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1. 发明申请

WO1996028447A1 PYRROLOCARBAZOLE DERIVATIVES 审中-公开
标题翻译：吡咯烷酮衍生物
公开(公告)号：WO1996028447A1
公开(公告)日：1996-09-19
申请号：PCT/JP1996000557
申请日：1996-03-07
申请人： KYOWA HAKKO KOGYO CO., LTD. , IKUINA, Yoji , MURAKATA, Chikara , SAITOH, Yutaka , SHIOTSU, Yukimasa , IIDA, Takako , TAMAOKI, Tatsuya , YAMASHITA, Kinya , AKINAGA, Shiro
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Pyrrolocarbazole derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R represents lower alkyl or aralkyl; R represents hydrogen, optionally substituted lower alkyl, lower alkenyl or optionally substituted aralkyl; R , R , R , R and R are the same or different and each represents hydrogen, halogeno, nitro, optionally substituted lower alkanoyl, NR R or OR ; and R represents hydrogen or forms together with R -CONR -, provided that R , R , R , R , R , R and R do not represent hydrogen at the same time when R is benzyl. The compounds have the effect of promoting the production of thrombocytes and thus are useful in the treatment of thrombocytopenia.
摘要翻译：由通式（I）表示的吡咯并咔唑衍生物或其药理学上可接受的盐，其中R 1表示低级烷基或芳烷基; R 2表示氢，任选取代的低级烷基，低级烯基或任选取代的芳烷基; R 3，R 4，R 5，R 6和R 7相同或不同，各自表示氢，卤代，硝基，任选取代的低级烷酰基，NR 9 R 10 >或OR <11>; R 8表示氢或与R 3 -CONR 12一起形成，条件是R 2，R 3，R 4，R 5，R 6，R 当R 1是苄基时，R 7和R 8不同时代表氢。这些化合物具有促进凝血细胞生成的作用，因此可用于治疗血小板减少症。

2. 发明申请

WO1995034570A1 PROCESS FOR PRODUCING DISACCHARIDES AND NOVEL SACCHARIDES 审中-公开
标题翻译：生产不同品种和新颖食品的方法
公开(公告)号：WO1995034570A1
公开(公告)日：1995-12-21
申请号：PCT/JP1994002060
申请日：1994-12-08
申请人： KYOWA HAKKO KOGYO CO., LTD. , AISAKA, Kazuo , SAITOH, Yutaka , UOSAKI, Youichi
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07H03/08
CPC分类号： C07H3/04 , C12P19/12
摘要： A process for producing a disaccharide by conducting the condensation reaction of beta -glucose-1-phosphate with a monosaccharide in an aqueous medium in the presence of an enzyme source originating in a microorganism of the genus Cattellatospora, Kineosporia, Propionibacterium or Enterococcus and having a sugar phosphorolytic activity, and harvesting the disaccharide formed in the medium. The obtained novel disaccharides are useful as medicine, food, cosmetic and enzyme stabilizer.
摘要翻译：一种通过在起源于卡耳菌属，动球菌属，丙酸杆菌属或肠球菌属的微生物的酶源的存在下在水性介质中进行β-葡萄糖-1-磷酸酯与单糖的缩合反应来生产二糖的方法，糖溶磷活性，并收获培养基中形成的二糖。获得的新型二糖可用作药物，食品，化妆品和酶稳定剂。

