专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1997031103A1 METHOD FOR DETERMINING 1,5-ANHYDROGLUCITOL 审中-公开
标题翻译：用于测定1,5-ANHYDROGLUCITOL的方法
公开(公告)号：WO1997031103A1
公开(公告)日：1997-08-28
申请号：PCT/JP1997000440
申请日：1997-02-19
申请人： KYOWA HAKKO KOGYO CO., LTD. , AISAKA, Kazuo , TAZOE, Sakae , ANDO, Katsuhiko , OCHIAI, Keiko
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C12N09/24
CPC分类号： C12Q1/34 , C12N9/2402 , C12Q1/48 , C12Y302/01028 , G01N2333/355 , G01N2333/924 , Y10S435/872
摘要： A method for determining 1,5-anhydroglucitol characterized by adding 1,5-anhydroglucitol contained in a sample to an enzyme whose activity is inhibited by the glucitol in a concentration-dependent manner and assaying the activity of the enzyme thus inhibited; a reagent for determining 1,5-anhydroglucitol comprising an enzyme whose activity is inhibited by the glucitol in a concentration-dependent manner, a substrate of the enzyme, and a reagent for determining a substance generated by the activity of said enzyme; a novel trehalase having a Ki value of 0.33 mM or below with respect to 1,5-anhydroglucitol; and a process for producing a novel trehalase having the above-mentioned physicochemical property characterized by culturing strains belonging to the genus Nocardia and capable of producing the trehalase in a culture medium and harvesting the trehalase thus produced from the culture.
摘要翻译：一种测定1,5-脱水葡萄糖醇的方法，其特征在于将样品中所含的1,5-脱水葡萄糖醇以浓度依赖性方式抑制葡萄糖醇的活性，并测定被抑制的酶的活性; 一种用于测定1,5-脱水葡萄糖醇的试剂，其包含其浓度依赖性方式的葡萄糖醇的活性被抑制的酶，酶的底物和用于测定由所述酶的活性产生的物质的试剂; 相对于1,5-脱水葡萄糖醇，Ki值为0.33mM以下的新型海藻糖酶; 以及具有上述物理化学性质的新型海藻糖酶的制备方法，其特征在于培养属于诺卡氏菌属的菌株，并能够在培养基中生产海藻糖酶，并从培养物中收获由此产生的海藻糖酶。

2. 发明申请

WO1997029099A1 COMPOUNDS UCT1072 审中-公开
标题翻译：化合物UCT1072
公开(公告)号：WO1997029099A1
公开(公告)日：1997-08-14
申请号：PCT/JP1997000282
申请日：1997-02-06
申请人： KYOWA HAKKO KOGYO CO., LTD. , MIZUKAMI, Tamio , ASAI, Akira , ANDO, Katsuhiko , KAKITA, Shingo , MIHARA, Akira , KITA, Katsunori , SUZUKI, Yasuhiro , ASHIZAWA, Tadashi
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D307/77
CPC分类号： C07D307/77 , C07D493/04 , C12P17/04
摘要： Compounds UCT1072 represented by general formula (I), wherein R and R are united to form -CH(OH)CH2O- or -CH2CH2CH(OH)CH2-.
摘要翻译：由通式（I）表示的化合物UCT1072，其中R 1和R 2结合形成-CH（OH）CH 2 O-或-CH 2 CH 2 CH（OH）CH 2 - 。

