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1. 发明申请

WO2007001624A2 MEDICAL AND DENTAL IMPLANT DEVICES FOR CONTROLLED DRUG DELIVERY 审中-公开
标题翻译：用于控制药物输送的医疗和牙科植入装置
公开(公告)号：WO2007001624A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/017062
申请日：2006-05-04
申请人： MICROCHIPS, INC. , SANTINI , John, T., Jr. , HUTCHINSON, Charles, E. , PROOS, Elizabeth, Rees
发明人： SANTINI , John, T., Jr. , HUTCHINSON, Charles, E. , PROOS, Elizabeth, Rees
IPC分类号： A61F2/30 , A61F2/28
CPC分类号： A61C8/0012 , A61C8/0016 , A61C19/063 , A61C2008/0046 , A61F2/30744 , A61F2/30756 , A61F2/30767 , A61F2/30771 , A61F2/36 , A61F2/3662 , A61F2/3676 , A61F2/38 , A61F2/446 , A61F2002/2817 , A61F2002/2828 , A61F2002/2832 , A61F2002/2835 , A61F2002/30004 , A61F2002/30013 , A61F2002/30062 , A61F2002/30224 , A61F2002/30261 , A61F2002/30266 , A61F2002/30462 , A61F2002/30677 , A61F2002/30808 , A61F2002/3081 , A61F2002/30874 , A61F2002/30878 , A61F2002/30937 , A61F2002/3617 , A61F2002/4631 , A61F2002/4636 , A61F2002/482 , A61F2210/0004 , A61F2220/0075 , A61F2230/0069 , A61F2230/0082 , A61F2250/0014 , A61F2250/0024 , A61F2310/00011 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61K9/0024 , A61L15/585 , A61L24/043 , A61L27/54 , A61L27/56 , A61L28/0026 , A61L2300/252 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/602 , A61L2430/02 , C08L31/04
摘要： Implantable devices and methods for use in the treatment of osteonecrosisare provided. The device includes at least one implant device body adapted for insertion into one or more channels or voids in bone tissue; a plurality of discrete reservoirs, which may preferably be microreservoirs, located in the surface of the at least one implant device body; and at least one release system disposed in one or more of the plurality of reservoirs, wherein the release system includes at least one drug selected from the group consisting of bone growth promoters, angiogenesis promoters, analgesics, anesthetics, antibiotics, and combinations thereof. The device body may be formed of a bone graft material, a polymer, a metal, a ceramic, or a combination thereof. The device body may be a monolithic structure, such as one having a cylindrical shape, or it may be in the form of multiple units, such as a plurality of beads.
摘要翻译：提供了用于治疗骨坏死的植入式装置和方法。所述装置包括适于插入到骨组织中的一个或多个通道或空隙中的至少一个植入物装置主体; 位于至少一个植入装置主体的表面中的多个分立储存器，其优选地可以是微贮器; 以及设置在所述多个贮存器中的一个或多个储存器中的至少一个释放系统，其中所述释放系统包括选自骨生长促进剂，血管生成促进剂，止痛剂，麻醉剂，抗生素及其组合中的至少一种药物。装置主体可以由骨移植材料，聚合物，金属，陶瓷或其组合形成。装置主体可以是诸如具有圆柱形形状的整体结构，或者其可以是多个单元的形式，例如多个珠。

