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1. 发明申请

WO2011075665A3 BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE 审中-公开
标题翻译： BETA-细胞复制促进其使用的化合物和方法
公开(公告)号：WO2011075665A3
公开(公告)日：2011-11-17
申请号：PCT/US2010061075
申请日：2010-12-17
申请人： HARVARD COLLEGE , BRIGHAM & WOMENS HOSPITAL , JOSLIN DIABETES CENTER INC , ANNES JUSTIN P , MELTON DOUGLAS A , RUBIN LEE L , WEIR GORDON
发明人： ANNES JUSTIN P , MELTON DOUGLAS A , RUBIN LEE L , WEIR GORDON
IPC分类号： C12N5/071 , A61K31/7042 , A61K35/39 , A61P3/10 , C12N5/02
CPC分类号： A61K31/7042 , C12N5/0676 , C12N2500/40 , C12N2501/65 , G01N33/507
摘要： In the invention provides for a method of stimulating or increasing ß-cell replication or growth, by contacting a ß-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK).
摘要翻译：在本发明提供了用于刺激或增加β-细胞复制或生长，由SS-细胞与腺苷激酶抑制剂（ADK）接触的方法，S-腺苷高半胱氨酸水解酶的抑制剂（SAHH）或AMP的活化剂活化蛋白激酶（AMPK）。

2. 发明专利

AU2010330823A1 Beta-cell replication promoting compounds and methods of their use 未知
公开(公告)号：AU2010330823A1
公开(公告)日：2012-07-05
申请号：AU2010330823
申请日：2010-12-17
申请人： JOSLIN DIABETES CENTER INC , HARVARD COLLEGE , BRIGHAM & WOMENS HOSPITAL INC
发明人： ANNES JUSTIN P , MELTON DOUGLAS A , RUBIN LEE L , WEIR GORDON
IPC分类号： A61K31/7042 , A61K35/39 , A61P3/10 , C12N5/02 , C12N5/071
摘要： In the invention provides for a method of stimulating or increasing &bgr;-cell replication or growth, by contacting a &bgr;-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK).

3. 发明专利

CA2784596A1 BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE 未知
公开(公告)号：CA2784596A1
公开(公告)日：2011-06-23
申请号：CA2784596
申请日：2010-12-17
申请人： JOSLIN DIABETES CENTER INC , BRIGHAM & WOMENS HOSPITAL , HARVARD COLLEGE
发明人： ANNES JUSTIN P , MELTON DOUGLAS A , RUBIN LEE L , WEIR GORDON
IPC分类号： C12N5/071 , A61K31/7042 , A61K35/39 , A61P3/10 , C12N5/02
摘要： In the invention provides for a method of stimulating or increasing ß-cell replication or growth, by contacting a ß-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK).

4. 发明专利

SG181703A1 BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE 未知
公开(公告)号：SG181703A1
公开(公告)日：2012-07-30
申请号：SG2012043915
申请日：2010-12-17
申请人： HARVARD COLLEGE , BRIGHAM & WOMENS HOSPITAL , JOSLIN DIABETES CENTER INC
发明人： ANNES JUSTIN P , MELTON DOUGLAS A , RUBIN LEE L , WEIR GORDON
摘要： In the invention provides for a method of stimulating or increasing &bgr;-cell replication or growth, by contacting a &bgr;-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK).

5. 发明公开

EP2513298A4 BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE 审中-公开
标题翻译： β细胞的复制促进剂化合物及其使用方法
公开(公告)号：EP2513298A4
公开(公告)日：2013-03-27
申请号：EP10838303
申请日：2010-12-17
申请人： HARVARD COLLEGE , BRIGHAM & WOMENS HOSPITAL , JOSLIN DIABETES CENTER INC
发明人： ANNES JUSTIN P , MELTON DOUGLAS A , RUBIN LEE L , WEIR GORDON
IPC分类号： C12N5/071 , A61K31/7042 , A61K31/7076 , A61K35/39 , A61P3/10 , C12N5/02 , G01N33/50
CPC分类号： A61K31/7042 , C12N5/0676 , C12N2500/40 , C12N2501/65 , G01N33/507

6. 发明申请

WO2009132083A3 COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS 审中-公开
标题翻译：用于促进PDX1 +胰腺细胞产生的组合物和方法
公开(公告)号：WO2009132083A3
公开(公告)日：2010-03-25
申请号：PCT/US2009041381
申请日：2009-04-22
申请人： HARVARD COLLEGE , GEN HOSPITAL CORP , CHEN SHUIBING , MELTON DOUGLAS A , BOROWIAK MALGORZALA , LAMENZO JULIA , SCHREIBER STUART L , PENG LEE F , RUBIN LEE L , DAVIDOW LANCE , LAM KEVIN
发明人： CHEN SHUIBING , MELTON DOUGLAS A , BOROWIAK MALGORZALA , LAMENZO JULIA , SCHREIBER STUART L , PENG LEE F , RUBIN LEE L , DAVIDOW LANCE , LAM KEVIN
IPC分类号： C12N5/0735 , C12N1/38 , C12N5/071
CPC分类号： C12N5/0678 , C12N5/0606 , C12N5/0676 , C12N2501/115 , C12N2501/119 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2501/42 , C12N2501/727 , C12N2501/998 , C12N2501/999 , C12N2506/02
摘要： Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
摘要翻译：本文公开的某些实施例涉及通过将人胚胎干细胞暴露于有效量的表I所列的至少一种化合物来产生胰腺细胞或胰腺细胞前体的方法，以将人胚胎干细胞分化成胰腺细胞或胰腺细胞细胞前体。还描述了使用这些方法生产的试剂盒和胰腺细胞系。