3. 发明申请

WO1995008542A1 FARNESYLTRANSFERASE INHIBITOR 审中-公开
标题翻译：农药残留抑制剂
公开(公告)号：WO1995008542A1
公开(公告)日：1995-03-30
申请号：PCT/JP1994001543
申请日：1994-09-20
申请人： KYOWA HAKKO KOGYO CO., LTD. , KANDA, Yutaka , SAITOH, Yutaka , AKASAKA, Kazuhito , MIZUKAMI, Tamio , NAKANO, Hirofumi
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D241/08
CPC分类号： C07D513/08 , A61K31/495 , A61K31/54 , C07D241/08
摘要： A farnesyltransferase inhibitor and an antitumor drug each containing a piperazinedione derivative represented by general formula (I) as the active ingredient, wherein R and R are the same or different from each other and each represents lower alkyl, lower alkoxyalkyl, or (un)substituted aryl or aralkyl; R and R are the same or different from each other and each represents mercapto, lower alkanoylthio, aroylthio, lower alkoxycarbonylthio or aryloxycarbonylthio, or R and R are combined with each other to represent a disulfide bond; and R and R are the same or different from each other and each represents hydrogen, lower alkyl, lower alkoxyalkyl, hydroxyalkyl, lower alkanoyloxyalkyl, aroyloxyalkyl, aralkyloxyalkyl or aralkyl.
摘要翻译：一种法呢基转移酶抑制剂和抗肿瘤药，各自含有由通式（I）表示的哌嗪二酮衍生物作为活性成分，其中R 1和R 2彼此相同或不同，并且各自表示低级烷基，低级烷氧基烷基，或（未）取代的芳基或芳烷基; R 3和R 4彼此相同或不同，并且各自表示巯基，低级烷酰硫基，芳酰硫基，低级烷氧基羰基硫基或芳氧基羰硫基，或R 3和R 4彼此结合以表示二硫键 R 5和R 6彼此相同或不同，各自表示氢，低级烷基，低级烷氧基烷基，羟烷基，低级烷酰氧基烷基，芳酰氧基烷基，芳烷氧基烷基或芳烷基。

4. 发明申请

WO1996033989A1 RADICICOL DERIVATIVES 审中-公开
标题翻译： RADICICOL衍生物
公开(公告)号：WO1996033989A1
公开(公告)日：1996-10-31
申请号：PCT/JP1996001158
申请日：1996-04-26
申请人： KYOWA HAKKO KOGYO CO., LTD. , AGATSUMA, Tsutomu , SAITOH, Yutaka , YAMASHITA, Yoshinori , MIZUKAMI, Tamio , AKINAGA, Shiro , GOMI, Katsushige , AKASAKA, Kazuhito , TAKAHASHI, Isami
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D313/00
CPC分类号： C07D313/00
摘要： Radicicol derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R and R may be the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert -butyldimethylsilyl; and (1) when X represents halogeno, then Y represents oxygen or R -O-N (R being hydrogen or (un)substituted lower alkyl) and R represents hydrogen, alkanoyl, alkenoyl, etc.; while (2) when X is combined with R to represent a single bond, Y represents R -O-N (R being the same as R ). The derivatives have a tyrosine kinase inhibitory activity and thus have various pharmacological activities such as antitumor, antibacterial and immunosuppressive effects.
摘要翻译：由通式（I）表示的脱甲硅烷醇衍生物或其药理学上可接受的盐，其中R 1和R 2可以相同或不同，各自代表氢，链烷酰基，烯酰基或叔丁基二甲基甲硅烷基 ; 和（1）当X表示卤代时，则Y表示氧或R 4 -O-N（R 4表示氢或（取代的）低级烷基），R 3表示氢，烷酰基，烯酰基等。而（2）当X与R 3结合以表示单键时，Y表示R 4B -O-N（R 4与R 4相同）。该衍生物具有酪氨酸激酶抑制活性，因此具有各种药理活性，如抗肿瘤，抗菌和免疫抑制作用。