2. 发明申请

WO2006085908A2 DEVICES AND METHODS FOR MEASURING AND ENHANCING DRUG OR ANALYTE TRANSPORT TO/FROM MEDICAL IMPLANT 审中-公开
标题翻译：用于测量和增强药物或分析至/从医疗植入物运输的装置和方法
公开(公告)号：WO2006085908A2
公开(公告)日：2006-08-17
申请号：PCT/US2005/019021
申请日：2005-06-01
申请人： MICROCHIPS, INC. , HERMAN, Stephen, J. , KRIEGER, Timothy , SANTINI, John, T., Jr. , PRESCOTT, James, H. , STAPLES, Mark, Andrew , LIPKA, Sara, A.
发明人： HERMAN, Stephen, J. , KRIEGER, Timothy , SANTINI, John, T., Jr. , PRESCOTT, James, H. , STAPLES, Mark, Andrew , LIPKA, Sara, A.
IPC分类号： A61M37/00 , A61K9/00 , A61N1/30 , A61N1/05 , A61K49/00 , A61B5/00
CPC分类号： A61K9/0009 , A61B5/03 , A61B5/04001 , A61B5/042 , A61B5/076 , A61B5/14528 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/686 , A61K9/0024 , A61K9/0097 , A61M37/00 , A61N1/05 , A61N1/30 , A61N1/306
摘要： Methods and devices are provided for enhancing mass transport through any fibrous tissue capsule that may form around an implanted medical device following implantation. Methods and devices are also provided to enhance vascularization around the implanted device, which also will aid in mass transport to/from the device. The device preferably comprises multiple reservoirs containing (i) a drug formulation for short- or long-term, controlled drug delivery, (ii) sensors for sensing an analyte in the patient, or (iii) a combination thereof.
摘要翻译：提供的方法和装置用于增强通过植入后可能在植入的医疗装置周围形成的任何纤维组织胶囊的质量传递。还提供了方法和装置以增强植入装置周围的血管化，这也有助于大量运输到装置。装置优选地包括多个储存器，其包含（i）用于短期或长期，受控药物递送的药物制剂，（ii）用于感测患者中的分析物的传感器，或（iii）其组合。

3. 发明申请

WO2006055593A2 FABRICATION METHODS AND STRUCTURES FOR MICRO-RESERVOIR DEVICES 审中-公开
标题翻译：微型储存装置的制造方法和结构
公开(公告)号：WO2006055593A2
公开(公告)日：2006-05-26
申请号：PCT/US2005/041453
申请日：2005-11-15
申请人： MICROCHIPS, INC. , MALONEY, John, M. , SBIAA, Zouhair , SANTINI, John, T., Jr. , SHEPPARD, Norman, F., Jr. , UHLAND, Scott, A.
发明人： MALONEY, John, M. , SBIAA, Zouhair , SANTINI, John, T., Jr. , SHEPPARD, Norman, F., Jr. , UHLAND, Scott, A.
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , A61K9/0024 , A61K9/0097 , B01L2200/12 , B01L2300/0819 , B01L2400/0677
摘要： Methods are provided for making a multi-reservoir device comprising (i) patterning one or more photoresist layers on a substrate; (ii) depositing onto the substrate at least one metal layer by a sputtering process to form a plurality of reservoir caps and conductive traces; (iii) removing the photoresist layers using a liftoff process; (iv) forming a plurality of reservoirs in the substrate; (v) loading each reservoir with reservoir contents (such as a drug or sensor); and (vi) sealing each reservoir. Optionally, the reservoir cap comprises a first conductive metal layer coated with one or more protective noble metal films. To enhance the resistance of the substrate (e.g., a silicon substrate) to etching in vivo, the interior sidewalls of the reservoirs optionally can include a protective coating (e.g., gold, platinum, carbon, silicon carbide, silicon dioxide, and platinum silicide), or sidewalls comprising silicon can be doped with boron or another impurity.
摘要翻译：提供了用于制造多贮存器器件的方法，其包括（i）在衬底上图案化一个或多个光致抗蚀剂层; （ii）通过溅射工艺将至少一个金属层沉积在衬底上以形成多个储存器盖和导电迹线; （iii）使用剥离工艺除去光致抗蚀剂层; （iv）在所述基板中形成多个储存器; （v）向每个储存器装载储存器内容物（例如药物或传感器）; 和（vi）密封每个储存器。可选地，储存器盖包括涂覆有一个或多个保护性贵金属膜的第一导电金属层。为了增强衬底（例如，硅衬底）在体内蚀刻的电阻，存储器的内部侧壁任选地可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅和硅化铂）或包含硅的侧壁可以掺杂硼或另一种杂质。

