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1. 发明申请

US20100224769A1 Method of calibrating an apparatus for measuring radon and/or its progeny in an air sample 有权
标题翻译：校准用于测量空气样品中氡和/或其后代的装置的方法
公开(公告)号：US20100224769A1
公开(公告)日：2010-09-09
申请号：US12379947
申请日：2009-03-05
申请人： Derek R. Lane-Smith
发明人： Derek R. Lane-Smith
IPC分类号： G01D18/00 , G01N33/00
CPC分类号： G01D18/00
摘要： A method of calibrating an apparatus for measuring Radon and/or its progeny in an air sample, includes providing an apparatus for measuring Radon in an air sample that includes a preset offset voltage corresponding to a threshold conductivity value and a preselected reading value for indicating a concentration of Radon and/or its progeny, exposing the apparatus to a calibration area for measuring conductivity of the air therein, comparing the measured conductivity value of the air with the preset offset value for conductivity, and setting a lower threshold conductivity value and corresponding threshold reading value same as the preselected reading value, if the measured conductivity of the air is determined to be lower than the preset offset value for conductivity.
摘要翻译：校准用于在空气样品中测量氡和/或其后代的装置的方法包括提供用于测量空气样品中的氡的装置，其包括对应于阈值电导率值的预设偏移电压和用于指示氡和/或其后代的浓度，将设备暴露于用于测量其中的空气的电导率的校准区域，将测得的空气的电导率与预设的电导率偏移值进行比较，并设置较低的阈值电导率值和相应的阈值读取值与预先选择的读取值相同，如果测得的空气的电导率被确定为低于预设的电导率偏移值。

2. 发明申请

US20090176304A1 Method for in vivo, ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling 审中-公开
标题翻译：体内，体外和体外修复和再生软骨和胶原蛋白和骨重塑的方法
公开(公告)号：US20090176304A1
公开(公告)日：2009-07-09
申请号：US11980967
申请日：2008-07-11
申请人： R. Lane Smith , Dennis R. Carter , David J. Schurman
发明人： R. Lane Smith , Dennis R. Carter , David J. Schurman
IPC分类号： C12N5/08 , C12N5/06
CPC分类号： C12N5/0655 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2240/001 , A61F2310/00365 , A61K35/12 , A61K35/32 , C12N2500/02 , C12N2521/00
摘要： A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.
摘要翻译：一种体内，体外和体外再生软骨和胶原蛋白的方法。通过间歇施加的静水压力，体内，离体和体外再生和从头形成关节软骨和胶原。外部间隔负荷的应用由反复施加的静水压力组成，随后由复原期间中断。在生理水平5-10MPA下间歇4小时的间歇静水压力的应用，随后的恢复期直到约20小时，所述压力在体外施加于软骨细胞，体外离体外植体和体内至软体在关节关节的关节间隙内保持完整的软骨。间隔负荷导致基质降解酶，促炎细胞因子和趋化因子的选择性抑制，其吸引炎症细胞进入关节腔，并选择性降低抑制II型胶原表达的生长因子的基因表达。

3. 发明授权

US5284830A Thyroid-derived chondrocyte-stimulating factor 失效
标题翻译：甲状腺来源的软骨细胞刺激因子
公开(公告)号：US5284830A
公开(公告)日：1994-02-08
申请号：US654965
申请日：1991-02-13
申请人： R. Lane Smith , Deryk G. Jones
发明人： R. Lane Smith , Deryk G. Jones
IPC分类号： A61K38/00 , A61K38/22 , A61K39/395 , A61K47/48 , A61L27/22 , A61P43/00 , C07K1/16 , C07K1/30 , C07K14/435 , C07K14/51 , C07K14/705 , C07K16/00 , C07K16/22 , C12N5/06 , C12P21/08 , G01N33/53 , A61K37/36 , C07K3/02 , C07K15/06
CPC分类号： A61K47/48238 , A61L27/227 , C07K14/51 , C07K16/22 , A61K38/00 , Y10S530/854
摘要： Thyroid-derived chondrocyte stimulating factor (TDCSF) is a high molecular weight complex (greater than 500 kd) of proteinaceous subunits which can be at least partially dissociated into active portions by 8 M urea. TDCSF stimulates articular chondrocyte and synovial fibroblast growth under serum-free conditions. TDCSF is useful for the culture of chondrocytes and fibroblasts in vitro as a serum substitute; for developing cartilage implants in vitro; and for in vivo use in cartilage and bone defect repair and degenerative joint diseases. TDCSF is stabilized in the presence of reducing agents for disulfide bonds. Antibodies for and conjugates of TDCSF are also disclosed.
摘要翻译：甲状腺来源的软骨细胞刺激因子（TDCSF）是蛋白质亚基的高分子量复合物（大于500kd），其可以通过8M尿素至少部分地分解为活性部分。 TDCSF在无血清条件下刺激关节软骨细胞和滑膜成纤维细胞生长。 TDCSF可用于体外培养软骨细胞和成纤维细胞作为血清替代物; 用于在体外开发软骨植入物; 并用于体内用于软骨和骨缺损修复和退行性关节疾病。 TDCSF在二硫键还原剂存在下稳定。还公开了TDCSF的抗体和缀合物。

