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1. 发明授权

US5132322A Etoposide analogues 失效
标题翻译：依托泊苷类似物
公开(公告)号：US5132322A
公开(公告)日：1992-07-21
申请号：US406330
申请日：1989-09-12
申请人： Kuo-Hsiung Lee , Zhe Oing Wang , J. Phillip Bowen , Dora M. Schnur , Yung-Chi Cheng , Su-Ying Liu , Yao H. Kuo , Masami Mori
发明人： Kuo-Hsiung Lee , Zhe Oing Wang , J. Phillip Bowen , Dora M. Schnur , Yung-Chi Cheng , Su-Ying Liu , Yao H. Kuo , Masami Mori
IPC分类号： C07D493/04
CPC分类号： C07D493/04
摘要： Compounds that are analogs of etoposide and exhibit antitumor activity are disclosed. The compounds of the present invention have the following formula: ##STR1## where: R.sub.1 is .beta.-OCH.sub.2 CH.sub.2 NH.sub.2 .beta.-NHCH(CH.sub.3)CH.sub.2 OH, .beta.-NHCH.sub.2 CH(CH.sub.3)OH, .beta.-Cl, .beta.-Br, .beta.-OH, .alpha.-OH, .beta.-NH, .alpha.-NH.sub.2, .beta.-NHCH.sub.2 CH.sub.2 OH, .alpha.-NHCH.sub.2 CH.sub.2 OH, .beta.-NHCH.sub.2 CH.sub.2 CH.sub.3, .beta.-NHCH.sub.2 CH.sub.2 OCH.sub.3, .beta.-NHCH.sub.2 CH.dbd.CH.sub.2, .beta.-NHCH.sub.2 CH(OH)CH.sub.3, .beta.-NHCH.sub.2 CH.sub.2 CH.sub.2 OH, .beta.-OCH.sub.2 CH.sub.2 OH, ##STR2## R.sub.2 is H, or Br; R.sub.1 is H, or Br;R.sub.4 is H, or Br;R.sub.5 is H, or Br; andR.sub.6 is H, or --CH.sub.3.
摘要翻译：公开了依托泊苷的类似物并表现出抗肿瘤活性的化合物。本发明的化合物具有下式：其中：R1为β-OCH2CH2NH2β-NHCH（CH3）CH2OH，β-NHCH2CH（CH3）OH，β-Cl，β-Br，β-OH，α -OH，β-NH，α-NH 2，β-NHCH 2 CH 2 OH，α-NHCH 2 CH 2 OH，β-NHCH 2 CH 2 CH 3，β-NHCH 2 CH 2 OCH 3，β-NHCH 2 CH = CH 2，β-NHCH 2 CH（OH）CH 3，β-NHCH 2 CH 2 CH 2 OH，图像> R2是H或Br; R1是H或Br; R4是H或Br; R5是H或Br; 且R6为H或-CH3。

2. 发明授权

US5196452A Macrocyclic anti-viral compound and method 失效
标题翻译：大环抗病毒化合物及方法
公开(公告)号：US5196452A
公开(公告)日：1993-03-23
申请号：US647720
申请日：1991-01-29
申请人： Kou M. Hwang , You M. Qi , Su-Ying Liu
发明人： Kou M. Hwang , You M. Qi , Su-Ying Liu
IPC分类号： A61K31/18 , A61K31/185 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/795 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/58 , C07C309/60 , C07C309/77 , C07C311/29 , C07C311/37 , C07C311/48 , C07C317/22 , C07C323/21
CPC分类号： A61K31/795 , A61K31/18 , A61K31/185 , A61K31/19 , A61K31/215 , A61K31/255 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/58 , C07C309/60 , C07C309/77 , C07C311/29 , C07C311/37 , C07C311/48 , C07C317/22 , C07C323/21
摘要： A compound and method for inhibiting cell infection by an enveloped virus. The compound is a macrocyclic chromotropic acid derivative which can be substituted at a variety of naphthalene ring and bridge positions. The compound may be administered parenterally, orally, or topically for treating infection by enveloped viruses.
摘要翻译：用于抑制包膜病毒细胞感染的化合物和方法。该化合物是可在各种萘环和桥位置被取代的大环变色酸衍生物。该化合物可以肠胃外，口服或局部施用以治疗包膜病毒的感染。

