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1. 发明申请

WO2005072822A1 CONTROL OF ATRIAL DEFIBRILLATION THERAPY BASED ON HEMODYNAMIC SENSOR FEEDBACK 审中-公开
标题翻译：基于HEMODYNAMIC传感器反馈的ATRIAL DEFIBRILLATION治疗控制
公开(公告)号：WO2005072822A1
公开(公告)日：2005-08-11
申请号：PCT/US2005/001065
申请日：2005-01-12
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , EULER, David, E. , WARMAN, Eduardo, N. , UJHELYI, Michael, R. , MEHRA, Rahul , ZIEGLER, Paul, D. , MUSLEY, Shailesh, K., V. , DISTAD, Charles, E. , RITSCHER, David, E.
发明人： HETTRICK, Douglas, A. , EULER, David, E. , WARMAN, Eduardo, N. , UJHELYI, Michael, R. , MEHRA, Rahul , ZIEGLER, Paul, D. , MUSLEY, Shailesh, K., V. , DISTAD, Charles, E. , RITSCHER, David, E.
IPC分类号： A61N1/37
CPC分类号： A61N1/3702 , A61N1/3621 , A61N1/365 , A61N1/36564 , A61N1/395 , A61N1/3962
摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDs) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
摘要翻译：公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMD）递送的除颤疗法。血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。因此，对于血液动力学良性心律失常，禁止使用除颤疗法。

2. 发明申请

WO2004089447A1 APPARATUS AND SYSTEM FOR DELIVERY OF DRUG THERAPIES 审中-公开
标题翻译：用于输送药物治疗的装置和系统
公开(公告)号：WO2004089447A1
公开(公告)日：2004-10-21
申请号：PCT/US2004/010428
申请日：2004-04-05
申请人： MEDTRONIC, INC. , UIJHELYI, Michael, R. , MEHRA, Rahul , MIN, Xiaoyi
发明人： UIJHELYI, Michael, R. , MEHRA, Rahul , MIN, Xiaoyi
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M5/14244 , A61M5/16813 , A61M2205/0266 , A61N1/0568
摘要： A medical delivery system for delivering a fluid to a desired location within a body that includes a first member (204) having an aperture (206), and a second member (202) adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device (209), formed by at least one of the first member and the second member. The medical delivery system includes means (214, 222) made from shape memory allay for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture, thus to form a kind of shutter or slide valve.
摘要翻译：一种用于将流体输送到主体内的期望位置的医疗输送系统，该医疗输送系统包括具有孔（206）的第一构件（204）和适于定位在第一构件上方的第二构件（202）。待输送的流体被包含在由第一构件和第二构件中的至少一个形成的流体存储装置（209）内。医疗输送系统包括由形状记忆体制成的装置（214,222），用于在通过孔的流体的第一状态阻止通道和能够使流体从外部流出的第二状态之间重新定位第一构件相对于第二构件流体存储装置通过孔，从而形成一种快门或滑阀。

