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1. 发明公开

EP2166938A1 METHOD AND APPARATUS FOR DETECTING NOISE IN AN IMPLANTABLE MEDICAL DEVICE 有权转让
标题翻译：设备中的噪声可植入医疗设备的检测
公开(公告)号：EP2166938A1
公开(公告)日：2010-03-31
申请号：EP08756684.0
申请日：2008-06-04
申请人： MEDTRONIC, INC. , Ritscher, David E.
发明人： KRAUSE, Paul, G. , KLECKNER, Karen J. , LU, Steven Ning , KASZAS, Cameron J. , HEMMING, Michael T.
IPC分类号： A61B5/0456 , A61B5/0464 , A61B5/0468 , A61N1/362 , A61N1/37 , A61B5/046 , A61N1/39
CPC分类号： A61N1/3704 , A61B5/0031 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/7203 , A61N1/3925 , A61N1/3956
摘要： ABSTRACT An implantable medical device and associated method monitor a physiological signal for sensing physiological events and detecting a physiological condition in response to the sensed physiological events. The device senses a first event from the physiological signal, senses a noise signal in the physiological signal and senses a next event from the physiological signal wherein the first event and the next event define a signal interval. The signal interval is declared as a noisy interval in response to the sensed noise signal.

2. 发明申请

WO2005072822A1 CONTROL OF ATRIAL DEFIBRILLATION THERAPY BASED ON HEMODYNAMIC SENSOR FEEDBACK 审中-公开
标题翻译：基于HEMODYNAMIC传感器反馈的ATRIAL DEFIBRILLATION治疗控制
公开(公告)号：WO2005072822A1
公开(公告)日：2005-08-11
申请号：PCT/US2005/001065
申请日：2005-01-12
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , EULER, David, E. , WARMAN, Eduardo, N. , UJHELYI, Michael, R. , MEHRA, Rahul , ZIEGLER, Paul, D. , MUSLEY, Shailesh, K., V. , DISTAD, Charles, E. , RITSCHER, David, E.
发明人： HETTRICK, Douglas, A. , EULER, David, E. , WARMAN, Eduardo, N. , UJHELYI, Michael, R. , MEHRA, Rahul , ZIEGLER, Paul, D. , MUSLEY, Shailesh, K., V. , DISTAD, Charles, E. , RITSCHER, David, E.
IPC分类号： A61N1/37
CPC分类号： A61N1/3702 , A61N1/3621 , A61N1/365 , A61N1/36564 , A61N1/395 , A61N1/3962
摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDs) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
摘要翻译：公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMD）递送的除颤疗法。血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。因此，对于血液动力学良性心律失常，禁止使用除颤疗法。

3. 发明申请

WO2008151231A1 METHOD AND APPARATUS FOR DETECTING NOISE IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于检测可植入医疗装置中的噪声的方法和装置
公开(公告)号：WO2008151231A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065767
申请日：2008-06-04
申请人： MEDTRONIC, INC. , RITSCHER, David E. , KRAUSE, Paul, G. , KLECKNER, Karen J. , LU, Steven Ning , KASZAS, Cameron J. , HEMMING, Michael T.
发明人： KRAUSE, Paul, G. , KLECKNER, Karen J. , LU, Steven Ning , KASZAS, Cameron J. , HEMMING, Michael T.
IPC分类号： A61B5/0456 , A61B5/0464 , A61B5/0468 , A61N1/362 , A61N1/37 , A61B5/046 , A61N1/39
CPC分类号： A61N1/3704 , A61B5/0031 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/7203 , A61N1/3925 , A61N1/3956
摘要： ABSTRACT An implantable medical device and associated method monitor a physiological signal for sensing physiological events and detecting a physiological condition in response to the sensed physiological events. The device senses a first event from the physiological signal, senses a noise signal in the physiological signal and senses a next event from the physiological signal wherein the first event and the next event define a signal interval. The signal interval is declared as a noisy interval in response to the sensed noise signal.
摘要翻译：摘要一种植入式医疗装置和相关联的方法监测用于感测生理事件的生理信号并且响应于感测到的生理事件来检测生理状况。该装置从生理信号感测第一事件，感测生理信号中的噪声信号，并感测来自生理信号的下一个事件，其中第一事件和下一个事件定义信号间隔。响应于感测的噪声信号，信号间隔被声明为噪声间隔。

