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    • 1. 发明申请
    • SYNTHETIC MOLECULAR SPRING DEVICE
    • 合成分子弹簧装置
    • WO02073062B1
    • 2003-12-11
    • PCT/US0207178
    • 2002-03-12
    • YEDA RES & DEVYERUSHALMI ROIESCHERZ AVIGDORSHEINBEIN SOL
    • YERUSHALMI ROIESCHERZ AVIGDOR
    • B82B1/00C07D487/22C07K14/00F03G7/00F16F1/00F16F1/36F16F3/00
    • F16F1/3605F16F1/00F16F3/00
    • Synthetic molecular spring device featuring: (a) a synthetic molecular assembly, SMA, each scalable chemical module including; (i) at least one atom, M, (ii) at least one complexing group, CG, complexed to an atom, M, (iii) at least one axial ligand, AL, reversibly physicochemically paired with at least one atom, M complexed to a complexing group, CG, (iv) at least one substantially elastic molecular linker, ML, having body and two ends with at least one chemically bonded to another component of SMA; (b) activating mechanism, AM, operatively directed to an atom-axial ligand pair, whereby following activating mechanism, AM, sending activating signal, AS/AS', to an atom-axial ligand pair for physicochemically modifying the atom-axial ligand pair, there is activating at least one cycle of spring-type elastic reversible transitions between contracted and expanded linear conformational states of molecular linker, ML. Optionally includes (v) chemical connectors, CC, and/or, (vi) binding sites, BS.
    • 合成分子弹簧装置,其特征在于:(a)合成分子组件,SMA,每个可扩展化学模块包括: (i)至少一个原子M,(ii)至少一个络合基团CG,与原子M络合,(iii)至少一个轴向配体AL,可逆地与至少一个原子物理化学配对,M络合 (iv)至少一种基本上弹性的分子连接体ML,其具有主体和两个末端,并且至少一个化学连接到SMA的另一个组分; (b)激活机制AM,其操作性地指向原子 - 轴向配体对,由此以下激活机制AM将激活信号AS / AS'发送至原子 - 轴向配体对以物理修饰原子 - 轴向配体对 ,在分子接头ML的收缩和扩展线性构象状态之间激活至少一个春季型弹性可逆转变的循环。 任选地包括(v)化学连接体,CC和/或(vi)结合位点BS。
    • 4. 发明申请
    • METHOD USING A SYNTHETIC MOLECULAR SPRING DEVICE IN A SYSTEM FOR DYNAMICALLY CONTROLLING A SYSTEM PROPERTY AND A CORRESPONDING SYSTEM THEREOF
    • 使用合成分子弹簧装置在系统中动态控制系统属性的方法及其相关系统
    • WO2004011821A2
    • 2004-02-05
    • PCT/IL2003/000612
    • 2003-07-24
    • YEDA RESEARCH AND DEVELOPMENT CO. LTD.SCHERZ, AvigdorYERUSHALMI, Roie
    • SCHERZ, AvigdorYERUSHALMI, Roie
    • F16F
    • F16F1/00F16F3/00G02F2001/01791
    • Using a synthetic molecular spring device in a system for dynamically controlling a system property, such as momentum, topography, and electronic behavior. System features (a) the synthetic molecular spring device having (i) at least one synthetic molecular assembly each featuring at least one chemical unit including at least one: (1) atom; (2) complexing group complexed to at least one atom; (3) axial ligand reversibly physicochemically paired with at least one complexed atom; and (4) substantially elastic molecular linker; and, (ii) an activating mechanism directed to at least one atom-axial ligand pair; and, (b) a selected unit operatively coupled to synthetic molecular assembly, and exhibiting the system property. Activating mechanism sends an activating signal to atom-axial ligand pairs, for physicochemically modifying atom-axial ligand pairs, thereby activating at least one cycle of spring-type elastic reversible transitions between contracted and expanded linear conformational states of substantially elastic molecular linkers, causing dynamically controllable change in the system property.