4. 发明授权

US06528052B1 Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling 有权
标题翻译：体外离体和体外修复和再生软骨和胶原和骨重塑的方法
公开(公告)号：US06528052B1
公开(公告)日：2003-03-04
申请号：US09677109
申请日：2000-09-29
申请人： R. Lane Smith , Dennis R. Carter , David J. Schurman
发明人： R. Lane Smith , Dennis R. Carter , David J. Schurman
IPC分类号： C12N500
CPC分类号： C12N5/0655 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2240/001 , A61F2310/00365 , A61K35/12 , A61K35/32 , C12N2500/02 , C12N2521/00
摘要： A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene, expression of growth factors that are inhibitory to type II collagen expression.
摘要翻译：一种体内，体外和体外再生软骨和胶原蛋白的方法。通过间歇施加的静水压力，体内，离体和体外再生和从头形成关节软骨和胶原。外部间隔负荷的应用由反复施加的静水压力组成，随后由复原期间中断。在生理水平5-10MPA下间歇4小时的间歇静水压力的应用，随后的恢复期直到约20小时，所述压力在体外施加于软骨细胞，体外离体外植体和体内至软体在关节关节的关节间隙内保持完整的软骨。间隔负荷导致基质降解酶，促炎细胞因子和趋化因子的选择性抑制，其吸引炎症细胞进入关节腔，并选择性降低基因，抑制II型胶原表达的生长因子的表达。

5. 发明申请

US20140219972A1 TISSUE ENGINEERING USING PROGENITOR CELLS TO CATALYZE TISSUE FORMATION BY PRIMARY CELLS 审中-公开
标题翻译：组织工程使用原核细胞催化原代细胞组织形成
公开(公告)号：US20140219972A1
公开(公告)日：2014-08-07
申请号：US14173628
申请日：2014-02-05
申请人： Janice Lai , William Maloney , R. Lane Smith , Fan Yang
发明人： Janice Lai , William Maloney , R. Lane Smith , Fan Yang
IPC分类号： A61K35/12 , A61K35/32
CPC分类号： A61K35/35 , A61K35/28 , A61K35/32 , A61K35/34 , A61K35/51 , A61K35/545
摘要： Methods of regenerating tissue using progenitor cells in combination with primary cells from a target tissue are disclosed. In particular, progenitor cells catalyze proliferation and tissue production by primary cells allowing the use of fewer primary cells from a target tissue for effective tissue regeneration. Cell-based therapies combining progenitor cells and primary cells can be used for repair and regeneration of damaged tissue and organs for treating bodily injuries and degenerative diseases. For example, adipose-derived stem cells and neonatal articular chondrocytes, co-encapsulated in mixed or bilayered cultures in a hydrogel comprising chondroitin sulfate methacrylate and poly(ethylene)glycol diacrylate, generated cartilage that could be used for treatment of traumatic injuries or diseases involving cartilage degeneration. Moreover, the inventors showed that progenitor cells could be used to stimulate cartilage formation with a minimal number of primary cells, as few as 1% or less, in mixed cultures containing primary cells and progenitor cells.
摘要翻译：公开了使用祖细胞与来自靶组织的原代细胞组合再生组织的方法。特别地，祖细胞催化原代细胞的增殖和组织产生，从而允许使用较少的来自靶组织的原代细胞用于有效的组织再生。结合祖细胞和原代细胞的基于细胞的疗法可用于损伤组织和器官的修复和再生，用于治疗身体损伤和退行性疾病。例如，由包含硫酸软骨素甲基丙烯酸酯和聚（乙二醇）二丙烯酸酯的水凝胶共混包封在混合或双层培养物中的脂肪来源的干细胞和新生儿关节软骨细胞产生的软骨可用于治疗创伤性损伤或涉及软骨变性。此外，发明人显示，在含有原代细胞和祖细胞的混合培养物中，祖细胞可用于刺激在最少数量的原代细胞中形成软骨，少至1％或更少。

