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1. 发明授权

US07872029B2 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states 失效
标题翻译：查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂
公开(公告)号：US07872029B2
公开(公告)日：2011-01-18
申请号：US12229340
申请日：2008-08-22
申请人： J. Phillip Bowen , Thomas Philip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
发明人： J. Phillip Bowen , Thomas Philip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
IPC分类号： C07D213/02 , A61K31/44
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiogenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译：本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管生成是其中一个因素的一些病症或疾病状态，包括血管生成皮肤疾病如牛皮癣，痤疮，酒渣鼻，疣，湿疹，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。

2. 发明申请

US20050271989A1 Draft inducer system 审中-公开
标题翻译：牵引诱导系统
公开(公告)号：US20050271989A1
公开(公告)日：2005-12-08
申请号：US11195099
申请日：2005-08-02
申请人： Fred Brown , Phillip Bowen , Jeffrey From
发明人： Fred Brown , Phillip Bowen , Jeffrey From
IPC分类号： F23L17/00 , F23N3/08 , F23N3/00
CPC分类号： F23L17/005 , F23N3/082 , F23N2023/08 , F23N2025/10
摘要： A draft inducer system has a voltage reducer capable of converting an input AC voltage to a reduced voltage, and an inducer unit capable of being coupled with the voltage reducer. The voltage reducer includes a reducer housing, a set of prongs extending from the reducer housing, and an output interface capable of delivering the reduced voltage. The set of prongs is capable of plugging into an AC outlet. The inducer unit has a unit housing, an air moving device within the unit housing, and a mixing chamber formed by the unit housing. The mixing chamber has an exhaust input to receive exhaust from a burning fuel, and an ambient air input for receiving ambient air. The ambient air mixes with the exhaust in the mixing chamber to produce mixed air. Accordingly, the mixing chamber also has a mix output capable of directing the mixed air from the mixing chamber.
摘要翻译：牵引诱导器系统具有能够将输入AC电压转换为降低的电压的电压降低器，以及能够与减压器耦合的感应单元。减压器包括减速器壳体，从减速器壳体延伸的一组尖头，以及能够递送降低的电压的输出接口。该组插脚可插入交流电源插座。导流单元具有单元壳体，单元壳体内的空气移动装置，以及由单元壳体形成的混合室。混合室具有用于接收来自燃烧燃料的排气的排气输入和用于接收环境空气的环境空气输入。环境空气与混合室中的废气混合以产生混合空气。因此，混合室还具有能够从混合室引导混合空气的混合输出。

3. 发明授权

US06462075B1 Chalcone and its analogs as agents for the inhibition of angiogensis and related disease states 失效
标题翻译：查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂
公开(公告)号：US06462075B1
公开(公告)日：2002-10-08
申请号：US09748599
申请日：2000-12-26
申请人： J. Phillip Bowen , Thomas Phillip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
发明人： J. Phillip Bowen , Thomas Phillip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
IPC分类号： C07D31100
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, incluidng angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译：本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管发生是一个因素的许多病症或疾病状态，包括血管性皮肤疾病如银屑病，痤疮，酒渣鼻，疣，湿疹，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。

4. 发明授权

US07052271B2 Draft inducer system 失效
标题翻译：牵引诱导系统
公开(公告)号：US07052271B2
公开(公告)日：2006-05-30
申请号：US10655534
申请日：2003-09-04
申请人： Fred A. Brown , Phillip Bowen , Jeffrey E. From
发明人： Fred A. Brown , Phillip Bowen , Jeffrey E. From
IPC分类号： F23N3/00
CPC分类号： F23L17/005 , F23N3/082 , F23N2023/08 , F23N2025/10
摘要： A draft inducer system has a voltage reducer capable of converting an input AC voltage to a reduced voltage, and an inducer unit capable of being coupled with the voltage reducer. The voltage reducer includes a reducer housing, a set of prongs extending from the reducer housing, and an output interface capable of delivering the reduced voltage. The set of prongs is capable of plugging into an AC outlet. The inducer unit has a unit housing, an air moving device within the unit housing, and a mixing chamber formed by the unit housing. The mixing chamber has an exhaust input to receive exhaust from a burning fuel, and an ambient air input for receiving ambient air. The ambient air mixes with the exhaust in the mixing chamber to produce mixed air. Accordingly, the mixing chamber also has a mix output capable of directing the mixed air from the mixing chamber.
摘要翻译：牵引诱导器系统具有能够将输入AC电压转换为降低的电压的电压降低器，以及能够与减压器耦合的感应单元。减压器包括减速器壳体，从减速器壳体延伸的一组尖头，以及能够递送降低的电压的输出接口。该组插脚可插入交流电源插座。导流单元具有单元壳体，单元壳体内的空气移动装置，以及由单元壳体形成的混合室。混合室具有用于接收来自燃烧燃料的排气的排气输入和用于接收环境空气的环境空气输入。环境空气与混合室中的废气混合以产生混合空气。因此，混合室还具有能够从混合室引导混合空气的混合输出。