3. 发明申请

WO9907872A9 PROCESS FOR THE PREPARATION OF HMG-CoA REDUCTASE INHIBITORS 审中-公开
标题翻译：制备HMG-CoA还原酶抑制剂的方法
公开(公告)号：WO9907872A9
公开(公告)日：2003-06-26
申请号：PCT/JP9803396
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK , TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
发明人： TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
IPC分类号： C12P7/62 , C12P17/06 , C12N1/20
CPC分类号： C12R1/07 , C12P7/62 , C12P17/06
摘要： A process for the preparation of compounds represented by general formula (II-a) (wherein R is hydrogen, optionally substituted alkyl or alkali metal; and R is optionally substituted alkyl or aryl) or lactones (II-b) derived therefrom through ring closure, which comprises treating a compound resulting from a bacillus and represented by general formula (I-a) (wherein R and R are each as described above) or a lactone (I-b) derived therefrom through ring closure with an enzyme source having the activity of forming the compounds (II-a) or (II-b) from the compounds (I-a) or (I-b) in a reaction fluid to form the compound (II-a) or (II-b) in the reaction fluid, and recovering the compound (II-a) or (II-b) from the reaction fluid.
摘要翻译：制备由通式（II-a）表示的化合物（其中R 1为氢，任选取代的烷基或碱金属; R 2为任选取代的烷基或芳基）或内酯（II-b）的方法），其包括处理由芽孢杆菌产生并由通式（Ia）表示的化合物（其中R 1和R 2各自如上所述）或由其衍生的内酯（Ib）通过具有在反应流体中从化合物（Ia）或（Ib）形成化合物（II-a）或（II-b）的活性的酶源的闭环以形成化合物（II-a）或（II -b），并从反应液中回收化合物（II-a）或（II-b）。

4. 发明申请

WO1997037034A1 PHYSIOLOGICALLY ACTIVE SUBSTANCE EI-2128-1 审中-公开
标题翻译：生理活性物质EI-2128-1
公开(公告)号：WO1997037034A1
公开(公告)日：1997-10-09
申请号：PCT/JP1997001135
申请日：1997-04-02
申请人： KYOWA HAKKO CO., LTD. , TANAKA, Takeo , KOIZUMI, Fumito , AGATSUMA, Tsutomu , KONDO, Hidemasa , SAITOH, Yutaka , ANDO, Katsuhiko , MATSUDA, Yuzuru
发明人： KYOWA HAKKO CO., LTD.
IPC分类号： C12P17/04
CPC分类号： C07D493/20 , C12P17/181
摘要： A novel compound EI-2128-1 represented by formula (I) and having an IL-1 production inhibitory effect.
摘要翻译：由式（I）表示的具有IL-1产生抑制作用的新化合物EI-2128-1。

5. 发明申请

WO1995026960A1 PHYSIOLOGICALLY ACTIVE SUBSTANCE EI-1507 审中-公开
标题翻译：生理活性物质EI-1507
公开(公告)号：WO1995026960A1
公开(公告)日：1995-10-12
申请号：PCT/JP1995000625
申请日：1995-03-31
申请人： KYOWA HAKKO KOGYO CO., LTD. , TSUKUDA, Eiji , TANAKA, Takeo , OCHIAI, Keiko , ANDO, Katsuhiko , KONDO, Hidemasa , TESHIBA, Sadao , AGATSUMA, Tsutomu , YOSHIDA, Mayumi , MATSUDA, Yuzuru
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D303/32
CPC分类号： C12P17/02 , C07D303/32
摘要： A physiologically active substance EI-1507 represented by general formula (I), wherein X and Y are combined together to represent oxygen, or each independently represents hydrogen or hydroxyl.
摘要翻译：由通式（I）表示的生理活性物质EI-1507，其中X和Y组合在一起代表氧，或各自独立地表示氢或羟基。

6. 发明申请

WO1994022806A1 PHYSIOLOGICALY ACTIVE SUBSTANCE RES-1149-1 AND DERIVATIVE THEREOF 审中-公开
标题翻译：生理活性物质RES-1149-1及其衍生物
公开(公告)号：WO1994022806A1
公开(公告)日：1994-10-13
申请号：PCT/JP1994000506
申请日：1994-03-29
申请人： KYOWA HAKKO KOGYO CO., LTD. , OGAWA, Tatsuhiro , TANAKA, Takeo , TSUKUDA, Eiji , UOSAKI, Youichi , YOSHIDA, Mayumi , ANDO, Katsuhiko , IWASAKI, Toshiaki , KITA, Katsunori , MATSUDA, Yuzuru
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07C69/013
CPC分类号： A61K31/215 , C07C69/013 , C12P7/62
摘要： A physiologically active substance RES-1149-1 having excellent effects of antagonizing endoserine and suppressing the rise of the intracellular calcium level and represented by general formula (I) and a derivative thereof, wherein R represents C2 - C22 alkyl or alkenyl, (un)substituted aryl or (un)substituted heterocyclic group.
摘要翻译：具有优异的拮抗内啡肽的效果的生理活性物质RES-1149-1，抑制由通式（I）表示的细胞内钙水平升高及其衍生物，其中R表示C2-C22烷基或链烯基，（un）取代的芳基或（未）取代的杂环基。

