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1. 发明授权

US08494818B2 Analyzing spectral data for the selection of a calibration model 有权
标题翻译：分析校准模型选择的光谱数据
公开(公告)号：US08494818B2
公开(公告)日：2013-07-23
申请号：US12736929
申请日：2009-05-06
申请人： Philippe Hubert , Eric Ziemons , François Moonen
发明人： Philippe Hubert , Eric Ziemons , François Moonen
IPC分类号： G06F17/10
CPC分类号： G01N21/274 , G01N21/3554 , G01N21/359 , G01N2201/129
摘要： The invention relates to a method of analyzing spectral data for the selection of a calibration model, relating spectra of a substance to a physical or chemical parameter of the substance, over a predetermined range of the physical or chemical parameter, comprising the steps: a) capturing spectral data of the substance with respective values of the physical or chemical parameter over the predetermined range, b) creating a plurality of calibration models using the captured spectral data in dependence upon the values of the physical or chemical parameter based on the calibration data using statistical resampling methods, c) calculating tolerance intervals of the results at each reference level for each calibration model, and d) displaying the tolerance intervals at each reference level over the predetermined range for each calibration model. In this way, a possibility for analyzing spectra data is provided which is useful in spectroscopic applications for automated calibration model selection and makes analytical interpretation and evaluation easier and more accurate.
摘要翻译：本发明涉及一种分析用于选择校准模型的光谱数据的方法，所述校准模型在物理或化学参数的预定范围内将物质的光谱与物质的物理或化学参数相关联，包括以下步骤：a）以预定范围的物理或化学参数的相应值捕获物质的光谱数据; b）使用所捕获的光谱数据，根据基于校准数据的物理或化学参数的值，使用所捕获的光谱数据创建多个校准模型，所述校准模型使用统计重采样方法，c）计算每个校准模型的每个参考水平处的结果的容差间隔，以及d）在每个校准模型的预定范围上显示每个参考水平的公差间隔。以这种方式，提供了分析光谱数据的可能性，其在用于自动校准模型选择的光谱应用中是有用的，并且使分析解释和评估更容易和更准确。

2. 发明申请

US20100081629A1 LOW MOLECULAR WEIGHT HEPARINS INCLUDING AT LEAST ONE COVALENT BOND WITH BIOTIN OR A BIOTIN DERIVATIVE, METHOD FOR MAKING SAME AND USE THEREOF 审中-公开
标题翻译：低分子量重量包括至少一种与生物或生物素衍生物的共价键，其制备方法及其用途
公开(公告)号：US20100081629A1
公开(公告)日：2010-04-01
申请号：US12539224
申请日：2009-08-11
申请人： Christian Viskov , Philippe Hubert , Pierre Mourier
发明人： Christian Viskov , Philippe Hubert , Pierre Mourier
IPC分类号： A61K31/727 , C07H1/00
CPC分类号： C08B37/0075 , A61K31/715
摘要： The invention relates to biotinylated low molecular weight heparins comprising constituent polysaccharides having at their reducing ends at least one covalent bond with biotin or a biotin derivative, and also to the process for preparing them, to pharmaceutical compositions containing them and to their therapeutic use.
摘要翻译：本发明涉及生物素化的低分子量肝素，其包含在其还原端与生物素或生物素衍生物具有至少一个共价键的组成多糖，以及其制备方法，含有它们的药物组合物及其治疗用途。

3. 发明申请

US20100075922A1 HEPARINS INCLUDING AT LEAST ONE COVALENT BOND WITH BIOTIN OR A BIOTIN DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF 审中-公开
标题翻译：包括至少一种与生物素或生物素衍生物的共价键的蛋白质，其制备方法及其用途
公开(公告)号：US20100075922A1
公开(公告)日：2010-03-25
申请号：US12539237
申请日：2009-08-11
申请人： Christian VISKOV , Philippe HUBERT , Pierre MOURIER
发明人： Christian VISKOV , Philippe HUBERT , Pierre MOURIER
IPC分类号： A61K31/727 , C08B37/10 , C12P19/26 , A61P9/00
CPC分类号： C08B37/0075 , A61K31/715 , A61K31/727
摘要： The invention relates to biotinylated heparins comprising constituent polysaccharides having at their reducing ends at least one covalent bond with biotin or a biotin derivative, and also to the process for preparing them, to pharmaceutical compositions containing them and to their therapeutic use. The biotinylated polysaccharides are of the formula (I) with the variables as defined herein.
摘要翻译：本发明涉及生物素化肝素，其包含在其还原端与生物素或生物素衍生物具有至少一个共价键的组成多糖，以及其制备方法，含有它们的药物组合物及其治疗用途。生物素化的多糖具有式（I），其变量如本文所定义。