6. 发明授权

US5536724A Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins 失效
标题翻译：抗炎和抗肿瘤的5-脱氮氨基蝶呤和5,10-二氮芥
公开(公告)号：US5536724A
公开(公告)日：1996-07-16
申请号：US140793
申请日：1993-10-21
申请人： Joseph I. DeGraw , William T. Colwell , Francis M. Sirotnak , R. Lane Smith , James R. Piper
发明人： Joseph I. DeGraw , William T. Colwell , Francis M. Sirotnak , R. Lane Smith , James R. Piper
IPC分类号： C07D471/04 , C07D475/08 , A61K31/505 , C07D213/81 , C07D333/38
CPC分类号： C07D471/04 , C07D475/08
摘要： Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins and their 5 and 10 alkyl analogs. A method for the treatment and prevention of inflammatory disease, such as rheumatoid arthritis, and for suppression and prevention of neoplastic growth in tumors and in blood forming tissues. A process for preparation of 10-deazaaminopterins.
摘要翻译：抗炎和抗肿瘤的5-脱氮opter素和5,10-二氮杂opter素及其5和10个烷基类似物。用于治疗和预防炎性疾病如类风湿性关节炎以及用于抑制和预防肿瘤和血液形成组织中的肿瘤生长的方法。一种制备10-脱氮基蝶呤的方法。

7. 发明授权

US08921109B2 Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof 有权
标题翻译：具有狭义地均匀垂直和非随机组织的孔隙率和孔密度的细胞支持基质及其制备方法
公开(公告)号：US08921109B2
公开(公告)日：2014-12-30
申请号：US11523833
申请日：2006-09-19
申请人： R. Lane Smith , Laurence J. B. Tarrant , Akihiko Kusanagi , Hans Peter Ingemar Claesson
发明人： R. Lane Smith , Laurence J. B. Tarrant , Akihiko Kusanagi , Hans Peter Ingemar Claesson
IPC分类号： C12N5/00 , A61L27/38 , A61L27/24 , A61L27/56 , C12N5/077 , C12N5/07 , A61F2/30 , A61F2/08 , A61F2/38
CPC分类号： C12N5/0068 , A61F2/08 , A61F2/30756 , A61F2/3872 , A61F2002/30062 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/3817 , A61L27/3843 , A61L27/56 , A61L2400/18 , A61L2430/06 , A61L2430/10 , C12N5/0655 , C12N2533/54 , C12N2535/00
摘要： A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.
摘要翻译：具有狭义地均匀垂直和非随机组织的孔隙率和孔密度的细胞支持基质及其制备方法。适用于制备细胞或非细胞植入物的基质，用于生长和从头形成关节透明样软骨。一种凝胶基质复合体系，其包含基于胶原的基质，其具有能够在体内和体外从软骨细胞产生透明样软骨的狭义孔隙度。

