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1. 发明申请

WO2006118854A2 METHOD AND APPARATUS FOR DETECTION OF TACHYARRHYTHMIA USING CYCLE LENGTHS 审中-公开
标题翻译：使用循环长度检测川AR嗪的方法和装置
公开(公告)号：WO2006118854A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/015480
申请日：2006-04-24
申请人： MEDTRONIC, INC. , SARKAR, Shantanu , RITSCHER, David, E.
发明人： SARKAR, Shantanu , RITSCHER, David, E.
IPC分类号： A61B5/0464
CPC分类号： A61B5/0464
摘要： A method and apparatus for detecting atrial arrhythmias and discriminating atrial fibrillation (AF) and organized atrial tachycardia (OAT) that includes defining a threshold detection criteria for a cluster signature evidence metric corresponding to a Lorenz distribution of ventricular cycle lengths representative of AF or OAT. Using a signal containing VCL information, a number of consecutive ventricular cycle lengths are determined during a selected time interval for generating a one-dimensional or a two-dimensional histogram as a numerical representation of a Lorenz plot of VCLs. A number of cluster signature metrics are computed using the stored ventricular cycle length information, and a cluster signature evidence metric is computed from the cluster signature metrics. AF or OAT is detected if a comparative analysis of a corresponding cluster signature evidence metric meets a respective threshold detection criteria.
摘要翻译：一种用于检测心房心律失常和鉴别心房颤动（AF）和组织性房性心动过速（OAT）的方法和装置，其包括定义与代表AF或OAT的心室周期长度的洛伦兹分布相对应的簇签名证据度量的阈值检测标准。使用包含VCL信息的信号，在选择的时间间隔期间确定多个连续心室周期长度，以生成一维或二维直方图作为VCL的洛伦兹图的数值表示。使用存储的心室周期长度信息来计算多个聚类签名度量，并且从集群签名度量计算聚类签名证据度量。如果相应的集群签名证据量度的比较分析满足相应的阈值检测标准，则检测到AF或OAT。

2. 发明申请

WO2012135775A1 HEART FAILURE MONITORING 审中-公开
标题翻译：心力衰竭监测
公开(公告)号：WO2012135775A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/031708
申请日：2012-03-30
申请人： MEDTRONIC, INC. , SARKAR, Shantanu , REDEMSKE, Jodi L. , WARMAN, Eduardo N. , HETTRICK, Douglas A. , OUSDIGIAN, Kevin T.
发明人： SARKAR, Shantanu , REDEMSKE, Jodi L. , WARMAN, Eduardo N. , HETTRICK, Douglas A. , OUSDIGIAN, Kevin T.
IPC分类号： A61B5/00
CPC分类号： A61B5/0006 , A61B5/0004 , A61B5/7275 , G06F19/00 , G06F19/3418 , G16H40/40 , G16H50/30
摘要： Techniques for transmitting diagnostic information stored in an implantable medical device (IMD) based on patient hospitalization are described. For example, the IMD may transmit higher resolution diagnostic information to a clinician and/or an external device during a hospitalization period to aid the clinician in evaluating heart failure treatment and when discharge is proper. This higher resolution diagnostic information may include one or more patient metrics automatically generated and transmitted by the IMD at least once every two hours. During a post-hospitalization period, the IMD may transmit lower resolution diagnostic information to a clinician that indicates a risk level of re-hospitalization. The lower resolution diagnostic information may include the risk level and/or patient metrics once a day, for example. In this manner, the IMD transmitted diagnostic information may be tailored to the specific heart failure monitoring needed by the patient.
摘要翻译：描述了基于患者住院时间传送存储在可植入医疗装置（IMD）中的诊断信息的技术。例如，IMD可以在住院期间向临床医师和/或外部设备传送更高分辨率的诊断信息，以帮助临床医师评价心力衰竭治疗以及放电是否合适。该更高分辨率的诊断信息可以包括由IMD自动生成和发送的至少每两小时一次的一个或多个患者度量。在住院后期间，IMD可以向临床医生传递较低分辨率的诊断信息，指示重新住院的风险水平。例如，较低分辨率诊断信息可以包括一天一次的风险水平和/或患者度量。以这种方式，IMD传输的诊断信息可以针对患者所需的特定心力衰竭监测。