4. 发明申请

WO2006118854A3 METHOD AND APPARATUS FOR DETECTION OF TACHYARRHYTHMIA USING CYCLE LENGTHS 审中-公开
标题翻译：使用循环长度检测川AR嗪的方法和装置
公开(公告)号：WO2006118854A3
公开(公告)日：2007-08-23
申请号：PCT/US2006015480
申请日：2006-04-24
申请人： MEDTRONIC INC , SARKAR SHANTANU , RITSCHER DAVID E
发明人： SARKAR SHANTANU , RITSCHER DAVID E
IPC分类号： A61B5/0464
CPC分类号： A61B5/0464
摘要： A method and apparatus for detecting atrial arrhythmias and discriminating atrial fibrillation (AF) and organized atrial tachycardia (OAT) that includes defining a threshold detection criteria for a cluster signature evidence metric corresponding to a Lorenz distribution of ventricular cycle lengths representative of AF or OAT. Using a signal containing VCL information, a number of consecutive ventricular cycle lengths are determined during a selected time interval for generating a one-dimensional or a two-dimensional histogram as a numerical representation of a Lorenz plot of VCLs. A number of cluster signature metrics are computed using the stored ventricular cycle length information, and a cluster signature evidence metric is computed from the cluster signature metrics. AF or OAT is detected if a comparative analysis of a corresponding cluster signature evidence metric meets a respective threshold detection criteria.
摘要翻译：一种用于检测心房心律失常和鉴别心房颤动（AF）和组织性房性心动过速（OAT）的方法和装置，其包括定义与代表AF或OAT的心室周期长度的洛伦兹分布相对应的簇签名证据度量的阈值检测标准。使用包含VCL信息的信号，在选择的时间间隔期间确定多个连续心室周期长度，以生成一维或二维直方图作为VCL的洛伦兹图的数值表示。使用存储的心室周期长度信息来计算多个聚类签名度量，并且从集群签名度量计算聚类签名证据度量。如果相应的集群签名证据量度的比较分析满足相应的阈值检测标准，则检测到AF或OAT。

5. 发明申请

WO2009091348A1 METHOD AND APPARATUS FOR DETECTION OF TACHYARRHYTHMIA USING CYCLE LENGTHS 审中-公开
标题翻译：使用循环长度检测TACHYARRHYTHMIA的方法和装置
公开(公告)号：WO2009091348A1
公开(公告)日：2009-07-23
申请号：PCT/US2006/016300
申请日：2006-04-27
申请人： MEDTRONIC, INC. , SARKER, Shantanu , RITSCHER, David, E.
发明人： SARKER, Shantanu , RITSCHER, David, E.
IPC分类号： A61B5/0464 , A61B5/046
CPC分类号： A61B5/0464 , A61B5/046
摘要： A multi-layer method for detecting atrial arrhythmias using ventricular cycle length information that includes performing a base layer algorithm for detecting the onset and offset of an atrial tachyarrhythmia. The multi-layer method further includes one or more higher layer algorithms executed in response to a base layer detection to confirm or reject the base layer detection. The base layer is designed to operate with high sensitivity to atrial fibrillation and/or organized atrial tachycardia and the higher layer is designed to operate with high sensitivity and high specificity to atrial fibrillation and/or organized atrial tachycardia.
摘要翻译：一种用于使用心室周期长度信息来检测心房心律失常的多层方法，其包括执行用于检测心房快速性心律失常的发作和偏移的基本层算法。多层方法还包括响应于基层检测而执行的一个或多个更高层算法来确认或拒绝基层检测。基层被设计为以高灵敏度对心房颤动和/或有组织的心房心动过速进行操作，并且较高层被设计为以高灵敏度和高特异性对心房颤动和/或有组织的心房心动过速进行操作。