4. 发明申请

WO2005010240A3 LOW TEMPERATURE METHODS FOR HERMETICALLY SEALING RESERVOIR DEVICES 审中-公开
公开(公告)号：WO2005010240A3
公开(公告)日：2005-02-03
申请号：PCT/US2004/023137
申请日：2004-07-19
申请人： MICROCHIPS, INC. , COPPETA, Jonathan, R. , UHLAND, Scott, A. , POLITO, Benjamin, F. , SHEPPARD, Norman, F., Jr. , FEAKES, Christina, M. , SNELL, Douglas , SANTINI, John, T., Jr.
发明人： COPPETA, Jonathan, R. , UHLAND, Scott, A. , POLITO, Benjamin, F. , SHEPPARD, Norman, F., Jr. , FEAKES, Christina, M. , SNELL, Douglas , SANTINI, John, T., Jr.
IPC分类号： C25D5/10
摘要： Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. The reservoir can be a micro-reservoir. The containment device can comprises an array of two or more of reservoirs, and the method comprises hermetically sealing each of the two or more reservoirs.

5. 发明申请

WO2006085908A3 DEVICES AND METHODS FOR MEASURING AND ENHANCING DRUG OR ANALYTE TRANSPORT TO/FROM MEDICAL IMPLANT 审中-公开
公开(公告)号：WO2006085908A3
公开(公告)日：2006-08-17
申请号：PCT/US2005/019021
申请日：2005-06-01
申请人： MICROCHIPS, INC. , HERMAN, Stephen, J. , KRIEGER, Timothy , SANTINI, John, T., Jr. , PRESCOTT, James, H. , STAPLES, Mark, Andrew , LIPKA, Sara, A.
发明人： HERMAN, Stephen, J. , KRIEGER, Timothy , SANTINI, John, T., Jr. , PRESCOTT, James, H. , STAPLES, Mark, Andrew , LIPKA, Sara, A.
IPC分类号： A61M37/00 , A61K9/00 , A61N1/30 , A61N1/05 , A61K49/00 , A61B5/00
摘要： Methods and devices are provided for enhancing mass transport through any fibrous tissue capsule that may form around an implanted medical device following implantation. Methods and devices are also provided to enhance vascularization around the implanted device, which also will aid in mass transport to/from the device. The device preferably comprises multiple reservoirs containing (i) a drug formulation for short- or long-term, controlled drug delivery, (ii) sensors for sensing an analyte in the patient, or (iii) a combination thereof.

6. 发明申请

WO2006026768A1 MULTI-CAP RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS 审中-公开
标题翻译：用于控制释放或储存的内容的多储层储存装置
公开(公告)号：WO2006026768A1
公开(公告)日：2006-03-09
申请号：PCT/US2005/031501
申请日：2005-09-01
申请人： MICROCHIPS, INC. , SANTINI, John, T., Jr. , SBIAA, Zouhair , COPPETA, Jonathan, R.
发明人： SANTINI, John, T., Jr. , SBIAA, Zouhair , COPPETA, Jonathan, R.
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61N1/05 , B01L2300/0627 , B01L2300/0819 , B01L2400/0677 , Y10T436/25
摘要： Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.
摘要翻译：提供了一种储存器装置，其中单个储存器具有至少两个开口，其间具有支撑结构，并且通过覆盖开口的储存器盖封闭以控制储存器内容物的释放或暴露。在一个实施例中，该装置是可植入医疗装置，并且提供药物的受控释放或传感器的暴露。该装置包括基板; 设置在基板中的至少一个储存器，储存器具有两个或更多个开口; 水库内容位于水库; 两个或更多个分立的储存器盖，每个储存器盖密封地覆盖至少一个储存器开口; 以及用于选择性地使贮存器盖分解或渗透的控制装置。