3. 发明授权

US07709538B2 ST104P, an anti-angiogenic agent 有权
标题翻译： ST104P，一种抗血管生成剂
公开(公告)号：US07709538B2
公开(公告)日：2010-05-04
申请号：US12172948
申请日：2008-07-14
申请人： Ming-Hong Tai , Su-Ying Liu
发明人： Ming-Hong Tai , Su-Ying Liu
IPC分类号： A61K31/05
CPC分类号： A61K31/185
摘要： The present invention relates to a method of treating a non-tumor condition or disease associated with angiogenesis in a human or animal comprises administering thereto an effective angiogenesis inhibiting dose of a tetrameric cyclic compound of 4,5-dihydroxynaphthalene-2,7, disulfonic acid linked by methylene bridges in a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及在人或动物中治疗与血管生成相关的非肿瘤状况或疾病的方法，包括向其施用有效的血管生成抑制剂量的4,5-二羟基萘-2,7，二磺酸的四聚环状化合物通过亚甲基桥连接在可药用载体中。

4. 发明申请

US20080269350A1 ST104P, AN ANTI-ANGIOGENIC AGENT 有权
标题翻译： ST104P，抗生素发生剂
公开(公告)号：US20080269350A1
公开(公告)日：2008-10-30
申请号：US12172948
申请日：2008-07-14
申请人： Ming-Hong Tai , Su-Ying Liu
发明人： Ming-Hong Tai , Su-Ying Liu
IPC分类号： A61K31/10 , A61P43/00
CPC分类号： A61K31/185
摘要： The present invention relates to a method of treating a non-tumor condition or disease associated with angiogenesis in a human or animal comprises administering thereto an effective angiogenesis inhibiting dose of a tetrameric cyclic compound of 4,5-dihydroxynaphthalene-2,7, disulfonic acid linked by methylene bridges in a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及在人或动物中治疗与血管生成相关的非肿瘤状况或疾病的方法，包括向其施用有效的血管生成抑制剂量的4,5-二羟基萘-2,7，二磺酸的四聚环状化合物通过亚甲基桥连接在可药用载体中。

5. 发明申请

US20070299138A1 ST104P, An Anti-Angiogenic Agent 审中-公开
标题翻译： ST104P，抗血管生成剂
公开(公告)号：US20070299138A1
公开(公告)日：2007-12-27
申请号：US11830334
申请日：2007-07-30
申请人： Ming-Hong Tai , Su-Ying Liu
发明人： Ming-Hong Tai , Su-Ying Liu
IPC分类号： A61K31/185 , A61P9/00
CPC分类号： A61K31/185
摘要： The present invention relates to a method of treating a subject suffering non-tumor condition or disease associated with angiogenesis which comprises administering the subject in need of the treatment with an effective angiogenesis inhibiting dose of a tetrameric cyclic compound of 4,5-dihydroxynaphthalene-2,7, disulfonic acid linked by methylene bridges in a pharmaceutical acceptable carrier.
摘要翻译：本发明涉及一种治疗患有非肿瘤病症或与血管发生相关的疾病的受试者的方法，该方法包括以有效的血管生成抑制剂量施用需要治疗的受试者，所述四聚体环状化合物为4,5-二羟基萘-2 7，在药学上可接受的载体中通过亚甲基桥连接的二磺酸。

6. 发明授权

US5312837A Method of treating viral infections with aryl macrocyclic compounds 失效
标题翻译：用芳基大环化合物治疗病毒感染的方法
公开(公告)号：US5312837A
公开(公告)日：1994-05-17
申请号：US791920
申请日：1991-11-13
申请人： Kou M. Hwang , You M. Qi , Su-Ying Liu
发明人： Kou M. Hwang , You M. Qi , Su-Ying Liu
IPC分类号： A61K31/18 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/505 , A61K31/66 , A61K31/765 , A61K31/795 , A61K31/80 , A61P31/12 , C07C59/52 , C07C65/105 , C07C309/11 , C07C309/24 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/58 , C07C309/60 , C07C309/73 , C07C309/75 , C07C309/77 , C07C311/16 , C07C311/29 , C07C311/37 , C07C311/48 , C07C313/04 , C07C317/22 , C07C323/21 , C07D257/10 , C07F9/38
CPC分类号： A61K31/66 , A61K31/18 , A61K31/185 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/765 , A61K31/795 , A61K31/80 , C07C309/11 , C07C309/24 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/58 , C07C309/60 , C07C309/73 , C07C309/75 , C07C309/77 , C07C311/29 , C07C311/37 , C07C311/48 , C07C313/04 , C07C317/22 , C07C323/21 , C07C59/52 , C07C65/105 , C07D257/10 , C07F9/3834 , C07F9/3882 , C07C2103/92
摘要： A method for inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a macrocyclic compound composed of aryl ring subunits connected one to another by ring-attached bridge linkages, and containing sulfonic acid-derived substituents carried on non-bridge atoms of the subunits.
摘要翻译：一种通过向感染部位施用治疗有效量的由环连接的桥键连接的芳环亚单元构成的大环化合物并含有携带磺酸衍生的取代基的方法，所述方法包括：在亚单位的非桥原子上。