    • 在系统中使用合成分子弹簧装置来动态地控制系统属性,例如动量,地形和电子行为。 系统特征(a)合成分子弹簧装置,其具有(i)至少一个合成分子组合,每个合成分子组合具有包含至少一个:(1)原子的至少一个化学单元; (2)与至少一个原子络合的络合基团; (3)轴向配体与至少一个复合原子可逆地物理化学配对; 和(4)基本上弹性的分子接头; 和(ii)针对至少一个原子 - 轴配体对的激活机制; 和(b)选择的单元,其可操作地耦合到合成分子组件,并显示出系统性质。 激活机制将激活信号发送到原子 - 轴配体对,用于物理化学修饰原子 - 轴配体对,由此激活基本上弹性的分子接头的收缩和扩展的线性构象状态之间的弹簧型弹性可逆转换的至少一个循环, 系统性能的可控变化。
    • 8. 发明申请
    • SYNTHETIC MOLECULAR SPRING DEVICE
    • 合成分子弹簧装置
    • WO2004011821A3
    • 2004-12-16
    • PCT/IL0300612
    • 2003-07-24
    • YEDA RES & DEVSCHERZ AVIGDORYERUSHALMI ROIE
    • SCHERZ AVIGDORYERUSHALMI ROIE
    • B82B3/00B82B1/00F16F1/00F16F3/00F03G7/00
    • F16F1/00F16F3/00G02F2001/01791
    • Using a synthetic molecular spring device in a system for dynamically controlling a system property, such as momentum, topography, and electronic behavior. System features (a) the synthetic molecular spring device having (i) at least one synthetic molecular assembly each featuring at least one chemical unit including at least one: (1) atom; (2) complexing group complexed to at least one atom; (3) axial ligand reversibly physicochemically paired with at least one complexed atom; and (4) substantially elastic molecular linker; and, (ii) an activating mechanism directed to at least one atom-axial ligand pair; and, (b) a selected unit operatively coupled to synthetic molecular assembly, and exhibiting the system property. Activating mechanism sends an activating signal to atom-axial ligand pairs, for physicochemically modifying atom-axial ligand pairs, thereby activating at least one cycle of spring-type elastic reversible transitions between contracted and expanded linear conformational states of substantially elastic molecular linkers, causing dynamically controllable change in the system property.
    • 在系统中使用合成分子弹簧装置来动态地控制系统属性,例如动量,地形和电子行为。 系统特征(a)合成分子弹簧装置,其具有(i)至少一个合成分子组合,每个合成分子组合具有包含至少一个:(1)原子的至少一个化学单元; (2)与至少一个原子络合的络合基团; (3)轴向配体与至少一个复合原子可逆地物理化学配对; 和(4)基本上弹性的分子接头; 和(ii)针对至少一个原子 - 轴配体对的激活机制; 和(b)选择的单元,其可操作地耦合到合成分子组件,并显示出系统性质。 激活机制将激活信号发送到原子 - 轴配体对,用于物理化学修饰原子 - 轴配体对,由此激活基本上弹性的分子接头的收缩和扩展的线性构象状态之间的弹簧型弹性可逆转换的至少一个循环, 系统性能的可控变化。
    • 9. 发明申请
    • SYNTHETIC MOLECULAR SPRING DEVICE
    • 合成分子弹簧装置
    • WO2002073062A2
    • 2002-09-19
    • PCT/US2002/007178
    • 2002-03-12
    • YEDA RESEARCH DEVELOPMENT CO. LTD.SHEINBEIN, SolYERUSHALMI, RoieSCHERZ, Avigdor
    • YERUSHALMI, RoieSCHERZ, Avigdor
    • F16F
    • F16F1/3605F16F1/00F16F3/00
    • Synthetic molecular spring device featuring: (a) a synthetic molecular assembly, SMA, each scalable chemical module including; (i) at least one atom, M, (ii) at least one complexing group, CG, complexed to an atom, M, (iii) at least one axial ligand, AL, reversibly physicochemically paired with at least one atom, M complexed to a complexing group, CG, (iv) at least one substantially elastic molecular linker, ML, having body and two ends with at least one chemically bonded to another component of SMA; (b) activating mechanism, AM, operatively directed to an atom-axial ligand pair, whereby following activating mechanism, AM, sending activating signal, AS/AS', to an atom-axial ligand pair for physicochemically modifying the atom-axial ligand pair, there is activating at least one cycle of spring-type elastic reversible transitions between contracted and expanded linear conformational states of molecular linker, ML. Optionally includes (v) chemical connectors, CC, and/or, (vi) binding sites, BS.
    • 合成分子弹簧装置,其特征在于:(a)合成分子组装,SMA,每个可伸缩化学模块包括; (i)至少一个原子,M,(ii)至少一个与原子配位的络合基团CG,(iii)至少一个轴向配体,AL,与至少一个原子可逆地物理化学配对,M络合的 复合基团,CG,(iv)至少一个基本上弹性的分子接头ML,其具有主体和两个末端,至少一个化学键合到SMA的另一个组分; (b)活化机制AM,可操作地导向原子 - 轴配体对,由此在激活机制AM之后,将激活信号AS / AS'发送到原子 - 轴配体对,用于物理化学修饰原子 - 轴配体对 ,激活了分子连接子的收缩和扩展的线性构象状态之间的弹簧型弹性可逆转换的至少一个循环。 可选地包括(v)化学连接剂,CC和/或(vi)结合位点,BS。