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1. 发明专利

JPH0120858B2 失效
公开(公告)号：JPH0120858B2
公开(公告)日：1989-04-18
申请号：JP8879785
申请日：1985-04-26
申请人： SANKYO KK , ROOTO SEIYAKU KK
发明人： MURAYAMA SHOHACHIRO
IPC分类号： A23F3/34 , A23L2/38

2. 发明专利

JPS6176412A Remedy for tragomaschalia 失效
标题翻译：补救措施
公开(公告)号：JPS6176412A
公开(公告)日：1986-04-18
申请号：JP19902984
申请日：1984-09-21
申请人： Rooto Seiyaku Kk , Tsunematsu Takemoto
发明人： TAKEMOTO TSUNEMATSU , HAYASHI SHINICHI , NISHIMOTO KIJU
IPC分类号： A61K8/00 , A61K8/11 , A61K8/97 , A61Q15/00
摘要： PURPOSE: To remedy for tragomaschalia that contains, as an active ingredient, an essence of AMACHAZURU (Gynostemma pentaphyllum Makino), thus showing treating effect by oral administration with low toxicity.
CONSTITUTION: The objective remedy is obtained by using, as an active ingredient, an essence of AMACHAZURU. The essence is obtained by extracting the whole plant with hot water or by drying the plant and crushing it into a powder. when the essence is orally given by 0.05W5g/day, preferably 0.1W2g/day for 6 months, the effect is developed. Since the toxicity of the essence is very low, it can be given for a long period of time.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：治疗含有AMACHAZURU（绞股蓝绞股蓝）的精华作为活性成分的疟原虫，因此通过口服低毒处理效果显着。构成：通过使用AMACHAZURU的精华作为活性成分，获得客观的补救。通过用热水提取整个植物或通过干燥植物并将其粉碎成粉末获得本质。当精华以0.05-5g /天，优选0.1-2g /天口服给药6个月时，发挥作用。由于本质的毒性非常低，可以长时间给予。

3. 发明专利

JPS59130821A Vehicle for direct tableting 失效
标题翻译：直接烘烤车
公开(公告)号：JPS59130821A
公开(公告)日：1984-07-27
申请号：JP628683
申请日：1983-01-17
申请人： Rooto Seiyaku Kk
发明人： MASUMOTO TAKESHI , YOSHIDA AKIYOSHI , HAYASHI SHINICHI
IPC分类号： A61K9/20 , A61K47/00 , A61K47/36
摘要： PURPOSE: To provide the titled vehicle exhibiting excellent bonding property even in the case of high drug content, capable of giving a tablet having excellent disintegrability, and composed of water-insoluble glucan produced by Streptococcus mutans.
CONSTITUTION: The objective vehicle for direct tableting is an insoluble glucan produced by Streptococcus mutans, having swelling and sticking properties and having the following characteristics. (i) The contents of α-1,3-bonded segment, the α-1,6-bonded segment and the branched segment are 30W80mol%, 10W 50mol% and 3W25mol%, respectively, by gas chromatography: (ii) The true density is 1.5W1.8g/cm
3 : (iii) The apparent density is 0.1W0.2g/cm
3 before tapping and 0.3W0.4g/cm
3 after tapping: (iv) sedimentation volume is 14W15cm
3 /g: and (v) It is insoluble in water, dilute acid and organic solvents, and partly soluble in dilute alkali. It is preferable to use Streptococcus mutans OMZ176 strain having the highest productivity of the insoluble glucan.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：即使在药物含量高的情况下也能提供具有优异粘合性的标题载体，能够得到具有优异崩解性的片剂，并且由变形链球菌生产的水不溶性葡聚糖构成。构成：用于直接压片的目标载体是由变形链球菌产生的不溶性葡聚糖，具有溶胀和粘附性质并具有以下特征。（i）通过气相色谱分别，α-1,3-键合片段，α-1,6键合片段和支链片段的含量分别为30-80mol％，10〜50mol％和3-25mol％（ii）真实密度为1.5-1.8g / cm 3：（iii）出料前表观密度为0.1-0.2g / cm 3，攻丝后为0.3-0.4g / cm 3;（iv ）沉淀体积为14-15cm 3 / g，（v）不溶于水，稀酸和有机溶剂，部分溶于稀碱。优选使用具有最高生产能力的不溶性葡聚糖的变形链球菌OMZ176菌株。

