPHYLL DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：阳离子型二氯丙烯衍生物及其用途
公开(公告)号：WO2005120573A3
公开(公告)日：2006-01-26
申请号：PCT/IL2005000602
申请日：2005-06-07
申请人： YEDA RES & DEV , SCHERZ AVIGDOR , BRANDIS ALEXANDER , SALOMON YORAM , EREN DORON , COHEN AVRAHAM
发明人： SCHERZ AVIGDOR , BRANDIS ALEXANDER , SALOMON YORAM , EREN DORON , COHEN AVRAHAM
IPC分类号： A61K31/409 , A61K41/00 , A61P35/00 , C07D487/22
CPC分类号： A61K31/409 , A61K41/0071
摘要： The invention provides cationic tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one positively charged group and/or at least one basic group that is converted to a positively charged group under physiological conditions, preferably Bchls having an onium group derived from a N-containing aliphatic or heterocyclic radical such as ammonium, guanidinium, imidazolium, pyridinium, and the like or a phosphonium, arsonium, oxonium, sulfonium, selenonium, telluronium, stibonium, or bismuthonium group, or a basic group that is converted to such onium groups under physiological conditions, said groups being bound to one or more of the positions 17
摘要翻译：本发明提供了在生理条件下含有至少一个带正电基团和/或至少一个碱性基团的阳离子四环和五环细菌叶绿素衍生物（Bchls），优选地具有衍生自N- 含有脂族或杂环基团如铵，胍，咪唑鎓，吡啶鎓等，或鏻，ium，氧鎓，锍，硒鎓，碲鎓，锑或铋鎓基团或转化为这样的鎓基团的碱性基团生理条件下，所述基团与一个或多个位置17

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