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1. 发明申请

WO2006026768A1 MULTI-CAP RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS 审中-公开
标题翻译：用于控制释放或储存的内容的多储层储存装置
公开(公告)号：WO2006026768A1
公开(公告)日：2006-03-09
申请号：PCT/US2005/031501
申请日：2005-09-01
申请人： MICROCHIPS, INC. , SANTINI, John, T., Jr. , SBIAA, Zouhair , COPPETA, Jonathan, R.
发明人： SANTINI, John, T., Jr. , SBIAA, Zouhair , COPPETA, Jonathan, R.
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61N1/05 , B01L2300/0627 , B01L2300/0819 , B01L2400/0677 , Y10T436/25
摘要： Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.
摘要翻译：提供了一种储存器装置，其中单个储存器具有至少两个开口，其间具有支撑结构，并且通过覆盖开口的储存器盖封闭以控制储存器内容物的释放或暴露。在一个实施例中，该装置是可植入医疗装置，并且提供药物的受控释放或传感器的暴露。该装置包括基板; 设置在基板中的至少一个储存器，储存器具有两个或更多个开口; 水库内容位于水库; 两个或更多个分立的储存器盖，每个储存器盖密封地覆盖至少一个储存器开口; 以及用于选择性地使贮存器盖分解或渗透的控制装置。

2. 发明申请

WO2008008845A2 MULTI-RESERVOIR PUMP DEVICE FOR DIALYSIS, BIOSENSING, OR DELIVERY OF SUBSTANCES 审中-公开
标题翻译：用于透析，生物传感或物质输送的多储液泵装置
公开(公告)号：WO2008008845A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073271
申请日：2007-07-11
申请人： MICROCHIPS, INC. , SANTINI, John, T. , CIMA, Michael, F. , COPPETA, Jonathan, R. , PRESCOTT, James, H. , SBIAA, Zouhair , STAPLES, Mark, A.
发明人： SANTINI, John, T. , CIMA, Michael, F. , COPPETA, Jonathan, R. , PRESCOTT, James, H. , SBIAA, Zouhair , STAPLES, Mark, A.
IPC分类号： A61M37/00 , A61M5/14
CPC分类号： A61M37/0015 , A61M5/1409 , A61M5/14248 , A61M5/1452 , A61M5/14526 , A61M2005/14204 , A61M2005/14268 , A61M2037/0023
摘要： A pump patch device is provided for drug delivery. The device may include a substrate having a plurality of discrete reservoirs, each reservoir having a reservoir opening; a drug disposed in the reservoirs; a pump for delivering a carrier fluid through or adjacent to the reservoir openings; a flow channel for receiving and combining the carrier fluid from the pump with the drug from the reservoirs to form a fluidized drug; and a needle for delivering the fluidized drug into the skin or another biological tissue of a patient. A device is provided for use in dialysis that includes a non-disposable module including a pump or pressure generator; and a disposable cassette operably connected to the pump or pressure generator and including a plurality of discrete reservoirs containing drug and sensors. A fluidics connection device is provided that includes a compression cold weld seal for a microfluidic via.
摘要翻译：提供用于药物输送的泵补片装置。该装置可以包括具有多个不连续的储存器的基底，每个储存器具有储存器开口; 放置在储存器中的药物; 用于通过或邻近贮存器开口输送载液的泵; 用于接收和组合来自泵的载体流体与来自储存器的药物以形成流化药物的流动通道; 以及用于将流化药物输送到患者的皮肤或另一生物组织中的针。提供用于透析的装置，其包括包括泵或压力发生器的非一次性模块; 以及可操作地连接到泵或压力发生器并包括多个含有药物和传感器的不连续储存器的一次性盒。提供流体连接装置，其包括用于微流体通孔的压缩冷焊接密封。

3. 发明申请

WO2005010240A3 LOW TEMPERATURE METHODS FOR HERMETICALLY SEALING RESERVOIR DEVICES 审中-公开
公开(公告)号：WO2005010240A3
公开(公告)日：2005-02-03
申请号：PCT/US2004/023137
申请日：2004-07-19
申请人： MICROCHIPS, INC. , COPPETA, Jonathan, R. , UHLAND, Scott, A. , POLITO, Benjamin, F. , SHEPPARD, Norman, F., Jr. , FEAKES, Christina, M. , SNELL, Douglas , SANTINI, John, T., Jr.
发明人： COPPETA, Jonathan, R. , UHLAND, Scott, A. , POLITO, Benjamin, F. , SHEPPARD, Norman, F., Jr. , FEAKES, Christina, M. , SNELL, Douglas , SANTINI, John, T., Jr.
IPC分类号： C25D5/10
摘要： Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. The reservoir can be a micro-reservoir. The containment device can comprises an array of two or more of reservoirs, and the method comprises hermetically sealing each of the two or more reservoirs.