3. 发明申请

WO2013120525A1 GENERATING FINGERPRINTED CONTENT DATA FOR PROVISION TO RECEIVERS 审中-公开
标题翻译：产生用于接收者的指纹内容数据
公开(公告)号：WO2013120525A1
公开(公告)日：2013-08-22
申请号：PCT/EP2012/052625
申请日：2012-02-15
申请人： IRDETO BV , PICKERING, Anthony , MEHRA, Rahul , HIETBRINK, Erik
发明人： PICKERING, Anthony , MEHRA, Rahul , HIETBRINK, Erik
IPC分类号： H04N21/234 , H04N21/2343 , H04N21/8358 , H04N21/4405 , H04N21/2389 , G06T1/00 , H04N21/2347
CPC分类号： H04L9/3247 , H04L2209/608 , H04N21/234345 , H04N21/23476 , H04N21/23892 , H04N21/23897 , H04N21/44055 , H04N21/8358
摘要： A method for generating, from initial content data, output content data for provision to one or more receivers, wherein the initial content data is encoded according to a coding scheme, wherein for a quantity of data encoded according to the coding scheme, the coding scheme provides a mechanism for including in the quantity of encoded data additional data such that a decoder for the coding scheme, upon decoding the quantity of encoded data, does not use the additional data to generate decoded data, the method comprising: selecting one or more portions of the initial content data; for each selected portion, generating a data construct that comprises a plurality of data structures, each data structure comprising data, including a version of the selected portion, that is encrypted using a corresponding encryption process different from each encryption process used to encrypt data in the other data structures, wherein the data construct is arranged such that using a decryption process that corresponds to the encryption process for one data structure on the encrypted data in each data structure in the data construct produces a quantity of data encoded according to the coding scheme that uses the mechanism so that a decoder for the coding scheme would not use any data structure in the data construct other than said one data structure; and using the generated data constructs in the initial content data instead of their corresponding selected portions to form the output content data.
摘要翻译：一种用于从初始内容数据生成用于提供给一个或多个接收器的输出内容数据的方法，其中，根据编码方案对初始内容数据进行编码，其中对于根据编码方案编码的数据量，编码方案提供了一种用于在编码数据量中包括附加数据的机制，使得用于编码方案的解码器在解码编码数据量时不使用附加数据来生成解码数据，该方法包括：选择一个或多个部分的初始内容数据; 对于每个所选择的部分，生成包括多个数据结构的数据结构，每个数据结构包括数据，包括所选部分的版本，其使用与用于加密数据的每个加密过程不同的对应加密过程进行加密其他数据结构，其中数据结构被布置为使得对应于数据结构中的每个数据结构中的加密数据的一个数据结构的加密处理的解密处理产生根据编码方案编码的数据量，使用该机制，使得用于编码方案的解码器不会在除所述一个数据结构之外的数据结构中使用任何数据结构; 以及在初始内容数据中使用生成的数据结构而不是其对应的所选部分来形成输出内容数据。

4. 发明申请

WO2004098707A3 AUTOMATIC ADJUSTING R-WAVE SYNCHRONIZATION ALGORITHM FOR ATRIAL CARDIOVERSION AND DEFIBRILLATION 审中-公开
标题翻译：自动调整R波同步算法用于ATRIAL CARDIOVERSION和DEFIBRILLATION
公开(公告)号：WO2004098707A3
公开(公告)日：2006-02-09
申请号：PCT/US2004011748
申请日：2004-04-16
申请人： MEDTRONIC INC , MONGEON LUC R , MEHRA RAHUL
发明人： MONGEON LUC R , MEHRA RAHUL
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3987
摘要： An implantable medical device system and method are provided for synchronizing atrial cardioversion shocks to the ventricular rhythm using an adjustable atrial cardioversion/defibrillation ventricular refractory period. Upon determining a need for an atrial shock therapy, the method determines if the ventricular rate meets synchronization criteria based on an upper ventricular refractory period limit. If synchronization criteria are not met, the refractory period is automatically adjusted in stepwise decrements until the synchronization criteria are met, or until a lower refractory period limit is exceeded. If synchronization criteria are met, an atrial shock is synchronized to the next ventricular depolarization occurring outside the current refractory period. If the lower refractory period limit is exceeded, the atrial therapy is aborted.
摘要翻译：提供了一种植入式医疗装置系统和方法，用于使用可调节心房复律/除颤心室不应期使心房心律转复冲击与心室节律同步。在确定需要心房休克治疗后，该方法确定心室率是否满足基于上心室不应期限的同步标准。如果不符合同步标准，则可以逐步递减地自动调整不应期，直到达到同步标准，或直到超过较低的不应期限为止。如果符合同步标准，心房休克与当前不应期以外发生的下一次心室去极化同步。如果超过较低的不应期限，则中止心房治疗。