4. 发明申请

US20050164983A1 Carboxyl-reduced derivatives of dermatan sulfate, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them 审中-公开
标题翻译：硫酸皮肤素的羧基还原衍生物，其制备方法，作为药物的用途以及含有它们的药物组合物
公开(公告)号：US20050164983A1
公开(公告)日：2005-07-28
申请号：US11016501
申请日：2004-12-17
申请人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
发明人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
IPC分类号： A61K31/737
CPC分类号： C08B37/0069
摘要： The present invention relates to the carboxyl-reduced derivatives of dermatan sulfate of formula (I): in which R1, R2, R3 or R4 represents H or SO3M, n is an integer of between 0 and 150, M is an alkali metal, isolated or as mixtures, to the diastereoisomers thereof, to the process for the preparation thereof, to the uses thereof as a medicinal product and to the pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的硫酸皮肤素的羧基还原衍生物：其中R 1，R 2，R 3，或R 4代表H或SO 3 M，n为0至150的整数，M为与其非对映异构体分离或作为混合物的碱金属，其制备方法，其作为药用产品的用途和含有它们的药物组合物。

5. 发明申请

US20110071807A1 ANALYSING SPECTRAL DATA FOR THE SELECTION OF A CALIBRATION MODEL 有权
标题翻译：分析用于选择校准模型的光谱数据
公开(公告)号：US20110071807A1
公开(公告)日：2011-03-24
申请号：US12736929
申请日：2009-05-06
申请人： Philippe Hubert , Eric Ziemons , François Moonen
发明人： Philippe Hubert , Eric Ziemons , François Moonen
IPC分类号： G06F17/10
CPC分类号： G01N21/274 , G01N21/3554 , G01N21/359 , G01N2201/129
摘要： The invention relates to a method of analyzing spectral data for the selection of a calibration model, relating spectra of a substance to a physical or chemical parameter of the substance, over a predetermined range of the physical or chemical parameter, comprising the steps: a) capturing spectral data of the substance with respective values of the physical or chemical parameter over the predetermined range, b) creating a plurality of calibration models using the captured spectral data in dependence upon the values of the physical or chemical parameter based on the calibration data using statistical resampling methods, c) calculating tolerance intervals of the results at each reference level for each calibration model, and d) displaying the tolerance intervals at each reference level over the predetermined range for each calibration model. In this way, a possibility for analyzing spectra data is provided which is useful in spectroscopic applications for automated calibration model selection and makes analytical interpretation and evaluation easier and more accurate.
摘要翻译：本发明涉及一种分析用于选择校准模型的光谱数据的方法，所述校准模型在物理或化学参数的预定范围内将物质的光谱与物质的物理或化学参数相关联，包括以下步骤：a）以预定范围的物理或化学参数的相应值捕获物质的光谱数据; b）使用所捕获的光谱数据，根据基于校准数据的物理或化学参数的值，使用所捕获的光谱数据创建多个校准模型，所述校准模型使用统计重采样方法，c）计算每个校准模型的每个参考水平处的结果的容差间隔，以及d）在每个校准模型的预定范围上显示每个参考水平的公差间隔。以这种方式，提供了分析光谱数据的可能性，其在用于自动校准模型选择的光谱应用中是有用的，并且使分析解释和评估更容易和更准确。