4. 发明申请

WO2005016558A2 METHODS FOR ACCELERATED RELEASE OF MATERIAL FROM A RESERVOIR DEVICE 审中-公开
标题翻译：从储层装置加速释放材料的方法
公开(公告)号：WO2005016558A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/025110
申请日：2004-08-04
申请人： MICROCHIPS, INC. , COPPETA, Jonathan, R. , MALONEY, John, M. , POLITO, Benjamin, F. , SANTINI, JR., John, T. , SHEPPARD, JR., Norman, F. , UHLAND, Scott, A.
发明人： COPPETA, Jonathan, R. , MALONEY, John, M. , POLITO, Benjamin, F. , SANTINI, JR., John, T. , SHEPPARD, JR., Norman, F. , UHLAND, Scott, A.
IPC分类号： B05C11/10
CPC分类号： A61K9/0097 , A61K9/0009 , A61K9/0024 , A61M5/14276 , A61M2205/0266
摘要： Methods and devices are provided for selective release or exposure of reservoir contents, such as a drug formulation or diagnostic reagent, sealed in a reservoir, e.g., a microreservoir. The devices comprise a substrate; one or more reservoirs located in and defined by the substrate; reservoir contents located inside the reservoirs; a reservoir cap or rupturable layer sealing an outlet of the reservoir; and means for disintegrating the reservoir cap or rupturing the rupturable layer; and means for accelerating the release of the reservoir contents from the reservoir through the outlet, or for enhancing diffusional mass transport of a material into or out of the reservoir. The means for accelerating can, for example, include a shape memory material. In a preferred embodiment, the device is adapted for implantation into a human or animal body and comprises an array of several discrete reservoir, each one being individually openable at a desired time.
摘要翻译：提供了用于选择性释放或暴露密封在储存器（例如微储器）中的储存容器（例如药物制剂或诊断试剂）的方法和装置。这些器件包括衬底; 一个或多个位于衬底中并由衬底限定的储器; 位于储层内的储层内容物; 储存器盖或可破裂层，其密封储存器的出口; 以及用于分解所述容器盖或破裂所述可破裂层的装置; 以及用于加速贮存器内容物通过出口从贮存器释放或者用于增强材料进出贮存器的扩散传质的装置。用于加速的装置可以例如包括形状记忆材料。在一个优选的实施方案中，该装置适合于植入人体或动物体内，并且包括几个不连续储存器的阵列，每个储存器在期望的时间可单独打开。

5. 发明申请

WO2012027137A1 IMPLANTABLE BIOSENSOR DEVICE AND METHODS OF USE THEREOF 审中-公开
标题翻译：可植入生物传感器装置及其使用方法
公开(公告)号：WO2012027137A1
公开(公告)日：2012-03-01
申请号：PCT/US2011/047607
申请日：2011-08-12
申请人： MICROCHIPS, INC. , COPPETA, Jonathan, R. , FARRA, Robert , HILTS, Kenneth, L. , SHEPPARD, Norman, F., Jr.
发明人： COPPETA, Jonathan, R. , FARRA, Robert , HILTS, Kenneth, L. , SHEPPARD, Norman, F., Jr.
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2562/046 , A61B2562/066
摘要： Sensor devices and methods are provided for detecting the presence or concentration of an analyte in fluid. The device has a reservoir; a working electrode located within the reservoir; a catalyst covering at least part of the working electrode; an oxygen-generating auxiliary electrode in the reservoir; and a reservoir cap to isolate the working and auxiliary electrodes within the reservoir. The device further includes means for selectively rupturing the cap to permit analyte from outside the reservoir to contact the catalyst. The methods may include in vivo glucose monitoring and may include implanting the device in a patient; disintegrating a reservoir cap to permit glucose to enter the reservoir; generating oxygen using the oxygen-generating auxiliary electrode; and using a working electrode to oxidize hydrogen peroxide produced by the reaction of the oxygen with glucose in the presence of glucose oxidase, and thereby detecting endogenous glucose in the patient.
摘要翻译：提供了传感器装置和方法，用于检测流体中分析物的存在或浓度。设备有一个水库; 位于储存器内的工作电极; 覆盖工作电极的至少一部分的催化剂; 储存器中的产氧辅助电极; 以及用于隔离储存器内的工作和辅助电极的储存器盖。该装置还包括用于选择性地破裂盖以允许来自储存器外部的分析物与催化剂接触的装置。所述方法可以包括体内葡萄糖监测，并且可以包括将装置植入患者体内; 分解储存器盖以允许葡萄糖进入储存器; 使用产生氧的辅助电极产生氧气; 并且在葡萄糖氧化酶的存在下使用工作电极氧化由氧与葡萄糖的反应产生的过氧化氢，从而检测患者的内源性葡萄糖。

