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    • 5. 发明申请
    • TISSUE ENGINEERING USING PROGENITOR CELLS TO CATALYZE TISSUE FORMATION BY PRIMARY CELLS
    • 组织工程使用原核细胞催化原代细胞组织形成
    • US20140219972A1
    • 2014-08-07
    • US14173628
    • 2014-02-05
    • Janice LaiWilliam MaloneyR. Lane SmithFan Yang
    • Janice LaiWilliam MaloneyR. Lane SmithFan Yang
    • A61K35/12A61K35/32
    • A61K35/35A61K35/28A61K35/32A61K35/34A61K35/51A61K35/545
    • Methods of regenerating tissue using progenitor cells in combination with primary cells from a target tissue are disclosed. In particular, progenitor cells catalyze proliferation and tissue production by primary cells allowing the use of fewer primary cells from a target tissue for effective tissue regeneration. Cell-based therapies combining progenitor cells and primary cells can be used for repair and regeneration of damaged tissue and organs for treating bodily injuries and degenerative diseases. For example, adipose-derived stem cells and neonatal articular chondrocytes, co-encapsulated in mixed or bilayered cultures in a hydrogel comprising chondroitin sulfate methacrylate and poly(ethylene)glycol diacrylate, generated cartilage that could be used for treatment of traumatic injuries or diseases involving cartilage degeneration. Moreover, the inventors showed that progenitor cells could be used to stimulate cartilage formation with a minimal number of primary cells, as few as 1% or less, in mixed cultures containing primary cells and progenitor cells.
    • 公开了使用祖细胞与来自靶组织的原代细胞组合再生组织的方法。 特别地,祖细胞催化原代细胞的增殖和组织产生,从而允许使用较少的来自靶组织的原代细胞用于有效的组织再生。 结合祖细胞和原代细胞的基于细胞的疗法可用于损伤组织和器官的修复和再生,用于治疗身体损伤和退行性疾病。 例如,由包含硫酸软骨素甲基丙烯酸酯和聚(乙二醇)二丙烯酸酯的水凝胶共混包封在混合或双层培养物中的脂肪来源的干细胞和新生儿关节软骨细胞产生的软骨可用于治疗创伤性损伤或涉及 软骨变性。 此外,发明人显示,在含有原代细胞和祖细胞的混合培养物中,祖细胞可用于刺激在最少数量的原代细胞中形成软骨,少至1%或更少。
    • 8. 发明申请
    • Key control system using separated ID and location detection mechanisms
    • 使用分离的ID和位置检测机制的关键控制系统
    • US20050024211A1
    • 2005-02-03
    • US10924330
    • 2004-08-23
    • William Maloney
    • William Maloney
    • G06K17/00G08B13/14
    • G08B13/2417A47G29/10G06K7/10079G06K17/00G06K2017/0045G07C2009/00936G08B13/2462
    • An object control and tracking system and related methods using separate object identification and location detection mechanisms for objects, such as keys, that are maintained in a secure enclosure, such as a key drawer. A plurality of object slots are located on the top tray of the enclosure to receive object tags that include both an RFID tag and an object to be tracked. The objects (e.g., keys) are attached to a portion of the object tags that are outside of the enclosure. Presence detectors are used to determine if an object tag is present in the corresponding slot of the enclosure. RFID sensors located on opposite interior side walls of the enclosure interrogate each RFID tag to determine the presence of each RFID tag within the enclosure. The object control and tracking system includes a controller, a memory for storing an object control database, and related processing logic operating on the controller to control scanning of the presence detectors to determine an object tag's presence in a corresponding slot, to identify each object present in the enclosure and to compare the identified objects with an object control database to determine each object removed or replaced since the previous database update.
    • 对象控制和跟踪系统及相关方法,使用单独的对象识别和位置检测机制来保护诸如键盘之类的安全机壳中的对象(例如键)。 多个对象槽位于机壳的顶部托盘上,以接收包括RFID标签和要跟踪的对象的物体标签。 对象(例如,键)附接到外壳外部的对象标签的一部分。 存在检测器用于确定对象标签是否存在于机箱的相应插槽中。 位于外壳的相对内侧壁上的RFID传感器询问每个RFID标签以确定外壳内每个RFID标签的存在。 对象控制和跟踪系统包括控制器,用于存储对象控制数据库的存储器和在控制器上操作的相关处理逻辑,以控制存在检测器的扫描,以确定对象标签在相应时隙中的存在,以识别存在的每个对象 并将识别的对象与对象控制数据库进行比较,以确定自上一次数据库更新以来删除或替换的每个对象。