6. 发明授权

US4960152A Device for compensating by supplying a measured amount of fluid and its application for replenishing a hydraulic circuit 失效
标题翻译：通过供应测量量的液体进行补偿的装置及其补充液压回路的应用
公开(公告)号：US4960152A
公开(公告)日：1990-10-02
申请号：US348529
申请日：1989-05-08
申请人： Philippe Hubert , Eric Martin
发明人： Philippe Hubert , Eric Martin
IPC分类号： G01F17/00 , B67D7/36 , F04B49/10 , F16N19/00 , G01F13/00
CPC分类号： B67D7/36 , F16N19/006 , G01F13/00 , Y10T137/7339 , Y10T137/8359
摘要： The device includes a main receptacle (1) having an overflow pipe (2) and a secondary receptacle (9) mounted so as to be freely movable in the vertical direction inside the main receptacle (1). The inner space of the secondary receptacle (9) communicates with a drainage pipe (8) for fluid lost by the hydraulic installation. The secondary receptacle (9) floats in the fluid contained in the main receptacle (1). The immersion level of the secondary receptacle (9) increases, depending on the amount of lost fluid received by the secondary receptacle (9), and the supply of fluid from the main receptacle (1) is caused by the immersion of the secondary receptacle (9).
摘要翻译：该装置包括具有溢流管（2）的主容器（1）和安装成可在主容器（1）内沿垂直方向自由移动的次级容器（9）。辅助容器（9）的内部空间与用于由液压装置流体损失的排水管（8）连通。副容器（9）漂浮在容纳在主容器（1）中的流体中。次级容器（9）的浸入水平根据次级容器（9）接收的流体损失量而增加，并且来自主容器（1）的流体的供应是由次级容器（ 9）。

7. 发明授权

US4394725A Apparatus and method for transferring information units between processes in a multiprocessing system 失效
标题翻译：用于在多处理系统中的处理之间传送信息单元的装置和方法
公开(公告)号：US4394725A
公开(公告)日：1983-07-19
申请号：US966371
申请日：1978-12-04
申请人： Jacques Bienvenu , Patrick Dufond , Claude Carre , Duc L. Tuong , Henri Verdier , Philippe-Hubert deRivet , John J. Bradley , Benjamin S. Franklin
发明人： Jacques Bienvenu , Patrick Dufond , Claude Carre , Duc L. Tuong , Henri Verdier , Philippe-Hubert deRivet , John J. Bradley , Benjamin S. Franklin
IPC分类号： G06F9/46 , G06F9/00
CPC分类号： G06F9/52
摘要： A method of and apparatus for executing a family of instructions provides synchronization of processes in a multiprocessing system. Representations of processes awaiting data (information units) such as the completion of an asynchronous operation or the availability of a resource are stored in a memory in a first queue and representations of information units available to processes are stored in memory in a second queue. Transfer of information units between processes is controlled by data elements known as "semaphores" stored in the memory. Each semaphore contains a field having a numerical value identifying which of the two different kinds of queues is present. When a P instruction is executed by a process indicating that the process requires data in order to continue operating or a V instruction is executed indicating that an information unit is available for transfer to another process, a semaphore is addresses and its field tested to determine whether processes or information units are available to enable the information transfer between processes to be effected. Once the information transfer is completed, the field of the addressed semaphore is up-dated.
摘要翻译：用于执行指令族的方法和装置提供多处理系统中的进程的同步。等待数据（信息单元）的处理（诸如异步操作的完成或资源的可用性）的表示被存储在第一队列中的存储器中，并且可用于处理的信息单元的表示被存储在第二队列中的存储器中。在进程之间传送信息单元由存储在存储器中的被称为“信号量”的数据元素控制。每个信号量包含具有数值的字段，其识别两种不同类型的队列中存在哪一种。当通过指示该过程需要数据以继续操作的指令执行P指令或执行表示信息单元可用于传送到另一进程的V指令时，信号量是地址，并且其字段被测试以确定是否流程或信息单元可用于实现进程之间的信息传递。一旦信息传递完成，寻址的信号量的字段就被更新。