7. 发明授权

US07273890B1 ST104P, an anti-angiogenic agent 有权
标题翻译： ST104P，一种抗血管生成剂
公开(公告)号：US07273890B1
公开(公告)日：2007-09-25
申请号：US10865480
申请日：2004-06-08
申请人： Su-Ying Liu , Ming-Hong Tai
发明人： Su-Ying Liu , Ming-Hong Tai
IPC分类号： A61K31/05
CPC分类号： A61K31/185
摘要： The anti-angiogenic functions of a polysulfated, cyclic compound, ST104P, were investigated. ST104P exhibited excellent water solubility and low cytotoxicity to endothelial cells. ST104P potently inhibited the secretion of matrix metalloproteinase (MMPs) by endothelial cells. Moreover, ST104 also perturbed the migration and tube formation of endothelial cells. Application of ST104P abolished the neovascularization in chicken choroiallantoic membrane (CAM) in a dose-dependent manner. Besides, repeated administration of ST104P into Lewis lung carcinoma resulted in delayed tumor growth and prolonged the life span of tumor-bearing mice. These results indicated that ST104P inhibited angiogenesis and may hold promises for treatment of cancer and diseases or conditions caused by excessive angiogenesis.
摘要翻译：研究了多硫酸化环状化合物ST104P的抗血管生成功能。 ST104P显示出优异的水溶性和对内皮细胞的低细胞毒性。 ST104P能有效地抑制内皮细胞分泌基质金属蛋白酶（MMPs）。此外，ST104还扰乱了内皮细胞的迁移和管形成。 ST104P的应用以剂量依赖的方式消除了鸡绒毛膜膜（CAM）中的新生血管形成。此外，将ST104P重复给予Lewis肺癌导致肿瘤生长延迟，延长荷瘤小鼠的寿命。这些结果表明，ST104P抑制血管生成，可能有助于治疗癌症和由过度血管发生引起的疾病或病症。

8. 发明授权

US5441983A Treatment of infection by enveloped virus with calix(N)arene compounds 失效
标题翻译：用杯状（N）芳烃化合物治疗包膜病毒感染
公开(公告)号：US5441983A
公开(公告)日：1995-08-15
申请号：US928108
申请日：1992-08-06
申请人： Kou M. Hwang , You M. Qi , Su-Ying Liu , William Choy , Jen Chen
发明人： Kou M. Hwang , You M. Qi , Su-Ying Liu , William Choy , Jen Chen
IPC分类号： A61K31/18 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/505 , A61K31/66 , A61K31/765 , A61K31/795 , A61K31/80 , A61P31/12 , C07C59/52 , C07C65/105 , C07C309/11 , C07C309/24 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/58 , C07C309/60 , C07C309/73 , C07C309/75 , C07C309/77 , C07C311/16 , C07C311/29 , C07C311/37 , C07C311/48 , C07C313/04 , C07C317/22 , C07C323/21 , C07D257/10 , C07F9/38
CPC分类号： A61K31/66 , A61K31/18 , A61K31/185 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/765 , A61K31/795 , A61K31/80 , C07C309/11 , C07C309/24 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/58 , C07C309/60 , C07C309/73 , C07C309/75 , C07C309/77 , C07C311/29 , C07C311/37 , C07C311/48 , C07C313/04 , C07C317/22 , C07C323/21 , C07C59/52 , C07C65/105 , C07D257/10 , C07F9/3834 , C07F9/3882 , C07C2103/92
摘要： A method for inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a calix(n)arene compound derivatized, at its ring positions meta to the bridge attachements to the ring, with polar substitutent having a terminal carboxylate, phosphate, or sulfonate groups, including esters and amides which are cleavable in vivo. The compound may be administered orally, or topically, e.g., for treatment of herpes virus.
摘要翻译：一种通过向感染部位施用治疗有效量的在其与所述环附着的环的位置上衍生化的杯状（n）芳族化合物化合物的方法，所述方法具有极性取代基，其具有末端羧酸盐，磷酸盐或磺酸盐基团，包括在体内可切割的酯和酰胺。化合物可以口服或局部施用，例如用于治疗疱疹病毒。