5. 发明申请

WO2005105206A1 AUTOMATIC OPTIMIZATION OF LOWR CARDIAC PACING RATE 审中-公开
标题翻译：自动优化LOWR CARDIAC PACING RATE
公开(公告)号：WO2005105206A1
公开(公告)日：2005-11-10
申请号：PCT/US2005/011853
申请日：2005-04-08
申请人： MEDTRONIC, INC. , ZIEGLER, Paul, D. , HETTRICK, Douglas, A. , MEHRA, Rahul
发明人： ZIEGLER, Paul, D. , HETTRICK, Douglas, A. , MEHRA, Rahul
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3622
摘要： A method and device for determining an optimal lower rate (100) and adjusting the programmed lower pacing rate to the optimal rate (145) that includes monitoring a parameter (116) in response to therapy delivered (115) at a first rate during a first time period to generate first parameter data (120), and determining whether the therapy was delivered for a predetermined portion of the first time period (117). The parameter is monitored (116) in response to the therapy delivered (115) at a next rate (110) during a next time period (115) to generate next parameter data (116), and a determination is made as to whether the therapy was delivered for a predetermined portion of the next time period (117). A metric corresponding to the first parameter data is determined to generate a first parameter metric (135), and corresponding to the next parameter data to generate a next parameter metric (135) used for determining an optimal therapy delivery rate (140).
摘要翻译：一种用于确定最佳较低速率（100）并且将编程的较低起搏速率调整到最佳速率（145）的方法和装置，其包括响应于在第一次速率期间以第一速率传送（115）的治疗来监视参数（116）产生第一参数数据（120）的时间段，以及确定治疗是否在第一时间段（117）的预定部分被递送。响应于在下一个时间段（115）期间以下一个速率（110）递送的治疗（115）来响应参数（116）以产生下一个参数数据（116），并且确定治疗被递送下一个时间段（117）的预定部分。确定对应于第一参数数据的度量以产生第一参数度量（135），并且对应于下一参数数据以生成用于确定最佳治疗传送率（140）的下一个参数度量（135）。

6. 发明申请

WO2005105205A1 METHOD AND APPARATUS FOR CONTROLLING DELIVERY OF PACING PULSES IN RESPONSE TO INCREASED ECTOPIC FREQUENCY 审中-公开
标题翻译：控制输送脉冲的方法和装置对增加的频率频率的响应
公开(公告)号：WO2005105205A1
公开(公告)日：2005-11-10
申请号：PCT/US2005/012143
申请日：2005-04-08
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , ZIEGLER, Paul, D. , MITTELSTADT, Jacqueline , MEHRA, Rahul
发明人： HETTRICK, Douglas, A. , ZIEGLER, Paul, D. , MITTELSTADT, Jacqueline , MEHRA, Rahul
IPC分类号： A61N1/362
CPC分类号： A61N1/3621
摘要： A method and device for controlling delivery of therapy in an implantable device that includes sensing a plurality of events, detecting whether there is an increase in the frequency of first events of the plurality of events corresponding to onset of a second event of the plurality of sensed events, adjusting parameters associated with delivery of the therapy in response to the detected increased frequency of first sensed events, and delivering the therapy using the adjusted parameters.
摘要翻译：一种用于控制可植入装置中治疗传递的方法和装置，包括感测多个事件，检测是否存在与多个感测的第二事件的开始对应的多个事件的第一事件的频率的增加事件，响应于检测到的第一感测事件的增加的频率调整与治疗的递送相关联的参数，以及使用调整的参数递送治疗。