7. 发明专利

BR112012014925A2 compostos promotores de replicação de células beta e métodos de uso dos mesmos 未知
公开(公告)号：BR112012014925A2
公开(公告)日：2017-03-01
申请号：BR112012014925
申请日：2010-12-17
申请人： JOSLIN DIABETES CENTER INC , HARVARD COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL INC
发明人： ANNES JUSTIN P , MELTON DOUGLAS A , RUBIN LEE L , WEIR GORDON
IPC分类号： A61K35/39 , A61K31/7042 , A61P3/10 , C12N5/02 , C12N5/071
摘要： compostos promotores de replicação de células beta e métodos de uso dos mesmos a invenção fornece um método de estimulação ou aumento da replicação ou crescimento de células por contato de uma célula como um inibidor de adenosina cinase (adk), um inibidor de s-adenosilhomocisteina hidrolase ( sahh) ou um ativador de proteinocinase ativada por amp (ampk).

8. 发明专利

CA3010799A1 TREATMENT WITH GDF11 PREVENTS WEIGHT GAIN, IMPROVES GLUCOSE TOLERANCE AND REDUCES HEPATOSTEATOSIS 未知
公开(公告)号：CA3010799A1
公开(公告)日：2017-07-13
申请号：CA3010799
申请日：2017-01-06
申请人： HARVARD COLLEGE , BRIGHAM & WOMENS HOSPITAL INC
发明人： BARRANDON ORNELLA , POGGLIOLI TOMMASO , MELTON DOUGLAS A , LEE RICHARD T
IPC分类号： A61K38/19 , A61P1/16 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , C07K14/00 , C12N5/071
摘要： Disclosed herein are a means to prevent and/or ameliorate age, disease and obesity associated metabolic diseases, such as diabetes and impaired glucose tolerance. Also disclosed are compositions and methods that relate to the findings that GDF11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis in aged mice administered a high fat diet. In particular, the methods and compositions described herein relate to increasing the level of GDF11 in a subject, thereby treating or preventing the development of obesity in the subject, reducing the metabolic consequences of obesity and improving the subject's metabolic health.

9. 发明专利

HK1257377A1 使用GDF11的治療預防體重增加、改善葡萄糖耐量並且減少肝臟脂肪變性未知
公开(公告)号：HK1257377A1
公开(公告)日：2019-10-18
申请号：HK18116585
申请日：2018-12-26
申请人： HARVARD COLLEGE , BRIGHAM & WOMENS HOSPITAL INC
发明人： BARRANDON ORNELLA , POGGIOLI TOMMASO , MELTON DOUGLAS A , LEE RICHARD T
IPC分类号： A61K20060101 , A61P20060101 , C07K20060101 , C12N20060101

10. 发明申请

WO2010022395A3 METHODS OF REPROGRAMMING CELLS 审中-公开
标题翻译：重编程细胞的方法
公开(公告)号：WO2010022395A3
公开(公告)日：2010-06-10
申请号：PCT/US2009054789
申请日：2009-08-24
申请人： HARVARD COLLEGE , MELTON DOUGLAS A , ZHOU QIAO
发明人： MELTON DOUGLAS A , ZHOU QIAO
IPC分类号： C12N15/63 , C12N5/10 , C12N15/12
CPC分类号： C12N5/0676 , C12N2501/60 , C12N2799/022
摘要： The present invention provides methods of reprogramming cells, for example, directly reprogramming a somatic cell of a first cell type into a somatic cell of a second cell type, are described herein. In particular, the present invention generally relates to methods for reprogramming a cell of an endoderm origin to a cell having pancreatic ß-cell characteristics. The present invention also relates to an isolated population comprising reprogrammed cells, compositions and their use in the treatment of diabetes mellitus. In particular, the present invention relates to reprogramming a cell of an endoderm origin to a cell having pancreatic ß-cell characteristics by increasing the protein expression of at least one transcription factor selected from Pdx1, Ngn3 or MafA in the cell of endoderm origin to reprogram the cell of an endoderm cell to a cell which exhibits at least one or at least two characteristics of an endogenous pancreatic ß-cell.
摘要翻译：本发明提供了重编程细胞的方法，例如，将第一细胞类型的体细胞直接重编程为第二细胞类型的体细胞。具体而言，本发明一般涉及用于将内胚层起源的细胞重编程为具有胰腺β-细胞特征的细胞的方法。本发明还涉及包含重编程细胞的分离群体，组合物及其在治疗糖尿病中的用途。具体而言，本发明涉及通过将选自内胚层来源的细胞中的Pdx1，Ngn3或MafA中的至少一种转录因子的蛋白质表达增加至重编程序，将内胚层来源的细胞重编程为具有胰腺β-细胞特征的细胞将内胚层细胞的细胞与显示内源性胰腺β细胞的至少一种或至少两种特征的细胞接触。

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