3. 发明申请

WO2012125226A1 APPARATUS FOR NOISE REJECTION IN ATRIAL ARRHYTHMIA DETECTION 审中-公开
标题翻译：阿司匹林雷诺霉素检测中的噪声抑制装置
公开(公告)号：WO2012125226A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/022342
申请日：2012-01-24
申请人： MEDTRONIC, INC. , SARKAR, Shantanu
发明人： SARKAR, Shantanu
IPC分类号： A61B5/0402 , A61N1/362 , A61N1/37
CPC分类号： A61N1/371 , A61B5/0402 , A61B5/686 , A61B5/7203 , A61N1/3621
摘要： A medical device performs a method for determining a cardiac event by obtaining a signal comprising cardiac cycle length information in a patient and determining cardiac cycle lengths during an established time interval. Noise is detected during the time interval and a cardiac cycle length corresponding to a time of the detected noise is rejected. Cycle length differences are determined from the cycle lengths not rejected during the time interval. The cardiac event is determined in response to the cycle length differences.
摘要翻译：医疗装置通过获得包括患者心脏周期长度信息的信号并且在建立的时间间隔内确定心动周期长度来执行用于确定心脏事件的方法。在时间间隔期间检测到噪声，并且拒绝与检测到的噪声的时间相对应的心脏周期长度。周期长度差异是从时间间隔内未被拒绝的周期长度确定的。心脏事件是根据周期长度差异来确定的。

4. 发明申请

WO2012125225A1 METHODS FOR ECTOPY REJECTION FOR ATRIAL FIBRILLATION DETECTION BASED ON VENTRICULAR CYCLE LENGTHS 审中-公开
标题翻译：基于静脉循环长度的急性心肌梗死检测方法
公开(公告)号：WO2012125225A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/022337
申请日：2012-01-24
申请人： MEDTRONIC, INC. , SARKAR, Shantanu , WARMAN, Eduardo N.
发明人： SARKAR, Shantanu , WARMAN, Eduardo N.
IPC分类号： A61B5/00 , A61N1/362 , A61N1/368
CPC分类号： A61B5/0468 , A61B5/7282 , A61N1/3624 , A61N1/395
摘要： A medical device performs a method to classify a cardiac rhythm. Differences between cycle lengths in a first heart chamber are determined during an established time interval. Evidence of ectopy associated with irregular coupling intervals is detected from the signal during the established time interval. A rhythm classification output corresponding to a second heart chamber at the expiration of the established time interval is provided in response to the consecutive cycle length differences and the evidence of ectopy associated with irregular coupling intervals.
摘要翻译：医疗器械执行心律的分类方法。在建立的时间间隔期间确定第一心室中的循环长度之间的差异。在建立的时间间隔期间从信号中检测到与不规则耦合间隔相关的异常的证据。响应于连续循环长度差异和与不规则耦合间隔相关联的异常的证据，提供对应于在建立的时间间隔期满时的第二心室的节律分类输出。

5. 发明申请

WO2010051123A1 INTRATHORACIC IMPEDANCE MEASUREMENT FOR COMPUTING A MAP OF THORACIC CONDUCTIVITY 审中-公开
标题翻译：用于计算导管电导率的静态阻抗测量
公开(公告)号：WO2010051123A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/059152
申请日：2009-10-01
申请人： MEDTRONIC, INC. , HETTRICK, Douglas A. , SARKAR, Shantanu , ZIELINSKI, Todd M. , KNOX, Kevin P.
发明人： HETTRICK, Douglas A. , SARKAR, Shantanu , ZIELINSKI, Todd M. , KNOX, Kevin P.
IPC分类号： A61B5/053
CPC分类号： A61B5/0536 , A61B5/0537 , A61B5/0538 , A61B5/4878
摘要： An implantable medical device and associated methods monitor thoracic fluid status and discriminate thoracic fluid conditions. Intrathoracic impedance is measured along multiple intrathoracic measurement vectors using implanted electrodes. A map of thoracic conductivity is computed using the measured intrathoracic impedances. A thoracic fluid condition is detected in response to the computed map.
摘要翻译：可植入医疗器械及相关方法监测胸腔液状况并辨别胸腔液体状况。使用植入电极沿多个胸腔内测量载体测量胸内阻抗。使用测量的胸腔内阻抗计算胸导电图。根据计算的图检测胸部液体状况。