7. 发明申请

WO2004071576A1 ATRIAL FIBRILLATION DETECTION VIA A VENTRICULAR LEAD 审中-公开
标题翻译：通过透水导管进行ATRIAL FIBRILLATION检测
公开(公告)号：WO2004071576A1
公开(公告)日：2004-08-26
申请号：PCT/US2004/003252
申请日：2004-02-04
申请人： MEDTRONIC, INC. , FITTS, Stephanie, M. , MORKOWITZ, H., Toby , MEHRA, Rahul , HILL, Michael, R., S. , BROWN, Mark, L.
发明人： FITTS, Stephanie, M. , MORKOWITZ, H., Toby , MEHRA, Rahul , HILL, Michael, R., S. , BROWN, Mark, L.
IPC分类号： A61N1/39
CPC分类号： A61N1/37 , A61N1/3621 , A61N1/3925 , A61N1/395
摘要： Techniques for detecting atrial fibrillation via a ventricular lead are described. An implantable medical device according to the invention may monitor a ventricular depolarization rate via the ventricular lead in order to detect the effect of conducted atrial fibrillation of the ventricular rate. For example, the implantable medical device may detect an increase in the ventricular rate, or a decrease in the stability of the ventricular rate. The implantable medical device may also detect the effect of delivery of a pacing pulse on the length of an R-R interval subsequent to the delivery. A compensatory pause following delivery of a pacing pulse may indicate the presence of conducted atrial fibrillation. The implantable medical device may store information relating to detected episodes of atrial fibrillation for later review by a physician, so that atrial fibrillation may be diagnosed in situations where it might not otherwise be detected.
摘要翻译：描述了通过心室引导检测心房颤动的技术。根据本发明的可植入医疗装置可以通过心室导管监测心室去极化率，以便检测心室率的心房颤动的影响。例如，可植入医疗装置可以检测心室率的增加或心室率的稳定性的降低。可植入医疗装置还可以检测递送脉搏在递送之后的R-R间隔的长度上的影响。递送起搏脉搏后的补偿性暂停可能表明存在心房颤动。可植入医疗装置可以存储与检测到的心房纤维性颤动有关的信息，以供医生稍后检查，以便在可能不能检测到的情况下可以诊断心房颤动。

8. 发明申请

WO2005112808A1 DEVICE AND METHOD FOR DETERMINING TISSUE THICKNESS AND CREATING CARDIAC ABLATION LESIONS 审中-公开
标题翻译：用于确定组织厚度和创建心脏排斥反应的装置和方法
公开(公告)号：WO2005112808A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/015614
申请日：2005-05-05
申请人： MEDTRONIC, INC. , FRANCISCHELLI, David, E. , MEHRA, Rahul , WARMAN, Eduardo, N.
发明人： FRANCISCHELLI, David, E. , MEHRA, Rahul , WARMAN, Eduardo, N.
IPC分类号： A61B18/14
CPC分类号： A61B18/1442 , A61B2018/00666 , A61B2018/1861 , A61B2090/061 , A61B2090/064
摘要： A tissue ablation device (10) has a handle (12) and an ablation head (14) coupled to the handle. The ablation head has a first jaw (24), a second jaw, and an ablative element (28) coupled to at least one of the first and second jaws. A thickness measurement device (40) may be coupled to the ablation device to indicate the distance separating the first and second jaws. Further, a force measurement device (50) may be coupled to the ablation device to measure the force being applied by the first and second jaws to a piece of tissue. Further, a strain measurement device (60) may be coupled to the ablation device to indicate the strain resulting in a piece of tissue disposed between the first and second jaws when a stress is applied to the tissue.
摘要翻译：组织消融装置（10）具有手柄（12）和联接到手柄的消融头部（14）。消融头具有联接到第一和第二钳口中的至少一个的第一钳口（24），第二钳口和消融元件（28）。厚度测量装置（40）可以联接到消融装置以指示分离第一和第二钳口的距离。此外，力测量装置（50）可以联接到消融装置以测量由第一和第二钳口施加到一片组织上的力。此外，应变测量装置（60）可以联接到消融装置，以指示当将应力施加到组织时，产生设置在第一和第二钳口之间的一片组织的应变。