7. 发明申请

WO2004096176A2 SOLID DRUG FORMULATION AND DEVICE FOR STORAGE AND CONTROLLED DELIVERY THEREOF 审中-公开
标题翻译：固体药物制剂及其储存和控制输送装置
公开(公告)号：WO2004096176A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/012757
申请日：2004-04-26
申请人： MICROCHIPS, INC. , PRESCOTT, James, H. , UHLAND, Scott, A. , STAPLES, Mark, A. , SANTINI, John, T., Jr
发明人： PRESCOTT, James, H. , UHLAND, Scott, A. , STAPLES, Mark, A. , SANTINI, John, T., Jr
IPC分类号： A61K9/00
CPC分类号： A61K9/0097 , A61K9/0009 , A61K9/0024 , A61K38/09
摘要： Devices and methods are provided for the storage and controlled release of a solid form of a drug. The device comprises a body portion; one or more reservoirs located in and defined by the body portion; a solid matrix which comprises a drug and which is contained in each of the one or more reservoirs; and one or more excipient materials dispersed throughout pores or interstices within the solid matrix and substantially filling any space not otherwise occupied by the solid matrix within each of the one or more reservoirs, wherein the excipient material enhances stability of the drug while stored in the one or more reservoirs or enhances release of the drug from each reservoir. In an alternative embodiment, the device provides for the storage and controlled exposure of a chemical sensor material.
摘要翻译：提供了用于药物的固体形式的储存和控制释放的装置和方法。该装置包括主体部分; 一个或多个储存器，位于主体部分中并由主体部分限定; 固体基质，其包含药物并且包含在所述一个或多个储存器中的每一个中; 以及分散在固体基质内的整个孔或间隙中的一种或多种赋形剂材料，并且基本上填充所述一个或多个储存器中的每一个中未被固体基质占据的任何空间，其中所述赋形剂材料增强了药物的稳定性，同时储存在所述储存器中或更多的储存器或增强药物从每个储存器的释放。在替代实施例中，该装置提供化学传感器材料的存储和受控曝光。

8. 发明申请

WO2008154416A3 ELECTROCHEMICAL BIOSENSORS AND ARRAYS 审中-公开
公开(公告)号：WO2008154416A3
公开(公告)日：2008-12-18
申请号：PCT/US2008/066172
申请日：2008-06-06
申请人： MICROCHIPS, INC. , SHEPPARD, Norman, F., Jr. , SANTINI, John, T., Jr.
发明人： SHEPPARD, Norman, F., Jr. , SANTINI, John, T., Jr.
IPC分类号： A61B5/00 , C12Q1/00 , G01N27/49 , G01N33/487
摘要： Electrochemical sensor devices are provided, in various amperometric, potentiometric, and conductometric sensor device configurations. An amperometric sensor device (100) may include a structural body (102) which has at least one reservoir (110) that has at least one opening; a working electrode (112) located within the reservoir; analyte sensor chemistry (122) located within the reservoir and deposited on at least the working electrode; an auxiliary electrode (116) located outside of the reservoir; a reference electrode (114); at least one reservoir cap (118) closing the opening to isolate the working electrode and analyte sensor chemistry within the reservoir and to prevent an analyte outside of the reservoir from contacting the analyte sensor chemistry; and means for rupturing or displacing the reservoir cap to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry.