4. 发明专利

JP2942087B2 失效
公开(公告)号：JP2942087B2
公开(公告)日：1999-08-30
申请号：JP3481993
申请日：1993-01-29
申请人： ROOTO SEIYAKU KK
发明人： KOIKE TETSUHISA
IPC分类号： G01N33/543

5. 发明专利

JPS59184198A Pfaffocide 失效
标题翻译： PFAFFOCIDE
公开(公告)号：JPS59184198A
公开(公告)日：1984-10-19
申请号：JP5754783
申请日：1983-03-31
申请人： Toshio Odajima , Rooto Seiyaku Kk , Tsunematsu Takemoto
发明人： TAKEMOTO TSUNEMATSU , ODAJIMA TOSHIO , HAYASHI SHINICHI , NISHIMOTO KIJIYUU , NAKAI SHIROU , TAKAGI NORIKO , WATANABE YOSHIE
IPC分类号： C07H15/256 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07H15/24
摘要： NEW MATERIAL:A compound shown by the formula [R
1 is β-D-glucuronopyranosyl, β-D-xylopyranosyl(1→2)-β-D-glucuronopyranosyl, or β-D-xylopyranosyl (1→2)-β-D(6-O-n-butyl or methyl)glucuronopyranosyl; R
2 is H, or β-D-glucopyranosyl].
USE: An antitumor agent.
PREPARATION: Root of Pfaffia paniculata Kuntze is ground, extracted with water or an alcohol, concentrated, its fraction soluble in butanol is purified by column chromatography using active carbon or silica gel, to give a compound shown by the formula.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新物质：由式[R1为β-D-葡糖醛酸吡喃糖基，β-D-吡喃木糖基（12）-β-D-葡萄糖醛酸吡喃糖基或β-D-吡喃木糖基（12）-β-D（6 - 丁基或甲基）葡萄糖醛酸吡喃糖基; R2是H或β-D-吡喃葡萄糖基]。用途：抗肿瘤剂。制备：将茯苓根粉碎，用水或酒精提取，浓缩，其可溶于丁醇的级分通过使用活性炭或硅胶的柱色谱纯化，得到式中所示的化合物。

6. 发明专利

JP2904993B2 失效
公开(公告)号：JP2904993B2
公开(公告)日：1999-06-14
申请号：JP7125892
申请日：1992-03-27
申请人： ROOTO SEIYAKU KK
发明人： TANIZAWA OSAMU , OKAYAMA HIROTO , SAJI FUMITAKA , AZUMA CHIHIRO , KIMURA TADASHI
IPC分类号： A61K38/095 , A61K31/00 , A61K38/00 , A61P13/02 , A61P15/00 , A61P15/04 , C07K14/705 , C07K14/72 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/91 , G01N33/53

7. 发明专利

JPS6136213A Composition for oral cavity application 失效
标题翻译：口腔应用组合物
公开(公告)号：JPS6136213A
公开(公告)日：1986-02-20
申请号：JP15816484
申请日：1984-07-27
申请人： Rooto Seiyaku Kk
发明人： HAYASHI SHINICHI , YOSHIDA AKIYOSHI , KAMETAKA SHIGERU , KOIKE TETSUHISA
IPC分类号： A61K8/00 , A61K8/63 , A61K31/19 , A61K31/215 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/63 , Y10S514/835
摘要： PURPOSE: To provide the titled composition containing a specific 5-membered triterpene compound, exhibiting specific antibacterial activity against Streptococcus mutans, and effective to prevent dental caries.
CONSTITUTION: The objective composition contains the compound of formula (R
1 is CH
3 , CHO or CH
2 O; R
2 and R
3 are CH
3 or COOH; R
4 is H, CH
3 , COOH or COOCH
3 ; R
5 and R
6 are H, CH
3 or OH; A is two H or O), e.g. oleanolic acid, ursonic acid, etc. as essential component. The compound of formula has specific antibacterial activity against S.Mutans and/or an activity to inhibit the adhesion of insoluble glucan produced by S.Mutans and its extoenzyme to the surface of the tooth. The use of a compound having both activities is preferable. The content of the compound in the composition is preferably ≥0.001%(W/V), especially ≥0.01%(W/V).
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：提供含有特异性5元三萜化合物的标题化合物，对变形链球菌具有特异性抗菌活性，有效预防龋齿。构成：目标组合物含有式（R1是CH3，CHO或CH2O; R2和R3是CH3或COOH; R4是H，CH3，COOH或COOCH3; R5和R6是H，CH3或OH; H或O），例如齐墩果酸，尿烷酸等作为必需成分。该化合物对S.Mutans具有特异的抗菌活性和/或抑制由S.Mutans及其精氨酸产生的不溶性葡聚糖与牙齿表面的粘附的活性。优选使用具有两种活性的化合物。组合物中化合物的含量优选> 0.001％（W / V），特别是> = 0.01％（W / V）。