8. 发明授权

US08074487B2 Method of calibrating an apparatus for measuring radon and/or its progeny in an air sample 有权
标题翻译：校准用于测量空气样品中氡和/或其后代的装置的方法
公开(公告)号：US08074487B2
公开(公告)日：2011-12-13
申请号：US12379947
申请日：2009-03-05
申请人： Derek R. Lane-Smith
发明人： Derek R. Lane-Smith
IPC分类号： G01N21/00
CPC分类号： G01D18/00
摘要： A method of calibrating an apparatus for measuring Radon and/or its progeny in an air sample, includes providing an apparatus for measuring Radon in an air sample that includes a preset offset voltage corresponding to a threshold conductivity value and a preselected reading value for indicating a concentration of Radon and/or its progeny, exposing the apparatus to a calibration area for measuring conductivity of the air therein, comparing the measured conductivity value of the air with the preset offset value for conductivity, and setting a lower threshold conductivity value and corresponding threshold reading value same as the preselected reading value, if the measured conductivity of the air is determined to be lower than the preset offset value for conductivity.
摘要翻译：校准用于在空气样品中测量氡和/或其后代的装置的方法包括提供用于测量空气样品中的氡的装置，其包括对应于阈值电导率值的预设偏移电压和用于指示氡和/或其后代的浓度，将设备暴露于用于测量其中的空气的电导率的校准区域，将测得的空气的电导率与预设的电导率偏移值进行比较，并设置较低的阈值电导率值和相应的阈值读取值与预先选择的读取值相同，如果测得的空气的电导率被确定为低于预设的电导率偏移值。

9. 发明申请

US20090227487A1 METHODS FOR THE CONTROL OF MACROPHAGE-ASSOCIATED INFLAMMATION 审中-公开
标题翻译：用于控制大面积相关感染的方法
公开(公告)号：US20090227487A1
公开(公告)日：2009-09-10
申请号：US12397925
申请日：2009-03-04
申请人： Jeremy Pearl , Ting Ma , William H. Robinson , R. Lane Smith , Stuart B. Goodman
发明人： Jeremy Pearl , Ting Ma , William H. Robinson , R. Lane Smith , Stuart B. Goodman
IPC分类号： A61K38/02 , A61P29/00
CPC分类号： A61K38/16
摘要： Particle induced inflammatory diseases are treated by administration of an effective dose of an inhibitor of MyD88 adaptor protein.
摘要翻译：通过施用有效剂量的MyD88衔接蛋白的抑制剂来治疗颗粒诱导的炎性疾病。

10. 发明授权

US5374550A Thyroid-derived chondrocyte-stimulating factor 失效
标题翻译：甲状腺来源的软骨细胞刺激因子
公开(公告)号：US5374550A
公开(公告)日：1994-12-20
申请号：US152224
申请日：1993-11-12
申请人： R. Lane Smith , Deryk G. Jones
发明人： R. Lane Smith , Deryk G. Jones
IPC分类号： A61K38/00 , A61K38/22 , A61K39/395 , A61K47/48 , A61L27/22 , A61P43/00 , C07K1/16 , C07K1/30 , C07K14/435 , C07K14/51 , C07K14/705 , C07K16/00 , C07K16/22 , C12N5/06 , C12P21/08 , G01N33/53 , A61F2/08 , C12N5/08
CPC分类号： A61K47/48238 , A61L27/227 , C07K14/51 , C07K16/22 , A61K38/00 , Y10S530/854
摘要： Thyroid-derived chondrocyte stimulating factor (TDCSF) is a high molecular weight complex (greater than 500 kd) of proteinaceous subunits which can be at least partially dissociated into active portions by 8M urea. TDCSF stimulates articular chondrocyte and synovial fibroblast growth under serum-free conditions. TDCSF is useful for the culture of chondrocytes and fibroblasts in vitro as a serum substitute; for developing cartilage implants in vitro; and for in vivo use in cartilage and bone defect repair and degenerative joint diseases. TDCSF is stabilized in the presence of reducing agents for disulfide bonds. Antibodies for and conjugates of TDCSF are also disclosed.
摘要翻译：甲状腺来源的软骨细胞刺激因子（TDCSF）是蛋白质亚基的高分子量复合物（大于500kd），其可以通过8M尿素至少部分地分解成活性部分。 TDCSF在无血清条件下刺激关节软骨细胞和滑膜成纤维细胞生长。 TDCSF可用于体外培养软骨细胞和成纤维细胞作为血清替代物; 用于在体外开发软骨植入物; 并用于体内用于软骨和骨缺损修复和退行性关节疾病。 TDCSF在二硫键还原剂存在下稳定。还公开了TDCSF的抗体和缀合物。

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