9. 发明申请

WO2008154416A2 ELECTROCHEMICAL BIOSENSORS AND ARRAYS 审中-公开
标题翻译：电化学生物传感器和阵列
公开(公告)号：WO2008154416A2
公开(公告)日：2008-12-18
申请号：PCT/US2008066172
申请日：2008-06-06
申请人： MICROCHIPS INC , SHEPPARD NORMAN F JR , SANTINI JOHN T JR
发明人： SHEPPARD NORMAN F JR , SANTINI JOHN T JR
IPC分类号： A61B5/00 , C12Q1/00 , G01N27/49 , G01N33/487
CPC分类号： A61B5/14865 , A61B5/14532 , C12Q1/004 , G01N27/3272
摘要： Electrochemical sensor devices are provided, in various amperometric, potentiometric, and conductometric sensor device configurations. An amperometric sensor device may include a structural body which has at least one reservoir that has at least one opening; a working electrode located within the reservoir; analyte sensor chemistry located within the reservoir and deposited on at least the working electrode; an auxiliary electrode located outside of the reservoir; a reference electrode; at least one reservoir cap closing the opening to isolate the working electrode and analyte sensor chemistry within the reservoir and to prevent an analyte outside of the reservoir from contacting the analyte sensor chemistry; and means for rupturing or displacing the reservoir cap to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry.
摘要翻译：以各种电流，电位和电导率传感器装置配置提供电化学传感器装置。电流传感器装置可以包括具有至少一个具有至少一个开口的储存器的结构体; 位于储存器内的工作电极; 分析物传感器化学位于储层内并沉积在至少工作电极上; 位于储存器外部的辅助电极; 参考电极; 至少一个储存器盖封闭所述开口以将所述工作电极和所述分析物传感器化学物质隔离在所述储存器内并防止所述储存器外的分析物接触所述分析物传感器化学物质; 以及用于破裂或移动储存器盖以允许来自储存器外部的分析物接触分析物传感器化学物质的装置。

10. 发明申请

WO2006055593A3 FABRICATION METHODS AND STRUCTURES FOR MICRO-RESERVOIR DEVICES 审中-公开
标题翻译：微型储存装置的制造方法和结构
公开(公告)号：WO2006055593A3
公开(公告)日：2007-04-19
申请号：PCT/US2005041453
申请日：2005-11-15
申请人： MICROCHIPS INC , MALONEY JOHN M , SBIAA ZOUHAIR , SANTINI JOHN T JR , SHEPPARD NORMAN F JR , UHLAND SCOTT A
发明人： MALONEY JOHN M , SBIAA ZOUHAIR , SANTINI JOHN T JR , SHEPPARD NORMAN F JR , UHLAND SCOTT A
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , A61K9/0024 , A61K9/0097 , B01L2200/12 , B01L2300/0819 , B01L2400/0677
摘要： Methods are provided for making a multi-reservoir device comprising (i) patterning one or more photoresist layers on a substrate; (ii) depositing onto the substrate at least one metal layer by a sputtering process to form a plurality of reservoir caps and conductive traces; (iii) removing the photoresist layers using a liftoff process; (iv) forming a plurality of reservoirs in the substrate; (v) loading each reservoir with reservoir contents (such as a drug or sensor); and (vi) sealing each reservoir. Optionally, the reservoir cap comprises a first conductive metal layer coated with one or more protective noble metal films. To enhance the resistance of the substrate (e.g., a silicon substrate) to etching in vivo, the interior sidewalls of the reservoirs optionally can include a protective coating (e.g., gold, platinum, carbon, silicon carbide, silicon dioxide, and platinum silicide), or sidewalls comprising silicon can be doped with boron or another impurity.
摘要翻译：提供了用于制造多贮存器器件的方法，包括（i）在衬底上图案化一个或多个光致抗蚀剂层; （ii）通过溅射工艺在衬底上沉积至少一个金属层，以形成多个储存器盖和导电迹线; （iii）使用剥离工艺除去光致抗蚀剂层; （iv）在所述基板中形成多个储存器; （v）向每个储存器装载储存器内容物（例如药物或传感器）; 和（vi）密封每个储存器。可选地，储存器盖包括涂覆有一个或多个保护性贵金属膜的第一导电金属层。为了增强衬底（例如，硅衬底）在体内蚀刻的电阻，存储器的内侧壁任选地可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅和硅化铂），或者包含硅的侧壁可以掺杂硼或另一种杂质。

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