8. 发明专利

JPS5971688A Activation of mycolytic activity of beta-1,3-d-glucanase 失效
标题翻译： BET-1,3-D-GLUCANASE酶活性的活化
公开(公告)号：JPS5971688A
公开(公告)日：1984-04-23
申请号：JP18342182
申请日：1982-10-18
申请人： Rooto Seiyaku Kk
发明人： YOSHIDA AKIYOSHI , KAMETAKA SHIGERU , HAYASHI SHINICHI
IPC分类号： A61K8/00 , A61K8/33 , A61K8/39 , A61K8/40 , A61K8/43 , A61K8/44 , A61K8/66 , A61K38/46 , A61P31/04 , A61Q11/00 , A61Q11/02 , C12N1/06 , C12N9/24 , C12N9/96
CPC分类号： C12Y302/01039 , C12N1/06 , C12N9/244 , C12N9/96 , C12Y302/01006 , Y10S435/824 , Y10S435/83 , Y10S435/839 , Y10S435/911 , Y10S435/917 , Y10S435/945
摘要： PURPOSE: To increase the mycolytic activity of β-1,3-D-glucanase, remarkably, by using β-1,3-D-glucanase together with a specific nonionic surface active agent, a cationic disinfectant, a preservative based on p-hydroxybenzoic acid ester, or a proteinase.
CONSTITUTION: β-1,3-D-glucanase is used in combination with one or more compounds selected from (A) an anionic surface active agent based on N-acyl- sarcosine, (B) a nonionic surface active agent selected from polyoxyethylene alkylphenyl ether, polyoxyethylene alkyl ether and polyoxyethylene polyoxypropylenealkyl ether, (C) a cationic disinfectant selected from benzalkonium chloride, ammonium chloride and chlorhexidine glucuronate, (D) p-hydroxybenzoate-type preservative selected from methylparaben and propylparaben, and (E) a proteinase.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：为了增加β-1,3-D-葡聚糖酶的解毒活性，显着地，通过使用β-1,3-D-葡聚糖酶与特定的非离子表面活性剂，阳离子消毒剂，基于对 - 羟基苯甲酸酯或蛋白酶。构型：β-1,3-D-葡聚糖酶与一种或多种选自（A）基于N-酰基肌氨酸的阴离子表面活性剂的化合物组合使用，（B）非离子表面活性剂，其选自聚氧乙烯烷基苯基乙醚，聚氧乙烯烷基醚和聚氧乙烯聚氧丙烯烷基醚，（C）选自苯扎氯铵，氯化铵和氯己定葡萄糖醛酸盐的阳离子消毒剂，（D）对羟基苯甲酸酯型防腐剂，选自对羟基苯甲酸甲酯和对羟基苯甲酸丙酯，和（E）蛋白酶。

9. 发明专利

JP2955405B2 失效
公开(公告)号：JP2955405B2
公开(公告)日：1999-10-04
申请号：JP24433391
申请日：1991-08-30
申请人： JEI ESU AARU KK , ROOTO SEIYAKU KK
发明人： IMAI SENZO , KODA YOSHIKO , NISHIHARA TOORU , KINOSHITA MASAHIKO
IPC分类号： G01N33/543 , G01N33/545

10. 发明专利

JP2891738B2 失效
公开(公告)号：JP2891738B2
公开(公告)日：1999-05-17
申请号：JP6505690
申请日：1990-03-15
申请人： ROOTO SEIYAKU KK
发明人： KATO TAMAKO , SEKIGUCHI TAMAYO , KAWAGUCHI MAKOTO
IPC分类号： A61K31/205 , A61K31/70 , A61K36/00 , A61K36/18 , A61K36/25 , A61K36/75 , A61K36/81 , A61P1/00 , A61P3/00 , A61P39/02 , A61P43/00 , A61K35/78

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