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1. 发明申请

WO1993024478A1 SUBSTITUTED HETEROCYCLIC DERIVATIVE HAVING SQUALENE EPOXIDASE INHIBITORY EFFECT AND USE THEREOF 审中-公开
标题翻译：具有平均环氧化酶抑制作用的取代的杂环衍生物及其用途
公开(公告)号：WO1993024478A1
公开(公告)日：1993-12-09
申请号：PCT/JP1993000723
申请日：1993-05-28
申请人： BANYU PHARMACEUTICAL CO., LTD. , TSUCHIYA, Yoshimi , NOMOTO, Takashi , MITSUYA, Morihiro , NONOSHITA, Katsumasa , HAYASHI, Masahiro , SATO, Toshihiko , SAWASAKI, Yoshio , KAMEI, Toshio
发明人： BANYU PHARMACEUTICAL CO., LTD.
IPC分类号： C07D333/16
CPC分类号： C07D333/08 , C07D333/16 , C07D333/18 , C07D333/24
摘要： A substituted heterocyclic derivative represented by general formula (I), wherein R represents a 5- or 6-membered heterocyclic group containing one or two heteroatoms selected from among nitrogen and other atoms; Q represents (II), (III), -CH=CH-CH2-, etc., -CH2-O-CH2-, or thrimethylene; X and Y may be the same or different from each other and each represents methylene, oxygen, etc., or alternatively X and Y may be combined together to represent vinylene, etc.; Q represents either (a) a 5- or 6-membered aromatic group represented by (IV) wherein A &cir& _, B &cir& _, D &cir& _ and E &cir& _ represent each nitrogen, etc., or =CH-; and p represents an integer of 0 or 1, or (b) a group represented by -F &cir& _-G &cir& _-I &cir& _- wherein F &cir& _, G &cir& _ and I &cir& _ may be the same or different from each other and each represents oxygen, etc., or =CH-; R represents lowr alkyl, etc.; Q represents ethylene, etc.; Q represents vinylene, etc.; R and R may be the same or different from each other and each represents lower alkyl, or alternatively R and R are combined together with the adjacent carbon atom to represent cycloalkyl; and R represents hydrogen, lower alkyl, etc.
摘要翻译：由通式（I）表示的取代的杂环衍生物，其中R表示含有一个或两个选自氮原子和其它原子的杂原子的5-或6-元杂环基; Q 1表示（II），（III），-CH = CH-CH 2 - 等，-CH 2 -O-CH 2 - 或三亚甲基; X和Y可以相同或不同，各自表示亚甲基，氧等，或者X和Y可以组合在一起代表亚乙烯基等; Q 2表示（a）由（IV）表示的5或6元芳族基团，其中A 1和R 3各自表示每个氮等，或= CH- ; 并且p表示0或1的整数，或（b）由-F 1和R 3表示的基团，其中F 1和R 3可以相同或不同彼此各自表示氧等，或= CH-; R 1表示低级烷基等; Q 3表示乙烯等。 Q 4表示亚乙烯基等; R 2和R 3可以彼此相同或不同，并且各自表示低级烷基，或者R 2和R 3与相邻的碳原子一起代表环烷基; R 4表示氢，低级烷基等。