6. 发明申请

WO2010014070A1 DETECTING WORSENING HEART FAILURE BASED ON IMPEDANCE MEASUREMENTS 审中-公开
标题翻译：基于阻抗测量检测心脏衰竭的心脏衰竭
公开(公告)号：WO2010014070A1
公开(公告)日：2010-02-04
申请号：PCT/US2008/009336
申请日：2008-07-31
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , STADLER, Robert, W. , SARKAR, Shantanu
发明人： HETTRICK, Douglas, A. , STADLER, Robert, W. , SARKAR, Shantanu
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/746
摘要： Techniques for processing impedance data to provide an early warning for heart failure decompensation are described. An example device may be configured to measure intrathoracic impedance values, and increment an index when a determined impedance is less than a reference impedance. The incrementing may be based on the difference between the reference impedances and the determined impedance. In some examples, the amount of incrementing is reduced based on a variability of the impedances, or increased over time so long as the index remains above a threshold, e.g., zero. In some examples, the manner is which the reference impedances are determined changes over time to, for example, address rapid changes in impedance after device or system implantation. In some examples, the index is compared to a threshold to determine whether to provide an alert. In some examples, two thresholds are used to provide hysteresis.
摘要翻译：描述了用于处理阻抗数据以提供心力衰竭失代偿的早期警告的技术。示例性装置可以被配置为测量胸内阻抗值，并且当确定的阻抗小于参考阻抗时增加指数。增量可以基于参考阻抗和确定的阻抗之间的差异。在一些示例中，只要索引保持高于阈值（例如零），基于阻抗的可变性减小增量的量，或随时间增加。在一些示例中，确定参考阻抗的方式随时间而变化，例如，在器件或系统植入之后，阻抗的快速变化。在一些示例中，将索引与阈值进行比较，以确定是否提供警报。在一些示例中，使用两个阈值来提供滞后。

7. 发明申请

WO2009134581A1 MULTI-FREQUENCY IMPEDANCE MONITORING SYSTEM 审中-公开
标题翻译：多频阻抗监测系统
公开(公告)号：WO2009134581A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/039314
申请日：2009-04-02
申请人： MEDTRONIC, INC. , ZIELINSKI, Todd, M. , HETTRICK, Douglas, A. , SARKAR, Shantanu
发明人： ZIELINSKI, Todd, M. , HETTRICK, Douglas, A. , SARKAR, Shantanu
IPC分类号： A61B5/05
CPC分类号： A61B5/0809 , A61B5/053 , A61B5/0538 , A61B5/4869 , A61B5/686 , A61B5/7257 , A61N1/36521
摘要： A system and method is provided to measure intrathoracic complex impedance and to identify and indicate disease conditions based on the impedance measurements. Multiple impedance vectors may be taken into account, and an optimal vector may be selected to provide the most useful impedance measurement for the identification and indication of disease conditions.
摘要翻译：提供了一种系统和方法来测量胸腔内复合阻抗，并根据阻抗测量来识别和指示疾病状况。可以考虑多个阻抗矢量，并且可以选择最佳矢量以提供用于疾病状况的识别和指示的最有用的阻抗测量。

8. 发明申请

WO2009131768A1 PRESSURE AND IMPEDANCE BASED DISCRIMINATION OF HEMODYNAMIC STABILITY 审中-公开
标题翻译：基于压力和阻力的血液动力学稳定性的辨别
公开(公告)号：WO2009131768A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/037109
申请日：2009-03-13
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , VINCENT, Kevin, P. , SARKAR, Shantanu , CHO, Yong, K. , ZIELINSKI, Todd, M.
发明人： HETTRICK, Douglas, A. , VINCENT, Kevin, P. , SARKAR, Shantanu , CHO, Yong, K. , ZIELINSKI, Todd, M.
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/36585 , A61B5/0535 , A61B5/0538 , A61B5/7264 , A61N1/00 , A61N1/36521 , A61N1/36564 , A61N1/3962
摘要： An implantable cardioverter defibrillator evaluates the hemodynamic stability of an arrhythmia to determine whether or not to defibrillate. The device obtains cardiac pressure and cardiac impedance data and evaluates a phase relationship between these parameters. Hemodynamically stable rhythms will result in an out of phase relationship.
摘要翻译：植入式心律转复除颤器评估心律失常的血液动力学稳定性，以确定是否除颤。该装置获得心脏压力和心脏阻抗数据，并评估这些参数之间的相位关系。血液动力学稳定的节律将导致异相关系。