9. 发明申请

WO2004098707A2 AUTOMATIC ADJUSTING R-WAVE SYNCHRONIZATION ALGORITHM FOR ATRIAL CARDIOVERSION AND DEFIBRILLATION 审中-公开
标题翻译：自动调整R波同步算法用于ATRIAL CARDIOVERSION和DEFIBRILLATION
公开(公告)号：WO2004098707A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/011748
申请日：2004-04-16
申请人： MEDTRONIC, INC. , MONGEON, Luc, R. , MEHRA, Rahul
发明人： MONGEON, Luc, R. , MEHRA, Rahul
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3987
摘要： An implantable medical device system and method are provided for synchronizing atrial cardioversion shocks to the ventricular rhythm using an adjustable atrial cardioversion/defibrillation ventricular refractory period. Upon determining a need for an atrial shock therapy, the method determines if the ventricular rate meets synchronization criteria based on an upper ventricular refractory period limit. If synchronization criteria are not met, the refractory period is automatically adjusted in stepwise decrements until the synchronization criteria are met, or until a lower refractory period limit is exceeded. If synchronization criteria are met, an atrial shock is synchronized to the next ventricular depolarization occurring outside the current refractory period. If the lower refractory period limit is exceeded, the atrial therapy is aborted.
摘要翻译：提供了一种植入式医疗装置系统和方法，用于使用可调节心房复律/除颤心室不应期使心房心律转复冲击与心室节律同步。在确定需要心房休克治疗时，该方法确定心室率是否满足基于上心室不应期限的同步标准。如果不符合同步标准，则可以逐步递减地自动调整不应期，直到达到同步标准，或直到超过较低的不应期限为止。如果符合同步标准，心房休克与当前不应期以外发生的下一次心室去极化同步。如果超过较低的不应期限，则中止心房治疗。

10. 发明申请

WO1997026044A1 METHOD AND APPARATUS FOR INDUCTION OF FIBRILLATION 审中-公开
标题翻译：用于诱导纤维化的方法和装置
公开(公告)号：WO1997026044A1
公开(公告)日：1997-07-24
申请号：PCT/US1996014969
申请日：1996-09-18
申请人： MEDTRONIC, INC. , DE GROOT, Paul, J. , MEHRA, Rahul
发明人： MEDTRONIC, INC.
IPC分类号： A61N01/39
CPC分类号： A61N1/385
摘要： A method and apparatus for inducing fibrillation in a patient, for example to verify the efficacy of a defibrillator system. In the disclosed embodiment, an implantable cardioverter-defibrillator has an output stage coupled via a plurality of leads to the patient's heart. When it is desired to induce fibrillation in the patient, the device's control circuitry initiates an output capacitor charging cycle and subsequent delivery of a multi-phase fibrillation inducing stimulus to the heart. The multiple phases of the stimulus reflect an incremental discharging of the output capacitor. In one embodiment, the stimulus has three phases, with the first two separated by a time interval equal to or slightly less than the patient's "vulnerability window", which is defined as the time period following a paced cardiac event during which repolarization of the cardiac muscle is occurring, rendering the heart susceptible to induced fibrillation. The final phase of the multi-phase waveform reflects an untruncated discharge of the remaining energy on the output capacitor.
摘要翻译：一种用于在患者中诱导纤维性颤动的方法和装置，例如以验证除颤器系统的功效。在所公开的实施例中，植入式心律转复除颤器具有通过多条引线耦合到患者心脏的输出级。当需要在患者体内引起纤维颤动时，该装置的控制电路启动输出电容器充电循环，并随后将多相原纤维诱发刺激递送至心脏。刺激的多个相位反映输出电容器的增量放电。在一个实施例中，刺激具有三个阶段，前两个时间间隔等于或略小于患者的“脆弱性窗口”，该时间间隔被定义为心脏复苏后的心跳事件之后的时间段肌肉正在发生，使心脏易受诱发纤颤。多相波形的最后阶段反映出输出电容器上剩余能量的未经截断的放电。

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