6. 发明申请

WO2004098704A1 METHOD FOR ELIMINATION OF VENTRICULAR PRO-ARRHYTHMIC EFFECT CAUSED BY ATRIAL THERAPY 审中-公开
标题翻译：消除由ATRIAL治疗引起的心房性心律失常效应的方法
公开(公告)号：WO2004098704A1
公开(公告)日：2004-11-18
申请号：PCT/US2004/013328
申请日：2004-04-29
申请人： MEDTRONIC, INC. , GILLBERG, jeffrey, M. , RITSCHER, David, E. , BROWN, Mark, L.
发明人： RITSCHER, David, E. , BROWN, Mark, L.
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： A system and method are provided for controlling atrial anti-tachycardia pacing (ATP) delivery based on detection of ventricular pro-arrhythmia during or immediately after atrial ATP. Ventricular pro-arrhythmia is detected based on one or more criteria relating to pro-arrhythmic changes including, but not limited to, ventricular rate changes, R-wave morphology changes, and/or 1:1 or nearly 1:1 atrial-ventricular conduction patterns persisting at high ventricular rates. Upon detecting ventricular pro-arrhythmia, a current atrial ATP sequence is aborted. Atrial ATP therapies may subsequently be temporarily or permanently disabled.
摘要翻译：提供了一种系统和方法，用于基于在心房ATP期间或之后立即检测心室心律失常来控制心房抗心动过速起搏（ATP）递送。基于与心律失常变化相关的一个或多个标准检测心室心律失常，包括但不限于心室率变化，R波形态变化和/或1：1或接近1：1心房 - 心室传导模式持续高心率。当检测到心室心律失常时，当前的心房ATP序列被中止。心房ATP疗法随后可能被暂时或永久禁用。

7. 发明申请

WO2010033407A1 TIME BASED ARRHYTHMIA THERAPY EFFICACY CRITERIA 审中-公开
标题翻译：基于时间的ARRHYTHMIA治疗效果标准
公开(公告)号：WO2010033407A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/056327
申请日：2009-09-09
申请人： MEDTRONIC, INC. , GILLIS, Anne, M. , ANDERSON, Katherine, H. , HETTRICK, Douglas, A. , RITSCHER, David, E.
发明人： GILLIS, Anne, M. , ANDERSON, Katherine, H. , HETTRICK, Douglas, A. , RITSCHER, David, E.
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61B5/0215 , A61B5/0464 , A61B5/11 , A61B5/145 , A61B5/7264 , A61N1/3624 , A61N1/3962
摘要： An implantable medical device and associated method classify therapy outcomes and heart rhythms in association with therapy outcome. A therapy success time interval is started in response to delivering an arrhythmia therapy. If normal sinus rhythm is detected after the therapy success time interval expires, the delivered therapy is classified as unsuccessful and the detected arrhythmia is classified as a self-terminating rhythm.
摘要翻译：可植入医疗器械和相关方法将治疗结果和心律相结合的治疗结果进行分类。响应于递送心律失常疗法开始治疗成功时间间隔。如果治疗成功时间间隔到期后检测到正常的窦性心律，则将所传递的治疗分类为不成功，并将检测到的心律失常归类为自终止节律。

8. 发明申请

WO2006118854A2 METHOD AND APPARATUS FOR DETECTION OF TACHYARRHYTHMIA USING CYCLE LENGTHS 审中-公开
标题翻译：使用循环长度检测川AR嗪的方法和装置
公开(公告)号：WO2006118854A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/015480
申请日：2006-04-24
申请人： MEDTRONIC, INC. , SARKAR, Shantanu , RITSCHER, David, E.
发明人： SARKAR, Shantanu , RITSCHER, David, E.
IPC分类号： A61B5/0464
CPC分类号： A61B5/0464
摘要： A method and apparatus for detecting atrial arrhythmias and discriminating atrial fibrillation (AF) and organized atrial tachycardia (OAT) that includes defining a threshold detection criteria for a cluster signature evidence metric corresponding to a Lorenz distribution of ventricular cycle lengths representative of AF or OAT. Using a signal containing VCL information, a number of consecutive ventricular cycle lengths are determined during a selected time interval for generating a one-dimensional or a two-dimensional histogram as a numerical representation of a Lorenz plot of VCLs. A number of cluster signature metrics are computed using the stored ventricular cycle length information, and a cluster signature evidence metric is computed from the cluster signature metrics. AF or OAT is detected if a comparative analysis of a corresponding cluster signature evidence metric meets a respective threshold detection criteria.
摘要翻译：一种用于检测心房心律失常和鉴别心房颤动（AF）和组织性房性心动过速（OAT）的方法和装置，其包括定义与代表AF或OAT的心室周期长度的洛伦兹分布相对应的簇签名证据度量的阈值检测标准。使用包含VCL信息的信号，在选择的时间间隔期间确定多个连续心室周期长度，以生成一维或二维直方图作为VCL的洛伦兹图的数值表示。使用存储的心室周期长度信息来计算多个聚类签名度量，并且从集群签名度量计算聚类签名证据度量。如果相应的集群签名证据量度的比较分析满足相应的阈值检测标准，则检测到AF或OAT。

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