9. 发明申请

WO2008055002A1 METHODS AND APPARATUS FOR MANUALLY SUSPENDING INTRATHORACIC IMPEDANCE FLUID STATUS MEASUREMENTS 审中-公开
标题翻译：手术阻塞流体状态测量的方法和装置
公开(公告)号：WO2008055002A1
公开(公告)日：2008-05-08
申请号：PCT/US2007/081716
申请日：2007-10-18
申请人： MEDTRONIC, INC. , VITENSE, Holly, S. , WANG, Li , DIRNBERGER, Denise , RHODES, Melissa, M. , HETTRICK, Douglas, A. , SARKAR, Shantanu
发明人： VITENSE, Holly, S. , WANG, Li , DIRNBERGER, Denise , RHODES, Melissa, M. , HETTRICK, Douglas, A. , SARKAR, Shantanu
IPC分类号： A61B5/00
CPC分类号： A61N1/37258 , A61B5/0031 , A61B5/0215 , A61B5/053 , A61N1/37247 , G16H40/63
摘要： The capability to suspend a patient alert relating to a monitored physiologic parameters addresses a need to selectively shut off a patient-alert signal or signals during the time a patient is being treated for an excursion in the parameter. Of course, in general a signal call attention to a patient's a potentially deleterious status or condition for which they should seek medical attention. Once a chronically-implanted monitoring device has detected or provided information about the parameter relative to a desired value, trend, or range and a clinician has been notified and intervened the alert signal is temporarily disabled for a predetermined period. That is, once the notification occurs and alert has served its purpose, the alert mechanism is selectively deactivated while the patient ostensibly begins to gradually correct the monitored physiologic parameter under a caregiver's direction and control. After which time, the alert will reactivate.
摘要翻译：暂停与所监测的生理参数相关的患者警报的能力解决了在患者被治疗参数期间偏移的时间期间选择性地切断病人警报信号或信号的需要。当然，一般来说，一个信号会引起对患者的一个潜在的有害的状态或状况的关注，他们应该寻求医疗护理。一旦长期植入的监测装置已经相对于期望值，趋势或范围已经检测或提供了关于参数的信息，并且已通知临床医生并且中介了警报信号暂时禁用预定时间段。也就是说，一旦通知发生并且警报已经达到其目的，则警告机制被选择性地去激活，同时患者表面上开始逐渐校正受照顾者的方向和控制下的监测的生理参数。之后，警报将重新启动。

10. 发明申请

WO2010056426A1 HEART FAILURE DECOMPENSATION DETERMINATION 审中-公开
标题翻译：心脏衰竭解决决定
公开(公告)号：WO2010056426A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/059151
申请日：2009-10-01
申请人： MEDTRONIC, INC. , CHO, Yong, K. , SARKAR, Shantanu , HETTRICK, Douglas, A. , TAEPKE, Robert, T., II
发明人： CHO, Yong, K. , SARKAR, Shantanu , HETTRICK, Douglas, A. , TAEPKE, Robert, T., II , BENNETT, Thomas, D.
IPC分类号： A61B5/021 , A61B5/053
CPC分类号： A61B5/0452 , A61B5/0215 , A61B5/053 , A61B5/0538 , A61N1/3627 , A61N1/36521 , A61N1/36564
摘要： Heart failure decompensation is detected by sensing at least one physiological signal. Values of at least two different heart failure variables are derived using one or more physiological signals and a threshold for the first heart failure variable is adjusted in response to the value of the second heart failure variable. The value of the first heart failure variable is compared to first threshold for detecting a heart failure condition.
摘要翻译：通过感测至少一个生理信号来检测心力衰竭失代偿。使用一个或多个生理信号导出至少两个不同的心力衰竭变量的值，并且响应于第二心力衰竭变量的值调整第一心力衰竭变量的阈值。将第一心力衰竭变量的值与用于检测心力衰竭状况的第一阈值进行比较。

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