9. 发明授权

US5409959A Antithrombotic treatment with calix(n)arene compounds 失效
标题翻译：用杯状（n）芳烃化合物进行抗血栓治疗
公开(公告)号：US5409959A
公开(公告)日：1995-04-25
申请号：US928118
申请日：1992-08-06
申请人： Kou M. Hwang , You M. Qi , Su-Ying Liu , Thomas C. Lee , William Choy , Jen Chen
发明人： Kou M. Hwang , You M. Qi , Su-Ying Liu , Thomas C. Lee , William Choy , Jen Chen
IPC分类号： A61K31/18 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/66 , A61K31/765 , A61K31/795 , A61K31/80 , A61P7/02 , C07C59/52 , C07C65/105 , C07C309/11 , C07C309/24 , C07C309/32 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/57 , C07C309/58 , C07C309/60 , C07C309/73 , C07C309/77 , C07C311/15 , C07C311/29 , C07C311/37 , C07C311/48 , C07C317/14 , C07C317/22 , C07C317/44 , C07C323/21 , C07F9/38 , A61K31/05
CPC分类号： A61K31/215 , A61K31/18 , A61K31/185 , A61K31/19 , A61K31/255 , A61K31/66 , A61K31/765 , A61K31/795 , A61K31/80 , C07C309/11 , C07C309/24 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/58 , C07C309/60 , C07C309/73 , C07C309/77 , C07C311/29 , C07C311/37 , C07C311/48 , C07C317/22 , C07C323/21 , C07C59/52 , C07C65/105 , C07F9/3834 , C07F9/3882
摘要： A method of inhibiting thrombus formation in a mammalian subject. The method involves administering to the subject a therapeutically effective dose of a calix(n)arene compound derivatized, at its ring positions meta to the bridge attachments to the ring, with polar substituents having terminal sulfonate groups, including esters and amides which are cleavable in vivo.
摘要翻译：抑制哺乳动物受试者血栓形成的方法。该方法包括向受试者施用治疗有效剂量的杯状（n）芳烃化合物，其衍生化在其环到桥附着环上的环位置，具有末端磺酸基团的极性取代基，包括酯和酰胺，其可以在体内。

10. 发明授权

US5166173A Method of treating herpes simplex virus infection 失效
标题翻译：治疗单纯疱疹病毒感染的方法
公开(公告)号：US5166173A
公开(公告)日：1992-11-24
申请号：US647469
申请日：1991-01-29
申请人： Kou M. Hwang , You M. Qi , Su-Ying Liu
发明人： Kou M. Hwang , You M. Qi , Su-Ying Liu
IPC分类号： A61K31/18 , A61K31/185 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/795 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/58 , C07C309/60 , C07C309/77 , C07C311/29 , C07C311/37 , C07C311/48 , C07C317/22 , C07C323/21
CPC分类号： A61K31/795 , A61K31/18 , A61K31/185 , A61K31/19 , A61K31/215 , A61K31/255 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/58 , C07C309/60 , C07C309/77 , C07C311/29 , C07C311/37 , C07C311/48 , C07C317/22 , C07C323/21
摘要： A method of inhibiting cell infection by herpes simplex virus-1 or -2. The method includes contacting the virus with a macrocyclic chromotropic acid compound, in an amount effective to inhibit cell infectivity of the virus.
摘要翻译：一种抑制单纯疱疹病毒-1型或-2型细胞感染的方法。该方法包括以有效抑制病毒细胞感染性的量使病毒与大环变色酸化合物接触。

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