6. 发明申请

WO2006052763A3 COMPRESSION AND COLD WELD SEALING METHODS AND DEVICES 审中-公开
公开(公告)号：WO2006052763A3
公开(公告)日：2006-05-18
申请号：PCT/US2005/040049
申请日：2005-11-04
申请人： MICROCHIPS, INC. , COPPETA, Jonathan, R. , SHELTON, Kurt , SHEPPARD, Norman, F., Jr. , SNELL, Douglas, B. , SANTINI, Catherine, M., B.
发明人： COPPETA, Jonathan, R. , SHELTON, Kurt , SHEPPARD, Norman, F., Jr. , SNELL, Douglas, B. , SANTINI, Catherine, M., B.
IPC分类号： B81B7/00
摘要： Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.

7. 发明申请

WO2007047556A2 PASSIVE WEAR-INDICATING SENSOR FOR IMPLANTABLE PROSTHETIC DEVICE 审中-公开
标题翻译：无源磨损传感器，用于可植入的前置设备
公开(公告)号：WO2007047556A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/040314
申请日：2006-10-16
申请人： MICROCHIPS, INC. , CIMA, Michael, J. , SANTINI JR., John, T. , SHELTON, Kurt , PRESCOTT, James, H. , STAPLES, Mark, A. , COPPETA, Jonathan, R.
发明人： CIMA, Michael, J. , SANTINI JR., John, T. , SHELTON, Kurt , PRESCOTT, James, H. , STAPLES, Mark, A. , COPPETA, Jonathan, R.
IPC分类号： A61F2/34
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61B6/037 , A61B6/481 , A61B8/481 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/389 , A61F2/40 , A61F2/4425 , A61F2/4657 , A61F2002/2817 , A61F2002/30004 , A61F2002/30062 , A61F2002/30075 , A61F2002/30113 , A61F2002/30154 , A61F2002/30156 , A61F2002/30326 , A61F2002/30673 , A61F2002/30677 , A61F2002/30682 , A61F2002/30733 , A61F2002/30787 , A61F2002/3081 , A61F2002/30838 , A61F2002/30878 , A61F2002/30884 , A61F2002/30904 , A61F2002/30971 , A61F2002/3401 , A61F2002/3456 , A61F2002/3469 , A61F2002/3495 , A61F2002/3611 , A61F2002/3625 , A61F2002/4662 , A61F2002/488 , A61F2210/0004 , A61F2210/0061 , A61F2230/0006 , A61F2230/0021 , A61F2230/0023 , A61F2250/0014 , A61F2250/0037 , A61F2310/00011 , A61F2310/00179 , A61L27/50
摘要： A method is provided for non-invasively detecting mechanical wear of a prosthetic device implanted in a patient, the method comprises using a non-invasive imaging technique to image the prosthetic device that includes a wear indicating composition; and detecting whether the wear indicating composition has been released from the prosthetic device, and, if so, the location, type, and/or amount thereof. The implant device includes a prosthetic device body having at least one outer surface area; at least one reservoir (e.g., a plurality of discretely spaced micro-reservoirs) in the device body; a wear indicator composition disposed in said at least one reservoir, wherein mechanical wear of the at least one outer surface area of the device body in vivo causes release of at least part of the wear indicator composition. The prosthetic device body may be one for replacement of a hip, a knee, a shoulder, an elbow, or a vertebra.
摘要翻译：提供了一种用于非侵入性地检测植入患者体内的假体装置的机械磨损的方法，所述方法包括使用非侵入性成像技术对包括磨损指示组合物的假体装置进行成像; 并且检测磨损指示组合物是否已经从假体装置释放，以及如果是，则其位置，类型和/或数量。植入装置包括具有至少一个外表面区域的假体装置主体; 装置主体中的至少一个储存器（例如，多个离散地间隔开的微贮器）; 布置在所述至少一个储存器中的磨损指示剂组合物，其中所述装置主体的所述至少一个外表面区域的体内机械磨损导致所述磨损指示剂组合物的至少一部分的释放。假体装置体可以是用于替换髋关节，膝盖，肩部，肘部或椎骨的修复体。

