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1. 发明申请

WO1993024478A1 SUBSTITUTED HETEROCYCLIC DERIVATIVE HAVING SQUALENE EPOXIDASE INHIBITORY EFFECT AND USE THEREOF 审中-公开
标题翻译：具有平均环氧化酶抑制作用的取代的杂环衍生物及其用途
公开(公告)号：WO1993024478A1
公开(公告)日：1993-12-09
申请号：PCT/JP1993000723
申请日：1993-05-28
申请人： BANYU PHARMACEUTICAL CO., LTD. , TSUCHIYA, Yoshimi , NOMOTO, Takashi , MITSUYA, Morihiro , NONOSHITA, Katsumasa , HAYASHI, Masahiro , SATO, Toshihiko , SAWASAKI, Yoshio , KAMEI, Toshio
发明人： BANYU PHARMACEUTICAL CO., LTD.
IPC分类号： C07D333/16
CPC分类号： C07D333/08 , C07D333/16 , C07D333/18 , C07D333/24
摘要： A substituted heterocyclic derivative represented by general formula (I), wherein R represents a 5- or 6-membered heterocyclic group containing one or two heteroatoms selected from among nitrogen and other atoms; Q represents (II), (III), -CH=CH-CH2-, etc., -CH2-O-CH2-, or thrimethylene; X and Y may be the same or different from each other and each represents methylene, oxygen, etc., or alternatively X and Y may be combined together to represent vinylene, etc.; Q represents either (a) a 5- or 6-membered aromatic group represented by (IV) wherein A &cir& _, B &cir& _, D &cir& _ and E &cir& _ represent each nitrogen, etc., or =CH-; and p represents an integer of 0 or 1, or (b) a group represented by -F &cir& _-G &cir& _-I &cir& _- wherein F &cir& _, G &cir& _ and I &cir& _ may be the same or different from each other and each represents oxygen, etc., or =CH-; R represents lowr alkyl, etc.; Q represents ethylene, etc.; Q represents vinylene, etc.; R and R may be the same or different from each other and each represents lower alkyl, or alternatively R and R are combined together with the adjacent carbon atom to represent cycloalkyl; and R represents hydrogen, lower alkyl, etc.
摘要翻译：由通式（I）表示的取代的杂环衍生物，其中R表示含有一个或两个选自氮原子和其它原子的杂原子的5-或6-元杂环基; Q 1表示（II），（III），-CH = CH-CH 2 - 等，-CH 2 -O-CH 2 - 或三亚甲基; X和Y可以相同或不同，各自表示亚甲基，氧等，或者X和Y可以组合在一起代表亚乙烯基等; Q 2表示（a）由（IV）表示的5或6元芳族基团，其中A 1和R 3各自表示每个氮等，或= CH- ; 并且p表示0或1的整数，或（b）由-F 1和R 3表示的基团，其中F 1和R 3可以相同或不同彼此各自表示氧等，或= CH-; R 1表示低级烷基等; Q 3表示乙烯等。 Q 4表示亚乙烯基等; R 2和R 3可以彼此相同或不同，并且各自表示低级烷基，或者R 2和R 3与相邻的碳原子一起代表环烷基; R 4表示氢，低级烷基等。

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