8. 发明授权

US4369494A Apparatus and method for providing synchronization between processes and events occurring at different times in a data processing system 失效
标题翻译：用于在数据处理系统中在不同时间发生的进程和事件之间提供同步的装置和方法
公开(公告)号：US4369494A
公开(公告)日：1983-01-18
申请号：US959096
申请日：1978-11-09
申请人： Jacques Bienvenu , Claude Carre , Patrick Dufond , Duc L. Tuong , Philippe-Hubert deRivet , Henri Verdier , John J. Bradley , Benjamin S. Franklin
发明人： Jacques Bienvenu , Claude Carre , Patrick Dufond , Duc L. Tuong , Philippe-Hubert deRivet , Henri Verdier , John J. Bradley , Benjamin S. Franklin
IPC分类号： G06F9/46 , G06F9/00
CPC分类号： G06F9/52
摘要： An information structure, or semaphore, serves as a signalling mechanism in process synchronization to connect a process and a non-simultaneously occurring event or resource. The semaphore is a data structure which stores representations of processes awaiting particular events or alternatively stores representations of events awaiting processes. Semaphore data structures are developed in two storage areas. First and second groups of process links are stored in the first storage area to establish, respectively, a first queue of processes ready to operate and a second queue, associated with the semaphore structure, of processes awaiting occurrences of a first particular event prior to being ready to operate. In the second storage area are stored first and second groups of message links to establish respectively a first queue, associated with a semaphore structure, representing second particular events and a second queue of unused links. A signal is generated in response to operation of a first process to denote the occurrence of a first event. In response to the signal, the first event is associated with a process represented by a process link in the second queue of process links when the first event is the first particular event. When no queue has a process link identifying a process awaiting the occurrence of the first event, a representation of the first event occurrence is stored in a message link of the second queue of message links to be transferred to the first queue of message links. Process and event occurrence representations are thus transferred among the process and event queues during synchronization that takes place between the processes and events.
摘要翻译：信息结构或信号量用作过程同步中的信号机制，以连接过程和非同时发生的事件或资源。信号量是存储等待特定事件的进程的表示的数据结构，或者存储等待进程的事件的表示。信号量数据结构在两个存储区域中开发。第一和第二组进程链接被存储在第一存储区域中，以分别建立与准备操作的进程的第一队列和与信号量结构相关联的第二队列等待在第一特定事件发生之前的进程准备操作。在第二存储区域中存储第一和第二组消息链路，以分别建立与表示第二特定事件的信号量结构相关联的第一队列和未使用链路的第二队列。响应于第一处理的操作来生成信号以表示第一事件的发生。响应于该信号，当第一事件是第一特定事件时，第一事件与由进程链接的第二队列中的进程链接表示的进程相关联。当没有队列具有标识处理等待第一事件发生的进程链接时，第一事件发生的表示被存储在消息链路的第二队列的消息链路中，以被传送到消息链路的第一队列。因此，进程和事件发生表示因此在进程和事件之间发生的同步期间在进程和事件队列之间传送。

9. 发明申请

US20050187187A1 Carboxyl-reduced derivatives of chondroitin sulfate, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them 审中-公开
标题翻译：硫酸软骨素的羧基还原的衍生物，其制备，其作为药用产品的用途和含有它们的药物组合物
公开(公告)号：US20050187187A1
公开(公告)日：2005-08-25
申请号：US11016175
申请日：2004-12-17
申请人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
发明人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
IPC分类号： A61K31/737 , C08B37/00
CPC分类号： C08B37/0069
摘要： The present invention relates to the carboxyl-reduced and chemoselectively O-sulfated derivatives of chondroitin sulfate of formula (I): in which R1, R2, R3 and R4 are H or SO3M, n is an integer of between 0 and 200, M is an alkali metal, isolated or as mixtures, to the diastereoisomers thereof, to the process for the preparation thereof, to the uses thereof as a medicinal product and to the pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的硫酸软骨素的羧基还原和化学选择性O-硫酸化衍生物：其中R 1，R 2，R 2， 3和R 4是H或SO 3 M，n是0和200之间的整数，M是碱金属，分离的或作为混合物，其非对映异构体，其制备方法，其作为药用产品的用途和含有它们的药物组合物。

10. 发明授权

US06603005B2 Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them 失效
标题翻译：杂环基烷基哌啶衍生物，它们的制备方法和含有它们的组合物
公开(公告)号：US06603005B2
公开(公告)日：2003-08-05
申请号：US09987386
申请日：2001-11-14
申请人： Eric Baque , Jean-Christophe Carry , Youssef El-Ahmad , Michel Evers , Philippe Hubert , Jean-Luc Malleron , Serge Mignani , Guy Pantel , Michel Tabart , Fabrice Viviani
发明人： Eric Baque , Jean-Christophe Carry , Youssef El-Ahmad , Michel Evers , Philippe Hubert , Jean-Luc Malleron , Serge Mignani , Guy Pantel , Michel Tabart , Fabrice Viviani
IPC分类号： C07D47102
CPC分类号： C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14
摘要： Heterocyclylalkylpiperidine derivatives of general formula (I) in their enantiomeric or diastereoisomeric forms or mixtures of these forms, and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as any salt thereof.
摘要翻译：通式（I）的杂环基烷基哌啶衍生物在它们的对映异构体或非对映异构体形式或这些形式的混合物中，和/或在适当时以其顺式或反式或其混合物以及其任何盐。

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