5. 发明申请

WO1995026573A1 SEMICONDUCTOR DEVICE FOR DETECTING LIGHT AND RADIATION, AND METHOD OF MANUFACTURING THE DEVICE 审中-公开
标题翻译：用于检测光和辐射的半导体器件及其制造方法
公开(公告)号：WO1995026573A1
公开(公告)日：1995-10-05
申请号：PCT/JP1995000559
申请日：1995-03-27
申请人： SEIKO INSTRUMENTS INC. , SAITOH, Yutaka , INOUE, Masahiro , YAMANAKA, Junko , IKEDA, Hirokazu
发明人： SEIKO INSTRUMENTS INC.
IPC分类号： H01L31/112
CPC分类号： H01L27/1443 , H01L27/14658
摘要： A light and radiation detector provided with a semiconductor element in which a MOS transistor and a depletion layer forming means which forms a depletion layer extended to the substrate area of the MOS transistor are formed on the same semiconductor substrate at a prescribed interval and a means which applies a reverse bias voltage to the depletion layer forming means. The detector is further provided with a P-N junction on the semiconductor substrate on which the MOS transistor is formed. The depletion layer resulting from the formation of the P-N junction operates as a detecting section. When light or radiation falls on the depletion layer, the impedance in the detecting section changes with the intensity of the incident light or radiation. Since the substrate potential of the MOS transistor changes with the impedance change, the change of drain current of the MOS transistor is a function of the intensity of the incident light or radiation. The change of the drain current is read out as a detection output. The light and radiation detector is high in operating speed and low in power consumption.
摘要翻译：一种具有半导体元件的光和辐射检测器，其中以规定的间隔在相同的半导体衬底上形成MOS晶体管和形成耗尽层的耗尽层形成装置，所述耗尽层形成装置延伸到MOS晶体管的衬底区域，向耗尽层形成装置施加反向偏置电压。检测器还在其上形成有MOS晶体管的半导体衬底上设置有P-N结。由形成P-N结产生的耗尽层作为检测部分进行操作。当光或辐射落在耗尽层上时，检测部分中的阻抗随入射光或辐射的强度而变化。由于MOS晶体管的衬底电位随着阻抗变化而变化，所以MOS晶体管的漏极电流的变化是入射光或辐射的强度的函数。读出漏极电流的变化作为检测输出。光和辐射检测器的运行速度高，功耗低。

6. 发明申请

WO1995008546A1 EPOXYCYCLOHEXENEDIONE DERIVATIVE 审中-公开
标题翻译：环氧化合物衍生物
公开(公告)号：WO1995008546A1
公开(公告)日：1995-03-30
申请号：PCT/JP1994001542
申请日：1994-09-20
申请人： KYOWA HAKKO KOGYO CO., LTD. , KANEKO, Masami , SAITOH, Yutaka , AKINAGA, Shiro , OKABE, Masami , AKASAKA, Kazuhito , NAKANO, Hirofumi
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D303/36
CPC分类号： C07D303/36
摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C10-C25 linear or branched alkanoyl, C10-C25 linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.
摘要翻译：由通式（I）表示的环氧环己烯二酮衍生物或其药学上可接受的盐，其中R表示C 10 -C 25直链或支链烷酰基，C10-C25直链烯酰基或由式（A）表示的基团，其中n表示1 该化合物具有抗菌和抗肿瘤活性。

7. 发明申请

WO1997037034A1 PHYSIOLOGICALLY ACTIVE SUBSTANCE EI-2128-1 审中-公开
标题翻译：生理活性物质EI-2128-1
公开(公告)号：WO1997037034A1
公开(公告)日：1997-10-09
申请号：PCT/JP1997001135
申请日：1997-04-02
申请人： KYOWA HAKKO CO., LTD. , TANAKA, Takeo , KOIZUMI, Fumito , AGATSUMA, Tsutomu , KONDO, Hidemasa , SAITOH, Yutaka , ANDO, Katsuhiko , MATSUDA, Yuzuru
发明人： KYOWA HAKKO CO., LTD.
IPC分类号： C12P17/04
CPC分类号： C07D493/20 , C12P17/181
摘要： A novel compound EI-2128-1 represented by formula (I) and having an IL-1 production inhibitory effect.
摘要翻译：由式（I）表示的具有IL-1产生抑制作用的新化合物EI-2128-1。