8. 发明申请

WO2013039621A2 METHODS AND SYSTEMS FOR MAKING MICROTABLETS FOR DRUG DELIVERY 审中-公开
标题翻译：制备用于药物递送的微阵列的方法和系统
公开(公告)号：WO2013039621A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/050244
申请日：2012-08-10
申请人： ON DEMAND THERAPEUTICS, INC. , COPPETA, Jonathan, R. , DYER, Robert , STEVENSON, Cynthia, L.
发明人： COPPETA, Jonathan, R. , DYER, Robert , STEVENSON, Cynthia, L.
IPC分类号： A61K39/395 , A61J3/10 , F26B19/00 , F26B5/06 , B01D9/04
CPC分类号： A61K9/19 , A61J3/10 , A61K9/2072 , A61K9/2095 , B30B11/027
摘要： Methods and systems are provided for making a drag micro tablet. The method includes loading a lyophilization capillary channel with a liquid drug solution; lyophilizing the liquid drug solution in the lyophilizalion capillary channel to produce a lyophilized drug formulation; compressing the lyophilized drug formulation in the !yophilization capillary channel, or in a compression, capillary channel, to form a microtablet: and ejecting the microtablet from the lyophilization capillary channel or compression capillary channel. The methods and systems may provide drug microtablets having improved content uniformity and reduced weight variability.
摘要翻译：提供了用于制造拖拉微片的方法和系统。该方法包括用液体药物溶液加载冻干毛细管通道; 将液体药物溶液冻干在冻干毛细管通道中以产生冻干药物制剂; 在冻干毛细管通道或压缩毛细管通道中压缩冻干药物制剂以形成微片，并从冻干毛细通道或压缩毛细管通道喷出微片。所述方法和系统可以提供具有改善的含量均匀性和降低的重量变异性的药物微片。

9. 发明申请

WO2002024295A3 OPTICAL SYSTEM MANUFACTURING AND ALIGNMENT SYSTEM 审中-公开
公开(公告)号：WO2002024295A3
公开(公告)日：2002-03-28
申请号：PCT/US2001/029329
申请日：2001-09-19
申请人： AXSUN TECHNOLOGIES, INC. , JENNER, Robert, K. , FLANDERS, Dale, C. , WHITNEY, Peter, S. , COPPETA, Jonathan, R.
发明人： JENNER, Robert, K. , FLANDERS, Dale, C. , WHITNEY, Peter, S. , COPPETA, Jonathan, R.
IPC分类号： G02B6/42
摘要： An optical component manipulation system (100) has two opposed jaws (120A, 120B), which can each be independently positioned relative to each other in a coordinate plane to thereby effect the desired positioning of optical components (10) within the larger system. Z-axis rigidity is provided by air-bearings (124A, 124B). Laser heating (220) of the jaws is used for solder, or similar heat driven bonding, processes.

10. 发明申请

WO2013023115A1 LASER-ACTIVATED DRUG DELIVERY DEVICE 审中-公开
标题翻译：激光激活药物递送装置
公开(公告)号：WO2013023115A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/050240
申请日：2012-08-10
申请人： ON DEMAND THERAPEUTICS, INC. , COPPETA, Jonathan, R. , DYER, Robert , TANEJA, Vipul , SANTINI, John, T.
发明人： COPPETA, Jonathan, R. , DYER, Robert , TANEJA, Vipul , SANTINI, John, T.
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051 , A61L27/54 , A61L2430/16
摘要： Devices (100, 180, 200, 300, 400, 470) and. methods are provided for selectively- delivering a drug by laser activation. The device includes structural elements forming a hermetic, enclosed reservoir, and at least one drug (140, 240, 340, 440) unit contained in the enclosed reservoir. The at least one drag unit includes a drug. The device is able to absorb laser irradiation effective to open the enclosed reservoir to permit release of the drug. The method includes implanting a drug delivery device into a tissue site of a patient, and irradiating at least a portion of the drug delivery device to breach the enclosed reservoir to permit the drug to be released in tissues at the tissue site.
摘要翻译：设备（100,180,200,300,400,470）和。提供了通过激光激活选择性递送药物的方法。该装置包括形成密封的封闭储存器的结构元件和包含在封闭储存器中的至少一种药物（140,240,340,440）单元。所述至少一个牵引单元包括药物。该装置能够吸收有效打开封闭储存器的激光照射以允许释放药物。该方法包括将药物递送装置植入患者的组织部位，以及照射药物递送装置的至少一部分以破坏封闭的容器以允许药物在组织部位的组织中释放。

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