5. 发明授权

US06369078B1 Solenopsin derivatives and analogues as fire ant suppressants 失效
标题翻译：索伦肽衍生物和类似物作为消防窒息剂
公开(公告)号：US06369078B1
公开(公告)日：2002-04-09
申请号：US09650257
申请日：2000-08-29
申请人： J. Phillip Bowen , M. Scott Furness , David Whitmire
发明人： J. Phillip Bowen , M. Scott Furness , David Whitmire
IPC分类号： A61K31445
CPC分类号： A01N43/40 , A61K31/445
摘要： The present invention relates to solenopsin alkaloid derivatives which are trans-2,6-disubstituted piperidines according to the structure: wherein R1 and R2 are selected from a C1 to C20 saturated or unsaturated linear, cyclic or branch-chained substituted or unsubstituted hydrocarbon group or a substituted or unsubstituted aromatic group, or an ester group. In certain preferred embodiments, where R1 or R2 contains an unsaturated group, such as an alkenyl group, the double bond in the alkenyl group preferably is found in the hydrocarbon chain between the carbon atom bonded to the piperidine ring and the adjacent carbon atom (&agr; and &bgr; carbons).
摘要翻译：本发明涉及根据以下结构的反式-2,6-二取代的哌啶的溶血素生物碱衍生物：其中R1和R2选自C1至C20饱和或不饱和的直链，环状或支链取代或未取代的烃基或取代或未取代的芳族基团或酯基。在某些优选的实施方案中，其中R 1或R 2含有不饱和基团如烯基，链烯基中的双键优选存在于与哌啶环键合的碳原子和相邻碳原子之间的烃链（α 和β碳）。

6. 发明授权

US5132322A Etoposide analogues 失效
标题翻译：依托泊苷类似物
公开(公告)号：US5132322A
公开(公告)日：1992-07-21
申请号：US406330
申请日：1989-09-12
申请人： Kuo-Hsiung Lee , Zhe Oing Wang , J. Phillip Bowen , Dora M. Schnur , Yung-Chi Cheng , Su-Ying Liu , Yao H. Kuo , Masami Mori
发明人： Kuo-Hsiung Lee , Zhe Oing Wang , J. Phillip Bowen , Dora M. Schnur , Yung-Chi Cheng , Su-Ying Liu , Yao H. Kuo , Masami Mori
IPC分类号： C07D493/04
CPC分类号： C07D493/04
摘要： Compounds that are analogs of etoposide and exhibit antitumor activity are disclosed. The compounds of the present invention have the following formula: ##STR1## where: R.sub.1 is .beta.-OCH.sub.2 CH.sub.2 NH.sub.2 .beta.-NHCH(CH.sub.3)CH.sub.2 OH, .beta.-NHCH.sub.2 CH(CH.sub.3)OH, .beta.-Cl, .beta.-Br, .beta.-OH, .alpha.-OH, .beta.-NH, .alpha.-NH.sub.2, .beta.-NHCH.sub.2 CH.sub.2 OH, .alpha.-NHCH.sub.2 CH.sub.2 OH, .beta.-NHCH.sub.2 CH.sub.2 CH.sub.3, .beta.-NHCH.sub.2 CH.sub.2 OCH.sub.3, .beta.-NHCH.sub.2 CH.dbd.CH.sub.2, .beta.-NHCH.sub.2 CH(OH)CH.sub.3, .beta.-NHCH.sub.2 CH.sub.2 CH.sub.2 OH, .beta.-OCH.sub.2 CH.sub.2 OH, ##STR2## R.sub.2 is H, or Br; R.sub.1 is H, or Br;R.sub.4 is H, or Br;R.sub.5 is H, or Br; andR.sub.6 is H, or --CH.sub.3.
摘要翻译：公开了依托泊苷的类似物并表现出抗肿瘤活性的化合物。本发明的化合物具有下式：其中：R1为β-OCH2CH2NH2β-NHCH（CH3）CH2OH，β-NHCH2CH（CH3）OH，β-Cl，β-Br，β-OH，α -OH，β-NH，α-NH 2，β-NHCH 2 CH 2 OH，α-NHCH 2 CH 2 OH，β-NHCH 2 CH 2 CH 3，β-NHCH 2 CH 2 OCH 3，β-NHCH 2 CH = CH 2，β-NHCH 2 CH（OH）CH 3，β-NHCH 2 CH 2 CH 2 OH，图像> R2是H或Br; R1是H或Br; R4是H或Br; R5是H或Br; 且R6为H或-CH3。