8. 发明申请

WO1997000260A1 DC107 DERIVATIVES 审中-公开
标题翻译： DC107衍生物
公开(公告)号：WO1997000260A1
公开(公告)日：1997-01-03
申请号：PCT/JP1996001646
申请日：1996-06-14
申请人： KYOWA HAKKO KOGYO CO., LTD. , KANDA, Yutaka , SAITOH, Yutaka , SAITO, Hiromitsu , ASHIZAWA, Tadashi , SUGIYAMA, Kazuyo , GOMI, Katsushige , KAKITA, Shingo , TAKAHASHI, Yuichi , MURAKATA, Chikara
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D513/08
CPC分类号： C07D513/08
摘要： DC107 derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R represents hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR , etc.; R represents hydrogen or COR ; R represents lower alkyl, lower alkenyl, aralkyl optionally substituted by optionally substituted aryl, lower alkoxyalkyl, aralkyloxyalkyl, optionally substituted aryloxyalkyl, lower alkoxycarbonylalkyl, lower alkanoyloxy-alkyl, alicyclic alkanoyloxyalkyl, etc., or R forms a single bond together with Y; Y forms a single bond together with R or Z; Z represents hydrogen or forms a single bond together with Y; and W represents oxygen or NR , excluding the compound (DC107) wherein R , R and Z are each hydrogen, R forms a single bond together with Y and W is oxygen.
摘要翻译：由通式（I）表示的DC107衍生物或其药学上可接受的盐，其中R 1表示氢，低级烷氧基烷基，芳烷氧基烷基，低级烷氧基烷氧基烷基，低级烷氧基烷氧基烷氧基烷基，芳烷基，四氢吡喃基，COR4等; R 2表示氢或COR 5; R 3表示低级烷基，低级烯基，任选被任意取代的芳基取代的芳烷基，低级烷氧基烷基，芳烷氧基烷基，任选取代的芳氧基烷基，低级烷氧基羰基烷基，低级烷酰氧基 - 烷基，脂环族烷酰氧基烷基等，或R 3形成单与Y键合; Y与R 3或Z一起形成单键; Z表示氢或与Y一起形成单键; W表示氧或NR 6，不包括其中R 1，R 2和Z各自为氢的化合物（DC107），R 3与Y一起形成单键，W是氧。

9. 发明申请

WO1994012458A1 SAINTOPIN DERIVATIVE 审中-公开
标题翻译： SAINTOPIN衍生物
公开(公告)号：WO1994012458A1
公开(公告)日：1994-06-09
申请号：PCT/JP1993001680
申请日：1993-11-17
申请人： KYOWA HAKKO KOGYO CO., LTD. , NAKANO, Hirofumi , FUJII, Noboru , YAMASHITA, Yoshinori , SAITOH, Yutaka , AGATSUMA, Tsutomu , ANDO, Katsuhiko , NISHIIE, Yasushi , KITA, Katsunori , MORISHIMA, Naoki , GOMI, Katsushige
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07C50/36
CPC分类号： C07C305/26 , C07C50/38 , C07C305/22 , C12P29/00
摘要： A saintopin E derivative represented by general formula (I) and useful as an antibacterial and antitumor agent, wherein when R represents hydrogen, then R represents SO2OH (in the case of UCE1022), while when R represents acetyl, then R represents hydrogen (in the case of saintopin E).
摘要翻译：由通式（I）表示的saintopin E衍生物，可用作抗细菌和抗肿瘤剂，其中当R 1表示氢时，R 2表示SO 2 OH（在UCE1022的情况下），而当R 1表示氢时，表示乙酰基，则R 2表示氢（在saintopin E的情况下）。

10. 发明申请

WO1994006799A1 THROMBOCYTOPENIA REMEDY 审中-公开
标题翻译：硫唑嘌呤补救
公开(公告)号：WO1994006799A1
公开(公告)日：1994-03-31
申请号：PCT/JP1993001346
申请日：1993-09-20
申请人： KYOWA HAKKO KOGYO CO., LTD. , TAMAOKI, Tatsuya , SHIOTSU, Yukimasa , MURAKATA, Chikara , AKINAGA, Shiro , OKABE, Masami , SAITOH, Yutaka , WATANABE, Junichi , SHIRAKI, Takako
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D487/14
CPC分类号： C07D498/22 , C07H9/06 , C07H19/044
摘要： A thrombocytopenia remedy containing an indolocarbazole derivative represented by general formula (I) or a pharmacologically acceptable salt thereof as the active ingredient, and a novel indolocarbazole derivative.
摘要翻译：含有由通式（I）表示的吲哚并咔唑衍生物或其药理学上可接受的盐作为活性成分的血小板减少症药物和新的吲哚并咔唑衍生物。

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