2. 发明申请

WO1996026925A1 ARYLTHIOACETAMIDE DERIVATIVES 审中-公开
标题翻译：三氯乙酰胺衍生物
公开(公告)号：WO1996026925A1
公开(公告)日：1996-09-06
申请号：PCT/JP1996000412
申请日：1996-02-23
申请人： BANYU PHARMACEUTICAL CO., LTD. , ISHIKAWA, Kiyofumi , HAYAMA, Takashi , KAMEI, Toshio , NAGATA, Yasufumi
发明人： BANYU PHARMACEUTICAL CO., LTD.
IPC分类号： C07D213/75
CPC分类号： C07D213/75 , C07D239/58
摘要： Arylthioacetamide derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein Ar represents phenyl, naphthyl or pyridyl optionally having one to four substituents selected from the group consisting of lower alkyl, lower alkoxy and halogeno; R represents hydrogen or lower alkyl; R and R may be the same or different and each represents hydrogen, lower alkyl, lower alkoxy, lower alkylthio, mono(lower alkyl)amino or di(lower alkyl)amino, provided that the lower alkyl, lower alkoxy, lower alkylthio, mono(lower alkyl)amino or di(lower alkyl)amino may be substituted by pyrrolidino, etc. at arbitrary hydrogen atoms; n represents 0, 1 or 2; and X represents CH or N. The compounds inhibit ACAT to thereby suppress the formation of cholesterol esters, are expected to be usable as a remedy or preventive for hypercholesterolemia, hyperlipidemia, arteriosclerosis and cardiac diseases, etc. accompanying the same.
摘要翻译：通式（I）表示的芳基硫代乙酰胺衍生物或其药学上可接受的盐，其中Ar表示苯基，萘基或任选具有一至四个选自低级烷基，低级烷氧基和卤代的取代基的吡啶基; R 1表示氢或低级烷基; R 2和R 3可以相同或不同，各自表示氢，低级烷基，低级烷氧基，低级烷硫基，单（低级烷基）氨基或二（低级烷基）氨基，条件是低级烷基，低级烷氧基，低级烷硫基，单（低级烷基）氨基或二（低级烷基）氨基可以在任意的氢原子被吡咯烷子基等取代; n表示0,1或2; 并且X表示CH或N.化合物抑制ACAT从而抑制胆固醇酯的形成，预期可用作补充或预防高胆固醇血症，高脂血症，动脉硬化和伴随其的心脏病等。

3. 发明申请

WO1990005132A1 SUBSTITUTED ALLYLAMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE 审中-公开
标题翻译：取代的全亚胺衍生物，其制备方法及其使用
公开(公告)号：WO1990005132A1
公开(公告)日：1990-05-17
申请号：PCT/JP1989000522
申请日：1989-05-25
申请人： BANYU PHARMACEUTICAL CO., LTD. , TAKEZAWA, Hiroshi , HAYASHI, Masahiro , IWASAWA, Yoshikazu , HOSOI, Masaaki , IIDA, Yoshiaki , TSUCHIYA, Yoshimi , HORIE, Masahiro , KAMEI, Toshio
发明人： BANYU PHARMACEUTICAL CO., LTD.
IPC分类号： C07D207/325
CPC分类号： C07D207/08 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/38 , C07D231/12 , C07D233/56 , C07D239/26 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/10 , C07D275/02 , C07D277/24 , C07D307/42 , C07D333/16 , C07D333/18 , C07D333/20 , C07D335/02 , C07D409/10 , C07D413/04 , C07D413/10 , C07D417/04
摘要： The invention relates to substituted allylamine derivatives and nontoxic salts thereof useful as a cholesterol-depressing agent and represented by general formula (I), [wherein A?1 and A2¿ each represents a methine group, N, O or S; Q?1 and Q2¿ may contain 1 to 2 hetero atoms and form a 5- or 6-membered aromatic ring together with A1 or A2; X and Y each represents O, S, a carbonyl group, -CHRa- (wherein Ra represents H or an alkyl group) or -NRb- (wherein Rb represents H or an alkyl group) or, when taken together, X and Y represent a vinylene group or an ethynylene group; R1 represents a 5- or 6-membered heterocyclic ring containing 1 to 4 hetero atoms; R2 represents an alkyl, allyl, propargyl or cyclopropyl group; R?3 and R4¿ each represents an alkyl group or, when taken together, R?3 and R4¿ represent a cycloalkane together with the adjacent carbon atom; R5 represents H, an alkyl or alkoxy group; and R?6 and R7¿ each represents H, halogen, -OH, -CN, an alkyl or alkoxy group, provided that when one of X and Y represents O, S or -NRb- (wherein Rb is the same as described above), the other represents a carbonyl group or -CHRa- (wherein Ra is the same as described above)], a process for their preparation, and their use for treatment of hypercholesteremia, hyperlipemia and arteriosclerosis.

4. 发明专利

JPS54156729A PENHOLDER 失效
公开(公告)号：JPS54156729A
公开(公告)日：1979-12-11
申请号：JP6392278
申请日：1978-05-30
申请人： KAMEI TOSHIO
发明人： KAMEI TOSHIO
IPC分类号： B43K29/00

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