7. 发明申请

WO1998020150A1 PROCESS FOR PREPARING CHOLESTEROL-LOWERING COMPOUND 审中-公开
标题翻译：制备胆固醇降低化合物的方法
公开(公告)号：WO1998020150A1
公开(公告)日：1998-05-14
申请号：PCT/JP1997004067
申请日：1997-11-07
申请人： KYOWA HAKKO KOGYO CO., LTD. , SAITOH, Chiaki , KUMAZAWA, Hideyo , AISAKA, Kazuo , MIZUKAMI, Toru , KATSUMATA, Ryoichi , ANDO, Katsuhiko , OCHIAI, Keiko , OUCHI, Kozo
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C12P33/00
CPC分类号： C12Y101/99001 , A23K20/189 , A23L5/25 , A23L13/48 , A23L15/25 , A23L17/65 , C12N9/0006 , C12P33/00
摘要： A process for preparing a practical cholesterol-lowering compound by converting the cholesterol contained in a food or feed to coprostanol having very low intestinal absorption by utilizing an enzymatic action. The content of cholesterol in cholesterol-containing materials such as meat, eggs, milk, fishery products, and cooked and processed foods containing these products, or feed for animals, poultry, fish culture and the like is lowered by treating these materials with three enzymes, i.e., a cholesterol dehydrogenase having an optimal pH value in a neutral pH range and a 4-cholesten-3-one dehydrogenase and a coprostan-3-one dehydrogenase both having an optimal pH value in a weakly acidic range, or cells containing these enzymes to convert cholesterol to coprostanol.
摘要翻译：通过利用酶作用将食物或饲料中所含的胆固醇转化为具有非常低肠吸收的coprostanol来制备实用的降胆固醇化合物的方法。通过用三种酶处理这些物质来降低含有含胆固醇的材料如肉，蛋，牛奶，渔业产品中含有这些产品的熟化和加工食品中的胆固醇含量，动物，家禽，鱼类培养物等的饲料即在中性pH范围内具有最佳pH值的胆固醇脱氢酶和在弱酸性范围内具有最佳pH值的4-胆甾烯-3-酮脱氢酶和副雄甾-3-酮脱氢酶，或含有这些的细胞将胆固醇转化为coprostanol的酶。

8. 发明申请

WO1994012458A1 SAINTOPIN DERIVATIVE 审中-公开
标题翻译： SAINTOPIN衍生物
公开(公告)号：WO1994012458A1
公开(公告)日：1994-06-09
申请号：PCT/JP1993001680
申请日：1993-11-17
申请人： KYOWA HAKKO KOGYO CO., LTD. , NAKANO, Hirofumi , FUJII, Noboru , YAMASHITA, Yoshinori , SAITOH, Yutaka , AGATSUMA, Tsutomu , ANDO, Katsuhiko , NISHIIE, Yasushi , KITA, Katsunori , MORISHIMA, Naoki , GOMI, Katsushige
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07C50/36
CPC分类号： C07C305/26 , C07C50/38 , C07C305/22 , C12P29/00
摘要： A saintopin E derivative represented by general formula (I) and useful as an antibacterial and antitumor agent, wherein when R represents hydrogen, then R represents SO2OH (in the case of UCE1022), while when R represents acetyl, then R represents hydrogen (in the case of saintopin E).
摘要翻译：由通式（I）表示的saintopin E衍生物，可用作抗细菌和抗肿瘤剂，其中当R 1表示氢时，R 2表示SO 2 OH（在UCE1022的情况下），而当R 1表示氢时，表示乙酰基，则R 2表示氢（在saintopin E的情况下）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式