7. 发明授权

US08168657B2 Solenopsin A, B and analogs and as novel angiogenesis inhibitors 有权
标题翻译：索伦肽A，B和类似物和新型血管生成抑制剂
公开(公告)号：US08168657B2
公开(公告)日：2012-05-01
申请号：US10502080
申请日：2003-01-24
申请人： J. Phillip Bowen , Jack L. Arbiser , David Whitmire , M. Scott Furness
发明人： J. Phillip Bowen , Jack L. Arbiser , David Whitmire , M. Scott Furness
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K31/451
摘要： The present invention relates to solenopsin A and its analogs for use as angiogenesis inhibitors. The present compounds unexpectedly exhibit good activity as angiogenesis inhibitors, which find use as antitumor/anticancer agents as well as to treat a number of conditions or disease states in which angiogenesis is a factor.
摘要翻译：本发明涉及用于血管生成抑制剂的索伦膦A及其类似物。本发明化合物意外地表现出作为血管生成抑制剂的良好活性，其可用作抗肿瘤/抗癌剂，以及治疗血管生成是其中一个因素的许多病症或疾病状态。

8. 发明申请

US20090018167A1 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states 失效
标题翻译：查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂
公开(公告)号：US20090018167A1
公开(公告)日：2009-01-15
申请号：US12229340
申请日：2008-08-22
申请人： J. Phillip Bowen , Thomas Philip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
发明人： J. Phillip Bowen , Thomas Philip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
IPC分类号： A61K31/444 , C07C49/76 , C07D311/04 , C07D307/30 , C07D213/44 , A61K31/44 , A61P25/02 , A61P19/02 , A61P17/10 , C07D211/82 , A61K31/12 , A61K31/352 , A61K31/341
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiogenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译：本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管生成是其中一个因素的一些病症或疾病状态，包括血管生成皮肤疾病如牛皮癣，痤疮，酒渣鼻，疣，湿疹，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。

9. 发明授权

US07432303B2 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states 失效
标题翻译：查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂
公开(公告)号：US07432303B2
公开(公告)日：2008-10-07
申请号：US11074545
申请日：2005-03-08
申请人： J. Phillip Bowen , Thomas Philip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
发明人： J. Phillip Bowen , Thomas Philip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
IPC分类号： C07C49/11 , C07C49/115 , A61K31/12
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译：本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管生成是其中一个因素的许多病症或疾病状态，包括银屑病，痤疮，酒渣鼻，疣，湿疹，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。

10. 发明授权

US06906105B2 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states 失效
标题翻译：查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂
公开(公告)号：US06906105B2
公开(公告)日：2005-06-14
申请号：US10198786
申请日：2002-07-18
申请人： J. Phillip Bowen , Thomas Philip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
发明人： J. Phillip Bowen , Thomas Philip Robinson , Tedman Ehlers , David Goldsmith , Jack Arbiser
IPC分类号： A61P17/00 , A61P35/00 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D207/32 , C07D207/333 , C07D213/50 , C07D307/46 , A61K31/12 , C07C49/213
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译：本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管生成是其中一个因素的许多病症或疾病状态，包括银屑病，痤疮，酒渣鼻，疣，湿疹，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。

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